{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:36:32Z","timestamp":1786984592712,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T00:00:00Z","timestamp":1753660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82103066"],"award-info":[{"award-number":["82103066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302887"],"award-info":[{"award-number":["82302887"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303210"],"award-info":[{"award-number":["82303210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372818"],"award-info":[{"award-number":["82372818"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.apsb.2025.07.040","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T23:59:37Z","timestamp":1753919977000},"page":"5294-5311","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Succinylation of tumor suppressor PPP2R1A K541 by HAT1 converses the role in modulation of gluconeogenesis\/lipogenesis remodeling to display oncogene function"],"prefix":"10.1016","volume":"15","author":[{"given":"Guang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongfeng","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihui","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.07.040_bib1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41568-021-00378-6","article-title":"Cancer metabolism: looking forward","volume":"21","author":"Martinez-Reyes","year":"2021","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2025.07.040_bib2","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.jhep.2019.06.001","article-title":"Molecular and histological correlations in liver cancer","volume":"71","author":"Calderaro","year":"2019","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2025.07.040_bib3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41568-021-00383-9","article-title":"The immunological and metabolic landscape in primary and metastatic liver cancer","volume":"21","author":"Li","year":"2021","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2025.07.040_bib4","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/s41575-021-00465-x","article-title":"Exploring liver cancer biology through functional genetic screens","volume":"18","author":"Wang","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.apsb.2025.07.040_bib5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.canlet.2019.11.029","article-title":"Mitochondrial metabolic reprogramming: an important player in liver cancer progression","volume":"470","author":"Jin","year":"2020","journal-title":"Cancer Lett"},{"key":"10.1016\/j.apsb.2025.07.040_bib6","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.apsb.2021.09.019","article-title":"Metabolic dysregulation and emerging therapeutical targets for hepatocellular carcinoma","volume":"12","author":"Du","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.07.040_bib7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cell.2016.12.039","article-title":"Understanding the intersections between metabolism and cancer biology","volume":"168","author":"Vander Heiden","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2025.07.040_bib8","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbcan.2019.05.006","article-title":"Gluconeogenesis in cancer cells - repurposing of a starvation-induced metabolic pathway?","volume":"1872","author":"Grasmann","year":"2019","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.apsb.2025.07.040_bib9","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.tcb.2022.02.003","article-title":"Regulation of gene expression by glycolytic and gluconeogenic enzymes","volume":"32","author":"Bian","year":"2022","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.apsb.2025.07.040_bib10","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1016\/j.jhep.2011.08.025","article-title":"The interaction of hepatic lipid and glucose metabolism in liver diseases","volume":"56","author":"Bechmann","year":"2012","journal-title":"J Hepatol"},{"key":"10.1016\/j.apsb.2025.07.040_bib11","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1038\/s41388-017-0070-6","article-title":"Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma","volume":"37","author":"Liu","year":"2018","journal-title":"Oncogene"},{"key":"10.1016\/j.apsb.2025.07.040_bib12","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.cmet.2012.09.002","article-title":"Expanding roles for SREBP in metabolism","volume":"16","author":"Shao","year":"2012","journal-title":"Cell Metab"},{"key":"10.1016\/j.apsb.2025.07.040_bib13","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/s41586-020-2183-2","article-title":"The gluconeogenic enzyme PCK1 phosphorylates INSIG1\/2 for lipogenesis","volume":"580","author":"Xu","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.07.040_bib14","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/cac2.12084","article-title":"A newly discovered role of metabolic enzyme PCK1 as a protein kinase to promote cancer lipogenesis","volume":"40","author":"Jiang","year":"2020","journal-title":"Cancer Commun (Lond)"},{"key":"10.1016\/j.apsb.2025.07.040_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2022.101097","article-title":"Pathological implication of protein post-translational modifications in cancer","volume":"86","author":"Pan","year":"2022","journal-title":"Mol Aspect Med"},{"key":"10.1016\/j.apsb.2025.07.040_bib16","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41392-020-0196-9","article-title":"Regulating tumor suppressor genes: post-translational modifications","volume":"5","author":"Chen","year":"2020","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.apsb.2025.07.040_bib17","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nrm.2016.140","article-title":"Metabolic regulation of gene expression through histone acylations","volume":"18","author":"Sabari","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.apsb.2025.07.040_bib18","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s13238-021-00846-7","article-title":"Metabolic reprogramming and epigenetic modifications on the path to cancer","volume":"13","author":"Sun","year":"2022","journal-title":"Protein Cell"},{"key":"10.1016\/j.apsb.2025.07.040_bib19","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.molcel.2019.05.034","article-title":"HAT1 coordinates histone production and acetylation via H4 promoter binding","volume":"75","author":"Gruber","year":"2019","journal-title":"Mol Cell"},{"key":"10.1016\/j.apsb.2025.07.040_bib20","doi-asserted-by":"crossref","first-page":"133","DOI":"10.20892\/j.issn.2095-3941.2021.0533","article-title":"Highlighted multi-modifications of enzymes: a novel succinylation mediated by histone acetyltransferase 1 in tumors","volume":"19","author":"Zhang","year":"2021","journal-title":"Cancer Biol Med"},{"key":"10.1016\/j.apsb.2025.07.040_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/nar\/gkaa1176","article-title":"Identification of lysine isobutyrylation as a new histone modification mark","volume":"49","author":"Zhu","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.apsb.2025.07.040_bib22","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41421-021-00344-4","article-title":"Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2","volume":"7","author":"Delaney","year":"2021","journal-title":"Cell Discov"},{"key":"10.1016\/j.apsb.2025.07.040_bib23","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202050967","article-title":"Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis","volume":"22","author":"Yang","year":"2021","journal-title":"EMBO Rep"},{"key":"10.1016\/j.apsb.2025.07.040_bib24","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.1038\/s41388-023-02850-z","article-title":"HMGB1\/SET\/HAT1 complex-mediated SASH1 repression drives glycolysis and metastasis in lung adenocarcinoma","volume":"42","author":"Kou","year":"2023","journal-title":"Oncogene"},{"key":"10.1016\/j.apsb.2025.07.040_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abe2967","article-title":"Druggable cancer phosphatases","volume":"13","author":"Vainonen","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.apsb.2025.07.040_bib26","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.20892\/j.issn.2095-3941.2022.0330","article-title":"Targeting PP2A for cancer therapeutic modulation","volume":"19","author":"Ronk","year":"2022","journal-title":"Cancer Biol Med"},{"key":"10.1016\/j.apsb.2025.07.040_bib27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.canlet.2013.02.036","article-title":"Phosphatase: PP2A structural importance, regulation and its aberrant expression in cancer","volume":"335","author":"Seshacharyulu","year":"2013","journal-title":"Cancer Lett"},{"key":"10.1016\/j.apsb.2025.07.040_bib28","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41436-020-00981-2","article-title":"The broad phenotypic spectrum of PPP2R1A-related neurodevelopmental disorders correlates with the degree of biochemical dysfunction","volume":"23","author":"Lenaerts","year":"2021","journal-title":"Genet Med"},{"key":"10.1016\/j.apsb.2025.07.040_bib29","doi-asserted-by":"crossref","first-page":"5719","DOI":"10.1158\/0008-5472.CAN-15-3342","article-title":"Recurrent PPP2R1A mutations in uterine cancer act through a dominant-negative mechanism to promote malignant cell growth","volume":"76","author":"Haesen","year":"2016","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2025.07.040_bib30","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.178823","article-title":"PCYT2 inhibits epithelial-mesenchymal transition in colorectal cancer by elevating YAP1 phosphorylation","volume":"9","author":"Zhou","year":"2024","journal-title":"JCI Insight"},{"key":"10.1016\/j.apsb.2025.07.040_bib31","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1038\/s41419-024-06996-w","article-title":"BRG1 promotes progression of B-cell acute lymphoblastic leukemia by disrupting PPP2R1A transcription","volume":"15","author":"Kang","year":"2024","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2025.07.040_bib32","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1038\/ncomms2507","article-title":"Real-time single-molecule co-immunoprecipitation analyses reveal cancer-specific Ras signalling dynamics","volume":"4","author":"Lee","year":"2013","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.07.040_bib33","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1002\/hep.29316","article-title":"Hepatitis B virus X protein-elevated MSL2 modulates hepatitis B virus covalently closed circular DNA by inducing degradation of APOBEC3B to enhance hepatocarcinogenesis","volume":"66","author":"Gao","year":"2017","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2025.07.040_bib34","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nature25003","article-title":"KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase","volume":"552","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.07.040_bib35","doi-asserted-by":"crossref","first-page":"2051","DOI":"10.1002\/hep.25899","article-title":"Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells","volume":"56","author":"Zhang","year":"2012","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2025.07.040_bib36","doi-asserted-by":"crossref","first-page":"4139","DOI":"10.1021\/acs.jafc.8b00732","article-title":"Analysis and evaluation of the inhibitory mechanism of a novel Angiotensin-I-Converting enzyme inhibitory peptide derived from casein hydrolysate","volume":"66","author":"Tu","year":"2018","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.apsb.2025.07.040_bib37","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.ijbiomac.2017.03.054","article-title":"Enzyme inhibition kinetics and molecular interactions of patatin peptides with angiotensin I-converting enzyme and renin","volume":"101","author":"Fu","year":"2017","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.apsb.2025.07.040_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/jmv.28966","article-title":"HBV confers innate immune evasion through triggering HAT1\/acetylation of H4K5\/H4K12\/miR-181a-5p or KPNA2\/cGAS-STING\/IFN-I signaling","volume":"95","author":"Zhao","year":"2023","journal-title":"J Med Virol"},{"key":"10.1016\/j.apsb.2025.07.040_bib39","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.1016\/j.molcel.2021.08.031","article-title":"Moonlighting functions of metabolic enzymes and metabolites in cancer","volume":"81","author":"Pan","year":"2021","journal-title":"Mol Cell"},{"key":"10.1016\/j.apsb.2025.07.040_bib40","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s40880-018-0301-4","article-title":"Lipid metabolism reprogramming and its potential targets in cancer","volume":"38","author":"Cheng","year":"2018","journal-title":"Cancer Commun (Lond)"},{"key":"10.1016\/j.apsb.2025.07.040_bib41","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s13045-022-01340-1","article-title":"Posttranslational control of lipogenesis in the tumor microenvironment","volume":"15","author":"Zhu","year":"2022","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.apsb.2025.07.040_bib42","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/s41401-022-00945-z","article-title":"Aspirin modulates succinylation of PGAM1K99 to restrict the glycolysis through NF-kappaB\/HAT1\/PGAM1 signaling in liver cancer","volume":"44","author":"Wang","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.apsb.2025.07.040_bib43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13046-019-1044-z","article-title":"Overexpressed histone acetyltransferase 1 regulates cancer immunity by increasing programmed death-ligand 1 expression in pancreatic cancer","volume":"38","author":"Fan","year":"2019","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.apsb.2025.07.040_bib44","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/s41419-021-04118-4","article-title":"Histone acetyltransferase 1 promotes gemcitabine resistance by regulating the PVT1\/EZH2 complex in pancreatic cancer","volume":"12","author":"Sun","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2025.07.040_bib45","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/s13046-020-01629-4","article-title":"Emerging roles and the regulation of aerobic glycolysis in hepatocellular carcinoma","volume":"39","author":"Feng","year":"2020","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.apsb.2025.07.040_bib46","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.trecan.2018.11.003","article-title":"Gluconeogenesis in cancer: function and regulation of PEPCK, FBPase, and G6Pase","volume":"5","author":"Wang","year":"2019","journal-title":"Trends Cancer"},{"key":"10.1016\/j.apsb.2025.07.040_bib47","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144703","article-title":"Gluconeogenic enzyme PCK1 deficiency promotes CHK2 O-GlcNAcylation and hepatocellular carcinoma growth upon glucose deprivation","volume":"131","author":"Xiang","year":"2021","journal-title":"J Clin Investig"},{"key":"10.1016\/j.apsb.2025.07.040_bib48","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.freeradbiomed.2019.01.030","article-title":"SIRT5-mediated SDHA desuccinylation promotes clear cell renal cell carcinoma tumorigenesis","volume":"134","author":"Ma","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.apsb.2025.07.040_bib49","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1038\/s41401-021-00841-y","article-title":"PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours","volume":"43","author":"Yuan","year":"2022","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.apsb.2025.07.040_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.04.022","article-title":"The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer","volume":"184","author":"Vervoort","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2025.07.040_bib51","doi-asserted-by":"crossref","first-page":"6757","DOI":"10.1158\/0008-5472.CAN-13-1002","article-title":"Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells","volume":"73","author":"Khanna","year":"2013","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2025.07.040_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccell.2020.05.019","article-title":"Selective inhibition of STRN3-Containing PP2A phosphatase restores Hippo tumor-suppressor activity in gastric cancer","volume":"38","author":"Tang","year":"2020","journal-title":"Cancer Cell"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525005222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525005222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T15:34:22Z","timestamp":1772897662000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383525005222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":52,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["S2211383525005222"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.07.040","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Succinylation of tumor suppressor PPP2R1A K541 by HAT1 converses the role in modulation of gluconeogenesis\/lipogenesis remodeling to display oncogene function","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.07.040","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}