{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:18:55Z","timestamp":1791299935484,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T00:00:00Z","timestamp":1743552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007620","name":"Department of Education of Liaoning Province","doi-asserted-by":"publisher","award":["LJKMZ20221365"],"award-info":[{"award-number":["LJKMZ20221365"]}],"id":[{"id":"10.13039\/501100007620","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20240050"],"award-info":[{"award-number":["GZC20240050"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013806","name":"Shenyang Pharmaceutical University","doi-asserted-by":"publisher","award":["YQ202208"],"award-info":[{"award-number":["YQ202208"]}],"id":[{"id":"10.13039\/501100013806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA0909900"],"award-info":[{"award-number":["2021YFA0909900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002338","name":"Ministry of Education of the People's Republic of China","doi-asserted-by":"publisher","award":["TMIT2024Y01"],"award-info":[{"award-number":["TMIT2024Y01"]}],"id":[{"id":"10.13039\/501100002338","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.apsb.2025.04.003","type":"journal-article","created":{"date-parts":[[2025,4,8]],"date-time":"2025-04-08T02:28:59Z","timestamp":1744079339000},"page":"2867-2883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Self-degradable \u201cgemini-like\u201d ionizable lipid-mediated delivery of siRNA for subcellular-specific gene therapy of hepatic diseases"],"prefix":"10.1016","volume":"15","author":[{"given":"Qiu","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zimeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhua","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongbing","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonggui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5470-1599","authenticated-orcid":false,"given":"Jin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qikun","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.04.003_bib1","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/bs.apha.2019.01.003","article-title":"Drug-induced liver injury in obesity and nonalcoholic fatty liver disease","volume":"85","author":"Allard","year":"2019","journal-title":"Adv Pharmacol"},{"key":"10.1016\/j.apsb.2025.04.003_bib2","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1021\/acsnano.5b05470","article-title":"Suppression of hepatic inflammation via systemic siRNA delivery by memrane-disruptive and endosomolytic helical polypeptide hybrid nanoparticles","volume":"10","author":"He","year":"2016","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2025.04.003_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nrd.2015.3","article-title":"Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies","volume":"15","author":"Musso","year":"2016","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2025.04.003_bib4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jconrel.2022.01.038","article-title":"Hepatic macrophage targeted siRNA lipid nanoparticles treat non-alcoholic steatohepatitis","volume":"343","author":"Zhou","year":"2022","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2025.04.003_bib5","doi-asserted-by":"crossref","first-page":"5136","DOI":"10.1039\/D1TB00736J","article-title":"Identification of a potent ionizable lipid for efficient macrophage transfection and systemic anti-interleukin-1b siRNA delivery against acute liver failure","volume":"9","author":"Ding","year":"2021","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.apsb.2025.04.003_bib6","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1016\/j.ymthe.2021.11.007","article-title":"Alterman, an RNAi therapeutic targeting hepatic DGAT2 in a genetically obese mouse model of nonalcoholic steatohepatitis","volume":"30","author":"Yenilmez","year":"2022","journal-title":"Mol Ther"},{"key":"10.1016\/j.apsb.2025.04.003_bib7","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.jhep.2010.04.008","article-title":"A position statement on NAFLD\/NASH based on the EASL 2009 special conference","volume":"53","author":"Ratziu","year":"2010","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2025.04.003_bib8","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41575-018-0009-6","article-title":"Triggering and resolution of inflammation in NASH","volume":"15","author":"Schuster","year":"2018","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.apsb.2025.04.003_bib9","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1038\/s41591-021-01489-1","article-title":"ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials","volume":"27","author":"Calle","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2025.04.003_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm1418","article-title":"Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia","volume":"8","author":"Hu","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.apsb.2025.04.003_bib11","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41392-021-00859-y","article-title":"Ionizable liposomal siRNA therapeutics enables potent and persistent treatment of Hepatitis B","volume":"7","author":"Huang","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.apsb.2025.04.003_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2022.121645","article-title":"An optimized ionizable cationic lipid for brain tumor-targeted siRNA delivery and glioblastoma immunotherapy","volume":"287","author":"Liu","year":"2022","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2025.04.003_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.202011068","article-title":"mRNA-loaded lipid-like nanoparticles for liver base editing via the optimization of central composite design","volume":"31","author":"Zheng","year":"2021","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2025.04.003_bib14","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41565-020-0669-6","article-title":"Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR\u2013Cas gene editing","volume":"15","author":"Cheng","year":"2020","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.apsb.2025.04.003_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202303261","article-title":"Lipid Nanoparticle (LNP) enables mRNA delivery for cancer therapy","volume":"35","author":"Zong","year":"2023","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2025.04.003_bib16","doi-asserted-by":"crossref","first-page":"5659","DOI":"10.1038\/s41467-024-50093-7","article-title":"Reformulating lipid nanoparticles for organ-targeted mRNA accumulation and translation","volume":"15","author":"Su","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.04.003_bib17","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jconrel.2024.10.028","article-title":"Paracyclophane-based ionizable lipids for efficient mRNA delivery in vivo","volume":"376","author":"Wu","year":"2024","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2025.04.003_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.103479","article-title":"The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory","volume":"24","author":"Ndeupen","year":"2021","journal-title":"iScience"},{"key":"10.1016\/j.apsb.2025.04.003_bib19","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.addr.2020.07.001","article-title":"Development of lipid-like materials for RNA delivery based on intracellular environment-responsive membrane destabilization and spontaneous collapse","volume":"154","author":"Tanaka","year":"2020","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.apsb.2025.04.003_bib20","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/s41563-020-00886-0","article-title":"Membrane-destabilizing ionizable phospholipids for organ-selective mRNA delivery and CRISPR\u2013Cas gene editing","volume":"20","author":"Liu","year":"2021","journal-title":"Nat Mater"},{"key":"10.1016\/j.apsb.2025.04.003_bib21","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1073\/pnas.1520244113","article-title":"Efficient delivery of genome-editing proteins using bioreducible lipid nanoparticles","volume":"113","author":"Wang","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.apsb.2025.04.003_bib22","doi-asserted-by":"crossref","first-page":"3211","DOI":"10.1038\/s41467-019-11193-x","article-title":"Probing the impact of sulfur\/selenium\/carbon linkages on prodrug nanoassemblies for cancer therapy","volume":"19","author":"Sun","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.04.003_bib23","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1021\/acs.nanolett.8b00737","article-title":"Disulfide bond-driven oxidation- and reduction-responsive prodrug nanoassemblies for cancer therapy","volume":"18","author":"Sun","year":"2018","journal-title":"Nano Lett"},{"key":"10.1016\/j.apsb.2025.04.003_bib24","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1002\/adhm.201200431","article-title":"A neutral envelope-type nanoparticle containing pH-responsive and SS-cleavable lipid-like material as a carrier for plasmid DNA","volume":"2","author":"Akita","year":"2013","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.apsb.2025.04.003_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/adfm.201910575","article-title":"Self-degradable lipid-like materials based on \u201chydrolysis accelerated by the intra-particle enrichment of reactant (HyPER)\u201d for messenger RNA delivery","volume":"30","author":"Tanaka","year":"2020","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2025.04.003_bib26","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1021\/acsbiomaterials.5b00203","article-title":"Molecular tuning of a vitamin E-scaffold pH-sensitive and reductive cleavable lipid-like material for accelerated in vivo hepatic siRNA delivery","volume":"1","author":"Akita","year":"2015","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.apsb.2025.04.003_bib27","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.biomaterials.2015.02.044","article-title":"Effects of mannose density on in vitro and in vivo cellular uptake and RNAi efficiency of polymeric nanoparticles","volume":"52","author":"Chu","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2025.04.003_bib28","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1021\/acs.langmuir.8b02100","article-title":"Zwitterionic hydrogels based on a degradable disulfide carboxybetaine cross-linker","volume":"35","author":"Jain","year":"2019","journal-title":"Langmuir"},{"key":"10.1016\/j.apsb.2025.04.003_bib29","article-title":"Elaborately engineering of lipid nanoparticle for targeting delivery of siRNA and suppressing acute liver injury","volume":"35","author":"Wang","year":"2024","journal-title":"Chin Chem Lett"},{"key":"10.1016\/j.apsb.2025.04.003_bib30","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.addr.2019.05.004","article-title":"Strategies, design, and chemistry in siRNA delivery systems","volume":"144","author":"Dong","year":"2019","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.apsb.2025.04.003_bib31","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2109256118","article-title":"On the mechanism of tissue-specific mRNA delivery by selective organ targeting nanoparticles","volume":"118","author":"Dilliard","year":"2021","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525002242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525002242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T12:22:53Z","timestamp":1762604573000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383525002242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S2211383525002242"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.04.003","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Self-degradable \u201cgemini-like\u201d ionizable lipid-mediated delivery of siRNA for subcellular-specific gene therapy of hepatic diseases","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}