{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:57:13Z","timestamp":1790873833069,"version":"4.1.0"},"reference-count":71,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T00:00:00Z","timestamp":1738972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82273935"],"award-info":[{"award-number":["82273935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104177"],"award-info":[{"award-number":["82104177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82222069"],"award-info":[{"award-number":["82222069"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872878"],"award-info":[{"award-number":["81872878"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073857"],"award-info":[{"award-number":["82073857"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["226-2024-00094"],"award-info":[{"award-number":["226-2024-00094"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.apsb.2025.02.004","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T03:06:27Z","timestamp":1739243187000},"page":"1626-1642","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Optineurin restrains CCR7 degradation to guide type II collagen-stimulated dendritic cell migration in rheumatoid arthritis"],"prefix":"10.1016","volume":"15","author":[{"given":"Wenxiang","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoxu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3260-2703","authenticated-orcid":false,"given":"Bowen","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longling","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-7966-2443","authenticated-orcid":false,"given":"Lijun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Difeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaojun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8026-0109","authenticated-orcid":false,"given":"Qinjie","family":"Weng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.02.004_bib1","first-page":"75","article-title":"Bispecific dendritic-T cell engager potentiates anti-tumor immunity","volume":"187","author":"Itai","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2025.02.004_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/science.abm5658","article-title":"Multimodal control of dendritic cell functions by nociceptors","volume":"379","author":"Hanc","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.apsb.2025.02.004_bib3","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1016\/j.immuni.2023.08.014","article-title":"Dendritic cells as shepherds of T cell immunity in cancer","volume":"56","author":"Pittet","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2025.02.004_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.841687","article-title":"New insights of CCR7 signaling in dendritic cell migration and inflammatory diseases","volume":"13","author":"Hong","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2025.02.004_bib5","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1038\/s41423-021-00726-4","article-title":"Dendritic cell migration in inflammation and immunity","volume":"18","author":"Liu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.apsb.2025.02.004_bib6","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/S0140-6736(23)01525-8","article-title":"Rheumatoid arthritis","volume":"402","author":"Di Matteo","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2025.02.004_bib7","doi-asserted-by":"crossref","first-page":"3656","DOI":"10.1002\/art.27756","article-title":"Therapeutic effect of tolerogenic dendritic cells in established collagen-induced arthritis is associated with a reduction in Th17 responses","volume":"62","author":"Stoop","year":"2010","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.apsb.2025.02.004_bib8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/s41590-020-00816-x","article-title":"The immunology of rheumatoid arthritis","volume":"22","author":"Weyand","year":"2021","journal-title":"Nat Immunol"},{"key":"10.1016\/j.apsb.2025.02.004_bib9","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/j.apsb.2023.12.007","article-title":"GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis","volume":"14","author":"Guo","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.02.004_bib10","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/rheumatology\/kead230","article-title":"EPCR deficiency ameliorates inflammatory arthritis in mice by suppressing the activation and migration of T cells and dendritic cells","volume":"63","author":"Xue","year":"2024","journal-title":"Rheumatol"},{"key":"10.1016\/j.apsb.2025.02.004_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adh1653","article-title":"Calcium channel beta3 subunit regulates ATP-dependent migration of dendritic cells","volume":"9","author":"Woo","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.apsb.2025.02.004_bib12","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1038\/nri.2016.116","article-title":"Dendritic cell migration in health and disease","volume":"17","author":"Worbs","year":"2017","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.apsb.2025.02.004_bib13","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s00296-017-3671-z","article-title":"The function of myeloid dendritic cells in rheumatoid arthritis","volume":"37","author":"Yu","year":"2017","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.apsb.2025.02.004_bib14","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1097\/BOR.0000000000000251","article-title":"The thymus and rheumatology: should we care?.","volume":"28","author":"Cosway","year":"2016","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.apsb.2025.02.004_bib15","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1111\/imr.13050","article-title":"Imaging dendritic cell functions","volume":"306","author":"Bosnjak","year":"2022","journal-title":"Immunol Rev"},{"key":"10.1016\/j.apsb.2025.02.004_bib16","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1002\/eji.200526000","article-title":"Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis","volume":"35","author":"Burkhardt","year":"2005","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.apsb.2025.02.004_bib17","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/1756-185X.14382","article-title":"Is collagen supplementation friend or foe in rheumatoid arthritis and osteoarthritis? A comprehensive systematic review","volume":"25","author":"Jabbari","year":"2022","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.apsb.2025.02.004_bib18","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.apsb.2023.09.013","article-title":"GRK2 inhibits Flt-1D macrophage infiltration and its proangiogenic properties in rheumatoid arthritis","volume":"14","author":"Yang","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.02.004_bib19","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1172\/JCI113929","article-title":"Immunohistochemical detection and immunochemical analysis of type II collagen degradation in human normal, rheumatoid, and osteoarthritic articular cartilages and in explants of bovine articular cartilage cultured with interleukin 1","volume":"83","author":"Dodge","year":"1989","journal-title":"J Clin Investig"},{"key":"10.1016\/j.apsb.2025.02.004_bib20","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1093\/rheumatology\/kep040","article-title":"A novel paradigm for dendritic cells as effectors of cartilage destruction","volume":"48","author":"Lakey","year":"2009","journal-title":"Rheumatol"},{"key":"10.1016\/j.apsb.2025.02.004_bib21","doi-asserted-by":"crossref","first-page":"7071","DOI":"10.4049\/jimmunol.169.12.7071","article-title":"A novel dendritic cell-induced model of erosive inflammatory arthritis: distinct roles for dendritic cells in T cell activation and induction of local inflammation","volume":"169","author":"Leung","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.apsb.2025.02.004_bib22","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.4049\/jimmunol.1402800","article-title":"Collagen induces maturation of human monocyte-derived dendritic cells by signaling through osteoclast-associated receptor","volume":"194","author":"Schultz","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.apsb.2025.02.004_bib23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41467-020-20307-9","article-title":"TARM1 contributes to development of arthritis by activating dendritic cells through recognition of collagens","volume":"12","author":"Yabe","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.02.004_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116258","article-title":"Roles and mechanisms of optineurin in bone metabolism","volume":"172","author":"Jin","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.apsb.2025.02.004_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2020.114157","article-title":"The diverse role of optineurin in pathogenesis of disease","volume":"180","author":"Guo","year":"2020","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.apsb.2025.02.004_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/15548627.2021.1908722","article-title":"Emerging views of OPTN (optineurin) function in the autophagic process associated with disease","volume":"18","author":"Qiu","year":"2022","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2025.02.004_bib27","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.apsb.2021.07.021","article-title":"Therapeutic regulation of autophagy in hepatic metabolism","volume":"12","author":"Byrnes","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.02.004_bib28","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.4103\/IJO.IJO_2570_22","article-title":"Molecular genetics of primary open-angle glaucoma","volume":"71","author":"Yadav","year":"2023","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.apsb.2025.02.004_bib29","doi-asserted-by":"crossref","first-page":"5391","DOI":"10.1007\/s10072-022-06125-5","article-title":"OPTN variants in ALS cases: a case report of a novel mutation and literature review","volume":"43","author":"Mou","year":"2022","journal-title":"Neurol Sci"},{"key":"10.1016\/j.apsb.2025.02.004_bib30","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbrc.2013.06.065","article-title":"IRF-1-binding site in the first intron mediates interferon-\u03b3-induced optineurin promoter activation","volume":"437","author":"Sudhakar","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.apsb.2025.02.004_bib31","doi-asserted-by":"crossref","first-page":"6198","DOI":"10.1038\/s41467-021-26477-4","article-title":"Optineurin modulates the maturation of dendritic cells to regulate autoimmunity through JAK2\u2013STAT3 signaling","volume":"12","author":"Wang","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.02.004_bib32","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1002\/art.41290","article-title":"Protective role of optineurin against joint destruction in rheumatoid\u00a0arthritis synovial fibroblasts","volume":"72","author":"Lee","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.apsb.2025.02.004_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155248","article-title":"Natural compounds as potential therapeutic candidates for multiple sclerosis: emerging preclinical evidence","volume":"123","author":"Yuan","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.apsb.2025.02.004_bib34","doi-asserted-by":"crossref","first-page":"95","DOI":"10.3390\/ijms24010095","article-title":"The anti-inflammatory and immunomodulatory activities of natural products to control autoimmune inflammation","volume":"24","author":"Moudgil","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2025.02.004_bib35","doi-asserted-by":"crossref","first-page":"238","DOI":"10.3390\/ijms24010238","article-title":"Regulation of myeloid dendritic cells by synthetic and natural compounds for the treatment of rheumatoid arthritis","volume":"24","author":"Umbreen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2025.02.004_bib36","doi-asserted-by":"crossref","first-page":"3930","DOI":"10.1016\/j.apsb.2023.03.017","article-title":"Aureane-type sesquiterpene tetraketides as a novel class of immunomodulators with interleukin-17A inhibitory activity","volume":"13","author":"Tang","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.02.004_bib37","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1016\/j.apsb.2024.02.002","article-title":"Spirohypertones A and B as potent antipsoriatics: tumor necrosis factor-\u03b1 inhibitors with unprecedented chemical architectures","volume":"14","author":"Duan","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.02.004_bib38","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1002\/term.3090","article-title":"Saikosaponin D: a potential therapeutic drug for osteoarthritis","volume":"14","author":"Jiang","year":"2020","journal-title":"J Tissue Eng Regen Med"},{"key":"10.1016\/j.apsb.2025.02.004_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111324","article-title":"Saikosaponin-d alleviates depression by promoting NLRP3 ubiquitination and inhibiting inflammasome activation","volume":"127","author":"Gao","year":"2024","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.apsb.2025.02.004_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107090","article-title":"The therapeutic effects of saikosaponins on depression through the modulation of neuroplasticity: from molecular mechanisms to potential clinical applications","volume":"201","author":"Chen","year":"2024","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.apsb.2025.02.004_bib41","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1038\/s41423-018-0056-5","article-title":"The chemokine receptor CCR7 is a promising target for rheumatoid arthritis therapy","volume":"16","author":"Moschovakis","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.apsb.2025.02.004_bib42","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1136\/ard-2023-224014","article-title":"Counteracting tryptophan metabolism alterations as a new therapeutic strategy for rheumatoid arthritis","volume":"83","author":"Moulin","year":"2024","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.apsb.2025.02.004_bib43","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1016\/j.apsb.2023.01.016","article-title":"Cholinergic dysfunction-induced insufficient activation of \u03b17 nicotinic acetylcholine receptor drives the development of rheumatoid arthritis through promoting protein citrullination via the SP3\/PAD4 pathway","volume":"13","author":"Lv","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.02.004_bib44","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/ard-2023-224852","article-title":"EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3","volume":"83","author":"Wu","year":"2024","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.apsb.2025.02.004_bib45","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.immuni.2019.01.021","article-title":"CCR7 chemokine receptor-inducible lnc-Dpf3 restrains dendritic cell migration by inhibiting HIF-1\u03b1-mediated glycolysis","volume":"50","author":"Liu","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2025.02.004_bib46","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1758-2946-6-13","article-title":"TCMSP: a database of systems pharmacology for drug discovery from herbal medicines","volume":"6","author":"Ru","year":"2014","journal-title":"J Cheminform"},{"key":"10.1016\/j.apsb.2025.02.004_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.117323","article-title":"A network pharmacology approach and experimental validation to investigate the anticancer mechanism of Qi-Qin-Hu-Chang formula against colitis-associated colorectal cancer through induction of apoptosis via JNK\/p38 MAPK signaling pathway","volume":"319","author":"Wu","year":"2024","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.apsb.2025.02.004_bib48","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s41065-023-00301-z","article-title":"Network pharmacology to unveil the mechanism of suanzaoren decoction in the treatment of Alzheimer's with diabetes","volume":"161","author":"Chen","year":"2024","journal-title":"Hereditas"},{"key":"10.1016\/j.apsb.2025.02.004_bib49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1089\/mab.2023.0019","article-title":"Prevention of collagen-induced arthritis by an anti-glycan monoclonal antibody reactive with 6-sulfo sialyl Lewis x in DBA\/1 mice","volume":"43","author":"Wei","year":"2024","journal-title":"Monoclon Antib Immunodiagn Immunother"},{"key":"10.1016\/j.apsb.2025.02.004_bib50","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1084\/jem.158.2.378","article-title":"Serum transfer of collagen-induced arthritis in mice","volume":"158","author":"Stuart","year":"1983","journal-title":"J Exp Med"},{"key":"10.1016\/j.apsb.2025.02.004_bib51","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s13075-023-03159-8","article-title":"The mechanism of dendritic cell-T cell crosstalk in rheumatoid arthritis","volume":"25","author":"Wang","year":"2023","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.apsb.2025.02.004_bib52","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/ard-2022-223645","article-title":"Immunomics analysis of rheumatoid arthritis identified precursor dendritic cells as a key cell subset of treatment resistance","volume":"82","author":"Yamada","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.apsb.2025.02.004_bib53","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/cei.12038","article-title":"Tolerogenic dendritic cell therapy for rheumatoid arthritis: where are we now?.","volume":"172","author":"Hilkens","year":"2013","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.apsb.2025.02.004_bib54","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.2147\/DDDT.S296862","article-title":"Chlorogenic acid inhibits human glioma U373 cell progression via regulating the SRC\/MAPKs signal pathway: based on network pharmacology analysis","volume":"15","author":"Zhou","year":"2021","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.apsb.2025.02.004_bib55","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1158\/2159-8290.CD-20-1571","article-title":"Loss of optineurin drives cancer immune evasion via palmitoylation-dependent IFNGR1 lysosomal sorting and degradation","volume":"11","author":"Du","year":"2021","journal-title":"Cancer Discov"},{"key":"10.1016\/j.apsb.2025.02.004_bib56","doi-asserted-by":"crossref","first-page":"2402","DOI":"10.1016\/j.apsb.2024.01.010","article-title":"Expanding the horizons of targeted protein degradation: a non-small molecule perspective","volume":"14","author":"Huang","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.02.004_bib57","first-page":"4463","article-title":"Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration","volume":"125","author":"Schaeuble","year":"2012","journal-title":"J Cell Sci"},{"key":"10.1016\/j.apsb.2025.02.004_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2023.113815","article-title":"Saikosaponin D exerts cytotoxicity on human endometrial cancer ishikawa cells by inducing apoptosis and inhibiting metastasis through MAPK pathways","volume":"177","author":"Tang","year":"2023","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.apsb.2025.02.004_bib59","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1089\/jmf.2013.2762","article-title":"Saikosaponin a and saikosaponin d inhibit proliferation and migratory activity of rat HSC-T6 cells","volume":"16","author":"Chen","year":"2013","journal-title":"J Med Food"},{"key":"10.1016\/j.apsb.2025.02.004_bib60","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1055\/s-2006-960195","article-title":"The effects of saikosaponin on macrophage functions and lymphocyte proliferation","volume":"57","author":"Ushio","year":"1991","journal-title":"Planta Med"},{"key":"10.1016\/j.apsb.2025.02.004_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.660","article-title":"Metformin promotes histone deacetylation of optineurin and suppresses tumour growth through autophagy inhibition in ocular melanoma","volume":"12","author":"Zhuang","year":"2022","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.apsb.2025.02.004_bib62","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s12276-021-00596-w","article-title":"Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response","volume":"53","author":"Xue","year":"2021","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.apsb.2025.02.004_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.155065","article-title":"Ginsenoside-Re inhibits experimental autoimmune encephalomyelitis as a mouse model of multiple sclerosis by downregulating TLR4\/MyD88\/NF-\u03baB signaling pathways","volume":"122","author":"Oh","year":"2024","journal-title":"Phytomedicine"},{"key":"10.1016\/j.apsb.2025.02.004_bib64","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.it.2024.02.003","article-title":"Lipopolysaccharide delivery systems in innate immunity","volume":"45","author":"Liu","year":"2024","journal-title":"Trends Immunol"},{"key":"10.1016\/j.apsb.2025.02.004_bib65","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1080\/13547500500214194","article-title":"Biomarkers for diagnosing and monitoring autoimmune diseases","volume":"10","author":"Prince","year":"2005","journal-title":"Biomarkers"},{"key":"10.1016\/j.apsb.2025.02.004_bib66","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.joca.2004.12.002","article-title":"New serum biochemical markers (Coll 2-1 and Coll 2-1 NO2) for studying oxidative-related type II collagen network degradation in patients with osteoarthritis and rheumatoid arthritis","volume":"13","author":"Deberg","year":"2005","journal-title":"Osteoarthr Cartilage"},{"key":"10.1016\/j.apsb.2025.02.004_bib67","doi-asserted-by":"crossref","first-page":"9884","DOI":"10.3390\/ijms24129884","article-title":"Significance of type II collagen posttranslational modifications: from autoantigenesis to improved diagnosis and treatment of rheumatoid arthritis","volume":"24","author":"Batsalova","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2025.02.004_bib68","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.4049\/jimmunol.177.4.2314","article-title":"Opposite fate of endocytosed CCR7 and its ligands: recycling versus degradation","volume":"177","author":"Otero","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.apsb.2025.02.004_bib69","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/mi.2016.65","article-title":"The ATG16L1 risk allele associated with Crohn's disease results in a Rac1-dependent defect in dendritic cell migration that is corrected by thiopurines","volume":"10","author":"Wildenberg","year":"2017","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.apsb.2025.02.004_bib70","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/rb\/rbx032","article-title":"Lactosylated N-alkyl polyethylenimine coated iron oxide nanoparticles induced autophagy in mouse dendritic cells","volume":"5","author":"Shen","year":"2018","journal-title":"Regen Biomater"},{"key":"10.1016\/j.apsb.2025.02.004_bib71","first-page":"228","article-title":"NOD-2 and TLR-4 signaling reinforces the efficacy of dendritic cells and reduces the dose of TB drugs against Mycobacterium tuberculosis. J Innate Immun","volume":"8","author":"Khan","year":"2016"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525000371?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525000371?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:18:02Z","timestamp":1762604282000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383525000371"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":71,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2211383525000371"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.02.004","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Optineurin restrains CCR7 degradation to guide type II collagen-stimulated dendritic cell migration in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}