{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T12:13:45Z","timestamp":1777896825786,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073297"],"award-info":[{"award-number":["82073297"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013115","name":"Zhejiang Provincial Program for the Cultivation of High-Level Innovative Health Talents","doi-asserted-by":"publisher","award":["2020-18"],"award-info":[{"award-number":["2020-18"]}],"id":[{"id":"10.13039\/501100013115","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","award":["2022C03155"],"award-info":[{"award-number":["2022C03155"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008990","name":"Science and Technology Department of Zhejiang Province","doi-asserted-by":"publisher","award":["2023C03112"],"award-info":[{"award-number":["2023C03112"]}],"id":[{"id":"10.13039\/501100008990","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004204","name":"Tongji University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004204","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.apsb.2025.09.042","type":"journal-article","created":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T03:30:15Z","timestamp":1759548615000},"page":"6444-6460","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer"],"prefix":"10.1016","volume":"15","author":[{"given":"Wei","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minmin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjie","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanlin","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinxin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahe","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youyou","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nengming","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1052-7060","authenticated-orcid":false,"given":"Jianqing","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.09.042_bib1","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1038\/s41392-023-01548-8","article-title":"A new wave of innovations within the DNA damage response","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.apsb.2025.09.042_bib2","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/s41580-022-00473-y","article-title":"Mechanisms of microtubule organization in differentiated animal cells","volume":"23","author":"Akhmanova","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.apsb.2025.09.042_bib3","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1093\/nar\/gkaa1202","article-title":"DNA damage alters nuclear mechanics through chromatin reorganization","volume":"49","author":"Dos Santos","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.apsb.2025.09.042_bib4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/s41586-018-0242-8","article-title":"Nuclear F-actin and myosins drive relocalization of heterochromatic breaks","volume":"559","author":"Caridi","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.09.042_bib5","doi-asserted-by":"crossref","first-page":"7978","DOI":"10.1158\/0008-5472.CAN-09-2177","article-title":"The cytoskeleton protein filamin-A is required for an efficient recombinational DNA double strand break repair","volume":"69","author":"Yue","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2025.09.042_bib6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.devcel.2012.05.008","article-title":"BRCA2 localization to the midbody by filamin A regulates cep55 signaling and completion of cytokinesis","volume":"23","author":"Mondal","year":"2012","journal-title":"Dev Cell"},{"key":"10.1016\/j.apsb.2025.09.042_bib7","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1083\/jcb.134.2.401","article-title":"Smoothelin, a novel cytoskeletal protein specific for smooth muscle cells","volume":"134","author":"van der Loop","year":"1996","journal-title":"J Cell Biol"},{"key":"10.1016\/j.apsb.2025.09.042_bib8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1161\/01.ATV.17.4.665","article-title":"Differentiation of smooth muscle cells in human blood vessels as defined by smoothelin, a novel marker for the contractile phenotype","volume":"17","author":"van der Loop","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.apsb.2025.09.042_bib9","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/jcb.10143","article-title":"Smoothelin contains a novel actin cytoskeleton localization sequence with similarity to troponin T","volume":"85","author":"Quensel","year":"2002","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.apsb.2025.09.042_bib10","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.yexcr.2003.09.005","article-title":"Biochemical evidence for interaction between smoothelin and filamentous actin","volume":"292","author":"Niessen","year":"2004","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.apsb.2025.09.042_bib11","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/his.12159","article-title":"Clinicopathological features of primary leiomyosarcoma of the gastrointestinal tract following recognition of gastrointestinal stromal tumours","volume":"63","author":"Yamamoto","year":"2013","journal-title":"Histopathology"},{"key":"10.1016\/j.apsb.2025.09.042_bib12","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1136\/jclinpath-2013-201797","article-title":"A study of alpha5 chain of collagen IV, caldesmon, placental alkaline phosphatase and smoothelin as immunohistochemical markers of gastrointestinal smooth muscle neoplasms","volume":"67","author":"Wong","year":"2014","journal-title":"J Clin Pathol"},{"key":"10.1016\/j.apsb.2025.09.042_bib13","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/modpathol.2009.9","article-title":"Differential expression of immunohistochemical markers in bladder smooth muscle and myofibroblasts, and the potential utility of desmin, smoothelin, and vimentin in staging of bladder carcinoma","volume":"22","author":"Council","year":"2009","journal-title":"Mod Pathol"},{"key":"10.1016\/j.apsb.2025.09.042_bib14","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1097\/PAS.0b013e3181b76477","article-title":"Smoothelin is a specific marker for smooth muscle neoplasms of the gastrointestinal tract","volume":"33","author":"Coco","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.apsb.2025.09.042_bib15","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1161\/CIRCULATIONAHA.107.743690","article-title":"Smoothelin-B deficiency results in reduced arterial contractility, hypertension, and cardiac hypertrophy in mice","volume":"118","author":"Rensen","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.apsb.2025.09.042_bib16","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1053\/j.gastro.2005.08.018","article-title":"Smoothelin-a is essential for functional intestinal smooth muscle contractility in mice","volume":"129","author":"Niessen","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.apsb.2025.09.042_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000110","article-title":"Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair","volume":"4","author":"Bennardo","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1016\/j.apsb.2025.09.042_bib18","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1101\/gad.13.20.2633","article-title":"XRCC3 promotes homology-directed repair of DNA damage in mammalian cells","volume":"13","author":"Pierce","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.apsb.2025.09.042_bib19","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/s12916-024-03581-y","article-title":"Phase 1b study of first-line fuzuloparib combined with modified FOLFIRINOX followed by fuzuloparib maintenance monotherapy in pancreatic adenocarcinoma","volume":"22","author":"Wei","year":"2024","journal-title":"BMC Med"},{"key":"10.1016\/j.apsb.2025.09.042_bib20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/1748-717X-7-62","article-title":"The combination of olaparib and camptothecin for effective radiosensitization","volume":"7","author":"Miura","year":"2012","journal-title":"Radiat Oncol"},{"key":"10.1016\/j.apsb.2025.09.042_bib21","doi-asserted-by":"crossref","first-page":"D955","DOI":"10.1093\/nar\/gks1111","article-title":"Genomics of drug sensitivity in cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells","volume":"41","author":"Yang","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.apsb.2025.09.042_bib22","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1158\/2159-8290.CD-15-0235","article-title":"Harnessing connectivity in a large-scale small-molecule sensitivity dataset","volume":"5","author":"Seashore-Ludlow","year":"2015","journal-title":"Cancer Discov"},{"key":"10.1016\/j.apsb.2025.09.042_bib23","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nchembio.1986","article-title":"Correlating chemical sensitivity and basal gene expression reveals mechanism of action","volume":"12","author":"Rees","year":"2016","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.apsb.2025.09.042_bib24","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.cell.2013.08.003","article-title":"An interactive resource to identify cancer genetic and lineage dependencies targeted by small molecules","volume":"154","author":"Basu","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2025.09.042_bib25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.tcb.2015.07.009","article-title":"Repair pathway choices and consequences at the double-strand break","volume":"26","author":"Ceccaldi","year":"2016","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.apsb.2025.09.042_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.107447","article-title":"5-Fluorouracil and other fluoropyrimidines in colorectal cancer: past, present and future","volume":"206","author":"Vodenkova","year":"2020","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.apsb.2025.09.042_bib27","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1158\/1078-0432.CCR-19-1089","article-title":"Targeting topoisomerase I in the era of precision medicine","volume":"25","author":"Thomas","year":"2019","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.apsb.2025.09.042_bib28","article-title":"Cisplatin and oxaliplatin: our current understanding of their actions","volume":"18","author":"Riddell","year":"2018","journal-title":"Met Ions Life Sci"},{"key":"10.1016\/j.apsb.2025.09.042_bib29","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1200\/JCO.2009.21.9170","article-title":"American society of clinical oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy","volume":"27","author":"Allegra","year":"2009","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.apsb.2025.09.042_bib30","first-page":"314","article-title":"The pattern of acute viral hepatitis in children\u2014a study based on seroepidemiology and biochemical profile","volume":"37","author":"Malik","year":"1987","journal-title":"J Pak Med Assoc"},{"key":"10.1016\/j.apsb.2025.09.042_bib31","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1038\/nrm.2017.48","article-title":"Non-homologous DNA end joining and alternative pathways to double-strand break repair","volume":"18","author":"Chang","year":"2017","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.apsb.2025.09.042_bib32","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1016\/j.apsb.2025.03.035","article-title":"SMAD4 depletion enhances NHEJ by regulating BRCA1 expression through ARIH1 in pancreatic cancer","volume":"15","author":"Song","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.09.042_bib33","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1016\/j.apsb.2023.05.017","article-title":"Pharmacological inhibition of BAP1 recruits HERC2 to competitively dissociate BRCA1\u2013BARD1, suppresses DNA repair and sensitizes CRC to radiotherapy","volume":"13","author":"Yue","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.09.042_bib34","first-page":"8563","article-title":"A PARP1\u2013BRG1\u2013SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites","volume":"47","author":"Chen","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.apsb.2025.09.042_bib35","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.molcel.2018.11.003","article-title":"The F-Box domain-dependent activity of EMI1 regulates PARPi sensitivity in triple-negative breast cancers","volume":"73","author":"Marzio","year":"2019","journal-title":"Mol Cell"},{"key":"10.1016\/j.apsb.2025.09.042_bib36","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1101\/gad.289439.116","article-title":"A phosphorylation-deubiquitination cascade regulates the BRCA2\u2013RAD51 axis in homologous recombination","volume":"30","author":"Luo","year":"2016","journal-title":"Genes Dev"},{"key":"10.1016\/j.apsb.2025.09.042_bib37","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.molcel.2017.04.022","article-title":"RFWD3-mediated ubiquitination promotes timely removal of both RPA and RAD51 from DNA damage sites to facilitate homologous recombination","volume":"66","author":"Inano","year":"2017","journal-title":"Mol Cell"},{"key":"10.1016\/j.apsb.2025.09.042_bib38","doi-asserted-by":"crossref","first-page":"5931","DOI":"10.1038\/ncomms6931","article-title":"FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51","volume":"6","author":"Chu","year":"2015","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.09.042_bib39","doi-asserted-by":"crossref","first-page":"6118","DOI":"10.1038\/s41467-020-19961-w","article-title":"Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens","volume":"11","author":"Clements","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.09.042_bib40","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ymthe.2024.01.005","article-title":"The landscape of nanoparticle-based siRNA delivery and therapeutic development","volume":"32","author":"Moazzam","year":"2024","journal-title":"Mol Ther"},{"key":"10.1016\/j.apsb.2025.09.042_bib41","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1021\/acs.accounts.9b00101","article-title":"Theranostic nanoparticles for RNA-based cancer treatment","volume":"52","author":"Revia","year":"2019","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.apsb.2025.09.042_bib42","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/acs.accounts.1c00544","article-title":"Chemistry of lipid nanoparticles for RNA delivery","volume":"55","author":"Eygeris","year":"2022","journal-title":"Acc Chem Res"},{"key":"10.1016\/j.apsb.2025.09.042_bib43","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0168-3659(02)00129-3","article-title":"Intracellular route and transcriptional competence of polyethylenimine\u2013DNA complexes","volume":"82","author":"Bieber","year":"2002","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2025.09.042_bib44","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.jconrel.2010.11.004","article-title":"Endosomal escape pathways for delivery of biologicals","volume":"151","author":"Varkouhi","year":"2011","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2025.09.042_bib45","doi-asserted-by":"crossref","first-page":"6986","DOI":"10.3390\/ijms23136986","article-title":"Molecular link between DNA damage response and microtubule dynamics","volume":"23","author":"Kim","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2025.09.042_bib46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0127321","article-title":"Recognition of DNA termini by the C-terminal region of the Ku80 and the DNA-dependent protein kinase catalytic subunit","volume":"10","author":"Woods","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2025.09.042_bib47","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1016\/j.it.2017.07.012","article-title":"DNA sensing across the tree of life","volume":"38","author":"Gallucci","year":"2017","journal-title":"Trends Immunol"},{"key":"10.1016\/j.apsb.2025.09.042_bib48","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1038\/s41557-022-00945-w","article-title":"Functional DNA-based cytoskeletons for synthetic cells","volume":"14","author":"Zhan","year":"2022","journal-title":"Nat Chem"},{"key":"10.1016\/j.apsb.2025.09.042_bib49","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41422-021-00584-9","article-title":"Regulators of tubulin polyglutamylation control nuclear shape and cilium disassembly by balancing microtubule and actin assembly","volume":"32","author":"Wang","year":"2022","journal-title":"Cell Res"},{"key":"10.1016\/j.apsb.2025.09.042_bib50","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41568-022-00535-5","article-title":"Targeting DNA damage response pathways in cancer","volume":"23","author":"Groelly","year":"2023","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2025.09.042_bib51","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.tig.2024.02.007","article-title":"FIRRM and FIGNL1: partners in the regulation of homologous recombination","volume":"40","author":"Tsaridou","year":"2024","journal-title":"Trends Genet"},{"key":"10.1016\/j.apsb.2025.09.042_bib52","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1158\/0008-5472.CAN-22-1535","article-title":"BRCA1-dependent and independent recruitment of PALB2\u2013BRCA2\u2013RAD51 in the DNA damage response and cancer","volume":"82","author":"Foo","year":"2022","journal-title":"Cancer Res"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525006501?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525006501?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:38:35Z","timestamp":1777624715000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383525006501"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2211383525006501"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.09.042","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The cytoskeletal protein smoothelin maintains homologous recombination repair by stabilizing RAD51 in an HUWE1-dependent manner in colorectal cancer","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.09.042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}