{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:44:58Z","timestamp":1790999098925,"version":"4.1.0"},"reference-count":51,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.apsb.2024.11.003","type":"journal-article","created":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T18:47:59Z","timestamp":1730832479000},"page":"296-313","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["N6-Methyladenosine modification of circDcbld2 in Kupffer cells promotes hepatic fibrosis via targeting miR-144-3p\/Et-1 axis"],"prefix":"10.1016","volume":"15","author":[{"given":"Sai","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijiao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoguo","family":"Suo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minglu","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoming","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2024.11.003_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1186\/s12916-014-0145-y","article-title":"Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis","volume":"12","author":"Mokdad","year":"2014","journal-title":"BMC Med"},{"key":"10.1016\/j.apsb.2024.11.003_bib2","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1016\/j.apsb.2021.12.007","article-title":"Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1","volume":"12","author":"Luo","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.11.003_bib3","doi-asserted-by":"crossref","first-page":"4222","DOI":"10.3748\/wjg.v25.i30.4222","article-title":"Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-beta\/Smad signaling pathway","volume":"25","author":"Zou","year":"2019","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.apsb.2024.11.003_bib4","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1016\/S0140-6736(14)60121-5","article-title":"Liver cirrhosis","volume":"383","author":"Tsochatzis","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2024.11.003_bib5","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.apsb.2023.10.023","article-title":"Epigenetic modification in liver fibrosis: promising therapeutic direction with significant challenges ahead","volume":"14","author":"Liu","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.11.003_bib6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jcmgh.2017.11.016","article-title":"Experimental nonalcoholic steatohepatitis and liver fibrosis are ameliorated by pharmacologic activation of Nrf2 (NF-E2 p45-related factor 2)","volume":"5","author":"Sharma","year":"2018","journal-title":"Cell Mol Gastroenterol Hepatol"},{"key":"10.1016\/j.apsb.2024.11.003_bib7","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.jhep.2017.05.022","article-title":"Cytotherapy with M1-polarized macrophages ameliorates liver fibrosis by modulating immune microenvironment in mice","volume":"67","author":"Ma","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2024.11.003_bib8","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1002\/hep.32640","article-title":"Macrophage-specific FGF12 promotes liver fibrosis progression in mice","volume":"77","author":"Li","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2024.11.003_bib9","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1038\/nri.2017.11","article-title":"Liver macrophages in tissue homeostasis and disease","volume":"17","author":"Krenkel","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.apsb.2024.11.003_bib10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41575-020-00372-7","article-title":"Molecular and cellular mechanisms of liver fibrosis and its regression","volume":"18","author":"Kisseleva","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.apsb.2024.11.003_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102274","article-title":"Mulberrin confers protection against hepatic fibrosis by Trim31\/Nrf2 signaling","volume":"51","author":"Ge","year":"2022","journal-title":"Redox Biol"},{"key":"10.1016\/j.apsb.2024.11.003_bib12","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1053\/j.gastro.2012.05.049","article-title":"Interleukin-17 signaling in inflammatory, Kupffer cells, and hepatic stellate cells exacerbates liver fibrosis in mice","volume":"143","author":"Meng","year":"2012","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2024.11.003_bib13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1097\/HEP.0000000000000287","article-title":"Regulatory role and translational potential of CCL11 in liver fibrosis","volume":"78","author":"Kong","year":"2023","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2024.11.003_bib14","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1002\/hep.28948","article-title":"The origin of fibrogenic myofibroblasts in fibrotic liver","volume":"65","author":"Kisseleva","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2024.11.003_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1186\/s12916-021-02085-3","article-title":"HBeAg mediates inflammatory functions of macrophages by TLR2 contributing to hepatic fibrosis","volume":"19","author":"Xie","year":"2021","journal-title":"BMC Med"},{"key":"10.1016\/j.apsb.2024.11.003_bib16","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1186\/s12943-019-1109-9","article-title":"Functions of N6-methyladenosine and its role in cancer","volume":"18","author":"He","year":"2019","journal-title":"Mol Cancer"},{"key":"10.1016\/j.apsb.2024.11.003_bib17","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1016\/j.apsb.2024.01.011","article-title":"Engagement of N6-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2","volume":"14","author":"Bai","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.11.003_bib18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nbt.2890","article-title":"Detecting and characterizing circular RNAs","volume":"32","author":"Jeck","year":"2014","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.apsb.2024.11.003_bib19","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.7150\/thno.51342","article-title":"N6-Methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization","volume":"11","author":"Chen","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.apsb.2024.11.003_bib20","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1158\/0008-5472.CAN-21-1628","article-title":"Activation of YAP1 by N-6-methyladenosine-modified circCPSF6 drives malignancy in hepatocellular carcinoma","volume":"82","author":"Chen","year":"2022","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2024.11.003_bib21","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.molcel.2017.02.021","article-title":"Translation of circRNAs","volume":"66","author":"Pamudurti","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.apsb.2024.11.003_bib22","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/nature11993","article-title":"Natural RNA circles function as efficient microRNA sponges","volume":"495","author":"Hansen","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2024.11.003_bib23","doi-asserted-by":"crossref","first-page":"2846","DOI":"10.1093\/nar\/gkw027","article-title":"Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2","volume":"44","author":"Du","year":"2016","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.apsb.2024.11.003_bib24","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1093\/jnci\/djx166","article-title":"Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis","volume":"110","author":"Yang","year":"2018","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.apsb.2024.11.003_bib25","doi-asserted-by":"crossref","first-page":"6502","DOI":"10.1038\/s41467-022-34287-5","article-title":"Circular RNA circBNC2 inhibits epithelial cell G2\u2013M arrest to prevent fibrotic maladaptive repair","volume":"13","author":"Wang","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2024.11.003_bib26","doi-asserted-by":"crossref","first-page":"5178","DOI":"10.1096\/fj.201902307RRR","article-title":"Exosomal miR-103-3p from LPS-activated THP-1 macrophage contributes to the activation of hepatic stellate cells","volume":"34","author":"Chen","year":"2020","journal-title":"FASEB J"},{"key":"10.1016\/j.apsb.2024.11.003_bib27","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1002\/hep.31068","article-title":"Circular RNA sequencing identifies circASAP1 as a key regulator in hepatocellular carcinoma metastasis","volume":"72","author":"Hu","year":"2020","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2024.11.003_bib28","doi-asserted-by":"crossref","first-page":"4851","DOI":"10.7150\/thno.42423","article-title":"Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p\/FBXW7 axis","volume":"10","author":"Chen","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.apsb.2024.11.003_bib29","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.omtn.2021.01.007","article-title":"Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p\/Smad7 axis","volume":"23","author":"Bu","year":"2021","journal-title":"Mol Ther-Nucl Acids"},{"key":"10.1016\/j.apsb.2024.11.003_bib30","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.toxlet.2019.07.021","article-title":"Circ_1639 induces cells inflammation responses by sponging miR-122 and regulating TNFRSF13C expression in alcoholic liver disease","volume":"314","author":"Lu","year":"2019","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.apsb.2024.11.003_bib31","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1002\/hep.29153","article-title":"Hepatic mitochondrial DNA\/Toll-like receptor 9\/MicroRNA-223 forms a negative feedback loop to limit neutrophil overactivation and acetaminophen hepatotoxicity in mice","volume":"66","author":"He","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2024.11.003_bib32","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00011-016-1020-4","article-title":"miR-200a controls hepatic stellate cell activation and fibrosis via SIRT1\/Notch1 signal pathway","volume":"66","author":"Yang","year":"2017","journal-title":"Inflamm Res"},{"key":"10.1016\/j.apsb.2024.11.003_bib33","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202002738R","article-title":"Circular RNA circUbe2k promotes hepatic fibrosis via sponging miR-149-5p\/TGF-beta2 axis","volume":"35","author":"Zhu","year":"2021","journal-title":"FASEB J"},{"key":"10.1016\/j.apsb.2024.11.003_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.121182","article-title":"Myc-mediated circular RNA circMcph1\/miR-370-3p\/Irak2 axis is a progressive regulator in hepatic fibrosis","volume":"312","author":"Xu","year":"2023","journal-title":"Life Sci"},{"key":"10.1016\/j.apsb.2024.11.003_bib35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.gene.2017.07.078","article-title":"Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation","volume":"629","author":"Chen","year":"2017","journal-title":"Gene"},{"key":"10.1016\/j.apsb.2024.11.003_bib36","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0016-5085(99)70461-0","article-title":"Hepatocyte apoptosis after bile duct ligation in the mouse involves Fas","volume":"117","author":"Miyoshi","year":"1999","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2024.11.003_bib37","doi-asserted-by":"crossref","first-page":"5165","DOI":"10.1111\/jcmm.13795","article-title":"Effects of FGF21-secreting adipose-derived stem cells in thioacetamide-induced hepatic fibrosis","volume":"22","author":"Kang","year":"2018","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.apsb.2024.11.003_bib38","doi-asserted-by":"crossref","first-page":"105838","DOI":"10.1016\/j.intimp.2019.105838","article-title":"Hesperetin derivative attenuates CCl4-induced hepatic fibrosis and inflammation by Gli-1-dependent mechanisms","volume":"76","author":"Chen","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.apsb.2024.11.003_bib39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.jhep.2020.02.031","article-title":"Alternatively activated macrophages promote resolution of necrosis following acute liver injury","volume":"73","author":"Starkey Lewis","year":"2020","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2024.11.003_bib40","doi-asserted-by":"crossref","first-page":"6119","DOI":"10.1038\/s41388-018-0383-0","article-title":"PSTPIP2 connects DNA methylation to macrophage polarization in CCl4-induced mouse model of hepatic fibrosis","volume":"37","author":"Yang","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.apsb.2024.11.003_bib41","doi-asserted-by":"crossref","first-page":"7405","DOI":"10.1111\/jcmm.15356","article-title":"PLK1 regulates hepatic stellate cell activation and liver fibrosis through Wnt\/beta-catenin signalling pathway","volume":"24","author":"Chen","year":"2020","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.apsb.2024.11.003_bib42","doi-asserted-by":"crossref","first-page":"4870","DOI":"10.1172\/JCI98156","article-title":"The innate immune receptor TREM-1 promotes liver injury and fibrosis","volume":"128","author":"Nguyen-Lefebvre","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.apsb.2024.11.003_bib43","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41576-019-0158-7","article-title":"The biogenesis, biology and characterization of circular RNAs","volume":"20","author":"Kristensen","year":"2019","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.apsb.2024.11.003_bib44","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abk2709","article-title":"Inhibition of METTL3 attenuates renal injury and inflammation by alleviating TAB3 m6A modifications via IGF2BP2-dependent mechanisms","volume":"14","author":"Wang","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.apsb.2024.11.003_bib45","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jgg.2013.10.002","article-title":"Methylation modifications in eukaryotic messenger RNA","volume":"41","author":"Liu","year":"2014","journal-title":"J Genet Genomics"},{"key":"10.1016\/j.apsb.2024.11.003_bib46","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gpb.2012.12.002","article-title":"N6-methyl-adenosine (m6A) in RNA: an old modification with a novel epigenetic function","volume":"11","author":"Niu","year":"2013","journal-title":"Genomics Proteomics Bioinformatics"},{"key":"10.1016\/j.apsb.2024.11.003_bib47","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1186\/s12943-020-01233-2","article-title":"Novel insights into the interplay between m(6)A modification and noncoding RNAs in cancer","volume":"19","author":"Yi","year":"2020","journal-title":"Mol Cancer"},{"key":"10.1016\/j.apsb.2024.11.003_bib48","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/s41419-021-03915-1","article-title":"Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation","volume":"12","author":"Wang","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2024.11.003_bib49","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jhep.2016.11.004","article-title":"Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression","volume":"66","author":"Ramirez","year":"2017","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2024.11.003_bib50","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12943-020-01286-3","article-title":"Circular RNA: metabolism, functions and interactions with proteins","volume":"19","author":"Zhou","year":"2020","journal-title":"Mol Cancer"},{"key":"10.1016\/j.apsb.2024.11.003_bib51","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/s41580-020-0243-y","article-title":"The expanding regulatory mechanisms and cellular functions of circular RNAs","volume":"21","author":"Chen","year":"2020","journal-title":"Nat Rev Mol Cell Biol"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383524004209?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383524004209?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T22:05:18Z","timestamp":1739916318000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383524004209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":51,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S2211383524004209"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2024.11.003","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"N6-Methyladenosine modification of circDcbld2 in Kupffer cells promotes hepatic fibrosis via targeting miR-144-3p\/Et-1 axis","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2024.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}