{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T17:10:57Z","timestamp":1789665057249,"version":"4.0.1"},"reference-count":64,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T00:00:00Z","timestamp":1762473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["2023A03J1037"],"award-info":[{"award-number":["2023A03J1037"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2023-I2M-QJ-010"],"award-info":[{"award-number":["2023-I2M-QJ-010"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Initiative for Innovative Medicine","doi-asserted-by":"publisher","award":["2023-I2M-2-006"],"award-info":[{"award-number":["2023-I2M-2-006"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402408"],"award-info":[{"award-number":["82402408"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271943"],"award-info":[{"award-number":["82271943"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515220159"],"award-info":[{"award-number":["2022A1515220159"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012660"],"award-info":[{"award-number":["2023A1515012660"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515220128"],"award-info":[{"award-number":["2023A1515220128"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M750452"],"award-info":[{"award-number":["2024M750452"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","award":["2022-RC350-04"],"award-info":[{"award-number":["2022-RC350-04"]}],"id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004024","name":"Jinan University","doi-asserted-by":"publisher","award":["JNU1AF-CFTP-2022-a01233"],"award-info":[{"award-number":["JNU1AF-CFTP-2022-a01233"]}],"id":[{"id":"10.13039\/501100004024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.apsb.2025.11.005","type":"journal-article","created":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T09:17:45Z","timestamp":1763111865000},"page":"522-538","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Engineered bacterial extracellular vesicles mediate pyroptosis to counteract m6A methylation-based immunosuppression after insufficient radiofrequency ablation of hepatocellular carcinoma"],"prefix":"10.1016","volume":"16","author":[{"given":"Zeyu","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0916-8822","authenticated-orcid":false,"given":"Jiaxin","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiming","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoxue","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pingping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Che","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunqian","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2549-629X","authenticated-orcid":false,"given":"Kuan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangping","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.11.005_bib1","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1002\/hep.29913","article-title":"Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American association for the study of liver diseases","volume":"68","author":"Marrero","year":"2018","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2025.11.005_bib2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/annonc\/mdy308","article-title":"Hepatocellular carcinoma: ESMO clinical practice guidelines for diagnosis, treatment and follow-up","volume":"29","author":"Vogel","year":"2018","journal-title":"Ann Oncol"},{"key":"10.1016\/j.apsb.2025.11.005_bib3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.2147\/JHC.S358539","article-title":"An overview of hepatocellular carcinoma after insufficient radiofrequency ablation","volume":"9","author":"Guo","year":"2022","journal-title":"J Hepatocell Carcinoma"},{"key":"10.1016\/j.apsb.2025.11.005_bib4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nrc3672","article-title":"Thermal ablation of tumours: biological mechanisms and advances in therapy","volume":"14","author":"Chu","year":"2014","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2025.11.005_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.canlet.2019.05.041","article-title":"Sublethal heat treatment of hepatocellular carcinoma promotes intrahepatic metastasis and stemness in a VEGFR1-dependent manner","volume":"460","author":"Tan","year":"2019","journal-title":"Cancer Lett"},{"key":"10.1016\/j.apsb.2025.11.005_bib6","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1158\/0008-5472.CAN-14-2905","article-title":"Heat shock factor 1 in protein homeostasis and oncogenic signal integration","volume":"75","author":"Home","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2025.11.005_bib7","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1002\/hep.31766","article-title":"Insufficient radiofrequency ablation promotes hepatocellular carcinoma metastasis through N6-methyladenosine mRNA methylation-dependent mechanism","volume":"74","author":"Su","year":"2021","journal-title":"Hepatology"},{"key":"10.1016\/j.apsb.2025.11.005_bib8","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s12943-021-01356-0","article-title":"The m6A RNA methylation regulates oncogenic signaling pathways driving cell malignant transformation and carcinogenesis","volume":"20","author":"Uddin","year":"2021","journal-title":"Mol Cancer"},{"key":"10.1016\/j.apsb.2025.11.005_bib9","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41392-020-00453-8","article-title":"HIF-1\u03b1-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.apsb.2025.11.005_bib10","doi-asserted-by":"crossref","first-page":"5421","DOI":"10.1038\/s41467-019-13204-3","article-title":"Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy","volume":"10","author":"Shi","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.11.005_bib11","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.3389\/fonc.2020.01308","article-title":"Palliative radiofrequency ablation accelerates the residual tumor progression through increasing tumor-infiltrating MDSCs and reducing T-cell-mediated antitumor immune responses in animal model","volume":"10","author":"Wu","year":"2020","journal-title":"Front Oncol"},{"key":"10.1016\/j.apsb.2025.11.005_bib12","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1172\/JCI80005","article-title":"Myeloid-derived suppressor cells in the tumor microenvironment: expect the unexpected","volume":"125","author":"Marvel","year":"2015","journal-title":"J Clin Investig"},{"key":"10.1016\/j.apsb.2025.11.005_bib13","doi-asserted-by":"crossref","first-page":"993","DOI":"10.7150\/thno.104872","article-title":"Metformin-based nanomedicines for reprogramming tumor immune microenvironment","volume":"15","author":"Liu","year":"2025","journal-title":"Theranostics"},{"key":"10.1016\/j.apsb.2025.11.005_bib14","article-title":"Metformin-mediated immunosuppressive microenvironment remodeling in combination with chemotherapy via a cspatial-specific multi-responsive carrier-free self-assembled nanoparticle","volume":"34","author":"Song","year":"2024","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2025.11.005_bib15","article-title":"Dendritic polymer-based nanomedicines remodel the tumor stroma: improve drug penetration and enhance antitumor immune response","volume":"36","author":"Zhang","year":"2024","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2025.11.005_bib16","doi-asserted-by":"crossref","DOI":"10.4028\/b-wjQRP6","article-title":"Arginine-loaded nano-calcium-phosphate-stabilized lipiodol pickering emulsions potentiates transarterial embolization-immunotherapy","volume":"12","author":"Wang","year":"2024","journal-title":"Adv Sci"},{"key":"10.1016\/j.apsb.2025.11.005_bib17","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1016\/j.tim.2023.05.010","article-title":"Bacterial extracellular vesicles: an emerging avenue to tackle diseases","volume":"31","author":"Xie","year":"2023","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.apsb.2025.11.005_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.101007","article-title":"Nanovaccines integrating endogenous antigens and pathogenic adjuvants elicit potent antitumor immunity","volume":"35","author":"Li","year":"2020","journal-title":"Nano Today"},{"key":"10.1016\/j.apsb.2025.11.005_bib19","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.tibtech.2022.03.005","article-title":"The tremendous biomedical potential of bacterial extracellular vesicles","volume":"40","author":"Xie","year":"2022","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.apsb.2025.11.005_bib20","article-title":"Biomineralized bacterial outer membrane vesicles potentiate safe and efficient tumor microenvironment reprogramming for anticancer therapy","volume":"32","author":"Qing","year":"2020","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2025.11.005_bib21","doi-asserted-by":"crossref","first-page":"2740","DOI":"10.1111\/ajt.15960","article-title":"B cell\u2013derived IL-1\u03b2 and IL-6 drive T cell reconstitution following lymphoablation","volume":"20","author":"Hasgur","year":"2020","journal-title":"Am J Transplant"},{"key":"10.1016\/j.apsb.2025.11.005_bib22","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2117636119","article-title":"Myeloid Caspase-8 restricts RIPK3-dependent proinflammatory IL-1\u03b2 production and CD4 T cell activation in autoimmune demyelination","volume":"119","author":"Kim","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2025.11.005_bib23","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/s41569-023-00946-3","article-title":"The role of the NLRP3 inflammasome and pyroptosis in cardiovascular diseases","volume":"21","author":"Toldo","year":"2023","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.apsb.2025.11.005_bib24","doi-asserted-by":"crossref","first-page":"4310","DOI":"10.7150\/thno.71086","article-title":"Pyroptosis in inflammatory diseases and cancer","volume":"12","author":"Rao","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.apsb.2025.11.005_bib25","doi-asserted-by":"crossref","first-page":"R568","DOI":"10.1016\/j.cub.2016.02.019","article-title":"Pyroptosis","volume":"26","author":"Vande Walle","year":"2016","journal-title":"Curr Biol"},{"key":"10.1016\/j.apsb.2025.11.005_bib26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/s41586-020-2079-1","article-title":"A bioorthogonal system reveals antitumour immune function of pyroptosis","volume":"579","author":"Wang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.11.005_bib27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-020-2071-9","article-title":"Gasdermin E suppresses tumour growth by activating antitumour immunity","volume":"579","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.11.005_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202270219","article-title":"Metal-cyclic dinucleotide nanomodulator-stimulated STING signaling for strengthened radioimmunotherapy of large tumors","volume":"18","author":"Wang","year":"2022","journal-title":"Small"},{"key":"10.1016\/j.apsb.2025.11.005_bib29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jconrel.2024.06.052","article-title":"Environmentally responsive hydrogel promotes vascular normalization to enhance STING antitumor immunity","volume":"372","author":"Wang","year":"2024","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2025.11.005_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122766","article-title":"Napabucasin deactivates STAT3 and promotes mitoxantrone-mediated cGAS\u2013STING activation for hepatocellular carcinoma chemo-immunotherapy","volume":"313","author":"Wang","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2025.11.005_bib31","doi-asserted-by":"crossref","first-page":"412","DOI":"10.3390\/ijms22010412","article-title":"TUNEL assay: a powerful tool for kidney injury evaluation","volume":"22","author":"Moore","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2025.11.005_bib32","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.biomaterials.2016.10.037","article-title":"Bacterial protoplast-derived nanovesicles for tumor-targeted delivery of chemotherapeutics","volume":"113","author":"Kim","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2025.11.005_bib33","article-title":"Conformational changes in a hyperthermostable glycoside hydrolase: enzymatic activity is a consequence of the loop dynamics and protonation balance","volume":"10","author":"Agarwal","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2025.11.005_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108053","article-title":"Mn2+ directly activates cGAS and structural analysis suggests Mn2+ induces a noncanonical catalytic synthesis of 2\u20323\u2032-cGAMP","volume":"32","author":"Zhao","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.apsb.2025.11.005_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0045185","article-title":"CD80 and CD86 differentially regulate mechanical interactions of T-cells with antigen-presenting dendritic cells and B-cells","volume":"7","author":"Lim","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2025.11.005_bib36","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s13073-020-00756-z","article-title":"Discovery of CD80 and CD86 as recent activation markers on regulatory T cells by protein-RNA single-cell analysis","volume":"12","author":"Trzupek","year":"2020","journal-title":"Genome Med"},{"key":"10.1016\/j.apsb.2025.11.005_bib37","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41541-024-00869-1","article-title":"High production of IL-12 by human dendritic cells stimulated with combinations of pattern-recognition receptor agonists","volume":"9","author":"Gilmour","year":"2024","journal-title":"npj Vaccines"},{"key":"10.1016\/j.apsb.2025.11.005_bib38","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41416-020-01048-4","article-title":"Cytotoxic CD8+ T cells in cancer and cancer immunotherapy","volume":"124","author":"Raskov","year":"2020","journal-title":"Br J Cancer"},{"key":"10.1016\/j.apsb.2025.11.005_bib39","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s40164-024-00561-z","article-title":"Natural killer cell-based cancer immunotherapy: from basics to clinical trials","volume":"13","author":"Shi","year":"2024","journal-title":"Exp Hematol Oncol"},{"key":"10.1016\/j.apsb.2025.11.005_bib40","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1002\/anie.201805664","article-title":"Chemodynamic therapy: tumour microenvironment-mediated fenton and fenton-like reactions","volume":"58","author":"Tang","year":"2018","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.apsb.2025.11.005_bib41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s13046-024-03115-7","article-title":"The crosstalk between immune cells and tumor pyroptosis: advancing cancer immunotherapy strategies","volume":"43","author":"Hu","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.apsb.2025.11.005_bib42","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/s41590-020-0669-6","article-title":"FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation","volume":"21","author":"Hu","year":"2020","journal-title":"Nat Immunol"},{"key":"10.1016\/j.apsb.2025.11.005_bib43","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/nri3839","article-title":"Perforin and granzymes: function, dysfunction and human pathology","volume":"15","author":"Voskoboinik","year":"2015","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.apsb.2025.11.005_bib44","doi-asserted-by":"crossref","first-page":"6995","DOI":"10.3390\/ijms22136995","article-title":"Macrophage polarization states in the tumor microenvironment","volume":"22","author":"Boutilier","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2025.11.005_bib45","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.jconrel.2024.01.048","article-title":"STING agonist-based hydrogel enhances immune activation in synergy with radiofrequency ablation for hepatocellular carcinoma treatment","volume":"369","author":"Ao","year":"2024","journal-title":"J Control Release"},{"key":"10.1016\/j.apsb.2025.11.005_bib46","doi-asserted-by":"crossref","first-page":"32818","DOI":"10.1021\/acsnano.4c11257","article-title":"Dual-synergistic nanomodulator alleviates exosomal PD-L1 expression enabling exhausted cytotoxic T lymphocytes rejuvenation for potentiated iRFA-treated hepatocellular carcinoma immunotherapy","volume":"18","author":"Zhu","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2025.11.005_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2024.122944","article-title":"Tumor vascular occlusion by calcium-based thermosensitizer provokes continuous cavitation effect and thermal energy transition efficiency of radiofrequency ablation therapy","volume":"315","author":"Zeng","year":"2025","journal-title":"Biomaterials"},{"key":"10.1016\/j.apsb.2025.11.005_bib48","doi-asserted-by":"crossref","first-page":"3901","DOI":"10.1158\/1078-0432.CCR-19-1321","article-title":"Dendritic cells, the T-cell-inflamed tumor microenvironment, and immunotherapy treatment response","volume":"26","author":"Garris","year":"2020","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.apsb.2025.11.005_bib49","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.actbio.2022.11.019","article-title":"Integrated manganese (III)-doped nanosystem for optimizing photothermal ablation: amplifying hyperthermia-induced STING pathway and enhancing antitumor immunity","volume":"155","author":"Xia","year":"2023","journal-title":"Acta Biomater"},{"key":"10.1016\/j.apsb.2025.11.005_bib50","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aay9013","article-title":"cGAS\u2013STING-mediated DNA sensing maintains CD8+ T cell stemness and promotes antitumor T cell therapy","volume":"12","author":"Li","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.apsb.2025.11.005_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.immuni.2018.09.016","article-title":"Tumor-derived cGAMP triggers a STING-mediated interferon response in non-tumor cells to activate the NK cell response","volume":"49","author":"Marcus","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2025.11.005_bib52","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.immuni.2018.03.017","article-title":"Manganese increases the sensitivity of the cGAS\u2013STING pathway for double-stranded DNA and is required for the host defense against DNA viruses","volume":"48","author":"Wang","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2025.11.005_bib53","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.apsb.2015.05.007","article-title":"HIF-1\u03b1 pathway: role, regulation and intervention for cancer therapy","volume":"5","author":"Masoud","year":"2015","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.11.005_bib54","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.semcancer.2022.04.002","article-title":"EGFR signaling pathway as therapeutic target in human cancers","volume":"85","author":"Levantini","year":"2022","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.apsb.2025.11.005_bib55","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s13046-024-03184-8","article-title":"HIF-1\u03b1\u2013HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma","volume":"43","author":"Geng","year":"2024","journal-title":"J Exp Clin Cancer Res"},{"key":"10.1016\/j.apsb.2025.11.005_bib56","article-title":"Multi-hierarchical Fe single atom nanozymes with axially-coordinated O-Fe-N4 active centers reshape macrophage epigenetics against immunosuppression","volume":"34","author":"Wang","year":"2024","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2025.11.005_bib57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.coche.2017.11.006","article-title":"CD8+ T cells and NK cells: parallel and complementary soldiers of immunotherapy","volume":"19","author":"Rosenberg","year":"2018","journal-title":"Curr Opin Chem Eng"},{"key":"10.1016\/j.apsb.2025.11.005_bib58","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00262-024-03795-2","article-title":"NKG2D-bispecific enhances NK and CD8+ T cell antitumor immunity","volume":"73","author":"Herault","year":"2024","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.apsb.2025.11.005_bib59","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.cell.2024.11.018","article-title":"Transplantation of gasdermin pores by extracellular vesicles propagates pyroptosis to bystander cells","volume":"188","author":"Wright","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2025.11.005_bib60","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/s41388-024-03013-4","article-title":"Targeting STING elicits GSDMD-dependent pyroptosis and boosts antitumor immunity in renal cell carcinoma","volume":"43","author":"Wu","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.apsb.2025.11.005_bib61","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2015.1016700","article-title":"Reprogramming the tumor microenvironment: tumor-induced immunosuppressive factors paralyze T cells","volume":"4","author":"Wu","year":"2015","journal-title":"OncoImmunology"},{"key":"10.1016\/j.apsb.2025.11.005_bib62","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41392-022-01252-z","article-title":"Multifaceted functions of STING in human health and disease: from molecular mechanism to targeted strategy","volume":"7","author":"Zhang","year":"2022","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.apsb.2025.11.005_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.canlet.2023.216409","article-title":"cGAS\u2013STING signaling in the tumor microenvironment","volume":"577","author":"Liu","year":"2023","journal-title":"Cancer Lett"},{"key":"10.1016\/j.apsb.2025.11.005_bib64","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.cell.2017.05.005","article-title":"Interferon-\u03b3 drives Treg fragility to promote antitumor immunity","volume":"169","author":"Overacre-Delgoffe","year":"2017","journal-title":"Cell"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221138352500735X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S221138352500735X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T17:07:05Z","timestamp":1771520825000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S221138352500735X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":64,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S221138352500735X"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.11.005","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered bacterial extracellular vesicles mediate pyroptosis to counteract m6A methylation-based immunosuppression after insufficient radiofrequency ablation of hepatocellular carcinoma","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.11.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}