{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T00:19:35Z","timestamp":1792887575137,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,10]],"date-time":"2025-03-10T00:00:00Z","timestamp":1741564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LZ22H290001"],"award-info":[{"award-number":["LZ22H290001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004863","name":"Zhejiang Chinese Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004863","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174095"],"award-info":[{"award-number":["82174095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.apsb.2025.03.017","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T15:11:42Z","timestamp":1742224302000},"page":"2687-2702","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma"],"prefix":"10.1016","volume":"15","author":[{"given":"Hongyan","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanyu","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ninghui","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mancang","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaofeng","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donghang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.03.017_bib1","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.molmed.2022.11.004","article-title":"Diverse effects of obesity on antitumor immunity and immunotherapy","volume":"29","author":"Dyck","year":"2023","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.apsb.2025.03.017_bib2","first-page":"88","article-title":"Global patterns in excess body weight and the associated cancer burden","volume":"69","author":"Sung","year":"2019","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.apsb.2025.03.017_bib3","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1056\/NEJMsr1606602","article-title":"Body fatness and cancer\u2014viewpoint of the IARC working group","volume":"375","author":"Lauby-Secretan","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apsb.2025.03.017_bib4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.metabol.2018.11.001","article-title":"Obesity and cancer risk: emerging biological mechanisms and perspectives","volume":"92","author":"Avgerinos","year":"2019","journal-title":"Metabolism"},{"key":"10.1016\/j.apsb.2025.03.017_bib5","doi-asserted-by":"crossref","first-page":"j477","DOI":"10.1136\/bmj.j477","article-title":"Adiposity and cancer at major anatomical sites: umbrella review of the literature","volume":"356","author":"Kyrgiou","year":"2017","journal-title":"BMJ"},{"key":"10.1016\/j.apsb.2025.03.017_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2019.10.013","article-title":"STAT3 activation-induced fatty acid oxidation in CD8+ T effector cells is critical for obesity-promoted breast tumor growth","volume":"31","author":"Zhang","year":"2020","journal-title":"Cell Metab"},{"key":"10.1016\/j.apsb.2025.03.017_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2020.11.009","article-title":"Obesity shapes metabolism in the tumor microenvironment to suppress anti-tumor immunity","volume":"183","author":"Ringel","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2025.03.017_bib8","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1158\/1078-0432.CCR-18-1550","article-title":"Immunotherapy of melanoma: facts and hopes","volume":"25","author":"Weiss","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.apsb.2025.03.017_bib9","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/S1470-2045(15)00083-2","article-title":"Pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory melanoma (KEYNOTE-002): a randomised, controlled, phase 2 trial","volume":"16","author":"Ribas","year":"2015","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.apsb.2025.03.017_bib10","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1136\/bjo-2022-322913","article-title":"Implications of LAG3 and CTLA4 immune checkpoints beyond PD-1\/PD-L1 as a potential target in determining the prognosis of uveal melanoma patients","volume":"108","author":"Kashyap","year":"2024","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.apsb.2025.03.017_bib11","article-title":"A high-fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and PMN-MDSC differentiation","volume":"121","author":"Chen","year":"2024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2025.03.017_bib12","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/j.cmet.2022.09.023","article-title":"The role of lipids in cancer progression and metastasis","volume":"34","author":"Martin-Perez","year":"2022","journal-title":"Cel Metab"},{"key":"10.1016\/j.apsb.2025.03.017_bib13","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1038\/s41586-024-07529-3","article-title":"Obesity induces PD-1 on macrophages to suppress anti-tumour immunity","volume":"630","author":"Bader","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.03.017_bib14","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nrc3380","article-title":"Immunogenic cell death and DAMPs in cancer therapy","volume":"12","author":"Krysko","year":"2012","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2025.03.017_bib15","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/cdd.2013.72","article-title":"Defective immunogenic cell death of HMGB1-deficient tumors: compensatory therapy with TLR4 agonists","volume":"21","author":"Yamazaki","year":"2014","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.apsb.2025.03.017_bib16","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/nm1523","article-title":"Calreticulin exposure dictates the immunogenicity of cancer cell death","volume":"13","author":"Obeid","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2025.03.017_bib17","first-page":"860","article-title":"Immunogenic cell death and emission of damps: calreticulin and ATP","volume":"2","author":"Krysko","year":"2012","journal-title":"Nanomed Biother Discov"},{"key":"10.1016\/j.apsb.2025.03.017_bib18","article-title":"Immunogenic cell death activates the tumor immune microenvironment to boost the immunotherapy efficiency","volume":"9","author":"Li","year":"2022","journal-title":"Adv Sci"},{"key":"10.1016\/j.apsb.2025.03.017_bib19","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jconrel.2021.07.038","article-title":"Recent progress in stimuli-responsive nanosystems for inducing immunogenic cell death","volume":"337","author":"Banstola","year":"2021","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2025.03.017_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.adf9382","article-title":"Metaflammation in obesity and its therapeutic targeting","volume":"15","author":"Schleh","year":"2023","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.apsb.2025.03.017_bib21","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1038\/s41568-021-00388-4","article-title":"Tumour fatty acid metabolism in the context of therapy resistance and obesity","volume":"21","author":"Hoy","year":"2021","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2025.03.017_bib22","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1021\/acsnano.2c11159","article-title":"Regulating the obesity-related tumor microenvironment to improve cancer immunotherapy","volume":"17","author":"Fang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2025.03.017_bib23","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1053\/j.gastro.2009.09.049","article-title":"Prolyl hydroxylase-3 is down-regulated in colorectal cancer cells and inhibits IKKbeta independent of hydroxylase activity","volume":"138","author":"Xue","year":"2010","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2025.03.017_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32575-z","article-title":"PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes","volume":"8","author":"Yano","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2025.03.017_bib25","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1016\/j.apsb.2024.04.010","article-title":"Endoplasmic reticulum-targeted delivery of celastrol and PD-L1 siRNA for reinforcing immunogenic cell death and potentiating cancer immunotherapy","volume":"14","author":"Wang","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.03.017_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120604","article-title":"Celastrol nanoemulsion induces immunogenicity and downregulates PD-L1 to boost abscopal effect in melanoma therapy","volume":"269","author":"Qiu","year":"2021","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2025.03.017_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.138781","article-title":"Hypoxia-responsive immunostimulatory nanomedicines synergize with checkpoint blockade immunotherapy for potentiating cancer immunotherapy","volume":"451","author":"Chen","year":"2023","journal-title":"Chem Eng J"},{"key":"10.1016\/j.apsb.2025.03.017_bib28","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.cell.2015.05.011","article-title":"Treatment of obesity with celastrol","volume":"161","author":"Liu","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2025.03.017_bib29","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41591-019-0358-x","article-title":"IL1R1 is required for celastrol's leptin-sensitization and antiobesity effects","volume":"25","author":"Feng","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2025.03.017_bib30","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.145306","article-title":"PERK in POMC neurons connects celastrol with metabolism","volume":"6","author":"He","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.apsb.2025.03.017_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105572","article-title":"Celastrol in metabolic diseases: progress and application prospects","volume":"167","author":"Xu","year":"2021","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.apsb.2025.03.017_bib32","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nrendo.2015.94","article-title":"Celastrol identified as a leptin sensitizer and potential novel treatment for obesity","volume":"11","author":"Greenhill","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"10.1016\/j.apsb.2025.03.017_bib33","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jare.2022.09.007","article-title":"Paclitaxel-loaded ginsenoside Rg3 liposomes for drug-resistant cancer therapy by dual targeting of the tumor microenvironment and cancer cells","volume":"49","author":"Zhu","year":"2023","journal-title":"J Adv Res"},{"key":"10.1016\/j.apsb.2025.03.017_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jconrel.2023.10.023","article-title":"Ginsenoside Rg3 endows liposomes with prolonged blood circulation and reduced accelerated blood clearance","volume":"364","author":"Xia","year":"2023","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2025.03.017_bib35","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj1262","article-title":"Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches","volume":"8","author":"Xia","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.apsb.2025.03.017_bib36","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41523-021-00324-7","article-title":"Interaction between CD36 and FABP4 modulates adipocyte-induced fatty acid import and metabolism in breast cancer","volume":"7","author":"Gyamfi","year":"2021","journal-title":"NPJ Breast Cancer"},{"key":"10.1016\/j.apsb.2025.03.017_bib37","doi-asserted-by":"crossref","first-page":"18249","DOI":"10.1002\/jcp.28456","article-title":"Conditioned media from adipocytes promote proliferation, migration, and invasion in melanoma and colorectal cancer cells","volume":"234","author":"Ko","year":"2019","journal-title":"J Cel Physiol"},{"key":"10.1016\/j.apsb.2025.03.017_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202103687","article-title":"YAP dictates mitochondrial redox homeostasis to facilitate obesity-associated breast cancer progression","volume":"9","author":"Dai","year":"2022","journal-title":"Adv Sci"},{"key":"10.1016\/j.apsb.2025.03.017_bib39","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s11658-023-00476-3","article-title":"Melanoma cells induce dedifferentiation and metabolic changes in adipocytes present in the tumor niche","volume":"28","author":"Simiczyjew","year":"2023","journal-title":"Cell Mol Biol Lett"},{"key":"10.1016\/j.apsb.2025.03.017_bib40","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s12951-021-01062-5","article-title":"Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies","volume":"19","author":"Wang","year":"2021","journal-title":"J Nanobiotechnology"},{"key":"10.1016\/j.apsb.2025.03.017_bib41","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.addr.2020.05.006","article-title":"Anticancer activities of phytoconstituents and their liposomal targeting strategies against tumor cells and the microenvironment","volume":"154\u2013155","author":"Zhang","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.apsb.2025.03.017_bib42","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.biochi.2018.05.012","article-title":"Quercetin inhibits glucose transport by binding to an exofacial site on GLUT1","volume":"151","author":"Hamilton","year":"2018","journal-title":"Biochimie"},{"key":"10.1016\/j.apsb.2025.03.017_bib43","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jconrel.2020.12.036","article-title":"Multifunctional ginsenoside Rg3-based liposomes for glioma targeting therapy","volume":"330","author":"Zhu","year":"2021","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2025.03.017_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2023.188946","article-title":"Reinforcing the immunogenic cell death to enhance cancer immunotherapy efficacy","volume":"1878","author":"Yu","year":"2023","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.apsb.2025.03.017_bib45","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2025.03.017_bib46","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41388-024-02954-0","article-title":"Obesity-associated epigenetic alterations and the obesity-breast cancer axis","volume":"43","author":"Lagarde","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.apsb.2025.03.017_bib47","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41416-018-0121-y","article-title":"Body mass index (BMI) trajectories and risk of colorectal cancer in the PLCO cohort","volume":"119","author":"Zheng","year":"2018","journal-title":"Br J Cancer"},{"key":"10.1016\/j.apsb.2025.03.017_bib48","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1158\/1078-0432.CCR-22-2661","article-title":"Obesity is associated with altered tumor metabolism in metastatic melanoma","volume":"29","author":"Hahn","year":"2023","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.apsb.2025.03.017_bib49","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1038\/s41467-024-50660-y","article-title":"A male mouse model for metabolic dysfunction-associated steatotic liver disease and hepatocellular carcinoma","volume":"15","author":"Jeong","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.03.017_bib50","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2209973120","article-title":"Obesity triggers tumoral senescence and renders poorly immunogenic malignancies amenable to senolysis","volume":"120","author":"Fournier","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2025.03.017_bib51","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1038\/s41467-024-47359-5","article-title":"Obesity-related T cell dysfunction impairs immunosurveillance and increases cancer risk","volume":"15","author":"Piening","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.03.017_bib52","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1038\/nm1643","article-title":"Dendritic cells: versatile controllers of the immune system","volume":"13","author":"Steinman","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2025.03.017_bib53","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1016\/j.immuni.2023.08.014","article-title":"Dendritic cells as shepherds of T cell immunity in cancer","volume":"56","author":"Pittet","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2025.03.017_bib54","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13046-020-01666-z","article-title":"Cancer-associated adipocytes: emerging supporters in breast cancer","volume":"39","author":"Zhao","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.apsb.2025.03.017_bib55","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1039\/D0NH00588F","article-title":"Tumor-targeted gene therapy with lipid nanoparticles inhibits tumor-associated adipocytes and remodels the immunosuppressive tumor microenvironment in triple-negative breast cancer","volume":"6","author":"Liu","year":"2021","journal-title":"Nanoscale Horiz"},{"key":"10.1016\/j.apsb.2025.03.017_bib56","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1182\/blood.2021013832","article-title":"Multiple myeloma cells induce lipolysis in adipocytes and uptake fatty acids through fatty acid transporter proteins","volume":"139","author":"Panaroni","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.apsb.2025.03.017_bib57","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3109\/01480545.2010.494664","article-title":"Toxic effects of celastrol on embryonic development of zebrafish (Danio rerio)","volume":"34","author":"Wang","year":"2011","journal-title":"Drug Chem Toxicol"},{"key":"10.1016\/j.apsb.2025.03.017_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104724","article-title":"A celastrol-based nanodrug with reduced hepatotoxicity for primary and metastatic cancer treatment","volume":"94","author":"Zhou","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.apsb.2025.03.017_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102077","article-title":"Celastrol inhibits intestinal lipid absorption by reprofiling the gut microbiota to attenuate high-fat diet-induced obesity","volume":"24","author":"Hua","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.apsb.2025.03.017_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114981","article-title":"Celastrol functions as an emerging manager of lipid metabolism: mechanism and therapeutic potential","volume":"164","author":"Gu","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.apsb.2025.03.017_bib61","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.metabol.2016.01.009","article-title":"Cascade regulation of PPAR\u03b3(2) and C\/EBP\u03b1 signaling pathways by celastrol impairs adipocyte differentiation and stimulates lipolysis in 3T3-L1 adipocytes","volume":"65","author":"Choi","year":"2016","journal-title":"Metabolism"},{"key":"10.1016\/j.apsb.2025.03.017_bib62","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1158\/0008-5472.CAN-23-0505","article-title":"Fueling the tumor microenvironment with cancer-associated adipocytes","volume":"83","author":"Bouche","year":"2023","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2025.03.017_bib63","article-title":"Dietary fructose-mediated adipocyte metabolism drives antitumor CD8+ T cell responses","volume":"35","author":"Zhang","year":"2023","journal-title":"Cel Metab"},{"key":"10.1016\/j.apsb.2025.03.017_bib64","article-title":"Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity","volume":"35","author":"Nava Lauson","year":"2023","journal-title":"Cel Metab"},{"key":"10.1016\/j.apsb.2025.03.017_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.03.023","article-title":"Physiologic medium rewires cellular metabolism and reveals uric acid as an endogenous inhibitor of UMP synthase","volume":"169","author":"Cantor","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2025.03.017_bib66","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.27713","article-title":"Environmental cystine drives glutamine anaplerosis and sensitizes cancer cells to glutaminase inhibition","volume":"6","author":"Muir","year":"2017","journal-title":"Elife"},{"key":"10.1016\/j.apsb.2025.03.017_bib67","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.cmet.2016.01.007","article-title":"Environment impacts the metabolic dependencies of Ras-driven non-small cell Lung cancer","volume":"23","author":"Davidson","year":"2016","journal-title":"Cel Metab"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221138352500156X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221138352500156X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:17:59Z","timestamp":1762604279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221138352500156X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":67,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S221138352500156X"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.03.017","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Celastrol-loaded ginsenoside Rg3 liposomes boost immunotherapy by remodeling obesity-related immunosuppressive tumor microenvironment in melanoma","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}