{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T12:13:16Z","timestamp":1778847196139,"version":"3.51.4"},"reference-count":62,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013068","name":"Key Technologies Research and Development Program of Guangzhou","doi-asserted-by":"publisher","award":["2024YFFO728801"],"award-info":[{"award-number":["2024YFFO728801"]}],"id":[{"id":"10.13039\/501100013068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52473137"],"award-info":[{"award-number":["52473137"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018556","name":"Science and Technology Program of Suzhou","doi-asserted-by":"publisher","award":["Su-2020-169"],"award-info":[{"award-number":["Su-2020-169"]}],"id":[{"id":"10.13039\/501100018556","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["ZYGD23011"],"award-info":[{"award-number":["ZYGD23011"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.apsb.2025.11.027","type":"journal-article","created":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T00:20:40Z","timestamp":1764202840000},"page":"900-912","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel fusion protein of COVID-19 virus enhancing protection of Syrian hamsters infected with SARS-CoV-2"],"prefix":"10.1016","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1239-634X","authenticated-orcid":false,"given":"Hanlu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tiantian","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yichao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fengmei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunhuan","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuning","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenhong","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxue","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenting","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weihua","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suqin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5448-2477","authenticated-orcid":false,"given":"Meng","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhanlong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6024-4187","authenticated-orcid":false,"given":"Yongping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.11.027_bib1","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/s41579-025-01185-8","article-title":"SARS-CoV-2 spike protein: structure, viral entry and variants","volume":"37","author":"Chen","year":"2025","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.apsb.2025.11.027_bib2","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1038\/s41591-024-03173-6","article-title":"Long COVID science, research and policy","volume":"30","author":"Al-Aly","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2025.11.027_bib3","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41392-023-01640-z","article-title":"The long-term health outcomes, pathophysiological mechanisms and multidisciplinary management of long COVID","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.apsb.2025.11.027_bib4","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41569-021-00631-3","article-title":"Cardiac involvement in the long-term implications of COVID-19","volume":"19","author":"Satterfield","year":"2022","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.apsb.2025.11.027_bib5","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.1038\/s41598-024-58430-y","article-title":"Patients with unmet social needs are at higher risks of developing severe long COVID-19 symptoms and neuropsychiatric sequela","volume":"14","author":"Eligulashvili","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2025.11.027_bib6","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/s41579-022-00846-2","article-title":"Long COVID: major findings, mechanisms and recommendations","volume":"21","author":"Davis","year":"2023","journal-title":"Nat Rev Microbiol"},{"key":"10.1016\/j.apsb.2025.11.027_bib7","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/S0140-6736(20)32656-8","article-title":"6-month consequences of COVID-19 in patients discharged from hospital: a cohort study","volume":"397","author":"Huang","year":"2021","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.apsb.2025.11.027_bib8","article-title":"The complexity of SARS-CoV-2 infection and the COVID-19 pandemic","volume":"13","author":"Torres","year":"2022","journal-title":"Front Microbiol"},{"key":"10.1016\/j.apsb.2025.11.027_bib9","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41573-023-00672-y","article-title":"Therapeutic strategies for COVID-19: progress and lessons learned","volume":"22","author":"Li","year":"2023","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2025.11.027_bib10","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41392-022-00950-y","article-title":"Advances in COVID-19 mRNA vaccine development","volume":"7","author":"Fang","year":"2022","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.apsb.2025.11.027_bib11","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.3390\/vaccines11061045","article-title":"A review of inactivated COVID-19 vaccine development in China: focusing on safety and efficacy in special populations","volume":"11","author":"Hu","year":"2023","journal-title":"Vaccines"},{"key":"10.1016\/j.apsb.2025.11.027_bib12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1146\/annurev-med-012621-102252","article-title":"COVID-19 vaccines: adenoviral vectors","volume":"73","author":"Jacob-Dolan","year":"2022","journal-title":"Annu Rev Med"},{"key":"10.1016\/j.apsb.2025.11.027_bib13","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.addr.2021.01.001","article-title":"Recombinant protein vaccines, a proven approach against coronavirus pandemics","volume":"170","author":"Pollet","year":"2021","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.apsb.2025.11.027_bib14","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/S0140-6736(22)00055-1","article-title":"Efficacy of the adjuvanted subunit protein COVID-19 vaccine, SCB-2019: a phase 2 and 3 multicentre, double-blind, randomised, placebo-controlled trial","volume":"399","author":"Bravo","year":"2022","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.apsb.2025.11.027_bib15","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1056\/NEJMc2206900","article-title":"Omicron SARS-CoV-2 neutralization from inactivated and ZF2001 vaccines","volume":"387","author":"Zhao","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apsb.2025.11.027_bib16","doi-asserted-by":"crossref","first-page":"3321","DOI":"10.1016\/j.apsb.2023.01.006","article-title":"Advanced subunit vaccine delivery technologies: from vaccine cascade obstacles to design strategies","volume":"13","author":"Hou","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.11.027_bib17","doi-asserted-by":"crossref","first-page":"eabg3055","DOI":"10.1126\/science.abg3055","article-title":"Estimated transmissibility and impact of SARS-CoV-2 lineage B.1.1.7 in England","volume":"372","author":"Davies","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.apsb.2025.11.027_bib18","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1038\/s41586-021-03402-9","article-title":"Detection of a SARS-CoV-2 variant of concern in South Africa","volume":"592","author":"Tegally","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.11.027_bib19","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.abh2644","article-title":"Genomics and epidemiology of the P.1 SARS-CoV-2 lineage in Manaus, Brazil","volume":"372","author":"Faria","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.apsb.2025.11.027_bib20","article-title":"Comparative transmissibility of SARS-CoV-2 variants delta and alpha in New England, USA","volume":"3","author":"Earnest","year":"2022","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.apsb.2025.11.027_bib21","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41586-021-03426-1","article-title":"Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7","volume":"593","author":"Davies","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.11.027_bib22","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2021.26.16.2100348","article-title":"Characteristics of SARS-CoV-2 variants of concern B.1.1.7, B.1.351 or P.1: data from seven EU\/EEA countries, weeks 38\/2020 to 10\/2021","volume":"26","author":"Funk","year":"2021","journal-title":"Euro Surveill"},{"key":"10.1016\/j.apsb.2025.11.027_bib23","article-title":"Emerging variants of SARS-CoV-2 and novel therapeutics against coronavirus (COVID-19)","author":"Aleem","year":"2023","journal-title":"StatPearls (Internet)"},{"key":"10.1016\/j.apsb.2025.11.027_bib24","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/s41586-021-03412-7","article-title":"Sensitivity of SARS-CoV-2 B.1.1.7 to mRNA vaccine-elicited antibodies","volume":"593","author":"Collier","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.11.027_bib25","doi-asserted-by":"crossref","first-page":"e283","DOI":"10.1016\/S2666-5247(21)00068-9","article-title":"SARS-CoV-2 spike E484K mutation reduces antibody neutralisation","volume":"2","author":"Jangra","year":"2021","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.apsb.2025.11.027_bib26","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1038\/s41586-021-03471-w","article-title":"Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma","volume":"593","author":"Cele","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.11.027_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2021.02.037","article-title":"Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera","volume":"184","author":"Zhou","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2025.11.027_bib28","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41586-021-04385-3","article-title":"Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies","volume":"602","author":"Cao","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2025.11.027_bib29","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.cytogfr.2023.11.005","article-title":"COVID-19: from emerging variants to vaccination","volume":"76","author":"Senevirathne","year":"2024","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.apsb.2025.11.027_bib30","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.apsb.2024.12.003","article-title":"Protection efficacy of mRNA-based SARS-CoV-2 variant vaccine in non-human primates","volume":"15","author":"Yi","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.11.027_bib31","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S1473-3099(22)00054-8","article-title":"Safety of mRNA vaccines administered during the initial 6 months of the US COVID-19 vaccination programme: an observational study of reports to the vaccine adverse event reporting system and v-safe","volume":"22","author":"Rosenblum","year":"2022","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.apsb.2025.11.027_bib32","doi-asserted-by":"crossref","first-page":"11464","DOI":"10.1021\/acs.analchem.2c02223","article-title":"Screened \u03b1-helix peptide inhibitor toward SARS-CoV-2 by blocking a prion-like domain in the receptor binding domain","volume":"94","author":"Wu","year":"2022","journal-title":"Anal Chem"},{"key":"10.1016\/j.apsb.2025.11.027_bib33","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.tim.2019.06.002","article-title":"Molecular mechanism of HIV-1 entry","volume":"27","author":"Chen","year":"2019","journal-title":"Trends Microbiol"},{"key":"10.1016\/j.apsb.2025.11.027_bib34","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1126\/science.abd2985","article-title":"Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity","volume":"370","author":"Cantuti-Castelvetri","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.apsb.2025.11.027_bib35","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41392-020-00426-x","article-title":"CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells","volume":"5","author":"Wang","year":"2020","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.apsb.2025.11.027_bib36","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020106765","article-title":"Infection and transmission of SARS-CoV-2 depend on heparan sulfate proteoglycans","volume":"40","author":"Bermejo-Jambrina","year":"2021","journal-title":"EMBO J"},{"key":"10.1016\/j.apsb.2025.11.027_bib37","doi-asserted-by":"crossref","first-page":"3339","DOI":"10.1016\/j.apsb.2023.05.030","article-title":"HR121 targeting HR2 domain in S2 subunit of spike protein can serve as a broad-spectrum SARS-CoV-2 inhibitor via intranasal administration","volume":"13","author":"Lu","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.11.027_bib38","doi-asserted-by":"crossref","first-page":"7580","DOI":"10.1038\/s41467-025-63101-1","article-title":"A broadly neutralizing antibody recognizes a unique epitope with a signature motif common across coronaviruses","volume":"16","author":"Yan","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.11.027_bib39","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1016\/j.apsb.2023.01.010","article-title":"A novel heterologous receptor-binding domain dodecamer universal mRNA vaccine against SARS-CoV-2 variants","volume":"13","author":"Qin","year":"2023","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.11.027_bib40","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41392-023-01396-6","article-title":"Potential recombination between SARS-CoV-2 and MERSCoV: calls for the development of Pan-CoV vaccines","volume":"8","author":"Wang","year":"2023","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.apsb.2025.11.027_bib41","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00554-20","article-title":"Single-dose, intranasal immunization with recombinant parainfluenza virus 5 expressing Middle East respiratory syndrome coronavirus (MERS-CoV) spike protein protects mice from fatal MERS-CoV infection","volume":"11","author":"Li","year":"2020","journal-title":"mBio"},{"key":"10.1016\/j.apsb.2025.11.027_bib42","doi-asserted-by":"crossref","first-page":"581","DOI":"10.3201\/eid1004.030458","article-title":"Inhibition of SARS coronavirus infection in vitro with clinically approved antiviral drugs","volume":"10","author":"Tan","year":"2004","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.apsb.2025.11.027_bib43","article-title":"Identification and characterization of a novel cell binding and cross-reactive region on spike protein of SARS-CoV-2","volume":"12","author":"Wang","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2025.11.027_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107823","article-title":"Anti-tumor effect of a novel soluble recombinant human endostatin: administered as a single agent or in combination with chemotherapy agents in mouse tumor models","volume":"9","author":"Ren","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2025.11.027_bib45","doi-asserted-by":"crossref","first-page":"897","DOI":"10.5966\/sctm.2016-0224","article-title":"Safety and efficacy of megakaryocytes induced from hematopoietic stem cells in murine and nonhuman primate models","volume":"6","author":"Guan","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.apsb.2025.11.027_bib46","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s13287-019-1275-0","article-title":"Safety and efficacy of ex vivo expanded CD34+ stem cells in murine and primate models","volume":"10","author":"Zhang","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.apsb.2025.11.027_bib47","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s13287-018-0769-5","article-title":"Evaluation of ex vivo produced endothelial progenitor cells for autologous transplantation in primates","volume":"9","author":"Qin","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.apsb.2025.11.027_bib48","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1756-8722-5-73","article-title":"A novel monoclonal antibody of human stem cell factor inhibits umbilical cord blood stem cell ex vivo expansion","volume":"5","author":"Fan","year":"2012","journal-title":"J Hematol Oncol"},{"key":"10.1016\/j.apsb.2025.11.027_bib49","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.omtn.2017.12.003","article-title":"In vivo SELEX of an inhibitory NSCLC-specific RNA aptamer from PEGylated RNA library","volume":"10","author":"Wang","year":"2018","journal-title":"Mol Ther Nucleic Acids"},{"key":"10.1016\/j.apsb.2025.11.027_bib50","article-title":"Characterization of A bifunctional synthetic RNA aptamer and A truncated form for ability to inhibit growth of non-small cell lung cancer","volume":"9","author":"Wang","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2025.11.027_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110428","article-title":"Cryo-EM structure of the SARS-CoV-2 Omicron spike","volume":"38","author":"Cerutti","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.apsb.2025.11.027_bib52","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1038\/s41589-022-01059-7","article-title":"Structure and activity of human TMPRSS2 protease implicated in SARS-CoV-2 activation","volume":"18","author":"Fraser","year":"2022","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.apsb.2025.11.027_bib53","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41594-020-0468-7","article-title":"SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects","volume":"27","author":"Wrobel","year":"2020","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.apsb.2025.11.027_bib54","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2209514119","article-title":"SARS-CoV-2 requires acidic pH to infect cells","volume":"119","author":"Kreutzberger","year":"2022","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2025.11.027_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2020.583523","article-title":"Investigation of the effect of temperature on the structure of SARS-CoV-2 spike protein by molecular dynamics simulations","volume":"7","author":"Rath","year":"2020","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.apsb.2025.11.027_bib56","article-title":"Therapeutic development targeting host heparan sulfate proteoglycan in SARS-CoV-2 infection","volume":"11","author":"Zhang","year":"2024","journal-title":"Front Med"},{"key":"10.1016\/j.apsb.2025.11.027_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116052","article-title":"Structure of a SARS-CoV-2 spike S2 subunit in a pre-fusion, open conformation","volume":"44","author":"Olmedillas","year":"2025","journal-title":"Cell Rep"},{"key":"10.1016\/j.apsb.2025.11.027_bib58","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/s41594-019-0334-7","article-title":"Structures of MERS-CoV spike glycoprotein in complex with sialoside attachment receptors","volume":"26","author":"Park","year":"2019","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.apsb.2025.11.027_bib59","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1038\/s41422-024-00958-9","article-title":"Structural basis for the recognition of HCoV-HKU1 by human TMPRSS2","volume":"34","author":"Xia","year":"2024","journal-title":"Cell Res"},{"key":"10.1016\/j.apsb.2025.11.027_bib60","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.1073\/pnas.1809667116","article-title":"Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A","volume":"116","author":"Hulswit","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2025.11.027_bib61","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1093\/nar\/gkae144","article-title":"Conserved structures and dynamics in 5\u2032-proximal regions of Betacoronavirus RNA genomes","volume":"52","author":"Moura","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.apsb.2025.11.027_bib62","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1016\/j.cell.2025.07.015","article-title":"Highly conserved Betacoronavirus sequences are broadly recognized by human T cells","volume":"188","author":"Pereira Neto","year":"2025","journal-title":"Cell"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525007774?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525007774?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:56:58Z","timestamp":1778846218000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383525007774"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":62,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2211383525007774"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.11.027","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel fusion protein of COVID-19 virus enhancing protection of Syrian hamsters infected with SARS-CoV-2","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.11.027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}