{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:43:54Z","timestamp":1788835434854,"version":"build-2803163510"},"reference-count":81,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,15]],"date-time":"2025-03-15T00:00:00Z","timestamp":1741996800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2021B014"],"award-info":[{"award-number":["CI2021B014"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023D003"],"award-info":[{"award-number":["CI2023D003"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023D008"],"award-info":[{"award-number":["CI2023D008"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023E002"],"award-info":[{"award-number":["CI2023E002"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2021A05101"],"award-info":[{"award-number":["CI2021A05101"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2021A05104"],"award-info":[{"award-number":["CI2021A05104"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515111188"],"award-info":[{"award-number":["2021A1515111188"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515110745"],"award-info":[{"award-number":["2022A1515110745"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515012164"],"award-info":[{"award-number":["2021A1515012164"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32101219"],"award-info":[{"award-number":["32101219"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304518"],"award-info":[{"award-number":["82304518"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103140"],"award-info":[{"award-number":["82103140"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373775"],"award-info":[{"award-number":["82373775"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2303600"],"award-info":[{"award-number":["2022YFC2303600"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFE0204500"],"award-info":[{"award-number":["2023YFE0204500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017380","name":"Science and Technology Foundation of Shenzhen City","doi-asserted-by":"publisher","award":["JCYJ20210324115800001"],"award-info":[{"award-number":["JCYJ20210324115800001"]}],"id":[{"id":"10.13039\/100017380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017380","name":"Science and Technology Foundation of Shenzhen City","doi-asserted-by":"publisher","award":["JCYJ20200109120205924"],"award-info":[{"award-number":["JCYJ20200109120205924"]}],"id":[{"id":"10.13039\/100017380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017380","name":"Science and Technology Foundation of Shenzhen City","doi-asserted-by":"publisher","award":["JCYJ20210324113608023"],"award-info":[{"award-number":["JCYJ20210324113608023"]}],"id":[{"id":"10.13039\/100017380","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["RCBS20210706092213007"],"award-info":[{"award-number":["RCBS20210706092213007"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.apsb.2025.03.039","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T04:15:00Z","timestamp":1742357700000},"page":"2559-2574","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["CDH17-targeting CAR-NK cells synergize with CD47 blockade for potent suppression of gastrointestinal cancers"],"prefix":"10.1016","volume":"15","author":[{"given":"Liuhai","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3654-456X","authenticated-orcid":false,"given":"Youbing","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwei","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqiao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinxi","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiexuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanchao","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-0105","authenticated-orcid":false,"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.03.039_bib1","first-page":"209","article-title":"Global cancer statistics 2020: globocan estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.apsb.2025.03.039_bib2","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1136\/jim-2020-001654","article-title":"Current immunotherapy in gastrointestinal malignancies a review","volume":"69","author":"Dahiya","year":"2021","journal-title":"J Investig Med"},{"key":"10.1016\/j.apsb.2025.03.039_bib3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1126\/science.aaa1348","article-title":"Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer","volume":"348","author":"Rizvi","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.apsb.2025.03.039_bib4","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4103\/apjon.apjon_4_17","article-title":"Immune checkpoint inhibitors: an innovation in immunotherapy for the treatment and management of patients with cancer","volume":"4","author":"Dine","year":"2017","journal-title":"Asia Pac J Oncol Nurs"},{"key":"10.1016\/j.apsb.2025.03.039_bib5","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s10555-020-09925-3","article-title":"Gastric cancer: a comprehensive review of current and future treatment strategies","volume":"39","author":"Sexton","year":"2020","journal-title":"Cancer Metastasis Rev"},{"key":"10.1016\/j.apsb.2025.03.039_bib6","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.3748\/wjg.v24.i20.2137","article-title":"Immune therapies in pancreatic ductal adenocarcinoma: where are we now?.","volume":"24","author":"Hilmi","year":"2018","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.apsb.2025.03.039_bib7","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1200\/JCO.2014.57.4244","article-title":"Safety and survival with GVAX pancreas prime and listeria monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer","volume":"33","author":"Le","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.apsb.2025.03.039_bib8","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.it.2013.07.005","article-title":"Location and cellular stages of natural killer cell development","volume":"34","author":"Yu","year":"2013","journal-title":"Trends Immunol"},{"key":"10.1016\/j.apsb.2025.03.039_bib9","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.1038\/s41423-021-00732-6","article-title":"Chimeric antigen receptor- and natural killer cell receptor-engineered innate killer cells in cancer immunotherapy","volume":"18","author":"Zhang","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.apsb.2025.03.039_bib10","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3390\/cancers11060769","article-title":"Natural killer cells as allogeneic effectors in adoptive cancer immunotherapy","volume":"11","author":"Lupo","year":"2019","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.apsb.2025.03.039_bib11","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3389\/fphar.2015.00021","article-title":"Advantages and applications of CAR-expressing natural killer cells","volume":"6","author":"Glienke","year":"2015","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2025.03.039_bib12","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/cac2.12321","article-title":"The establishment of polypeptide PSMA-targeted chimeric antigen receptor-engineered natural killer cells for castration-resistant prostate cancer and the induction of ferroptosis-related cell death","volume":"42","author":"Wu","year":"2022","journal-title":"Cancer Commun (Lond)"},{"key":"10.1016\/j.apsb.2025.03.039_bib13","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1053\/j.gastro.2021.12.281","article-title":"Off-the-shelf prostate stem cell antigen-directed chimeric antigen receptor natural killer cell therapy to treat pancreatic cancer","volume":"162","author":"Teng","year":"2022","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2025.03.039_bib14","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.3390\/ijms20133373","article-title":"Beyond N-cadherin, relevance of cadherins 5, 6 and 17 in cancer progression and metastasis","volume":"20","author":"Casal","year":"2019","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2025.03.039_bib15","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.canlet.2019.04.022","article-title":"Disruption of oncogenic liver-intestine cadherin (CDH17) drives apoptotic pancreatic cancer death","volume":"454","author":"Liu","year":"2019","journal-title":"Cancer Lett"},{"key":"10.1016\/j.apsb.2025.03.039_bib16","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s10120-020-01064-6","article-title":"A panel of intestinal differentiation markers (CDX2, GPA33, and LI-cadherin) identifies gastric cancer patients with favourable prognosis","volume":"23","author":"Lopes","year":"2020","journal-title":"Gastric Cancer"},{"key":"10.1016\/j.apsb.2025.03.039_bib17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1158\/1535-7163.MCT-20-0253","article-title":"Selective tumor cell apoptosis and tumor regression in CDH17-positive colorectal cancer models using BI 905711, a novel liver-sparing TRAILR2 agonist","volume":"20","author":"Garcia-Martinez","year":"2021","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.apsb.2025.03.039_bib18","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/hep.23143","article-title":"Targeting cadherin-17 inactivates Wnt signaling and inhibits tumor growth in liver carcinoma","volume":"50","author":"Liu","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2025.03.039_bib19","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.7150\/thno.17602","article-title":"Tumor-triggered drug release from calcium carbonate-encapsulated gold nanostars for near-infrared photodynamic\/photothermal combination antitumor therapy","volume":"7","author":"Liu","year":"2017","journal-title":"Theranostics"},{"key":"10.1016\/j.apsb.2025.03.039_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/mab.2017.0043","article-title":"Synergistic cytotoxic effect on gastric cancer cells of an immunotoxin cocktail in which antibodies recognize different epitopes on CDH17","volume":"37","author":"Kusano-Arai","year":"2018","journal-title":"Monoclon Antib Immunodiagn Immunother"},{"key":"10.1016\/j.apsb.2025.03.039_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202209393","article-title":"Surface-engineered extracellular vesicles with CDH17 nanobodies to efficiently deliver imaging probes and chemo-photothermal drugs for gastric cancer theragnostic","volume":"33","author":"Xia","year":"2023","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2025.03.039_bib22","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s40824-022-00312-3","article-title":"CDH17 nanobodies facilitate rapid imaging of gastric cancer and efficient delivery of immunotoxin","volume":"26","author":"Ma","year":"2022","journal-title":"Biomater Res"},{"key":"10.1016\/j.apsb.2025.03.039_bib23","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1126\/science.1238856","article-title":"Engineered SIRP\u03b1 variants as immunotherapeutic adjuvants to anticancer antibodies","volume":"341","author":"Weiskopf","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.apsb.2025.03.039_bib24","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2021-003737","article-title":"Delivery of CD47 blocker SIRP\u03b1-Fc by CAR-T cells enhances antitumor efficacy","volume":"10","author":"Chen","year":"2022","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.apsb.2025.03.039_bib25","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1182\/blood.2022016101","article-title":"Potentiating antibody-dependent killing of cancers with CAR T cells secreting CD47\u2013SIRP\u03b1 checkpoint blocker","volume":"141","author":"Dacek","year":"2023","journal-title":"Blood"},{"key":"10.1016\/j.apsb.2025.03.039_bib26","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/s41591-021-01625-x","article-title":"Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication","volume":"28","author":"Theruvath","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2025.03.039_bib27","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.1158\/1078-0432.CCR-20-3925","article-title":"Elucidation of tumor-stromal heterogeneity and the ligand-receptor interactome by single-cell transcriptomics in real-world pancreatic cancer biopsies","volume":"27","author":"Lee","year":"2021","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.apsb.2025.03.039_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.730","article-title":"Revealing the transcriptional heterogeneity of organ-specific metastasis in human gastric cancer using single-cell RNA sequencing","volume":"12","author":"Jiang","year":"2022","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.apsb.2025.03.039_bib29","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.152616","article-title":"Resolving the difference between left-sided and right-sided colorectal cancer by single-cell sequencing","volume":"7","author":"Guo","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.apsb.2025.03.039_bib30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol"},{"key":"10.1016\/j.apsb.2025.03.039_bib31","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1093\/bioinformatics\/btz625","article-title":"BBKNN: fast batch alignment of single cell transcriptomes","volume":"36","author":"Polanski","year":"2020","journal-title":"Bioinformatics"},{"key":"10.1016\/j.apsb.2025.03.039_bib32","doi-asserted-by":"crossref","first-page":"5233","DOI":"10.1038\/s41598-019-41695-z","article-title":"From Louvain to Leiden: guaranteeing well-connected communities","volume":"9","author":"Traag","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2025.03.039_bib33","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1126\/science.1254257","article-title":"Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma","volume":"344","author":"Patel","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.apsb.2025.03.039_bib34","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s43018-022-00344-7","article-title":"Potent suppression of neuroendocrine tumors and gastrointestinal cancers by CDH17CAR T cells without toxicity to normal tissues","volume":"3","author":"Feng","year":"2022","journal-title":"Nat Cancer"},{"key":"10.1016\/j.apsb.2025.03.039_bib35","doi-asserted-by":"crossref","first-page":"W556","DOI":"10.1093\/nar\/gkz430","article-title":"GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis","volume":"47","author":"Tang","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.apsb.2025.03.039_bib36","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.ymthe.2017.12.012","article-title":"Development of GPC3-specific chimeric antigen receptor-engineered natural killer cells for the treatment of hepatocellular carcinoma","volume":"26","author":"Yu","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.apsb.2025.03.039_bib37","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.3390\/cells9061382","article-title":"Anti-PSMA CAR-engineered NK-92 cells: an off-the-shelf cell therapy for prostate cancer","volume":"9","author":"Montagner","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.apsb.2025.03.039_bib38","first-page":"64","article-title":"A novel CD7 chimeric antigen receptor-modified NK-92MI cell line targeting T-cell acute lymphoblastic leukemia","volume":"9","author":"You","year":"2019","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.apsb.2025.03.039_bib39","doi-asserted-by":"crossref","DOI":"10.1136\/jitc-2024-008888","article-title":"Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin","volume":"12","author":"Zheng","year":"2024","journal-title":"J Immunother Cancer"},{"key":"10.1016\/j.apsb.2025.03.039_bib40","first-page":"951","article-title":"Click CAR-T cell engineering for robustly boosting cell immunotherapy in blood and subcutaneous xenograft tumor","volume":"6","author":"Pan","year":"2021","journal-title":"Bioact Mater"},{"key":"10.1016\/j.apsb.2025.03.039_bib41","article-title":"Bio-orthogonal T cell targeting strategy for robustly enhancing cytotoxicity against tumor cells","volume":"15","author":"Li","year":"2019","journal-title":"Small"},{"key":"10.1016\/j.apsb.2025.03.039_bib42","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41392-022-01058-z","article-title":"Natural killer cell homing and trafficking in tissues and tumors: from biology to application","volume":"7","author":"Ran","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.apsb.2025.03.039_bib43","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/s41423-024-01145-x","article-title":"Development of NK cell-based cancer immunotherapies through receptor engineering","volume":"21","author":"Page","year":"2024","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.apsb.2025.03.039_bib44","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1038\/s41423-024-01207-0","article-title":"CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors","volume":"21","author":"Peng","year":"2024","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.apsb.2025.03.039_bib45","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13045-019-0829-z","article-title":"Applications of patient-derived tumor xenograft models and tumor organoids","volume":"13","author":"Yoshida","year":"2020","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.apsb.2025.03.039_bib46","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1158\/1078-0432.CCR-19-1864","article-title":"Neoadjuvant therapy remodels the pancreatic cancer microenvironment via depletion of protumorigenic immune cells","volume":"26","author":"Mota Reyes","year":"2020","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.apsb.2025.03.039_bib47","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1158\/2326-6066.CIR-18-0367","article-title":"Natural killer cell recruitment and activation are regulated by CD47 expression in the tumor microenvironment","volume":"7","author":"Nath","year":"2019","journal-title":"Cancer Immunol Res"},{"key":"10.1016\/j.apsb.2025.03.039_bib48","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/s41575-018-0038-1","article-title":"Adiposity and gastrointestinal cancers: epidemiology, mechanisms and future directions","volume":"15","author":"Murphy","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.apsb.2025.03.039_bib49","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1186\/s12943-022-01663-0","article-title":"The journey of CAR-T therapy in hematological malignancies","volume":"21","author":"Lu","year":"2022","journal-title":"Mol Cancer"},{"key":"10.1016\/j.apsb.2025.03.039_bib50","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41571-022-00704-3","article-title":"Overcoming on-target, off-tumour toxicity of CAR T cell therapy for solid tumours","volume":"20","author":"Flugel","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.apsb.2025.03.039_bib51","doi-asserted-by":"crossref","first-page":"294","DOI":"10.2478\/jtim-2023-0105","article-title":"A first case report of using chimeric antigen receptor T-cell immunotherapy to treat high-risk smoldering multiple myeloma","volume":"11","author":"Liu","year":"2023","journal-title":"J Transl Int Med"},{"key":"10.1016\/j.apsb.2025.03.039_bib52","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/d41573-020-00099-9","article-title":"Cancer cell therapies: the clinical trial landscape","volume":"19","author":"Yu","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2025.03.039_bib53","doi-asserted-by":"crossref","first-page":"255","DOI":"10.2478\/jtim-2023-0111","article-title":"Mini-dose methotrexate combined with methylprednisolone as a first-line treatment for acute graft-versus-host disease: a phase 2 trial","volume":"11","author":"Xu","year":"2023","journal-title":"J Transl Int Med"},{"key":"10.1016\/j.apsb.2025.03.039_bib54","doi-asserted-by":"crossref","first-page":"4293","DOI":"10.1182\/blood-2009-05-222190","article-title":"NK cells mediate reduction of GVHD by inhibiting activated, alloreactive T cells while retaining GVT effects","volume":"115","author":"Olson","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.apsb.2025.03.039_bib55","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/s00262-017-2055-2","article-title":"Clinical grade manufacturing of genetically modified, CAR-expressing NK-92 cells for the treatment of ErbB2-positive malignancies","volume":"67","author":"Nowakowska","year":"2018","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.apsb.2025.03.039_bib56","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/hum.2018.247","article-title":"Preclinical assessment of suitable natural killer cell sources for chimeric antigen receptor natural killer-based \u201coff-the-shelf\u201d acute myeloid leukemia immunotherapies","volume":"30","author":"Kloess","year":"2019","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.apsb.2025.03.039_bib57","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3390\/antib8030041","article-title":"Bispecific T-cell redirection versus chimeric antigen receptor (CAR)-T cells as approaches to kill cancer cells","volume":"8","author":"Strohl","year":"2019","journal-title":"Antibodies"},{"key":"10.1016\/j.apsb.2025.03.039_bib58","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pep.2012.02.006","article-title":"A combined strategy improves the solubility of aggregation-prone single-chain variable fragment antibodies","volume":"83","author":"Sun","year":"2012","journal-title":"Protein Expr Purif"},{"key":"10.1016\/j.apsb.2025.03.039_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2020.102931","article-title":"CAR-T design: elements and their synergistic function","volume":"58","author":"Jayaraman","year":"2020","journal-title":"EBioMedicine"},{"key":"10.1016\/j.apsb.2025.03.039_bib60","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/emboj\/19.5.921","article-title":"Camel heavy-chain antibodies: diverse germline VHH and specific mechanisms enlarge the antigen-binding repertoire","volume":"19","author":"Nguyen","year":"2000","journal-title":"EMBO J"},{"key":"10.1016\/j.apsb.2025.03.039_bib61","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.3389\/fimmu.2017.01603","article-title":"Nanobodies and nanobody-based human heavy chain antibodies as antitumor therapeutics","volume":"8","author":"Peter","year":"2017","journal-title":"Front Immunol"},{"key":"10.1016\/j.apsb.2025.03.039_bib62","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1146\/annurev-biochem-063011-092449","article-title":"Natural single-domain antibodies","volume":"82","author":"Nanobodies","year":"2013","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.apsb.2025.03.039_bib63","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1093\/protein\/10.4.435","article-title":"Disrupting the hydrophobic patches at the antibody variable\/constant domain interface: improved in vivo folding and physical characterization of an engineered scFv fragment","volume":"10","author":"Nieba","year":"1997","journal-title":"Protein Eng"},{"key":"10.1016\/j.apsb.2025.03.039_bib64","article-title":"Clinical application and prospect of immune checkpoint inhibitors for CAR-NK cell in tumor immunotherapy","volume":"13","author":"Yang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.apsb.2025.03.039_bib65","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2022.2127508","article-title":"AAV-mediated gene transfer of a checkpoint inhibitor in combination with HER2-targeted CAR-NK cells as experimental therapy for glioblastoma","volume":"11","author":"Strecker","year":"2022","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.apsb.2025.03.039_bib66","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1038\/nm.3931","article-title":"CD47 blockade triggers T cell-mediated destruction of immunogenic tumors","volume":"21","author":"Liu","year":"2015","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2025.03.039_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242417634","article-title":"Breakthroughs in cancer immunotherapy: an overview of T cell, NK cell, M\u03c6, and DC-based treatments","volume":"24","author":"Lee","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2025.03.039_bib68","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1038\/leu.2017.223","article-title":"CD47 blockade enhances therapeutic activity of TCR mimic antibodies to ultra-low density cancer epitopes","volume":"31","author":"Mathias","year":"2017","journal-title":"Leukemia"},{"key":"10.1016\/j.apsb.2025.03.039_bib69","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.1158\/2767-9764.CRC-22-0266","article-title":"CD47-blocking antibody ZL-1201 promotes tumor-associated macrophage phagocytic activity and enhances the efficacy of the therapeutic antibodies and chemotherapy","volume":"2","author":"Cao","year":"2022","journal-title":"Cancer Res Commun"},{"key":"10.1016\/j.apsb.2025.03.039_bib70","article-title":"Anti-CD47 treatment stimulates phagocytosis of glioblastoma by M1 and M2 polarized macrophages and promotes M1 polarized macrophages in vivo","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2025.03.039_bib71","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ccr.2013.09.014","article-title":"Low-dose irradiation programs macrophage differentiation to an iNOS+\/M1 phenotype that orchestrates effective T cell immunotherapy","volume":"24","author":"Klug","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.apsb.2025.03.039_bib72","article-title":"Repolarization of tumor-infiltrating myeloid cells for augmentation of CAR T cell therapies","volume":"13","author":"Luo","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.apsb.2025.03.039_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2017.07.016","article-title":"Dendritic cells but not macrophages sense tumor mitochondrial DNA for cross-priming through signal regulatory protein alpha signaling","volume":"47","author":"Xu","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2025.03.039_bib74","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s13045-019-0732-7","article-title":"2B4 costimulatory domain enhancing cytotoxic ability of anti-CD5 chimeric antigen receptor engineered natural killer cells against T cell malignancies","volume":"12","author":"Xu","year":"2019","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.apsb.2025.03.039_bib75","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1080\/14728222.2024.2400075","article-title":"Looking ahead to targeting macrophages by CAR T- or NK-cells in blood cancers","volume":"28","author":"Kegyes","year":"2024","journal-title":"Expert Opin Ther Targets"},{"key":"10.1016\/j.apsb.2025.03.039_bib76","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2019.12.003","article-title":"IL-15 and GM-CSF stimulated macrophages enhances phagocytic activity in ENU induced leukemic mice","volume":"225","author":"Singha","year":"2020","journal-title":"Immunobiology"},{"key":"10.1016\/j.apsb.2025.03.039_bib77","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.imlet.2013.12.009","article-title":"Human NK cells and NK receptors","volume":"161","author":"Bellora","year":"2014","journal-title":"Immunol Lett"},{"key":"10.1016\/j.apsb.2025.03.039_bib78","article-title":"The imbalance in the relationship between inflammatory and regulatory cytokines during gestational toxoplasmosis can be harmful to fetuses: a systematic review","volume":"14","author":"Dos Santos","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.apsb.2025.03.039_bib79","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1144330","article-title":"Synergistic effect of CD47 blockade in combination with cordycepin treatment against cancer","volume":"14","author":"Feng","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.apsb.2025.03.039_bib80","article-title":"A systematic review on PD-1 blockade and PD-1 gene-editing of CAR-T cells for glioma therapy: from deciphering to personalized medicine","volume":"12","author":"Abdoli Shadbad","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.apsb.2025.03.039_bib81","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1038\/s41467-024-47692-9","article-title":"The STING agonist IMSA101 enhances chimeric antigen receptor T cell function by inducing IL-18 secretion","volume":"15","author":"Uslu","year":"2024","journal-title":"Nat Commun"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525001790?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525001790?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:54:47Z","timestamp":1778846087000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383525001790"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":81,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2211383525001790"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.03.039","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CDH17-targeting CAR-NK cells synergize with CD47 blockade for potent suppression of gastrointestinal cancers","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.03.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}