{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T18:12:02Z","timestamp":1794507122593,"version":"4.9.1"},"reference-count":54,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373864"],"award-info":[{"award-number":["82373864"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170472"],"award-info":[{"award-number":["82170472"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.apsb.2024.12.040","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T06:47:52Z","timestamp":1736059672000},"page":"1397-1414","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Nitazoxanide protects against heart failure with preserved ejection and metabolic syndrome induced by high-fat diet (HFD) plus L-NAME \u201ctwo-hit\u201d in mice"],"prefix":"10.1016","volume":"15","author":[{"given":"Jiahui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Congcong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangli","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenfeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9753-741X","authenticated-orcid":false,"given":"Deli","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2024.12.040_bib1","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1056\/NEJMoa2313917","article-title":"Semaglutide in patients with obesity-related heart failure and type 2 diabetes","volume":"390","author":"Kosiborod","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apsb.2024.12.040_bib2","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.freeradbiomed.2018.06.020","article-title":"Characterizations of mitochondrial uncoupling induced by chemical mitochondrial uncouplers in cardiomyocytes","volume":"124","author":"Gao","year":"2018","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.apsb.2024.12.040_bib3","doi-asserted-by":"crossref","first-page":"3145","DOI":"10.1111\/bph.13578","article-title":"Mitochondrial uncoupler carbonyl cyanide m-chlorophenylhydrazone induces vasorelaxation without involving K channel activation in smooth muscle cells of arteries","volume":"173","author":"Zhang","year":"2016","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2024.12.040_bib4","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.apsb.2018.07.010","article-title":"Mitochondrial uncoupler BAM15 inhibits artery constriction and potently activates AMPK in vascular smooth muscle cells","volume":"8","author":"Tai","year":"2018","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.12.040_bib5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.apsb.2017.06.001","article-title":"Mitochondrial uncoupler triclosan induces vasorelaxation of rat arteries","volume":"7","author":"Zhang","year":"2017","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.12.040_bib6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.phrs.2016.11.008","article-title":"Niclosamide ethanolamine inhibits artery constriction","volume":"115","author":"Li","year":"2017","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.apsb.2024.12.040_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2021.115426","article-title":"Chemical mitochondrial uncouplers share common inhibitory effect on NLRP3 inflammasome activation through inhibiting NF\u03baB nuclear translocation","volume":"414","author":"Hu","year":"2021","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1016\/j.apsb.2024.12.040_bib8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/bph.15949","article-title":"Repurposing nitazoxanide as a novel anti-atherosclerotic drug based on mitochondrial uncoupling mechanisms","volume":"180","author":"Ma","year":"2023","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2024.12.040_bib9","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1053\/j.gastro.2008.11.037","article-title":"Improved virologic response in chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon, and ribavirin","volume":"136","author":"Rossignol","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2024.12.040_bib10","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1002\/hep4.1339","article-title":"A pilot clinical trial of nitazoxanide in the treatment of chronic hepatitis B","volume":"3","author":"Rossignol","year":"2019","journal-title":"Hepatol Commun"},{"key":"10.1016\/j.apsb.2024.12.040_bib11","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.apsb.2021.09.009","article-title":"Anthelmintics nitazoxanide protects against experimental hyperlipidemia and hepatic steatosis in hamsters and mice","volume":"12","author":"Li","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.12.040_bib12","doi-asserted-by":"crossref","first-page":"3266","DOI":"10.1016\/j.apsb.2024.03.031","article-title":"The clinical antiprotozoal drug nitazoxanide and its metabolite tizoxanide extend Caenorhabditis elegans lifespan and healthspan","volume":"14","author":"Li","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.12.040_bib13","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/s41467-021-21931-9","article-title":"Xbp1s\u2013FoxO1 axis governs lipid accumulation and contractile performance in heart failure with preserved ejection fraction","volume":"12","author":"Schiattarella","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2024.12.040_bib14","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1111\/bph.16190","article-title":"Anthelmintic nitazoxanide protects against experimental pulmonary fibrosis","volume":"180","author":"Chen","year":"2023","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2024.12.040_bib15","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1111\/bph.16050","article-title":"Piezo1 channel activation stimulates ATP production through enhancing mitochondrial respiration and glycolysis in vascular endothelial cells","volume":"180","author":"Jiang","year":"2023","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2024.12.040_bib16","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/HYPERTENSIONAHA.116.07974","article-title":"Mitochondrial fission of smooth muscle cells is involved in artery constriction","volume":"68","author":"Liu","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.apsb.2024.12.040_bib17","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1007\/s00395-019-0721-6","article-title":"The different response of cardiomyocytes and cardiac fibroblasts to mitochondria inhibition and the underlying role of STAT3","volume":"114","author":"Zhao","year":"2019","journal-title":"Basic Res Cardiol"},{"key":"10.1016\/j.apsb.2024.12.040_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174614","article-title":"Anthelmintic niclosamide attenuates pressure-overload induced heart failure in mice","volume":"912","author":"Fu","year":"2021","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.apsb.2024.12.040_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2020.05.018","article-title":"Local mitochondrial ATP production regulates endothelial fatty acid uptake and transport","volume":"32","author":"Ibrahim","year":"2020","journal-title":"Cell Metab"},{"key":"10.1016\/j.apsb.2024.12.040_bib20","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1111\/bph.14153","article-title":"Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers","volume":"175","author":"Curtis","year":"2018","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.apsb.2024.12.040_bib21","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41586-019-1100-z","article-title":"Nitrosative stress drives heart failure with preserved ejection fraction","volume":"568","author":"Schiattarella","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2024.12.040_bib22","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1056\/NEJMoa2206286","article-title":"Dapagliflozin in heart failure with mildly reduced or preserved ejection fraction","volume":"387","author":"Solomon","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apsb.2024.12.040_bib23","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.1038\/s41591-021-01536-x","article-title":"The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial","volume":"27","author":"Nassif","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2024.12.040_bib24","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/ejhf.592","volume":"18","author":"Ponikowski","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.apsb.2024.12.040_bib25","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.3390\/cells11162511","article-title":"Endothelial cell dysfunction and nonalcoholic fatty liver disease (NAFLD): a concise review","volume":"11","author":"Nasiri Ansari","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.apsb.2024.12.040_bib26","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41580-022-00547-x","article-title":"New insights into activation and function of the AMPK","volume":"24","author":"Steinberg","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.apsb.2024.12.040_bib27","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1016\/j.apsb.2023.01.012","article-title":"Pathophysiology of obesity and its associated diseases","volume":"13","author":"Jin","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.12.040_bib28","article-title":"Endothelial\u2013mesenchymal transition in heart failure with a preserved ejection fraction: insights into the cardiorenal syndrome","volume":"14","author":"Valero","year":"2021","journal-title":"Circ Heart Fail"},{"key":"10.1016\/j.apsb.2024.12.040_bib29","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/ejhf.497","article-title":"Connecting heart failure with preserved ejection fraction and renal dysfunction: the role of endothelial dysfunction and inflammation","volume":"18","author":"Ter Maaten","year":"2016","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.apsb.2024.12.040_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116205","article-title":"The antiprotozoal drug nitazoxanide improves experimental liver fibrosis in mice","volume":"224","author":"Liu","year":"2024","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.apsb.2024.12.040_bib31","doi-asserted-by":"crossref","first-page":"2265","DOI":"10.1042\/CS20210127","article-title":"Lipotoxicity: a driver of heart failure with preserved ejection fraction?.","volume":"135","author":"Leggat","year":"2021","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.apsb.2024.12.040_bib32","doi-asserted-by":"crossref","first-page":"8137","DOI":"10.1038\/ncomms9137","article-title":"Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis","volume":"6","author":"Nowinski","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2024.12.040_bib33","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41467-017-02795-4","article-title":"AMPK activation counteracts cardiac hypertrophy by reducing O-GlcNAcylation","volume":"9","author":"G\u00e9linas","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2024.12.040_bib34","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1161\/CIRCULATIONAHA.121.055727","article-title":"DYRK1B\u2013STAT3 drives cardiac hypertrophy and heart failure by impairing mitochondrial bioenergetics","volume":"145","author":"Zhuang","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.apsb.2024.12.040_bib35","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1093\/eurjhf\/hfr080","article-title":"AKT signalling in the failing heart","volume":"13","author":"Chaanine","year":"2011","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.apsb.2024.12.040_bib36","doi-asserted-by":"crossref","first-page":"24194","DOI":"10.1074\/jbc.M802869200","article-title":"Resveratrol inhibits cardiac hypertrophy via AMP-activated protein kinase and Akt","volume":"283","author":"Chan","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2024.12.040_bib37","doi-asserted-by":"crossref","first-page":"H1941","DOI":"10.1152\/ajpheart.00338.2011","article-title":"Transactivated EGFR mediates \u03b11-AR-induced STAT3 activation and cardiac hypertrophy","volume":"301","author":"Li","year":"2011","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.apsb.2024.12.040_bib38","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1042\/BCJ20210144","article-title":"The insulin receptor family and protein kinase B (Akt) are activated in the heart by alkaline pH and \u03b11-adrenergic receptors","volume":"478","author":"Meijles","year":"2021","journal-title":"Biochem J"},{"key":"10.1016\/j.apsb.2024.12.040_bib39","article-title":"JAK\/STAT3 signaling in cardiac fibrosis: a promising therapeutic target","volume":"15","author":"Jiang","year":"2024","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2024.12.040_bib40","doi-asserted-by":"crossref","first-page":"4420","DOI":"10.1093\/eurheartj\/ehab389","article-title":"Heart failure with preserved ejection fraction in humans and mice: embracing clinical complexity in mouse models","volume":"42","author":"Withaar","year":"2021","journal-title":"Eur Heart J"},{"key":"10.1016\/j.apsb.2024.12.040_bib41","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1139\/cjpp-2017-0533","article-title":"Time-dependent therapeutic roles of nitazoxanide on high-fat diet\/streptozotocin-induced diabetes in rats: effects on hepatic peroxisome proliferator-activated receptor-gamma receptors","volume":"96","author":"Elaidy","year":"2018","journal-title":"Can J Physiol Pharmacol"},{"key":"10.1016\/j.apsb.2024.12.040_bib42","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.2165\/00003495-200767130-00015","article-title":"Nitazoxanide: a review of its use in the treatment of gastrointestinal infections","volume":"67","author":"Anderson","year":"2007","journal-title":"Drugs"},{"key":"10.1016\/j.apsb.2024.12.040_bib43","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1111\/j.1474-9726.2008.00407.x","article-title":"Mild mitochondrial uncoupling in mice affects energy metabolism, redox balance and longevity","volume":"7","author":"Caldeira da Silva","year":"2008","journal-title":"Aging Cell"},{"key":"10.1016\/j.apsb.2024.12.040_bib44","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1021\/acs.jmedchem.7b01182","article-title":"Small molecule mitochondrial uncouplers and their therapeutic potential","volume":"61","author":"Childress","year":"2018","journal-title":"J Med Chem"},{"key":"10.1016\/j.apsb.2024.12.040_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.molmet.2021.101178","article-title":"Therapeutic potential of mitochondrial uncouplers for the treatment of metabolic associated fatty liver disease and NASH","volume":"46","author":"Goedeke","year":"2021","journal-title":"Mol Metab"},{"key":"10.1016\/j.apsb.2024.12.040_bib46","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1042\/CS20100476","article-title":"Aging and vascular endothelial function in humans","volume":"120","author":"Seals","year":"2011","journal-title":"Clin Sci"},{"key":"10.1016\/j.apsb.2024.12.040_bib47","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1161\/01.CIR.100.11.1230","article-title":"Impairment of endothelium-dependent arterial relaxation by high-fat feeding in ApoE-deficient mice: toward normalization by human ApoA-I expression","volume":"100","author":"Deckert","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.apsb.2024.12.040_bib48","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.apsb.2016.12.009","article-title":"Arterial relaxation is coupled to inhibition of mitochondrial fission in arterial smooth muscle cells: comparison of vasorelaxant effects of verapamil and phentolamine","volume":"7","author":"Jin","year":"2017","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2024.12.040_bib49","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1161\/01.HYP.26.5.744","article-title":"L-NAME hypertension alters endothelial and smooth muscle function in rat aorta. Prevention by trandolapril and verapamil","volume":"26","author":"K\u00fcng","year":"1995","journal-title":"Hypertension"},{"key":"10.1016\/j.apsb.2024.12.040_bib50","first-page":"2013","article-title":"A novel controlled metabolic accelerator for the treatment of obesity-related heart failure with preserved ejection fraction: rationale and design of the phase 2a HuMAIN trial","volume":"26","author":"Kitzman","year":"2024","journal-title":"Eur J Heart Fail"},{"key":"10.1016\/j.apsb.2024.12.040_bib51","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s13181-011-0162-6","article-title":"2,4-Dinitrophenol (DNP): a weight loss agent with significant acute toxicity and risk of death","volume":"7","author":"Grundlingh","year":"2011","journal-title":"J Med Toxicol"},{"key":"10.1016\/j.apsb.2024.12.040_bib52","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jacbts.2021.07.010","article-title":"Relationship of nonalcoholic fatty liver disease and heart failure with preserved ejection fraction","volume":"6","author":"Salah","year":"2021","journal-title":"JACC Basic Transl Sci"},{"key":"10.1016\/j.apsb.2024.12.040_bib53","doi-asserted-by":"crossref","first-page":"97","DOI":"10.5603\/CJ.2020.0023","article-title":"Coding proposal on phenotyping heart failure with preserved ejection fraction: a practical tool for facilitating etiology-oriented therapy","volume":"27","author":"Ge","year":"2020","journal-title":"Cardiol J"},{"key":"10.1016\/j.apsb.2024.12.040_bib54","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1001\/jama.2023.2020","article-title":"Heart failure with preserved ejection fraction: a review","volume":"329","author":"Redfield","year":"2023","journal-title":"JAMA"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525000012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525000012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T15:23:32Z","timestamp":1744989812000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383525000012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2211383525000012"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2024.12.040","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nitazoxanide protects against heart failure with preserved ejection and metabolic syndrome induced by high-fat diet (HFD) plus L-NAME \u201ctwo-hit\u201d in mice","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2024.12.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}