{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T10:12:38Z","timestamp":1791454358175,"version":"4.3.3"},"reference-count":57,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2024YFA0919900"],"award-info":[{"award-number":["2024YFA0919900"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2021-I2M-1-029"],"award-info":[{"award-number":["2021-I2M-1-029"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006004","name":"Tohoku University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006004","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803403"],"award-info":[{"award-number":["81803403"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.apsb.2025.09.015","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T14:49:06Z","timestamp":1757774946000},"page":"966-978","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Complete biosynthesis of phenylspirodrimanes with unclustered genes in Stachybotrys chartarum"],"prefix":"10.1016","volume":"16","author":[{"given":"Jimei","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ridao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keping","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyang","family":"Sui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaotian","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kebo","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8187-1208","authenticated-orcid":false,"given":"Dawei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2989-9016","authenticated-orcid":false,"given":"Jungui","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.09.015_bib1","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1039\/b820413f","article-title":"Meroterpenoids produced by fungi","volume":"26","author":"Geris","year":"2009","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.apsb.2025.09.015_bib2","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1039\/C5NP00090D","article-title":"Biosynthesis of fungal meroterpenoids","volume":"33","author":"Matsuda","year":"2016","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.apsb.2025.09.015_bib3","series-title":"Fungal meroterpenoids. Comprehensive natural products III: chemistry and biology","first-page":"445","author":"Matsuda","year":"2020"},{"key":"10.1016\/j.apsb.2025.09.015_bib4","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1039\/D0NP00056F","article-title":"Chemistry of fungal meroterpenoid cyclases","volume":"38","author":"Barra","year":"2021","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.apsb.2025.09.015_bib5","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.1016\/j.tet.2013.07.029","article-title":"Reconstituted biosynthesis of fungal meroterpenoid andrastin A","volume":"69","author":"Matsuda","year":"2013","journal-title":"Tetrahedron"},{"key":"10.1016\/j.apsb.2025.09.015_bib6","doi-asserted-by":"crossref","first-page":"10962","DOI":"10.1021\/ja405518u","article-title":"Spiro-ring formation is catalyzed by a multifunctional dioxygenase in austinol biosynthesis","volume":"135","author":"Matsuda","year":"2013","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.apsb.2025.09.015_bib7","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1021\/ja209809t","article-title":"Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids austinol and dehydroaustinol in Aspergillus nidulans","volume":"134","author":"Lo","year":"2012","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.apsb.2025.09.015_bib8","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1021\/jacs.5b00570","article-title":"Uncovering the unusual D-ring construction in terretonin biosynthesis by collaboration of a multifunctional cytochrome P450 and a unique isomerase","volume":"137","author":"Matsuda","year":"2015","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.apsb.2025.09.015_bib9","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.apsb.2017.12.005","article-title":"Activation of an unconventional meroterpenoid gene cluster in Neosartorya glabra leads to the production of new berkeleyacetals","volume":"8","author":"Zhang","year":"2018","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.09.015_bib10","doi-asserted-by":"crossref","first-page":"15326","DOI":"10.1021\/ja508127q","article-title":"Complete biosynthetic pathway of anditomin: nature\u2019s sophisticated synthetic route to a complex fungal meroterpenoid","volume":"136","author":"Matsuda","year":"2014","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.apsb.2025.09.015_bib11","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1038\/s41467-018-04983-2","article-title":"Novofumigatonin biosynthesis involves a non-heme irondependent endoperoxide isomerase for orthoester formation","volume":"9","author":"Matsuda","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.09.015_bib12","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/S0040-4020(01)82703-4","article-title":"Some new terpenoid metabolites from an unidentified Fusarium species","volume":"25","author":"Ellestad","year":"1969","journal-title":"Tetrahedron"},{"key":"10.1016\/j.apsb.2025.09.015_bib13","doi-asserted-by":"crossref","first-page":"539","DOI":"10.7164\/antibiotics.21.539","article-title":"Ascochlorin, a new antibiotic, found by paper-disc agar-diffusion method. I. isolation, biological and chemical properties of ascochlorin","volume":"21","author":"Tamura","year":"1968","journal-title":"J Antibiot"},{"key":"10.1016\/j.apsb.2025.09.015_bib14","doi-asserted-by":"crossref","first-page":"676","DOI":"10.7164\/antibiotics.26.676","article-title":"Isolation and structure of ascofuranone and ascofranol, antibiotics with hypolipidemic activity","volume":"26","author":"Sasaki","year":"1973","journal-title":"J Antibiot"},{"key":"10.1016\/j.apsb.2025.09.015_bib15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s11101-014-9365-1","article-title":"Chemical and bioactive diversities of the genera Stachybotrys and Memnoniella secondary metabolites","volume":"14","author":"Wang","year":"2015","journal-title":"Phytochem Rev"},{"key":"10.1016\/j.apsb.2025.09.015_bib16","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/cbic.201600087","article-title":"Biosynthesis of LL-Z1272\u03b2: discovery of a new member of NRPS-like enzymes for aryl-aldehyde formation","volume":"17","author":"Li","year":"2016","journal-title":"Chembiochem"},{"key":"10.1016\/j.apsb.2025.09.015_bib17","doi-asserted-by":"crossref","first-page":"8269","DOI":"10.1073\/pnas.1819254116","article-title":"Complete biosynthetic pathways of ascofuranone and ascochlorin in Acremonium egyptiacum","volume":"116","author":"Araki","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.apsb.2025.09.015_bib18","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1039\/c39790000726","article-title":"Structure of K-76, a complement inhibitor produced by Stachybotrys complementi nov. sp. K-76","volume":"16","author":"Kaise","year":"1979","journal-title":"J Chem Soc Chem Commun"},{"key":"10.1016\/j.apsb.2025.09.015_bib19","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.3390\/md12041924","article-title":"Spirocyclic drimanes from the marine fungus Stachybotrys sp. strain MF347","volume":"12","author":"Wu","year":"2014","journal-title":"Mar Drugs"},{"key":"10.1016\/j.apsb.2025.09.015_bib20","doi-asserted-by":"crossref","first-page":"49910","DOI":"10.1039\/C7RA09859F","article-title":"Antiviral and anti-inflammatory meroterpenoids stachybonoids A\u2013F from the crinoid-derived fungus Stachybotrys chartarum 952","volume":"7","author":"Zhang","year":"2017","journal-title":"RSC Adv"},{"key":"10.1016\/j.apsb.2025.09.015_bib21","doi-asserted-by":"crossref","first-page":"3520","DOI":"10.1039\/C8RA10195G","article-title":"Seven new cytotoxic phenylspirodrimane derivatives from the endophytic fungus Stachybotrys chartarum","volume":"9","author":"Zhang","year":"2019","journal-title":"RSC Adv"},{"key":"10.1016\/j.apsb.2025.09.015_bib22","doi-asserted-by":"crossref","first-page":"2703","DOI":"10.1021\/acs.jnatprod.6b00641","article-title":"Stachybotrysin, an osteoclast differentiation inhibitor from the marine-derived fungus Stachybotrys sp. KCB13F013","volume":"79","author":"Kim","year":"2016","journal-title":"J Nat Prod"},{"key":"10.1016\/j.apsb.2025.09.015_bib23","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1021\/acs.jnatprod.7b00014","article-title":"Stachybotrysins A\u2212G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum","volume":"80","author":"Zhao","year":"2017","journal-title":"J Nat Prod"},{"key":"10.1016\/j.apsb.2025.09.015_bib24","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.bmcl.2017.12.039","article-title":"Bistachybotrysins A\u2013C, three phenylspirodrimane dimers with cytotoxicity from Stachybotrys chartarum","volume":"28","author":"Zhao","year":"2018","journal-title":"Bioorg Med Chem Lett"},{"key":"10.1016\/j.apsb.2025.09.015_bib25","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.cclet.2018.04.031","article-title":"Bistachybotrysins D and E, one stereoisomeric pair of cytotoxic phenylspirodrimane dimers from Stachybotrys chartarum","volume":"30","author":"Zhang","year":"2019","journal-title":"Chin Chem Lett"},{"key":"10.1016\/j.apsb.2025.09.015_bib26","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1039\/C9QO01284B","article-title":"Bistachybotrysins L\u2013V, bioactive phenylspirodrimane dimers from the fungus Stachybotrys chartarum","volume":"7","author":"Liu","year":"2020","journal-title":"Org Chem Front"},{"key":"10.1016\/j.apsb.2025.09.015_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2023.108363","article-title":"Structural diversification of phenylspirodrimane lactams by employing a biosynthetic intermediate","volume":"34","author":"Liu","year":"2023","journal-title":"Chin Chem Lett"},{"key":"10.1016\/j.apsb.2025.09.015_bib28","doi-asserted-by":"crossref","first-page":"7422","DOI":"10.1021\/jo030202o","article-title":"Total synthesis and structure revision of Stachybotrys spirolactams","volume":"68","author":"Deng","year":"2003","journal-title":"J Org Chem"},{"key":"10.1016\/j.apsb.2025.09.015_bib29","doi-asserted-by":"crossref","first-page":"9196","DOI":"10.1021\/jo4014047","article-title":"NIS\u2013PPh3: a selective reagent for the spiroannulation of o-allyl phenols. Total synthesis of corallidictyal D","volume":"78","author":"Cano","year":"2013","journal-title":"J Org Chem"},{"key":"10.1016\/j.apsb.2025.09.015_bib30","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.copbio.2020.11.016","article-title":"Enzymology and biosynthesis of the orsellinic acid derived medicinal meroterpenoids","volume":"69","author":"Tao","year":"2021","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.apsb.2025.09.015_bib31","doi-asserted-by":"crossref","first-page":"11797","DOI":"10.1073\/pnas.1222159110","article-title":"Mapping gene clusters within arrayed metagenomic libraries to expand the structural diversity of biomedically relevant natural products","volume":"110","author":"Owen","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2025.09.015_bib32","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1073\/pnas.1319584111","article-title":"Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A","volume":"110","author":"Yamanaka","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.apsb.2025.09.015_bib33","first-page":"937","article-title":"Fungal secondary metabolism from biochemistry to genomics","volume":"3","author":"Keller","year":"2005","journal-title":"Microbiology"},{"key":"10.1016\/j.apsb.2025.09.015_bib34","article-title":"Elucidation of palmarumycin spirobisnaphthalene biosynthesis reveals a set of previously unrecognized oxidases and reductases","volume":"63","author":"Zhao","year":"2024","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.apsb.2025.09.015_bib35","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1021\/ja1096682","article-title":"Genome-based deletion analysis reveals the prenyl xanthone biosynthesis pathway in Aspergillus nidulans","volume":"133","author":"Sanchez","year":"2010","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.apsb.2025.09.015_bib36","doi-asserted-by":"crossref","first-page":"13724","DOI":"10.1021\/jacs.5b06108","article-title":"Discovery of unclustered fungal indole diterpene biosynthetic pathways through combinatorial pathway reassembly in engineered yeast","volume":"137","author":"Tang","year":"2015","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.apsb.2025.09.015_bib37","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1126\/science.aac7202","article-title":"Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone","volume":"349","author":"Lau","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.apsb.2025.09.015_bib38","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/s41586-020-2546-8","article-title":"Discovery and engineering of colchicine alkaloid biosynthesis","volume":"584","author":"Nett","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.09.015_bib39","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41586-022-04950-4","article-title":"Biosynthesis of strychnine","volume":"607","author":"Hong","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.09.015_bib40","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1038\/nchem.764","article-title":"Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases","volume":"2","author":"Itoh","year":"2010","journal-title":"Nat Chem"},{"key":"10.1016\/j.apsb.2025.09.015_bib41","doi-asserted-by":"crossref","first-page":"5376","DOI":"10.1021\/acs.orglett.7b02653","article-title":"Late-stage terpene cyclization by an integral membrane cyclase in the biosynthesis of isoprenoid epoxycyclohexenone natural products","volume":"19","author":"Tang","year":"2017","journal-title":"Org Lett"},{"key":"10.1016\/j.apsb.2025.09.015_bib42","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1055\/s-1996-5528","article-title":"Neighbouring group assistance in the formation of phthalimidines from O-phthalaldehyde: an \u201cintramolecular auxiliary effect\u201d","volume":"8","author":"Allin","year":"1996","journal-title":"Synlett"},{"key":"10.1016\/j.apsb.2025.09.015_bib43","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1016\/S0040-4039(97)01146-5","article-title":"Synthesis and structure revision of the myo-inositol monophosphatase inhibitor L-671,776","volume":"38","author":"Falck","year":"1997","journal-title":"Tetrahedron Lett"},{"key":"10.1016\/j.apsb.2025.09.015_bib44","doi-asserted-by":"crossref","first-page":"611","DOI":"10.7164\/antibiotics.49.611","article-title":"Inhibitors of myo-inositol monophosphatase, ATCC 20928 factors A and C isolation, physico-chemical characterization and biological properties","volume":"49","author":"Stefanelli","year":"1996","journal-title":"J Antibiot"},{"key":"10.1016\/j.apsb.2025.09.015_bib45","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1039\/D3SC06001B","article-title":"Global genome mining-driven discovery of an unusual biosynthetic logic for fungal polyketide\u2013terpenoid hybrids","volume":"15","author":"Yan","year":"2024","journal-title":"Chem Sci"},{"key":"10.1016\/j.apsb.2025.09.015_bib46","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1039\/D1NP00004G","article-title":"Cytochrome P450 enzymes in fungal natural product biosynthesis","volume":"38","author":"Zhang","year":"2021","journal-title":"Nat Prod Rep"},{"key":"10.1016\/j.apsb.2025.09.015_bib47","doi-asserted-by":"crossref","first-page":"19176","DOI":"10.1074\/jbc.272.31.19176","article-title":"Cloning, yeast expression, and characterization of the coupling of two distantly related Arabidopsis thaliana NADPH-cytochrome P450 reductases with P450 CYP73A5","volume":"272","author":"Urban","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2025.09.015_bib48","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1021\/np400824u","article-title":"Chartarlactams A\u2212P, phenylspirodrimanes from the sponge-associated fungus Stachybotrys chartarum with antihyperlipidemic activities","volume":"77","author":"Li","year":"2014","journal-title":"J Nat Prod"},{"key":"10.1016\/j.apsb.2025.09.015_bib49","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1021\/jacs.8b13452","article-title":"Cryptic and stereospecific hydroxylation, oxidation, and reduction in platensimycin and platencin biosynthesis","volume":"141","author":"Dong","year":"2019","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.apsb.2025.09.015_bib50","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.1016\/j.tet.2013.07.029","article-title":"Reconstituted biosynthesis of fungal meroterpenoid andrastin A","volume":"69","author":"Matsuda","year":"2013","journal-title":"Tetrahedron"},{"key":"10.1016\/j.apsb.2025.09.015_bib51","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.apsb.2018.10.007","article-title":"Biosynthesis of clinically used antibiotic fusidic acid and identification of two short-chain dehydrogenase\/reductases with converse stereoselectivity","volume":"9","author":"Cao","year":"2019","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.09.015_bib52","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1039\/C5SC04027B","article-title":"The molecular steps of citrinin biosynthesis in fungi","volume":"7","author":"He","year":"2016","journal-title":"Chem Sci"},{"key":"10.1016\/j.apsb.2025.09.015_bib53","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1021\/acs.orglett.0c00440","article-title":"Biosynthesis of the prenylated salicylaldehyde flavoglaucin requires temporary reduction to salicyl alcohol for decoration before reoxidation to the final product","volume":"22","author":"Nies","year":"2020","journal-title":"Org Lett"},{"key":"10.1016\/j.apsb.2025.09.015_bib54","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1039\/D3OB01447A","article-title":"Microbial alcohol dehydrogenases: recent developments and applications in asymmetric synthesis","volume":"22","author":"Chadha","year":"2024","journal-title":"Org Biomol Chem"},{"key":"10.1016\/j.apsb.2025.09.015_bib55","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.phytol.2017.04.031","article-title":"Stachybotrysams A\u2013E, prenylated isoindolinone derivatives with anti-HIV activity from the fungus Stachybotrys chartarum","volume":"20","author":"Zhao","year":"2017","journal-title":"Phytochem Lett"},{"key":"10.1016\/j.apsb.2025.09.015_bib56","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1093\/bioinformatics\/bty604","article-title":"Understanding the evolution of functional redundancy in metabolic networks","volume":"34","author":"Sambamoorthy","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.apsb.2025.09.015_bib57","article-title":"Evolutionary design principles in metabolism","volume":"286","author":"Sambamoorthy","year":"2019","journal-title":"Proc R Soc A B"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525006124?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525006124?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:56:42Z","timestamp":1778846202000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383525006124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":57,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2211383525006124"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.09.015","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Complete biosynthesis of phenylspirodrimanes with unclustered genes in Stachybotrys chartarum","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.09.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}