{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T13:31:09Z","timestamp":1792589469955,"version":"4.5.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2025KY1032"],"award-info":[{"award-number":["2025KY1032"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009659","name":"Guangzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82501725"],"award-info":[{"award-number":["82501725"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21961142009"],"award-info":[{"award-number":["21961142009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.apsb.2025.12.002","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T16:39:44Z","timestamp":1764779984000},"page":"820-835","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["OTUD6A drives dopaminergic neuronal degeneration of Parkinson's disease through deubiquitinating ACTG1 in neuronal cells"],"prefix":"10.1016","volume":"16","author":[{"given":"Xia","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyao","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruya","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiyu","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhua","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jurui","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Houming","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8278-849X","authenticated-orcid":false,"given":"Guang","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.12.002_bib1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1615\/JEnvironPatholToxicolOncol.2018025666","article-title":"Melatonin improves behavioral and biochemical outcomes in a rotenone-induced rat model of Parkinson's disease","volume":"37","author":"Rasheed","year":"2018","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"10.1016\/j.apsb.2025.12.002_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1234974","article-title":"Case report: reversible encephalopathy caused by dyskinesia-hyperpyrexia syndrome","volume":"14","author":"Luo","year":"2023","journal-title":"Front Neurol"},{"key":"10.1016\/j.apsb.2025.12.002_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-92738-3","article-title":"Drosophila tubulin polymerization promoting protein mutants reveal pathological correlates relevant to human Parkinson's disease","volume":"11","author":"Xie","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2025.12.002_bib4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.gaitpost.2023.01.022","article-title":"Dopamine replacement therapy normalizes reactive step length to postural perturbations in Parkinson's disease","volume":"101","author":"Herbers","year":"2023","journal-title":"Gait Posture"},{"key":"10.1016\/j.apsb.2025.12.002_bib5","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00441-018-2813-2","article-title":"Molecular basis of dopamine replacement therapy and its side effects in Parkinson's disease","volume":"373","author":"You","year":"2018","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.apsb.2025.12.002_bib6","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1210\/jcem-45-4-841","article-title":"Failure of dopamine infusion to suppress the plasma prolactin response to sulpiride in normal and hyperprolactinemic subjects","volume":"45","author":"Crosignani","year":"1977","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.apsb.2025.12.002_bib7","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41419-020-03369-x","article-title":"Intranasal administration of \u03b1-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis","volume":"12","author":"Guo","year":"2021","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2025.12.002_bib8","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1042\/BST20211078","article-title":"Linear ubiquitination in immune and neurodegenerative diseases, and beyond","volume":"50","author":"Tokunaga","year":"2022","journal-title":"Biochem Soc Trans"},{"key":"10.1016\/j.apsb.2025.12.002_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101856","article-title":"Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury","volume":"86","author":"Mi","year":"2023","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.apsb.2025.12.002_bib10","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s12013-013-9634-4","article-title":"Neuronal ubiquitin homeostasis","volume":"67","author":"Hallengren","year":"2013","journal-title":"Cell Biochem Biophys"},{"key":"10.1016\/j.apsb.2025.12.002_bib11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1146\/annurev-biochem-060815-014922","article-title":"Ubiquitin ligases: structure, function, and regulation","volume":"86","author":"Zheng","year":"2017","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.apsb.2025.12.002_bib12","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fnmol.2020.00037","article-title":"Protein aggregation and dysfunction of autophagy\u2013lysosomal pathway: a vicious cycle in lysosomal storage diseases","volume":"13","author":"Monaco","year":"2020","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.apsb.2025.12.002_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arcmed.2020.09.007","article-title":"Proteasome subunits involved in neurodegenerative diseases","volume":"52","author":"Fern\u00e1ndez-Cruz","year":"2021","journal-title":"Arch Med Res"},{"key":"10.1016\/j.apsb.2025.12.002_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2025.115281","article-title":"Piceatannol upregulates USP14-mediated GPX4 deubiquitination to inhibit neuronal ferroptosis caused by cerebral ischemia\u2013reperfusion in mice","volume":"197","author":"Zhao","year":"2025","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.apsb.2025.12.002_bib15","first-page":"1394","article-title":"Cylindromatosis mediates neuronal cell death in vitro and in vivo. Cell Death differ","volume":"25","author":"Ganjam","year":"2018"},{"key":"10.1016\/j.apsb.2025.12.002_bib16","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s00018-023-05006-0","article-title":"Polymorphic USP8 allele promotes Parkinson's disease by inducing the accumulation of \u03b1-synuclein through deubiquitination","volume":"80","author":"Wu","year":"2023","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.apsb.2025.12.002_bib17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41420-021-00546-5","article-title":"Deubiquitinating enzyme USP30 negatively regulates mitophagy and accelerates myocardial cell senescence through antagonism of Parkin","volume":"7","author":"Pan","year":"2021","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.apsb.2025.12.002_bib18","doi-asserted-by":"crossref","DOI":"10.3892\/ijo.2022.5417","article-title":"Ovarian tumor deubiquitinase 6A regulates cell proliferation via deubiquitination of nucleolin and caspase-7","volume":"61","author":"Kim","year":"2022","journal-title":"Int J Oncol"},{"key":"10.1016\/j.apsb.2025.12.002_bib19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s42003-022-03133-1","article-title":"OTUD6A promotes prostate tumorigenesis via deubiquitinating Brg1 and AR","volume":"5","author":"Fu","year":"2022","journal-title":"Commun Biol"},{"key":"10.1016\/j.apsb.2025.12.002_bib20","doi-asserted-by":"crossref","first-page":"2531","DOI":"10.1038\/s41418-022-01036-6","article-title":"Deubiquitinase OTUD6A promotes breast cancer progression by increasing TopBP1 stability and rendering tumor cells resistant to DNA-damaging therapy","volume":"29","author":"Zhao","year":"2022","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.apsb.2025.12.002_bib21","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.bbi.2020.10.014","article-title":"Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson's disease via gut microbiota\u2013GLP-1 pathway","volume":"91","author":"Sun","year":"2021","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.apsb.2025.12.002_bib22","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.3390\/biomedicines10092278","article-title":"Synuclein proteins in MPTP-induced death of substantia nigra pars compacta dopaminergic neurons","volume":"10","author":"Goloborshcheva","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.apsb.2025.12.002_bib23","doi-asserted-by":"crossref","first-page":"4643","DOI":"10.3390\/ijms25094643","article-title":"Tyrosine hydroxylase inhibitors and dopamine receptor agonists combination therapy for Parkinson's disease","volume":"25","author":"Yi","year":"2024","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2025.12.002_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12575-023-00228-9","article-title":"MBD3 promotes epithelial\u2013mesenchymal transition in gastric cancer cells by upregulating ACTG1 via the PI3K\/AKT pathway","volume":"26","author":"Wang","year":"2024","journal-title":"Biol Proced Online"},{"key":"10.1016\/j.apsb.2025.12.002_bib25","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41419-023-06007-4","article-title":"Exosomal PGAM1 promotes prostate cancer angiogenesis and metastasis by interacting with ACTG1","volume":"14","author":"Luo","year":"2023","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2025.12.002_bib26","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/s41419-023-06310-0","article-title":"Loss of p53 function promotes DNA damage-induced formation of nuclear actin filaments","volume":"14","author":"Torii","year":"2023","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2025.12.002_bib27","first-page":"154","article-title":"Treating p53 mutant aggregation-associated cancer","volume":"10","author":"Kanapathipillai","year":"2018","journal-title":"Cancers(Basel)"},{"key":"10.1016\/j.apsb.2025.12.002_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2024.05.030","article-title":"TNF\u2013NF-\u03bab\u2013p53 axis restricts in vivo survival of hPSC-derived dopamine neurons","volume":"187","author":"Kim","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2025.12.002_bib29","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-1326-6-2","article-title":"6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death","volume":"6","author":"Bernstein","year":"2011","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.apsb.2025.12.002_bib30","doi-asserted-by":"crossref","DOI":"10.26508\/lsa.201900392","article-title":"Inhibition of the deubiquitinase USP8 corrects a Drosophila PINK1 model of mitochondria dysfunction","volume":"2","author":"von Stockum","year":"2019","journal-title":"Life Sci Alliance"},{"key":"10.1016\/j.apsb.2025.12.002_bib31","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.freeradbiomed.2016.04.015","article-title":"Mechanisms of mitophagy: PINK1, Parkin, USP30 and beyond","volume":"100","author":"Bingol","year":"2016","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.apsb.2025.12.002_bib32","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/s41419-022-04704-0","article-title":"Deubiquitylase OTUD3 prevents Parkinson's disease through stabilizing iron regulatory protein 2","volume":"13","author":"Jia","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2025.12.002_bib33","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.1002\/1878-0261.12825","article-title":"Deubiquitinase OTUD6A promotes proliferation of cancer cells via regulating Drp1 stability and mitochondrial fission","volume":"14","author":"Shi","year":"2020","journal-title":"Mol Oncol"},{"key":"10.1016\/j.apsb.2025.12.002_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2024.167061","article-title":"Deubiquitinase OTUD6a drives cardiac inflammation and hypertrophy by deubiquitination of STING","volume":"1870","author":"Fang","year":"2024","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.apsb.2025.12.002_bib35","article-title":"Deubiquitylating enzymes in cancer and immunity","volume":"10","author":"Ren","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.apsb.2025.12.002_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101077","article-title":"Deubiquitinating enzymes (DUBs): regulation, homeostasis, and oxidative stress response","volume":"297","author":"Snyder","year":"2021","journal-title":"J Biol Chem"},{"key":"10.1016\/j.apsb.2025.12.002_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125170","article-title":"A novel trans-acting lncRNA of ACTG1 that induces the remodeling of ovarian follicles","volume":"242","author":"Li","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.apsb.2025.12.002_bib38","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.2147\/OTT.S197844","article-title":"RRAD suppresses the Warburg effect by downregulating ACTG1 in hepatocellular carcinoma","volume":"12","author":"Yan","year":"2019","journal-title":"OncoTargets Ther"},{"key":"10.1016\/j.apsb.2025.12.002_bib39","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbrc.2021.01.057","article-title":"ACTG1 regulates intervertebral disc degeneration via the NF-\u03baB\u2013p65 and Akt pathways","volume":"545","author":"Wu","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.apsb.2025.12.002_bib40","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1007\/s11064-020-03081-4","article-title":"COX10-AS1 facilitates cell proliferation and inhibits cell apoptosis in glioblastoma cells at post-transcription level","volume":"45","author":"Zhou","year":"2020","journal-title":"Neurochem Res"},{"key":"10.1016\/j.apsb.2025.12.002_bib41","article-title":"Regulation of Actg1 and Gsta2 is possible mechanism by which capsaicin alleviates apoptosis in cell model of 6-OHDA-induced Parkinson's disease","volume":"40","author":"Liu","year":"2020","journal-title":"Biosci Rep"},{"key":"10.1016\/j.apsb.2025.12.002_bib42","volume":"vol 2022","author":"Luo","year":"2022"},{"key":"10.1016\/j.apsb.2025.12.002_bib43","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1111\/j.1471-4159.2007.05115.x","article-title":"6-Hydroxydopamine activates the mitochondrial apoptosis pathway through p38 MAPK-mediated, p53-independent activation of Bax and PUMA","volume":"104","author":"Gomez-Lazaro","year":"2008","journal-title":"J Neurochem"},{"key":"10.1016\/j.apsb.2025.12.002_bib44","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1038\/s41589-024-01676-4","article-title":"Identifying p53-independent apoptosis","volume":"20","author":"Song","year":"2024","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.apsb.2025.12.002_bib45","article-title":"Actin polymerization negatively regulates p53 function by impairing its nuclear import in response to DNA damage","volume":"8","author":"Wang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2025.12.002_bib46","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1007\/s13402-024-00923-z","article-title":"Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis","volume":"47","author":"Xue","year":"2024","journal-title":"Cell Oncol"},{"key":"10.1016\/j.apsb.2025.12.002_bib47","doi-asserted-by":"crossref","first-page":"e55833","DOI":"10.1371\/journal.pone.0055833","article-title":"CYLD regulates RhoA activity by modulating LARG ubiquitination","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.apsb.2025.12.002_bib48","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/ncomms1243","article-title":"The deubiquitinating enzyme USP17 is essential for GTPase subcellular localization and cell motility","volume":"2","author":"de la Vega","year":"2011","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.12.002_bib49","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1083\/jcb.201506048","article-title":"Ubiquitin ligase TRIM3 controls hippocampal plasticity and learning by regulating synaptic \u03b3-actin levels","volume":"211","author":"Schreiber","year":"2015","journal-title":"J Cell Biol"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525007932?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525007932?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:57:46Z","timestamp":1778846266000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383525007932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":49,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2211383525007932"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.12.002","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"OTUD6A drives dopaminergic neuronal degeneration of Parkinson's disease through deubiquitinating ACTG1 in neuronal cells","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.12.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}