{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T03:55:52Z","timestamp":1792036552012,"version":"4.4.0"},"reference-count":65,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,15]],"date-time":"2024-06-15T00:00:00Z","timestamp":1718409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LR21H300002"],"award-info":[{"award-number":["LR21H300002"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172458"],"award-info":[{"award-number":["82172458"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371589"],"award-info":[{"award-number":["82371589"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32000992"],"award-info":[{"award-number":["32000992"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073779"],"award-info":[{"award-number":["82073779"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2024,11]]},"DOI":"10.1016\/j.apsb.2024.06.009","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T07:27:53Z","timestamp":1718868473000},"page":"5008-5025","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Combination of anti-inflammatory therapy and RNA interference by light-inducible hybrid nanomedicine for osteoarthritis treatment"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2456-3014","authenticated-orcid":false,"given":"Li","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2653-6968","authenticated-orcid":false,"given":"Fu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuo","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chongzhi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1852-1387","authenticated-orcid":false,"given":"Qi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2063-0419","authenticated-orcid":false,"given":"Peihua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2571-7721","authenticated-orcid":false,"given":"Yuan","family":"Ping","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2024.06.009_bib1","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1016\/S0140-6736(19)30417-9","article-title":"Osteoarthritis","volume":"393","author":"Hunter","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2024.06.009_bib2","article-title":"Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies","volume":"29\u201330","author":"Cui","year":"2020","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.apsb.2024.06.009_bib3","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nrrheum.2017.50","article-title":"The role of metabolism in the pathogenesis of osteoarthritis","volume":"13","author":"Mobasheri","year":"2017","journal-title":"Nat Rev Rheumatol"},{"key":"10.1016\/j.apsb.2024.06.009_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121870","article-title":"Locally delivered modified citrus pectin \u2014 a galectin-3 inhibitor shows expected anti-inflammatory and unexpected regeneration-promoting effects on repair of articular cartilage defect","volume":"291","author":"Zhang","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2024.06.009_bib5","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1016\/j.joca.2016.07.017","article-title":"Disease-modifying treatments for osteoarthritis (DMOADs) of the knee and hip: lessons learned from failures and opportunities for the future","volume":"24","author":"Karsdal","year":"2016","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.apsb.2024.06.009_bib6","doi-asserted-by":"crossref","DOI":"10.1038\/boneres.2016.44","article-title":"Osteoarthritis: toward a comprehensive understanding of pathological mechanism","volume":"5","author":"Chen","year":"2017","journal-title":"Bone Res"},{"key":"10.1016\/j.apsb.2024.06.009_bib7","doi-asserted-by":"crossref","first-page":"R380","DOI":"10.1186\/ar1499","article-title":"Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function","volume":"7","author":"Yudoh","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.apsb.2024.06.009_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101249","article-title":"The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis","volume":"66","author":"Zheng","year":"2021","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.apsb.2024.06.009_bib9","article-title":"Targeting endogenous hydrogen peroxide at bone defects promotes bone repair","volume":"32","author":"Li","year":"2022","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2024.06.009_bib10","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2018.09.025","article-title":"Redox and NF-\u03baB signaling in osteoarthritis","volume":"132","author":"Lepetsos","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.apsb.2024.06.009_bib11","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/1759720X09359104","article-title":"Effects of diacerein at the molecular level in the osteoarthritis disease process","volume":"2","author":"Martel-Pelletier","year":"2010","journal-title":"Ther Adv Musculoskelet Dis"},{"key":"10.1016\/j.apsb.2024.06.009_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110594","article-title":"Diacerein: recent insight into pharmacological activities and molecular pathways","volume":"131","author":"Almezgagi","year":"2020","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.apsb.2024.06.009_bib13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1089\/ars.2021.0219","article-title":"Reversal of epigenetic peroxisome proliferator-activated receptor-\u03b3 suppression by diacerein alleviates oxidative stress and osteoarthritis in mice","volume":"37","author":"Chen","year":"2022","journal-title":"Antioxid Redox Sign"},{"key":"10.1016\/j.apsb.2024.06.009_bib14","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s40266-016-0347-4","article-title":"Diacerein: benefits, risks and place in the management of osteoarthritis. An opinion-based report from the ESCEO","volume":"33","author":"Pavelka","year":"2016","journal-title":"Drugs Aging"},{"key":"10.1016\/j.apsb.2024.06.009_bib15","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1166\/jbn.2013.1580","article-title":"Development of lipid nanoparticles of diacerein, an antiosteoarthritic drug for enhancement in bioavailability and reduction in its side effects","volume":"9","author":"Jain","year":"2013","journal-title":"J Biomed Nanotechnol"},{"key":"10.1016\/j.apsb.2024.06.009_bib16","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1016\/j.drudis.2018.05.023","article-title":"Recent advances in intra-articular drug delivery systems for osteoarthritis therapy","volume":"23","author":"Maudens","year":"2018","journal-title":"Drug Discov Today"},{"key":"10.1016\/j.apsb.2024.06.009_bib17","doi-asserted-by":"crossref","first-page":"4127","DOI":"10.1016\/j.apsb.2022.11.021","article-title":"Advancing drug delivery to articular cartilage: from single to multiple strategies","volume":"13","author":"Zhao","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.06.009_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119249","article-title":"A comparative pilot study of oral diacerein and locally treated diacerein-loaded nanoparticles in a model of osteoarthritis","volume":"581","author":"Jung","year":"2020","journal-title":"Int J Pharmacol"},{"key":"10.1016\/j.apsb.2024.06.009_bib19","article-title":"Pain in osteoarthritis from a symptom to a disease","author":"Serge","year":"2023","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"10.1016\/j.apsb.2024.06.009_bib20","doi-asserted-by":"crossref","first-page":"e49","DOI":"10.1093\/nar\/gnh044","article-title":"siRNA relieves chronic neuropathic pain","volume":"32","author":"Dorn","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.apsb.2024.06.009_bib21","doi-asserted-by":"crossref","first-page":"120187","DOI":"10.1016\/j.lfs.2021.120187","article-title":"Unlocking the potential of TRPV1 based siRNA therapeutics for the treatment of chemotherapy-induced neuropathic pain","volume":"288","author":"Akhilesh","year":"2022","journal-title":"Life Sci"},{"key":"10.1016\/j.apsb.2024.06.009_bib22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1146\/annurev-neuro-072116-031121","article-title":"Nerve growth factor and pain mechanisms","volume":"40","author":"Denk","year":"2017","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.apsb.2024.06.009_bib23","doi-asserted-by":"crossref","first-page":"2210","DOI":"10.1097\/j.pain.0000000000001625","article-title":"Nerve growth factor antibody for the treatment of osteoarthritis pain and chronic low-back pain: mechanism of action in the context of efficacy and safety","volume":"160","author":"Schmelz","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.apsb.2024.06.009_bib24","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1093\/rheumatology\/41.12.1413","article-title":"Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes","volume":"41","author":"Iannone","year":"2002","journal-title":"Rheumatology"},{"key":"10.1016\/j.apsb.2024.06.009_bib25","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/art.39523","article-title":"Nociceptive sensitizers are regulated in damaged joint tissues, including articular cartilage, when osteoarthritic mice display pain behavior","volume":"68","author":"Driscoll","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.apsb.2024.06.009_bib26","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.actbio.2014.09.020","article-title":"Degradable polymer-coated gold nanoparticles for co-delivery of DNA and siRNA","volume":"11","author":"Bishop","year":"2015","journal-title":"Acta Biomater"},{"key":"10.1016\/j.apsb.2024.06.009_bib27","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ijpharm.2017.01.022","article-title":"Gold nanostar-polymer hybrids for siRNA delivery: polymer design towards colloidal stability and in\u00a0vitro studies on breast cancer cells","volume":"519","author":"Sardo","year":"2017","journal-title":"Int J Pharmacol"},{"key":"10.1016\/j.apsb.2024.06.009_bib28","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1002\/adma.201402522","article-title":"A smart \"sense-act-treat\" system: combining a ratiometric pH sensor with a near infrared therapeutic gold nanocage","volume":"26","author":"Shi","year":"2014","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2024.06.009_bib29","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jconrel.2020.04.029","article-title":"Smart gold nanocages for mild heat-triggered drug release and breaking chemoresistance","volume":"323","author":"He","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2024.06.009_bib30","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.2147\/IJN.S161031","article-title":"Recent advances in functional nanostructures as cancer photothermal therapy","volume":"13","author":"Hussein","year":"2018","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.apsb.2024.06.009_bib31","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.jconrel.2020.08.055","article-title":"Nanomaterials-based photothermal therapy and its potentials in antibacterial treatment","volume":"328","author":"Chen","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2024.06.009_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202001806","article-title":"Noble metal nanomaterials for NIR-triggered photothermal therapy in cancer","volume":"10","author":"Lv","year":"2021","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.apsb.2024.06.009_bib33","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/j.apsb.2018.05.011","article-title":"Gold nanorods together with HSP inhibitor-VER-155008 micelles for colon cancer mild-temperature photothermal therapy","volume":"8","author":"Tang","year":"2018","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.06.009_bib34","article-title":"Gold nanoparticle based photothermal therapy: development and application for effective cancer treatment","volume":"22","author":"Yang","year":"2019","journal-title":"Sustain Mater Techno"},{"key":"10.1016\/j.apsb.2024.06.009_bib35","doi-asserted-by":"crossref","first-page":"146","DOI":"10.31635\/ccschem.020.201900084","article-title":"Natural polyphenol inspired polycatechols for efficient siRNA delivery","volume":"2","author":"Shen","year":"2020","journal-title":"CCS Chem"},{"key":"10.1016\/j.apsb.2024.06.009_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202101646","article-title":"Polycatechol mediated small interfering RNA delivery for the treatment of ulcerative colitis","volume":"31","author":"Fan","year":"2021","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2024.06.009_bib37","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1021\/acs.bioconjchem.9b00004","article-title":"Shape matters: gold nanoparticle shape impacts the biological activity of siRNA delivery","volume":"30","author":"Morgan","year":"2019","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.apsb.2024.06.009_bib38","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1021\/ar200061q","article-title":"Gold nanocages: from synthesis to theranostic applications","volume":"44","author":"Xia","year":"2011","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.apsb.2024.06.009_bib39","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.2217\/nnm-2016-0109","article-title":"Putting gold nanocages to work for optical imaging, controlled release and cancer theranostics","volume":"11","author":"Pang","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.apsb.2024.06.009_bib40","article-title":"Non-invasive thermal therapy for tissue engineering and regenerative medicine","volume":"18","author":"Li","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.apsb.2024.06.009_bib41","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202212730","article-title":"Localization of lesion cells and targeted mitochondria via embedded hydrogel microsphere using\u00a0heat transfer microneedles","volume":"33","author":"Lin","year":"2023","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2024.06.009_bib42","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s40820-021-00670-y","article-title":"Nanoparticle-cartilage interaction: pathology-based intra-articular drug delivery for osteoarthritis therapy","volume":"13","author":"Li","year":"2021","journal-title":"Nano-micro Lett"},{"key":"10.1016\/j.apsb.2024.06.009_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202107678","article-title":"Charge-guided micro\/nano-hydrogel microsphere for penetrating cartilage matrix","volume":"31","author":"Lin","year":"2021","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2024.06.009_bib44","article-title":"Inflammation-regulated auto aggregated hydrogel microspheres via anchoring cartilage deep matrix for genes delivery","volume":"33","author":"Chen","year":"2023","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2024.06.009_bib45","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1080\/17425247.2020.1796628","article-title":"Poly(beta-amino ester)s as gene delivery vehicles: challenges and opportunities","volume":"17","author":"Karlsson","year":"2020","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.apsb.2024.06.009_bib46","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj0624","article-title":"Genome-editing prodrug: targeted delivery and conditional stabilization of CRISPR-Cas9 for precision therapy of inflammatory disease","volume":"7","author":"Yan","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.apsb.2024.06.009_bib47","doi-asserted-by":"crossref","DOI":"10.1002\/adma.201703702","article-title":"A eutectic mixture of natural fatty acids can serve as the gating material for near-infrared-triggered drug release","volume":"29","author":"Zhu","year":"2017","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2024.06.009_bib48","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.nano.2016.10.001","article-title":"Poly-beta-amino-esters nano-vehicles based drug delivery system for cartilage","volume":"13","author":"Perni","year":"2017","journal-title":"Nanomed Nanotechnol Biol Med"},{"key":"10.1016\/j.apsb.2024.06.009_bib49","doi-asserted-by":"crossref","first-page":"5096","DOI":"10.1039\/C9TB02778E","article-title":"Optimisation and feature selection of poly-beta-amino-ester as a drug delivery system for cartilage","volume":"8","author":"Perni","year":"2020","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.apsb.2024.06.009_bib50","doi-asserted-by":"crossref","first-page":"5837","DOI":"10.1039\/D1TB01024G","article-title":"Poly beta amino ester coated emulsions of NSAIDs for cartilage treatment","volume":"9","author":"Saeedi","year":"2021","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.apsb.2024.06.009_bib51","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1021\/acs.chemmater.0c02571","article-title":"Delivery of CRISPR\/Cas9 plasmids by cationic gold nanorods: impact of the aspect ratio on genome editing and treatment of hepatic fibrosis","volume":"33","author":"Chen","year":"2021","journal-title":"Chem Mater"},{"key":"10.1016\/j.apsb.2024.06.009_bib52","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1073\/pnas.1912220117","article-title":"Near-infrared optogenetic engineering of photothermal nanoCRISPR for programmable genome editing","volume":"117","author":"Chen","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.apsb.2024.06.009_bib53","article-title":"Reprogramming the tumor microenvironment through second-near-infrared-window photothermal genome editing of PD-L1 mediated by supramolecular gold nanorods for enhanced cancer immunotherapy","volume":"33","author":"Tang","year":"2021","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2024.06.009_bib54","doi-asserted-by":"crossref","first-page":"3684","DOI":"10.1002\/adfm.201001329","article-title":"Gold nanocages: a novel class of multifunctional nanomaterials for theranostic applications","volume":"20","author":"Chen","year":"2010","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2024.06.009_bib55","article-title":"Trimanganese tetroxide nanozyme protects cartilage against degeneration by reducing oxidative stress in osteoarthritis","volume":"10","author":"Wang","year":"2023","journal-title":"Adv Sci"},{"key":"10.1016\/j.apsb.2024.06.009_bib56","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthritis Cartilage"},{"issue":"Suppl 3","key":"10.1016\/j.apsb.2024.06.009_bib57","doi-asserted-by":"crossref","first-page":"S17","DOI":"10.1016\/j.joca.2010.05.025","article-title":"The OARSI histopathology initiative\u2014recommendations for histological assessments of osteoarthritis in the mouse","volume":"18","author":"Glasson","year":"2010","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.apsb.2024.06.009_bib58","doi-asserted-by":"crossref","first-page":"R16","DOI":"10.1186\/ar4443","article-title":"Induction of nerve growth factor expression and release by mechanical and inflammatory stimuli in chondrocytes: possible involvement in osteoarthritis pain","volume":"16","author":"Pecchi","year":"2014","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.apsb.2024.06.009_bib59","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1136\/annrheumdis-2014-206295","article-title":"Oxidative changes and signalling pathways are pivotal in initiating age-related changes in articular cartilage","volume":"75","author":"Hui","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.apsb.2024.06.009_bib60","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.jbspin.2007.02.002","article-title":"Reactive oxygen species and superoxide dismutases: role in joint diseases","volume":"74","author":"Afonso","year":"2007","journal-title":"Jt Bone Spine"},{"key":"10.1016\/j.apsb.2024.06.009_bib61","doi-asserted-by":"crossref","first-page":"26035","DOI":"10.3390\/ijms161125943","article-title":"Chondrocyte apoptosis in the pathogenesis of osteoarthritis","volume":"16","author":"Hwang","year":"2015","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2024.06.009_bib62","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1756-9966-30-66","article-title":"Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c","volume":"30","author":"Ling","year":"2011","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.apsb.2024.06.009_bib63","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.3390\/ijms22041742","article-title":"Overview of MMP-13 as a Promising target for the treatment of osteoarthritis","volume":"22","author":"Hu","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2024.06.009_bib64","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.joca.2021.09.012","article-title":"Inhibition of ADAMTS-5: the right target for osteoarthritis?.","volume":"30","author":"Latourte","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.apsb.2024.06.009_bib65","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1002\/jcb.23298","article-title":"ADAMTS-4 and ADAMTS-5: key enzymes in osteoarthritis","volume":"112","author":"Verma","year":"2011","journal-title":"J Cel Biochem"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383524002405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383524002405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T20:13:58Z","timestamp":1732306438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383524002405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":65,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["S2211383524002405"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2024.06.009","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2024,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combination of anti-inflammatory therapy and RNA interference by light-inducible hybrid nanomedicine for osteoarthritis treatment","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2024.06.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}