{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:55:03Z","timestamp":1793879703434,"version":"4.7.0"},"reference-count":77,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T00:00:00Z","timestamp":1760918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023E005TS03"],"award-info":[{"award-number":["CI2023E005TS03"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023D003"],"award-info":[{"award-number":["CI2023D003"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023D008"],"award-info":[{"award-number":["CI2023D008"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023E005TS05"],"award-info":[{"award-number":["CI2023E005TS05"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2023E002"],"award-info":[{"award-number":["CI2023E002"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["CI2024E003"],"award-info":[{"award-number":["CI2024E003"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005892","name":"China Academy of Chinese Medical Sciences","doi-asserted-by":"publisher","award":["ZG2024001-05"],"award-info":[{"award-number":["ZG2024001-05"]}],"id":[{"id":"10.13039\/501100005892","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFA0908000"],"award-info":[{"award-number":["2020YFA0908000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3503904"],"award-info":[{"award-number":["2023YFC3503904"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2303603"],"award-info":[{"award-number":["2022YFC2303603"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005090","name":"Beijing Nova Program","doi-asserted-by":"publisher","award":["20250484875"],"award-info":[{"award-number":["20250484875"]}],"id":[{"id":"10.13039\/501100005090","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304812"],"award-info":[{"award-number":["82304812"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82521104"],"award-info":[{"award-number":["82521104"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.apsb.2025.10.020","type":"journal-article","created":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T08:06:59Z","timestamp":1761379619000},"page":"337-351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Gambogenic acid ameliorates inflammation by inhibiting HK1-mediated Warburg effect and NLRP3 inflammasome activation in sepsis"],"prefix":"10.1016","volume":"16","author":[{"given":"Huanhuan","family":"Pang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honglin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongda","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueling","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianfei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Lou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chong","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyan","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengnan","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoli","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0575-0105","authenticated-orcid":false,"given":"Jigang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengchao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.10.020_bib1","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1093\/bib\/bbz059","article-title":"Sepsis in the era of data-driven medicine: personalizing risks, diagnoses, treatments and prognoses","volume":"21","author":"Liu","year":"2020","journal-title":"Briefings Bioinf"},{"key":"10.1016\/j.apsb.2025.10.020_bib2","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.3390\/biom11071011","article-title":"Inflammation and cell death of the innate and adaptive immune system during sepsis","volume":"11","author":"Nedeva","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.apsb.2025.10.020_bib3","doi-asserted-by":"crossref","first-page":"3068","DOI":"10.1016\/j.apsb.2024.03.025","article-title":"Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice","volume":"14","author":"Li","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.10.020_bib4","doi-asserted-by":"crossref","first-page":"3756","DOI":"10.1016\/j.apsb.2023.06.012","article-title":"Gastrin attenuates sepsis-induced myocardial dysfunction by down-regulation of TLR4 expression in macrophages","volume":"13","author":"Fang","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.10.020_bib5","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0140-6736(19)32989-7","article-title":"Global, regional, and national sepsis incidence and mortality, 1990-2017: analysis for the global Burden of Disease Study","volume":"395","author":"Rudd","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2025.10.020_bib6","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40364-023-00450-3","article-title":"Usefulness of procalcitonin at admission as a risk-stratifying biomarker for 50-day in-hospital mortality among patients with community-acquired bloodstream infection: an observational cohort study","volume":"11","author":"Oussalah","year":"2023","journal-title":"Biomark Res"},{"key":"10.1016\/j.apsb.2025.10.020_bib7","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1186\/s13054-023-04571-x","article-title":"Defining critical illness using immunological endotypes in patients with and without sepsis: a cohort study","volume":"27","author":"Balch","year":"2023","journal-title":"Crit Care"},{"key":"10.1016\/j.apsb.2025.10.020_bib8","first-page":"56","article-title":"Sepsis-induced immunosuppression: mechanisms, diagnosis and current treatment options","volume":"9","author":"Liu","year":"2022","journal-title":"Mil Med Res"},{"key":"10.1016\/j.apsb.2025.10.020_bib9","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0140-6736(18)30696-2","article-title":"Sepsis and septic shock","volume":"392","author":"Cecconi","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2025.10.020_bib10","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00134-021-06506-y","article-title":"Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021","volume":"47","author":"Evans","year":"2021","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.apsb.2025.10.020_bib11","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/s41392-021-00816-9","article-title":"Signaling pathways and intervention therapies in sepsis","volume":"6","author":"Zhang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.apsb.2025.10.020_bib12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jgar.2017.06.013","article-title":"Sepsis and septic shock: new definitions, new diagnostic and therapeutic approaches","volume":"10","author":"Esposito","year":"2017","journal-title":"J Glob Antimicrob Resist"},{"key":"10.1016\/j.apsb.2025.10.020_bib13","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1097\/MOP.0000000000000753","article-title":"Precision medicine in pediatric sepsis","volume":"31","author":"Atreya","year":"2019","journal-title":"Curr Opin Pediatr"},{"key":"10.1016\/j.apsb.2025.10.020_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13054-022-03893-6","article-title":"Immune effects of PI3K\/Akt\/HIF-1\u03b1-regulated glycolysis in polymorphonuclear neutrophils during sepsis","volume":"26","author":"Pan","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.apsb.2025.10.020_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jare.2022.04.010","article-title":"EGFR promotes the apoptosis of CD4+ T lymphocytes through TBK1\/Glut1 induced Warburg effect in sepsis","volume":"44","author":"Huang","year":"2023","journal-title":"J Adv Res"},{"key":"10.1016\/j.apsb.2025.10.020_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2022.02.028","article-title":"Hexokinase 1 cellular localization regulates the metabolic fate of glucose","volume":"82","author":"De Jesus","year":"2022","journal-title":"Mol Cell"},{"key":"10.1016\/j.apsb.2025.10.020_bib17","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1158\/0008-5472.CAN-19-1789","article-title":"A tumor agnostic therapeutic strategy for hexokinase 1-Null\/Hexokinase 2-positive cancers","volume":"79","author":"Xu","year":"2019","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2025.10.020_bib18","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s40170-021-00277-2","article-title":"Loss of hexokinase 1 sensitizes ovarian cancer to high-dose metformin","volume":"9","author":"\u0160im\u010d\u00edkov\u00e1","year":"2021","journal-title":"Cancer Metabol"},{"key":"10.1016\/j.apsb.2025.10.020_bib19","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.cell.2016.05.076","article-title":"Hexokinase is an innate immune receptor for the detection of bacterial peptidoglycan","volume":"166","author":"Wolf","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2025.10.020_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.ade7652","article-title":"Hexokinase dissociation from mitochondria promotes oligomerization of VDAC that facilitates NLRP3 inflammasome assembly and activation","volume":"8","author":"Baik","year":"2023","journal-title":"Sci Immunol"},{"key":"10.1016\/j.apsb.2025.10.020_bib21","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abb8680","article-title":"Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease","volume":"6","author":"Zhang","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.apsb.2025.10.020_bib22","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1146\/annurev-immunol-081022-021207","article-title":"Structural mechanisms of NLRP3 inflammasome assembly and activation","volume":"41","author":"Fu","year":"2023","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.apsb.2025.10.020_bib23","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/nrd.2018.149","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2025.10.020_bib24","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1016\/j.apsb.2021.08.020","article-title":"Emerging role of natural products in cancer immunotherapy","volume":"12","author":"Dong","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.10.020_bib25","doi-asserted-by":"crossref","first-page":"4011","DOI":"10.1016\/j.apsb.2022.08.022","article-title":"New opportunities and challenges of natural products research: when target identification meets single-cell multiomics","volume":"12","author":"Zhu","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.10.020_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107182","article-title":"Design, synthesis, and biological evaluation of gambogenic acid derivatives: unraveling their anti-cancer effects by inducing pyroptosis","volume":"145","author":"Huang","year":"2024","journal-title":"Bioorg Chem"},{"key":"10.1016\/j.apsb.2025.10.020_bib27","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41419-018-0314-6","article-title":"Gambogenic acid inhibits fibroblast growth factor receptor signaling pathway in erlotinib-resistant non-small-cell lung cancer and suppresses patient-derived xenograft growth","volume":"9","author":"Xu","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2025.10.020_bib28","first-page":"1700","article-title":"Gambogenic acid inhibits the proliferation of small-cell lung cancer cells by arresting the cell cycle and inducing apoptosis","volume":"41","author":"Huang","year":"2019","journal-title":"Oncol Rep"},{"key":"10.1016\/j.apsb.2025.10.020_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2020.153306","article-title":"Gambogenic acid induces Noxa-mediated apoptosis in colorectal cancer through ROS-dependent activation of IRE1\u03b1\/JNK","volume":"78","author":"Zhao","year":"2020","journal-title":"Phytomedicine"},{"key":"10.1016\/j.apsb.2025.10.020_bib30","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/ptr.7614","article-title":"Gambogenic acid induces apoptosis and autophagy through ROS-mediated endoplasmic reticulum stress via JNK pathway in prostate cancer cells","volume":"37","author":"Wu","year":"2023","journal-title":"Phytother Res"},{"key":"10.1016\/j.apsb.2025.10.020_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154390","article-title":"Gambogenic acid alleviates kidney fibrosis via epigenetic inhibition of EZH2 to regulate Smad7-dependent mechanism","volume":"106","author":"Tao","year":"2022","journal-title":"Phytomedicine"},{"key":"10.1016\/j.apsb.2025.10.020_bib32","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/abbs\/gmw021","article-title":"Gambogenic acid inhibits LPS-simulated inflammatory response by suppressing NF-\u03baB and MAPK in macrophages","volume":"48","author":"Yu","year":"2016","journal-title":"Acta Biochim Biophys Sin"},{"key":"10.1016\/j.apsb.2025.10.020_bib33","doi-asserted-by":"crossref","first-page":"13250","DOI":"10.1039\/D2CC05278D","article-title":"Oridonin acts as a novel senolytic by targeting glutathione S-transferases to activate the ROS\u2013p38 signaling axis in senescent cells","volume":"58","author":"Zhang","year":"2022","journal-title":"Chem Commun"},{"key":"10.1016\/j.apsb.2025.10.020_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.chembiol.2022.06.011","article-title":"Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2\u2013LDHA-mediated Warburg effect in sepsis","volume":"29","author":"Zhang","year":"2022","journal-title":"Cell Chem Biol"},{"key":"10.1016\/j.apsb.2025.10.020_bib35","first-page":"22","article-title":"Celastrol mitigates inflammation in sepsis by inhibiting the PKM2-dependent Warburg effect","volume":"9","author":"Luo","year":"2022","journal-title":"Mil Med Res"},{"key":"10.1016\/j.apsb.2025.10.020_bib36","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1016\/j.apsb.2021.12.007","article-title":"Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1","volume":"12","author":"Luo","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.10.020_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2023.100978","article-title":"Multi-omics dissection of stage-specific artemisinin tolerance mechanisms in Kelch13-mutant Plasmodium falciparum","volume":"70","author":"Chen","year":"2023","journal-title":"Drug Resist Updates"},{"key":"10.1016\/j.apsb.2025.10.020_bib38","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.176","article-title":"Photoaffinity probe-based antimalarial target identification of artemisinin in the intraerythrocytic developmental cycle of Plasmodium falciparum","volume":"3","author":"Gao","year":"2024","journal-title":"Imeta"},{"key":"10.1016\/j.apsb.2025.10.020_bib39","first-page":"148","volume":"6","author":"Qiu","year":"2023"},{"key":"10.1016\/j.apsb.2025.10.020_bib40","article-title":"Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat Commun","volume":"6","author":"Wang","year":"2015"},{"key":"10.1016\/j.apsb.2025.10.020_bib41","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.15252\/embj.201694058","article-title":"A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination","volume":"36","author":"Wang","year":"2017","journal-title":"EMBO J"},{"key":"10.1016\/j.apsb.2025.10.020_bib42","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/s41419-022-04891-w","article-title":"Hexokinase 3 enhances myeloid cell survival via non-glycolytic functions","volume":"13","author":"Seiler","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2025.10.020_bib43","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.molcel.2023.02.022","article-title":"HK2: gatekeeping microglial activity by tuning glucose metabolism and mitochondrial functions","volume":"83","author":"Fang","year":"2023","journal-title":"Mol Cell"},{"key":"10.1016\/j.apsb.2025.10.020_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2018.02.012","article-title":"Mitochondria-endoplasmic reticulum contact sites function as immunometabolic hubs that orchestrate the rapid recall response of memory CD8+ T cells","volume":"48","author":"Bantug","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2025.10.020_bib45","doi-asserted-by":"crossref","first-page":"11633","DOI":"10.1021\/acs.jmedchem.2c00411","article-title":"Mapping the N-terminal hexokinase-I binding site onto voltage-dependent anion channel-1 to block peripheral nerve demyelination","volume":"65","author":"Gautier","year":"2022","journal-title":"J Med Chem"},{"key":"10.1016\/j.apsb.2025.10.020_bib46","first-page":"146","volume":"6","author":"Lin","year":"2023"},{"key":"10.1016\/j.apsb.2025.10.020_bib47","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1152\/japplphysiol.00207.2018","article-title":"Rapid radiochemical filter paper assay for determination of hexokinase activity and affinity for glucose-6-phosphate","volume":"127","author":"Hingst","year":"2019","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.apsb.2025.10.020_bib48","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1080\/15548627.2015.1042195","article-title":"HK2\/hexokinase-II integrates glycolysis and autophagy to confer cellular protection","volume":"11","author":"Tan","year":"2015","journal-title":"Autophagy"},{"key":"10.1016\/j.apsb.2025.10.020_bib49","first-page":"731","article-title":"Sepsis in older adults","volume":"31","author":"Rowe","year":"2017","journal-title":"Infect Dis Clin"},{"key":"10.1016\/j.apsb.2025.10.020_bib50","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/CMR.00031-13","article-title":"Early-onset neonatal sepsis","volume":"27","author":"Simonsen","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.apsb.2025.10.020_bib51","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.h3017","article-title":"Sepsis in children","volume":"350","author":"Plunkett","year":"2015","journal-title":"BMJ"},{"key":"10.1016\/j.apsb.2025.10.020_bib52","doi-asserted-by":"crossref","first-page":"S266","DOI":"10.1097\/PCC.0000000000000796","article-title":"Sepsis in pediatric cardiac intensive care","volume":"17","author":"Wheeler","year":"2016","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.apsb.2025.10.020_bib53","doi-asserted-by":"crossref","first-page":"e1179","DOI":"10.1097\/SLA.0000000000003784","article-title":"Pancreatic stone protein predicts sepsis in severely burned patients irrespective of trauma severity: a monocentric observational study","volume":"274","author":"Klein","year":"2021","journal-title":"Ann Surg"},{"key":"10.1016\/j.apsb.2025.10.020_bib54","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1097\/00000658-198709000-00012","article-title":"Burn wound sepsis may be promoted by a failure of local antibacterial host defenses","volume":"206","author":"Deitch","year":"1987","journal-title":"Ann Surg"},{"key":"10.1016\/j.apsb.2025.10.020_bib55","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1186\/s13054-020-02989-1","article-title":"The gut microbiome's role in the development, maintenance, and outcomes of sepsis","volume":"24","author":"Adelman","year":"2020","journal-title":"Crit Care"},{"key":"10.1016\/j.apsb.2025.10.020_bib56","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and septic shock","volume":"2","author":"Hotchkiss","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.apsb.2025.10.020_bib57","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1038\/s41581-023-00683-3","article-title":"Sepsis-associated acute kidney injury: consensus report of the 28th Acute Disease Quality Initiative workgroup","volume":"19","author":"Zarbock","year":"2023","journal-title":"Nat Rev Nephrol"},{"key":"10.1016\/j.apsb.2025.10.020_bib58","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s00134-022-06956-y","article-title":"How to use biomarkers of infection or sepsis at the bedside: guide to clinicians","volume":"49","author":"P\u00f3voa","year":"2023","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.apsb.2025.10.020_bib59","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1038\/s41392-022-01151-3","article-title":"Lactate metabolism in human health and disease","volume":"7","author":"Li","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.apsb.2025.10.020_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2016.01.001","article-title":"Current topics in HIV pathogenesis, part 2: inflammation drives a Warburg-like effect on the metabolism of HIV-infected subjects","volume":"28","author":"Aounallah","year":"2016","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.apsb.2025.10.020_bib61","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"Kelly","year":"2015","journal-title":"Cell Res"},{"key":"10.1016\/j.apsb.2025.10.020_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2024.155974","article-title":"Metabolic reprogramming in septic acute kidney injury: pathogenesis and therapeutic implications","volume":"158","author":"Liu","year":"2024","journal-title":"Metabolism"},{"key":"10.1016\/j.apsb.2025.10.020_bib63","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jcrc.2017.09.012","article-title":"Overcoming the Warburg effect: is it the key to survival in sepsis?.","volume":"43","author":"Bar-Or","year":"2018","journal-title":"J Crit Care"},{"key":"10.1016\/j.apsb.2025.10.020_bib64","doi-asserted-by":"crossref","first-page":"4436","DOI":"10.1038\/ncomms5436","article-title":"PKM2 regulates the Warburg effect and promotes HMGB1 release in sepsis","volume":"5","author":"Yang","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.10.020_bib65","doi-asserted-by":"crossref","first-page":"70","DOI":"10.3389\/fphys.2015.00070","article-title":"Warburg revisited: lessons for innate immunity and sepsis","volume":"6","author":"Srivastava","year":"2015","journal-title":"Front Physiol"},{"key":"10.1016\/j.apsb.2025.10.020_bib66","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s10020-023-00690-x","article-title":"Interferon-\u03b3 regulates immunosuppression in septic mice by promoting the Warburg effect through the PI3K\/AKT\/mTOR pathway","volume":"29","author":"Fu","year":"2023","journal-title":"Mol Med"},{"key":"10.1016\/j.apsb.2025.10.020_bib67","doi-asserted-by":"crossref","first-page":"469","DOI":"10.2147\/JIR.S446013","article-title":"Angiotensin-(1\u20137) modulates the Warburg effect to alleviate inflammation in LPS-induced macrophages and septic mice","volume":"17","author":"Yu","year":"2024","journal-title":"J Inflamm Res"},{"key":"10.1016\/j.apsb.2025.10.020_bib68","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/s42255-022-00642-5","article-title":"HK1 from hepatic stellate cell-derived extracellular vesicles promotes progression of hepatocellular carcinoma","volume":"4","author":"Chen","year":"2022","journal-title":"Nat Metab"},{"key":"10.1016\/j.apsb.2025.10.020_bib69","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1038\/s41588-022-01204-x","article-title":"Non-coding variants disrupting a tissue-specific regulatory element in HK1 cause congenital hyperinsulinism","volume":"54","author":"Wakeling","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.apsb.2025.10.020_bib70","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1002\/ptr.7767","article-title":"Inhibiting mitochondrial inflammation through Drp1\/HK1\/NLRP3 pathway: a mechanism of alpinetin attenuated aging-associated cognitive impairment","volume":"37","author":"Chen","year":"2023","journal-title":"Phytother Res"},{"key":"10.1016\/j.apsb.2025.10.020_bib71","doi-asserted-by":"crossref","first-page":"3105","DOI":"10.1038\/s41418-021-00804-0","article-title":"YTHDC1-mediated augmentation of miR-30d in repressing pancreatic tumorigenesis via attenuation of RUNX1-induced transcriptional activation of Warburg effect","volume":"28","author":"Hou","year":"2021","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.apsb.2025.10.020_bib72","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.tem.2022.07.005","article-title":"Location matters: hexokinase 1 in glucose metabolism and inflammation","volume":"33","author":"Sundaram","year":"2022","journal-title":"Trends Endocrinol Metabol"},{"key":"10.1016\/j.apsb.2025.10.020_bib73","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41467-024-52223-7","article-title":"The spatiotemporal transcriptional profiling of murine brain during cerebral malaria progression and after artemisinin treatment","volume":"16","author":"Chen","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.10.020_bib74","first-page":"30","article-title":"Identification of antimalarial targets of chloroquine by a combined deconvolution strategy of ABPP and MS-CETSA","volume":"9","author":"Gao","year":"2022","journal-title":"Mil Med Res"},{"key":"10.1016\/j.apsb.2025.10.020_bib75","first-page":"0459","article-title":"Dihydroartemisinin regulated the MMP-mediated cellular microenvironment to alleviate rheumatoid arthritis","volume":"7","author":"Guo","year":"2024","journal-title":"Research (Wash D C)"},{"key":"10.1016\/j.apsb.2025.10.020_bib76","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1038\/s41587-020-00778-3","article-title":"Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries","volume":"39","author":"Kuljanin","year":"2021","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.apsb.2025.10.020_bib77","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/s41565-023-01455-7","article-title":"Cholesterol modulates the physiological response to nanoparticles by changing the composition of protein corona","volume":"18","author":"Tang","year":"2023","journal-title":"Nat Nanotechnol"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525006975?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525006975?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:56:19Z","timestamp":1778846179000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383525006975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":77,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2211383525006975"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.10.020","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Gambogenic acid ameliorates inflammation by inhibiting HK1-mediated Warburg effect and NLRP3 inflammasome activation in sepsis","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.10.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}