{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T11:24:30Z","timestamp":1784719470728,"version":"3.55.0"},"reference-count":45,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T00:00:00Z","timestamp":1767139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82200851"],"award-info":[{"award-number":["82200851"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.apsb.2025.12.048","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T07:56:28Z","timestamp":1767686188000},"page":"4706-4724","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bladder adaptive hydrogel scaffold with dual release, antimicrobial, immunomodulatory, and repair: DRIVER for urinary tract infections"],"prefix":"10.1016","volume":"16","author":[{"given":"Zhimin","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiyu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2913-0891","authenticated-orcid":false,"given":"Changyang","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2025.12.048_bib1","doi-asserted-by":"crossref","first-page":"e605","DOI":"10.1016\/S1473-3099(25)00142-2","article-title":"Consensus position statement on advancing the classification of patients and tests of cure in studies of antibiotic treatment of complicated urinary tract infections","volume":"25","author":"Bjerklund Johansen","year":"2025","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.apsb.2025.12.048_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2025.107698","article-title":"Emergence of recurrent urinary tract infection: dissecting the mechanism of antimicrobial resistance, host-pathogen interaction, and hormonal imbalance","volume":"206","author":"Bhuiya","year":"2025","journal-title":"Microb Pathog"},{"key":"10.1016\/j.apsb.2025.12.048_bib3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.4103\/tcmj.tcmj_286_24","article-title":"Pathophysiology and potential treatment modalities in women with recurrent urinary tract infection","volume":"37","author":"Liao","year":"2025","journal-title":"Tzu Chi Med J"},{"key":"10.1016\/j.apsb.2025.12.048_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12866-024-03709-3","article-title":"Microbiota analysis of perimenopausal women experiencing recurrent vaginitis in conjunction with urinary tract infection","volume":"25","author":"Bi","year":"2025","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.apsb.2025.12.048_bib5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13567-025-01493-0","article-title":"Zoonotic potential of uropathogenic Escherichia coli lineages from companion animals","volume":"56","author":"Jousserand","year":"2025","journal-title":"Vet Res"},{"key":"10.1016\/j.apsb.2025.12.048_bib6","doi-asserted-by":"crossref","first-page":"406","DOI":"10.5152\/tud.2022.22119","article-title":"Intestinal microbiota correction in the treatment and prevention of urinary tract infection","volume":"48","author":"Sturov","year":"2022","journal-title":"Turk J Urol"},{"key":"10.1016\/j.apsb.2025.12.048_bib7","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.3390\/pathogens13121028","article-title":"Gut microbiome implication and modulation in the management of recurrent urinary tract infection","volume":"13","author":"Brigida","year":"2024","journal-title":"Pathogens"},{"key":"10.1016\/j.apsb.2025.12.048_bib8","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.actbio.2019.01.015","article-title":"Implantable antimicrobial biomaterials for local drug delivery in bone infection models","volume":"93","author":"Caplin","year":"2019","journal-title":"Acta Biomater"},{"key":"10.1016\/j.apsb.2025.12.048_bib9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1055\/s-0031-1273457","article-title":"Hydrogelexpander as drug delivery system for antibiotics","volume":"229","author":"Schittkowski","year":"2012","journal-title":"Klin Monbl Augenheilkd"},{"key":"10.1016\/j.apsb.2025.12.048_bib10","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1002\/nau.70025","article-title":"Dynamic analysis of the voiding patterns in bladder diaries collected in clinical practice","volume":"44","author":"Andreev","year":"2025","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.apsb.2025.12.048_bib11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/JU.0000000000000199","article-title":"The effect of bladder filling rate on the voiding behavior of patients with overactive bladder","volume":"202","author":"Redmond","year":"2019","journal-title":"J Urol"},{"key":"10.1016\/j.apsb.2025.12.048_bib12","doi-asserted-by":"crossref","first-page":"36366","DOI":"10.1021\/acsami.5c03787","article-title":"Magnetic-driven hydrogel robots loaded with mitomycin for active therapy of bladder cancer","volume":"17","author":"Jia","year":"2025","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.apsb.2025.12.048_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202505231","article-title":"Soft extrudable dendritic particles with nanostructured tendrils for local adhesion and drug release to bladder cancers","volume":"37","author":"Lee","year":"2025","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2025.12.048_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.137487","article-title":"Enhancing under-urine adhesion and bladder adaptation of silk fibroin hydrogels with tea polyphenols for hemorrhagic cystitis","volume":"283","author":"Chen","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.apsb.2025.12.048_bib15","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12951-024-02322-w","article-title":"Fabrication of levofloxacin-loaded porcine acellular dermal matrix hydrogel and functional assessment in urinary tract infection","volume":"22","author":"Yang","year":"2024","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.apsb.2025.12.048_bib16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/luts.12351","article-title":"Deficits of urothelial cell proliferation, cytoskeleton, and barrier function protein expressions in patients with recurrent and persistent urinary tract infections","volume":"13","author":"Jhang","year":"2021","journal-title":"Low Urin Tract Symptoms"},{"key":"10.1016\/j.apsb.2025.12.048_bib17","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/luts.12364","article-title":"Urothelial health after platelet-rich plasma injection in intractable recurrent urinary tract infection: improved cell proliferation, cytoskeleton, and barrier function protein expression","volume":"13","author":"Jiang","year":"2021","journal-title":"Low Urin Tract Symptoms"},{"key":"10.1016\/j.apsb.2025.12.048_bib18","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11934-018-0839-3","article-title":"Recurrent urinary tract infections in females and the overlap with overactive bladder","volume":"19","author":"Nik-Ahd","year":"2018","journal-title":"Curr Urol Rep"},{"key":"10.1016\/j.apsb.2025.12.048_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.4103\/tcmj.tcmj_38_20","article-title":"Recurrent urinary tract infection in women and overactive bladder \u2014 is there a relationship?.","volume":"33","author":"Ke","year":"2021","journal-title":"Tzu Chi Med J"},{"key":"10.1016\/j.apsb.2025.12.048_bib20","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s44254-023-00032-4","article-title":"The effect of perioperative AKI on surgical outcomes","volume":"1","author":"Shan","year":"2023","journal-title":"Anesthesiol Perioper Sci"},{"key":"10.1016\/j.apsb.2025.12.048_bib21","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1002\/nau.24479","article-title":"Lower urinary tract dysfunction in adult patients with mitochondrial disease. Neurourology and urodynamics","volume":"39","author":"Feeney","year":"2020","journal-title":"Neurourol Urodyn"},{"key":"10.1016\/j.apsb.2025.12.048_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.70009","article-title":"SIRT1 alleviates oxidative stress-induced mitochondrial dysfunction and mitochondria-associated membrane dysregulation in stress urinary incontinence","volume":"58","author":"Chen","year":"2025","journal-title":"Cell Prolif"},{"key":"10.1016\/j.apsb.2025.12.048_bib23","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1186\/s12866-024-03542-8","article-title":"Purified \u03b1-Amylase from Bacillus cereus exhibits antibiofilm and antiquorum sensing activities against uropathogenic Escherichia coli, downregulating fimH, and papC virulence genes: implications for urinary tract infections","volume":"24","author":"Abo-Kamar","year":"2024","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.apsb.2025.12.048_bib24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/milmed\/usae079","article-title":"PLGA nanoparticles formulations loaded with antibiotics induce sustained and controlled antibiotics release for prolonged antibacterial action against MRSA, and pseudomonas aeruginosa FRD1","volume":"189","author":"Guevara","year":"2024","journal-title":"Mil Med"},{"key":"10.1016\/j.apsb.2025.12.048_bib25","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.ijbiomac.2017.11.057","article-title":"Cellulose gum and copper nanoparticles based hydrogel as antimicrobial agents against urinary tract infection (UTI) pathogens","volume":"109","author":"Al-Enizi","year":"2018","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.apsb.2025.12.048_bib26","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1021\/acsabm.9b00814","article-title":"Superhydrophobic coatings for urinary catheters to delay bacterial biofilm formation and catheter-associated urinary tract infection","volume":"3","author":"Zhang","year":"2020","journal-title":"ACS Appl Bio Mater"},{"key":"10.1016\/j.apsb.2025.12.048_bib27","doi-asserted-by":"crossref","first-page":"6221","DOI":"10.1039\/C6TB01606E","article-title":"Robust and self-healable nanocomposite physical hydrogel facilitated by the synergy of ternary crosslinking points in a single network","volume":"4","author":"Shi","year":"2016","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.apsb.2025.12.048_bib28","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202006362","article-title":"Covalently crosslinked hydrogels via step-growth reactions: crosslinking chemistries, polymers, and clinical impact","volume":"33","author":"Gao","year":"2021","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2025.12.048_bib29","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.actbio.2021.01.038","article-title":"A double-crosslinked self-healing antibacterial hydrogel with enhanced mechanical performance for wound treatment","volume":"124","author":"Wang","year":"2021","journal-title":"Acta Biomater"},{"key":"10.1016\/j.apsb.2025.12.048_bib30","doi-asserted-by":"crossref","first-page":"7078","DOI":"10.1021\/acsnano.1c00204","article-title":"Dual-dynamic-bond cross-linked antibacterial adhesive hydrogel sealants with on-demand removability for post-wound-closure and infected wound healing","volume":"15","author":"Liang","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2025.12.048_bib31","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s12011-017-1174-0","article-title":"Chitosan-Zn chelate downregulates TLR4-NF-\u03baB signal pathway of inflammatory response and cell death-associated proteins compared to inorganic zinc","volume":"184","author":"Hu","year":"2018","journal-title":"Biol Trace Elem Res"},{"key":"10.1016\/j.apsb.2025.12.048_bib32","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3390\/polym13060904","article-title":"Antimicrobial actions and applications of chitosan","volume":"13","author":"Ke","year":"2021","journal-title":"Polymers"},{"key":"10.1016\/j.apsb.2025.12.048_bib33","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1016\/j.ajpath.2014.03.010","article-title":"Matrix hyaluronan-activated CD44 signaling promotes keratinocyte activities and improves abnormal epidermal functions","volume":"184","author":"Bourguignon","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.apsb.2025.12.048_bib34","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1080\/03008207.2018.1465053","article-title":"Hyaluronic acid promotes proliferation and migration of human meniscus cells via a CD44-dependent mechanism","volume":"60","author":"Murakami","year":"2019","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.apsb.2025.12.048_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115812","article-title":"The hyaluronan\/CD44 axis: a double-edged sword in cancer","volume":"24","author":"Cirillo","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.apsb.2025.12.048_bib36","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.ijbiomac.2022.05.199","article-title":"Zinc improves antibacterial, anti-inflammatory and cell motility activity of chitosan for wound healing applications","volume":"213","author":"Mutlu","year":"2022","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.apsb.2025.12.048_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2023.168090","article-title":"Structural mechanisms of mitochondrial quality control mediated by PINK1 and Parkin","volume":"435","author":"Trempe","year":"2023","journal-title":"J Mol Biol"},{"key":"10.1016\/j.apsb.2025.12.048_bib38","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1038\/s41556-024-01513-9","article-title":"The role of PINK1-Parkin in mitochondrial quality control","volume":"26","author":"Narendra","year":"2024","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.apsb.2025.12.048_bib39","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/10715762.2017.1414949","article-title":"Zinc prevents mitochondrial superoxide generation by inducing mitophagy in the setting of hypoxia\/reoxygenation in cardiac cells","volume":"52","author":"Bian","year":"2018","journal-title":"Free Radic Res"},{"key":"10.1016\/j.apsb.2025.12.048_bib40","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1021\/acs.est.1c07198","article-title":"Mitochondria-dependent oxidative stress mediates ZnO Nanoparticle (ZnO NP)-induced mitophagy and lipotoxicity in freshwater teleost fish","volume":"56","author":"Chen","year":"2022","journal-title":"Environ Sci Technol"},{"key":"10.1016\/j.apsb.2025.12.048_bib41","article-title":"Effect of zinc sulfate on biochemical parameters, histopathological, histochemical and immunological in male albino rats","volume":"6","author":"Alsailawi","year":"2024","journal-title":"Multidiscip Sci"},{"key":"10.1016\/j.apsb.2025.12.048_bib42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0946-672X(02)80020-7","article-title":"Zinc availability from zinc lipoate and zinc sulfate in growing rats","volume":"16","author":"Walter","year":"2002","journal-title":"J Trace Elem Med Biol"},{"key":"10.1016\/j.apsb.2025.12.048_bib43","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/jn\/118.10.1205","article-title":"The effect of past and current dietary Zn intake on Zn absorption and endogenous excretion in the rat","volume":"118","author":"Johnson","year":"1988","journal-title":"J Nutr"},{"key":"10.1016\/j.apsb.2025.12.048_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-13900-9","article-title":"C57BL\/6J mice best recapitulate fibrosis and inflammatory pathophysiology in syngeneic mouse model of endometriosis","volume":"15","author":"Anchan","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.apsb.2025.12.048_bib45","article-title":"Radiation cystitis modeling: a comparative study of bladder fibrosis radio-sensitivity in C57BL\/6, C3H, and BALB\/c mice","volume":"8","author":"Zwaans","year":"2020","journal-title":"Phys Rep"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525008639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383525008639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T20:10:37Z","timestamp":1783714237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383525008639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":45,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2211383525008639"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2025.12.048","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bladder adaptive hydrogel scaffold with dual release, antimicrobial, immunomodulatory, and repair: DRIVER for urinary tract infections","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2025.12.048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}