{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:46:33Z","timestamp":1785883593691,"version":"3.56.0"},"reference-count":47,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,19]],"date-time":"2025-12-19T00:00:00Z","timestamp":1766102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002367","name":"Chinese Academy of Sciences","doi-asserted-by":"publisher","award":["XDC0290302"],"award-info":[{"award-number":["XDC0290302"]}],"id":[{"id":"10.13039\/501100002367","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170935"],"award-info":[{"award-number":["32170935"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32130058"],"award-info":[{"award-number":["32130058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019958","name":"Shanghai Advanced Research Institute, Chinese Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC3401404"],"award-info":[{"award-number":["2022YFC3401404"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["24J22800600"],"award-info":[{"award-number":["24J22800600"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.apsb.2025.12.032","type":"journal-article","created":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T16:23:48Z","timestamp":1766507028000},"page":"3876-3891","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["A lymph node-targeted cell-nanoadjuvant conjugate enhances dendritic cell-T cell crosstalk for cancer immunotherapy"],"prefix":"10.1016","volume":"16","author":[{"given":"Shuangshuang","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenzhe","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindi","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyang","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesheng","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0574-6966","authenticated-orcid":false,"given":"Yaping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.12.032_bib1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/s41573-018-0006-z","article-title":"Delivery technologies for cancer immunotherapy","volume":"18","author":"Riley","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2025.12.032_bib2","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41577-019-0269-6","article-title":"Enhancing cancer immunotherapy with nanomedicine","volume":"20","author":"Irvine","year":"2020","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.apsb.2025.12.032_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.critrevonc.2024.104588","article-title":"Innovations in cancer immunotherapy: a comprehensive overview of recent breakthroughs and future directions","volume":"206","author":"Hsu","year":"2025","journal-title":"Crit Rev Oncol-Hematol"},{"key":"10.1016\/j.apsb.2025.12.032_bib4","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1038\/s41423-020-0488-6","article-title":"The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications","volume":"17","author":"Zhang","year":"2020","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.apsb.2025.12.032_bib5","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/s43018-022-00418-6","article-title":"Cancer vaccines: the next immunotherapy frontier","volume":"3","author":"Lin","year":"2022","journal-title":"Nat Cancer"},{"key":"10.1016\/j.apsb.2025.12.032_bib6","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.3390\/cells12172159","article-title":"Cancer vaccine therapeutics: limitations and effectiveness\u2014a literature review","volume":"12","author":"Kaczmarek","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.apsb.2025.12.032_bib7","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1001\/jamaoncol.2022.5370","article-title":"Association of autologous tumor lysate-loaded dendritic cell vaccination with extension of survival among patients with newly diagnosed and recurrent glioblastoma: a phase 3 prospective externally controlled cohort trial","volume":"9","author":"Liau","year":"2023","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.apsb.2025.12.032_bib8","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s43018-023-00668-y","article-title":"Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy","volume":"5","author":"Ghasemi","year":"2024","journal-title":"Nat Cancer"},{"key":"10.1016\/j.apsb.2025.12.032_bib9","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/cr.2016.157","article-title":"Dendritic cell-based immunotherapy","volume":"27","author":"Sabado","year":"2017","journal-title":"Cell Res"},{"key":"10.1016\/j.apsb.2025.12.032_bib10","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1016\/j.apsb.2022.05.032","article-title":"Spatio-temporal delivery of both intra- and extracellular toll-like receptor agonists for enhancing antigen-specific immune responses","volume":"12","author":"Wang","year":"2022","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.12.032_bib11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41568-024-00785-5","article-title":"Cross-priming in cancer immunology and immunotherapy","volume":"25","author":"Luri-Rey","year":"2025","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2025.12.032_bib12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/s41568-024-00787-3","article-title":"Dendritic cell maturation in cancer","volume":"25","author":"Moon","year":"2025","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2025.12.032_bib13","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41571-024-00859-1","article-title":"Dendritic cells as orchestrators of anticancer immunity and immunotherapy","volume":"21","author":"Heras-Murillo","year":"2024","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.apsb.2025.12.032_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114685","article-title":"Dendritic cell vaccines in breast cancer: immune modulation and immunotherapy","volume":"162","author":"Qian","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.apsb.2025.12.032_bib15","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1038\/s41467-019-13368-y","article-title":"Engineering dendritic cell vaccines to improve cancer immunotherapy","volume":"10","author":"Perez","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.12.032_bib16","doi-asserted-by":"crossref","first-page":"766","DOI":"10.3389\/fimmu.2019.00766","article-title":"Personalized dendritic cell vaccines\u2014recent breakthroughs and encouraging clinical results","volume":"10","author":"Mastelic-Gavillet","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.apsb.2025.12.032_bib17","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41568-021-00346-0","article-title":"Therapeutic cancer vaccines","volume":"21","author":"Saxena","year":"2021","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2025.12.032_bib18","article-title":"CCR7 mediated mimetic dendritic cell vaccine homing in lymph node for head and neck squamous cell carcinoma therapy","volume":"10","author":"Xu","year":"2023","journal-title":"Adv Sci"},{"key":"10.1016\/j.apsb.2025.12.032_bib19","doi-asserted-by":"crossref","DOI":"10.1002\/btm2.10400","article-title":"Magnetic nanoparticles enhance the cellular immune response of dendritic cell tumor vaccines by realizing the cytoplasmic delivery of tumor antigens","volume":"8","author":"Huang","year":"2023","journal-title":"Bioeng Transl Med"},{"key":"10.1016\/j.apsb.2025.12.032_bib20","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.omto.2019.03.007","article-title":"Enhancing dendritic cell therapy in solid tumors with immunomodulating conventional treatment","volume":"13","author":"Belderbos","year":"2019","journal-title":"Mol Ther Oncol"},{"key":"10.1016\/j.apsb.2025.12.032_bib21","doi-asserted-by":"crossref","first-page":"4835","DOI":"10.1038\/s41467-020-18570-x","article-title":"PD-L1 on dendritic cells attenuates T cell activation and regulates response to immune checkpoint blockade","volume":"11","author":"Peng","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.12.032_bib22","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/s43018-020-0075-x","article-title":"PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer","volume":"1","author":"Oh","year":"2020","journal-title":"Nat Cancer"},{"key":"10.1016\/j.apsb.2025.12.032_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav7431","article-title":"Dendritic cells dictate responses to PD-L1 blockade cancer immunotherapy","volume":"12","author":"Mayoux","year":"2020","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.apsb.2025.12.032_bib24","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.cell.2023.12.011","article-title":"Bispecific dendritic-T cell engager potentiates anti-tumor immunity","volume":"187","author":"Shapir Itai","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2025.12.032_bib25","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.4049\/jimmunol.1400489","article-title":"Nanoparticle-mediated combinatorial targeting of multiple human dendritic cell (DC) subsets leads to enhanced T cell activation via IL-15-dependent DC crosstalk","volume":"193","author":"Sehgal","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.apsb.2025.12.032_bib26","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1742-7843.2009.00375.x","article-title":"Abatacept, a Novel CD80\/86\u2013CD28 T cell co-stimulation modulator, in the treatment of rheumatoid arthritis","volume":"104","author":"Korhonen","year":"2009","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"10.1016\/j.apsb.2025.12.032_bib27","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.immuni.2018.09.024","article-title":"Successful anti-PD-1 cancer immunotherapy requires T cell-dendritic cell crosstalk involving the cytokines IFN-\u03b3 and IL-12","volume":"49","author":"Garris","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2025.12.032_bib28","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41392-023-01557-7","article-title":"Vaccine adjuvants: mechanisms and platforms","volume":"8","author":"Zhao","year":"2023","journal-title":"Signal Transduct Targeted Ther"},{"key":"10.1016\/j.apsb.2025.12.032_bib29","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/s41573-020-0074-8","article-title":"Antitumour dendritic cell vaccination in a priming and boosting approach","volume":"19","author":"Harari","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2025.12.032_bib30","doi-asserted-by":"crossref","first-page":"4118","DOI":"10.1039\/D3TB02861E","article-title":"Vaccine adjuvants: current status, research and development, licensing, and future opportunities","volume":"12","author":"Cui","year":"2024","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.apsb.2025.12.032_bib31","article-title":"Lymph-targeted high-density lipoprotein-mimetic nanovaccine for multi-antigenic personalized cancer immunotherapy","volume":"10","author":"Liu","year":"2024","journal-title":"Sci Adv"},{"key":"10.1016\/j.apsb.2025.12.032_bib32","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1021\/acs.nanolett.0c04783","article-title":"Engineering nanoscale artificial antigen-presenting cells by metabolic dendritic cell labeling to potentiate cancer immunotherapy","volume":"21","author":"Xiao","year":"2021","journal-title":"Nano Lett"},{"key":"10.1016\/j.apsb.2025.12.032_bib33","doi-asserted-by":"crossref","first-page":"185","DOI":"10.3390\/jfb16050185","article-title":"Nano\/micro-enabled modification and innovation of conventional adjuvants for next-generation vaccines","volume":"16","author":"Liu","year":"2025","journal-title":"J Funct Biomater"},{"key":"10.1016\/j.apsb.2025.12.032_bib34","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/s41578-021-00372-2","article-title":"Designing spatial and temporal control of vaccine responses","volume":"7","author":"Roth","year":"2022","journal-title":"Nat Rev Mater"},{"key":"10.1016\/j.apsb.2025.12.032_bib35","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3390\/chemistry7030097","article-title":"Revolutionizing cancer vaccine: the power of advanced nanotechnology","volume":"7","author":"Udayakumar","year":"2025","journal-title":"Chemistry"},{"key":"10.1016\/j.apsb.2025.12.032_bib36","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/s41551-021-00800-2","article-title":"Rejuvenation of tumour-specific T cells through bispecific antibodies targeting PD-L1 on dendritic cells","volume":"5","author":"Liu","year":"2021","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.apsb.2025.12.032_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaw6071","article-title":"A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer","volume":"6","author":"Ni","year":"2020","journal-title":"Sci Adv"},{"key":"10.1016\/j.apsb.2025.12.032_bib38","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1038\/s41467-019-12657-w","article-title":"The TLR7\/8 agonist R848 remodels tumor and host responses to promote survival in pancreatic cancer","volume":"10","author":"Michaelis","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2025.12.032_bib39","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/s41565-022-01296-w","article-title":"A nanoadjuvant that dynamically coordinates innate immune stimuli activation enhances cancer immunotherapy and reduces immune cell exhaustion","volume":"18","author":"Jin","year":"2023","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.apsb.2025.12.032_bib40","doi-asserted-by":"crossref","first-page":"4577","DOI":"10.1016\/j.apsb.2024.06.006","article-title":"Simultaneous enhancement of cellular and humoral immunity by the lymph node-targeted cholesterolized TLR7 agonist liposomes","volume":"14","author":"Wan","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.12.032_bib41","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1146\/annurev-immunol-101819-025146","article-title":"Dendritic cell regulation of T helper cells","volume":"39","author":"Yin","year":"2021","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.apsb.2025.12.032_bib42","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.apsb.2024.12.029","article-title":"Dendritic cells immunotargeted therapy for atherosclerosis","volume":"15","author":"Li","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2025.12.032_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202311574","article-title":"Supramolecular lipid nanoparticles based on host\u2013guest recognition: a new generation delivery system of mRNA vaccines for cancer immunotherapy","volume":"36","author":"Qi","year":"2024","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2025.12.032_bib44","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1038\/s41423-021-00726-4","article-title":"Dendritic cell migration in inflammation and immunity","volume":"18","author":"Liu","year":"2021","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.apsb.2025.12.032_bib45","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1158\/0008-5472.CAN-07-5644","article-title":"Subtypes of breast cancer show preferential site of relapse","volume":"68","author":"Smid","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2025.12.032_bib46","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1158\/2159-8290.CD-18-1177","article-title":"Insights into molecular classifications of triple-negative breast cancer: improving patient selection for treatment","volume":"9","author":"Garrido-Castro","year":"2019","journal-title":"Cancer Discov"},{"key":"10.1016\/j.apsb.2025.12.032_bib47","doi-asserted-by":"crossref","first-page":"3226","DOI":"10.1016\/j.apsb.2025.04.006","article-title":"Targeting stem-property and vasculogenic mimicry for sensitizing paclitaxel therapy of triple-negative breast cancer by biomimetic codelivery","volume":"15","author":"Wu","year":"2025","journal-title":"Acta Pharm Sin B"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525008408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525008408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:01:14Z","timestamp":1785880874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383525008408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":47,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2211383525008408"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.12.032","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A lymph node-targeted cell-nanoadjuvant conjugate enhances dendritic cell-T cell crosstalk for cancer immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.12.032","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}