{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T21:30:39Z","timestamp":1786483839071,"version":"build-2736575974"},"reference-count":61,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23S21900800"],"award-info":[{"award-number":["23S21900800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303787"],"award-info":[{"award-number":["82303787"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82073385"],"award-info":[{"award-number":["82073385"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZB20230522"],"award-info":[{"award-number":["GZB20230522"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2020M671234"],"award-info":[{"award-number":["2020M671234"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.apsb.2026.01.024","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T16:18:54Z","timestamp":1769185134000},"page":"4616-4633","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Engineering an immuno-nanoprodrug: Photo-controlled pyroptosis synergizing with acid-activatable immunometabolic blockade for potent cancer immunotherapy"],"prefix":"10.1016","volume":"16","author":[{"given":"Zhiliang","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengze","family":"Miao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8845-2172","authenticated-orcid":false,"given":"Rongrong","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongguang","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongjian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0574-4020","authenticated-orcid":false,"given":"Quangang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2026.01.024_bib1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/s41571-021-00552-7","article-title":"Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways","volume":"19","author":"Kraehenbuehl","year":"2022","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.apsb.2026.01.024_bib2","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/s43018-022-00418-6","article-title":"Cancer vaccines: the next immunotherapy frontier","volume":"3","author":"Lin","year":"2022","journal-title":"Nat Cancer"},{"key":"10.1016\/j.apsb.2026.01.024_bib3","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1038\/s41590-022-01141-1","article-title":"A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance","volume":"23","author":"Huang","year":"2022","journal-title":"Nat Immunol"},{"key":"10.1016\/j.apsb.2026.01.024_bib4","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41573-024-01081-5","article-title":"Vaccines for cancer prevention: exploring opportunities and navigating challenges","volume":"24","author":"Graciotti","year":"2024","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2026.01.024_bib5","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41568-021-00427-0","article-title":"Towards targeting of shared mechanisms of cancer metastasis and therapy resistance","volume":"22","author":"Weiss","year":"2022","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.apsb.2026.01.024_bib6","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1200\/JCO.2013.54.5996","article-title":"Nivolumab: promising survival signal coupled with limited toxicity raises expectations","volume":"32","author":"O'Sullivan Coyne","year":"2014","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.apsb.2026.01.024_bib7","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1056\/NEJMoa1606774","article-title":"Pembrolizumab versus chemotherapy for PD-L1-positive non-small-cell lung cancer","volume":"375","author":"Reck","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apsb.2026.01.024_bib8","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1056\/NEJMoa1504030","article-title":"Combined nivolumab and ipilimumab or monotherapy in untreated melanoma","volume":"373","author":"Larkin","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apsb.2026.01.024_bib9","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1056\/NEJMoa1613683","article-title":"Pembrolizumab as second-line therapy for advanced urothelial carcinoma","volume":"376","author":"Bellmunt","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apsb.2026.01.024_bib10","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202500825","article-title":"Restoring tumor cell immunogenicity through ion-assisted mRNA domestication for enhanced in situ cancer vaccination effect","volume":"12","author":"Liang","year":"2025","journal-title":"Adv Sci"},{"key":"10.1016\/j.apsb.2026.01.024_bib11","article-title":"Simultaneous reversal of T lymphocytes and cancer cells metabolism via a biomimetic heavy-atom-free photosensitizers-based combination therapies to boost cancer photoimmunotherapy","volume":"12","author":"Zhang","year":"2025","journal-title":"Adv Sci"},{"key":"10.1016\/j.apsb.2026.01.024_bib12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41573-024-01098-w","article-title":"Targeting metabolic dysfunction of CD8 T cells and natural killer cells in cancer","volume":"24","author":"Viel","year":"2024","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2026.01.024_bib13","article-title":"Innate immune activation with multifunctional nanoparticles for cancer immunotherapy","volume":"64","author":"Jiang","year":"2025","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.apsb.2026.01.024_bib14","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/s41573-024-00974-9","article-title":"Enhancing in situ cancer vaccines using delivery technologies","volume":"23","author":"Gong","year":"2024","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2026.01.024_bib15","article-title":"Disrupting intracellular homeostasis by copper-based nanoinducer with multiple enzyme-mimicking activities to induce disulfidptosis-enhanced pyroptosis for tumor immunotherapy","volume":"37","author":"Jin","year":"2024","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2026.01.024_bib16","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1038\/s41573-021-00154-z","article-title":"Channelling inflammation: gasdermins in physiology and disease","volume":"20","author":"Liu","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2026.01.024_bib17","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41577-019-0228-2","article-title":"The gasdermins, a protein family executing cell death and inflammation","volume":"20","author":"Broz","year":"2019","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.apsb.2026.01.024_bib18","article-title":"Creating single atomic coordination for hypoxia-resistant pyroptosis nano-inducer to boost anti-tumor immunotherapy","volume":"37","author":"Li","year":"2025","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2026.01.024_bib19","doi-asserted-by":"crossref","first-page":"6001","DOI":"10.1016\/j.apsb.2025.08.003","article-title":"Arsenic trioxide-based nanoparticles for enhanced chemotherapy by activating pyroptosis","volume":"15","author":"Wang","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2026.01.024_bib20","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1016\/j.apsb.2025.05.021","article-title":"Nanomedicine-induced pyroptosis for anti-tumor immunotherapy: mechanism analysis and application prospects","volume":"15","author":"Huang","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2026.01.024_bib21","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41573-024-00979-4","article-title":"Targeting ROS in cancer: rationale and strategies","volume":"23","author":"Glorieux","year":"2024","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2026.01.024_bib22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1186\/s12951-022-01719-9","article-title":"A mitochondria-anchored supramolecular photosensitizer as a pyroptosis inducer for potent photodynamic therapy and enhanced antitumor immunity","volume":"20","author":"Wang","year":"2022","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.apsb.2026.01.024_bib23","article-title":"Nanoengineered M1 macrophages enhance photodynamic therapy of melanoma through oxygen production and subsequent antitumor immunity","volume":"487","author":"Zhang","year":"2024","journal-title":"Chem Eng J"},{"key":"10.1016\/j.apsb.2026.01.024_bib24","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1021\/acs.jmedchem.1c02154","article-title":"Discovery of an amino acid-modified near-infrared aza-BODIPY photosensitizer as an immune initiator for potent photodynamic therapy in melanoma","volume":"65","author":"Yu","year":"2022","journal-title":"J Med Chem"},{"key":"10.1016\/j.apsb.2026.01.024_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbcan.2019.07.003","article-title":"Cell death in photodynamic therapy: from oxidative stress to anti-tumor immunity","volume":"1872","author":"Donohoe","year":"2019","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"10.1016\/j.apsb.2026.01.024_bib26","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41586-020-2071-9","article-title":"Gasdermin E suppresses tumour growth by activating anti-tumour immunity","volume":"579","author":"Zhang","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2026.01.024_bib27","doi-asserted-by":"crossref","first-page":"9413","DOI":"10.1021\/jacs.4c01929","article-title":"Mitochondria-targeting type-I photodrug: harnessing caspase-3 activity for pyroptotic oncotherapy","volume":"146","author":"Yi","year":"2024","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.apsb.2026.01.024_bib28","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nature22393","article-title":"Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin","volume":"547","author":"Wang","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2026.01.024_bib29","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/s41573-020-0077-5","article-title":"Targeting the epigenetic regulation of antitumour immunity","volume":"19","author":"Hogg","year":"2020","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2026.01.024_bib30","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1038\/s41576-022-00468-7","article-title":"Histone post-translational modifications\u2014cause and consequence of genome function","volume":"23","author":"Mill\u00e1n-Zambrano","year":"2022","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.apsb.2026.01.024_bib31","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1056\/NEJMoa2119771","article-title":"Demethylation and up-regulation of an oncogene after hypomethylating therapy","volume":"386","author":"Liu","year":"2022","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apsb.2026.01.024_bib32","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1158\/0008-5472.CAN-23-2785","article-title":"The DNA methyltransferase inhibitor 5-aza-4\u2032-thio-2\u2032-deoxycytidine induces C>G transversions and acute lymphoid leukemia development","volume":"84","author":"Bertoli","year":"2024","journal-title":"Cancer Res"},{"key":"10.1016\/j.apsb.2026.01.024_bib33","article-title":"A microenvironment dual-responsive nano-drug equipped with PD-L1 blocking peptide triggers immunogenic pyroptosis for prostate cancer self-synergistic immunotherapy","volume":"33","author":"Wang","year":"2023","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.apsb.2026.01.024_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2025.160833","article-title":"Combination of an LDH-based platform with microRNA for the treatment of myocardial ischemia\u2013reperfusion injury by pyroptosis inhibition via the CaSR\/PLC\u03b31\/IP3R pathway","volume":"508","author":"Wu","year":"2025","journal-title":"Chem Eng J"},{"key":"10.1016\/j.apsb.2026.01.024_bib35","article-title":"Etoposide-loaded layered double hydroxide achieves the best of both worlds: simultaneous breast carcinoma inhibition and embryo protection via selectively regulating Caspase 3-GSDME pyroptosis pathway","volume":"484","author":"Wang","year":"2024","journal-title":"Chem Eng J"},{"key":"10.1016\/j.apsb.2026.01.024_bib36","doi-asserted-by":"crossref","first-page":"16642","DOI":"10.1021\/jacs.3c04109","article-title":"Self-assembled nano-PROTAC enables near-infrared photodynamic proteolysis for cancer therapy","volume":"145","author":"Wang","year":"2023","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.apsb.2026.01.024_bib37","doi-asserted-by":"crossref","first-page":"6935","DOI":"10.1038\/s41467-024-51253-5","article-title":"Self-reporting photodynamic nanobody conjugate for precise and sustainable large-volume tumor treatment","volume":"15","author":"Chen","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2026.01.024_bib38","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2210385120","article-title":"Photoactivatable nanoagonists chemically programmed for pharmacokinetic tuning and in situ cancer vaccination","volume":"120","author":"Wan","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2026.01.024_bib39","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/s41557-022-00972-7","article-title":"Photocaged 5\u2032 cap analogues for optical control of mRNA translation in cells","volume":"14","author":"Kl\u00f6cker","year":"2022","journal-title":"Nat Chem"},{"key":"10.1016\/j.apsb.2026.01.024_bib40","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/s41557-022-00963-8","article-title":"Light-activated tetrazines enable precision live-cell bioorthogonal chemistry","volume":"14","author":"Liu","year":"2022","journal-title":"Nat Chem"},{"key":"10.1016\/j.apsb.2026.01.024_bib41","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/nmat2859","article-title":"Orally delivered thioketal nanoparticles loaded with TNF-\u03b1\u2013siRNA target inflammation and inhibit gene expression in the intestines","volume":"9","author":"Wilson","year":"2010","journal-title":"Nat Mater"},{"key":"10.1016\/j.apsb.2026.01.024_bib42","article-title":"Mechanistic investigation on oxidative degradation of ROS-responsive thioacetal\/thioketal moieties and their implications","volume":"1","author":"Liu","year":"2020","journal-title":"Cell Rep Phys Sci"},{"key":"10.1016\/j.apsb.2026.01.024_bib43","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/s41573-023-00670-0","article-title":"Overcoming barriers to patient adherence: the case for developing innovative drug delivery systems","volume":"22","author":"Baryakova","year":"2023","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2026.01.024_bib44","doi-asserted-by":"crossref","first-page":"14974","DOI":"10.1002\/anie.201908664","article-title":"A nanoemulsion with a porphyrin shell for cancer theranostics","volume":"58","author":"Hou","year":"2019","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.apsb.2026.01.024_bib45","doi-asserted-by":"crossref","first-page":"9950","DOI":"10.1021\/acs.jmedchem.0c00882","article-title":"Discovery of a monoiodo aza-BODIPY near-infrared photosensitizer: in vitro and in vivo evaluation for photodynamic therapy","volume":"63","author":"Yu","year":"2020","journal-title":"J Med Chem"},{"key":"10.1016\/j.apsb.2026.01.024_bib46","doi-asserted-by":"crossref","first-page":"7205","DOI":"10.1021\/acs.jmedchem.2c01653","article-title":"Discovery of subcellular-targeted aza-BODIPY photosensitizers for efficient photodynamic antitumor therapy","volume":"66","author":"Liu","year":"2023","journal-title":"J Med Chem"},{"key":"10.1016\/j.apsb.2026.01.024_bib47","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41571-020-0382-2","article-title":"The adenosine pathway in immuno-oncology","volume":"17","author":"Allard","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.apsb.2026.01.024_bib48","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1016\/j.apsb.2025.03.046","article-title":"Metabolic reprogramming nanomedicine potentiates colon cancer sonodynamic immunotherapy by inhibiting the CD39\/CD73\/ADO pathway","volume":"15","author":"Zhang","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2026.01.024_bib49","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1038\/s41590-023-01675-y","article-title":"The immunometabolic ecosystem in cancer","volume":"24","author":"Bantug","year":"2023","journal-title":"Nat Immunol"},{"key":"10.1016\/j.apsb.2026.01.024_bib50","doi-asserted-by":"crossref","first-page":"7962","DOI":"10.1021\/acsnano.4c15139","article-title":"MnO2-assisted photosynthetic bacteria interfering with the adenosine\u2013A2AR metabolic pathway to enhance tumor photothermal immunotherapy","volume":"19","author":"Zeng","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2026.01.024_bib51","article-title":"Targeting the negative feedback of adenosine\u2013A2AR metabolic pathway by a tailored nanoinhibitor for photothermal immunotherapy","volume":"9","author":"Liu","year":"2022","journal-title":"Adv Sci"},{"key":"10.1016\/j.apsb.2026.01.024_bib52","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/s41571-019-0203-7","article-title":"Navigating metabolic pathways to enhance antitumour immunity and immunotherapy","volume":"16","author":"Li","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.apsb.2026.01.024_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.138139","article-title":"Photothermal nanobomb blocking metabolic adenosine\u2013A2AR potentiates infiltration and activity of T cells for robust antitumor immunotherapy","volume":"450","author":"Zhao","year":"2022","journal-title":"Chem Eng J"},{"key":"10.1016\/j.apsb.2026.01.024_bib54","article-title":"Second near-infrared light-activatable polymeric nanoantagonist for photothermal immunometabolic cancer therapy","volume":"33","author":"Xu","year":"2021","journal-title":"Adv Mater"},{"key":"10.1016\/j.apsb.2026.01.024_bib55","first-page":"17046","article-title":"Exploring the immunomodulatory properties of red onion (Allium cepa L.) skin: isolation, structural elucidation, and bioactivity study of novel onion chalcones targeting the A2A adenosine receptor","volume":"71","author":"Zhang","year":"2023","journal-title":"J Agric Food Chem"},{"key":"10.1016\/j.apsb.2026.01.024_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2021.109434","article-title":"Dihydroartemisinin induces pyroptosis by promoting the AIM2\/caspase-3\/DFNA5 axis in breast cancer cells","volume":"340","author":"Li","year":"2021","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.apsb.2026.01.024_bib57","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41565-024-01833-9","article-title":"Chemistry, manufacturing and controls strategies for using novel excipients in lipid nanoparticles","volume":"20","author":"O'Brien Laramy","year":"2025","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.apsb.2026.01.024_bib58","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1021\/acs.nanolett.5c00358","article-title":"Acid-responsive biocompatible hydrogel modulating tumor DNA self-repair collaborated with chemotherapy for boosting STING pathway-associated immunotherapy","volume":"25","author":"Lin","year":"2025","journal-title":"Nano Lett"},{"key":"10.1016\/j.apsb.2026.01.024_bib59","doi-asserted-by":"crossref","first-page":"12439","DOI":"10.1021\/acs.jmedchem.4c01242","article-title":"Development of novel N-acylhydrazone derivatives with high anti-obesity activity and improved safety by exploring the pharmaceutical properties of aldehyde group","volume":"67","author":"Jiang","year":"2024","journal-title":"J Med Chem"},{"key":"10.1016\/j.apsb.2026.01.024_bib60","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/nrd.2016.268","article-title":"Strategies and challenges for the next generation of antibody\u2013drug conjugates","volume":"16","author":"Beck","year":"2017","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2026.01.024_bib61","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrd.2017.227","article-title":"Next generation antibody drugs: pursuit of the \u2018high-hanging fruit\u2019","volume":"17","author":"Carter","year":"2017","journal-title":"Nat Rev Drug Discov"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383526000535?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383526000535?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T20:58:22Z","timestamp":1786481902000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383526000535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":61,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2211383526000535"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2026.01.024","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineering an immuno-nanoprodrug: Photo-controlled pyroptosis synergizing with acid-activatable immunometabolic blockade for potent cancer immunotherapy","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2026.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}