{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:01:32Z","timestamp":1786114892050,"version":"build-2736575974"},"reference-count":68,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["21625111"],"award-info":[{"award-number":["21625111"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82571603"],"award-info":[{"award-number":["82571603"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012540","name":"Guangdong Province Introduction of Innovative R&amp;D Team","doi-asserted-by":"publisher","award":["2021ZT09Y552"],"award-info":[{"award-number":["2021ZT09Y552"]}],"id":[{"id":"10.13039\/100012540","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012541","name":"Guangdong Innovative and Entrepreneurial Research Team Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012541","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016691","name":"Guangdong Provincial Pearl River Talents Program","doi-asserted-by":"publisher","award":["0920220219"],"award-info":[{"award-number":["0920220219"]}],"id":[{"id":"10.13039\/100016691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018594","name":"Central University Basic Research Fund of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100018594","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Acta Pharmaceutica Sinica B"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.apsb.2026.04.001","type":"journal-article","created":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T11:22:41Z","timestamp":1775388161000},"page":"4389-4409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Attenuating AAV-triggered innate immunity in the adult mouse nervous system via cGAS\u2013STING pathway inhibition"],"prefix":"10.1016","volume":"16","author":[{"given":"Yaowei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiehao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2853-9040","authenticated-orcid":false,"given":"Yuxiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeru","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingqi","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0831-1419","authenticated-orcid":false,"given":"Kun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4632-5754","authenticated-orcid":false,"given":"Wen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7954-7214","authenticated-orcid":false,"given":"Wenliang","family":"Lei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1857-3670","authenticated-orcid":false,"given":"Gong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3816-8891","authenticated-orcid":false,"given":"Zheng","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.apsb.2026.04.001_bib1","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s41573-023-00766-7","article-title":"AAV-based in vivo gene therapy for neurological disorders","volume":"22","author":"Ling","year":"2023","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2026.04.001_bib2","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-024-01780-w","article-title":"Adeno-associated virus as a delivery vector for gene therapy of human diseases","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct Tar"},{"key":"10.1016\/j.apsb.2026.04.001_bib3","doi-asserted-by":"crossref","first-page":"4316","DOI":"10.1016\/j.apsb.2025.05.033","article-title":"Engineered tumor specific AAV for IL-12 delivery in ovarian cancer immunotherapy","volume":"15","author":"Tong","year":"2025","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2026.04.001_bib4","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1016\/S0140-6736(24)01447-8","article-title":"Safety and efficacy of ATSN-101 in patients with Leber congenital amaurosis caused by biallelic mutations in GUCY2D: a phase 1\/2, multicentre, open-label, unilateral dose escalation study","volume":"404","author":"Yang","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2026.04.001_bib5","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1056\/NEJMoa1908490","article-title":"Multiyear Follow-up of AAV5-hFVIII-SQ gene therapy for Hemophilia A","volume":"382","author":"Pasi","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apsb.2026.04.001_bib6","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1016\/S0140-6736(23)02874-X","article-title":"AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial","volume":"403","author":"Lv","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.apsb.2026.04.001_bib7","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.1016\/j.ymthe.2023.10.015","article-title":"Lethal immunotoxicity in high-dose systemic AAV therapy","volume":"31","author":"Duan","year":"2023","journal-title":"Mol Ther"},{"key":"10.1016\/j.apsb.2026.04.001_bib8","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1089\/hum.2020.182","article-title":"Moving forward after two deaths in a gene therapy trial of myotubular myopathy","volume":"31","author":"Wilson","year":"2020","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.apsb.2026.04.001_bib9","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1056\/NEJMoa2307798","article-title":"Death after high-dose rAAV9 gene therapy in a patient with Duchenne's muscular dystrophy","volume":"389","author":"Lek","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.apsb.2026.04.001_bib10","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1038\/s41583-018-0070-8","article-title":"CNS infection and immune privilege","volume":"19","author":"Forrester","year":"2018","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.apsb.2026.04.001_bib11","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41583-024-00829-7","article-title":"Gene therapy for CNS disorders: modalities, delivery and translational challenges","volume":"25","author":"Gao","year":"2024","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.apsb.2026.04.001_bib12","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tips.2021.03.004","article-title":"Delivering AAV to the central nervous and sensory systems","volume":"42","author":"Peters","year":"2021","journal-title":"Trends Pharmacol Sci"},{"key":"10.1016\/j.apsb.2026.04.001_bib13","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1038\/s41591-021-01522-3","article-title":"Toxicity after AAV delivery of RNAi expression constructs into nonhuman primate brain","volume":"27","author":"Keiser","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.apsb.2026.04.001_bib14","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/nn.2535","article-title":"Selective induction of astrocytic gliosis generates deficits in neuronal inhibition","volume":"13","author":"Ortinski","year":"2010","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.apsb.2026.04.001_bib15","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1016\/j.ymthe.2024.03.036","article-title":"An innate immune response to adeno-associated virus genomes decreases cortical dendritic complexity and disrupts synaptic transmission","volume":"32","author":"Suriano","year":"2024","journal-title":"Mol Ther"},{"key":"10.1016\/j.apsb.2026.04.001_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtm.2023.08.021","article-title":"High-titer AAV disrupts cerebrovascular integrity and induces lymphocyte infiltration in adult mouse brain","volume":"31","author":"Guo","year":"2023","journal-title":"Mol Ther, Methods Clin Dev"},{"key":"10.1016\/j.apsb.2026.04.001_bib17","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143780","article-title":"Overcoming innate immune barriers that impede AAV gene therapy vectors","volume":"131","author":"Muhuri","year":"2021","journal-title":"J Clin Investig"},{"key":"10.1016\/j.apsb.2026.04.001_bib18","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.7150\/thno.89380","article-title":"Understanding AAV vector immunogenicity: from particle to patient","volume":"14","author":"Dhungel","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.apsb.2026.04.001_bib19","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.ymthe.2019.12.010","article-title":"AAV vector immunogenicity in humans: a long journey to successful gene transfer","volume":"28","author":"Costa Verdera","year":"2020","journal-title":"Mol Ther"},{"key":"10.1016\/j.apsb.2026.04.001_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtm.2025.101420","article-title":"Intracranial AAV administration dose-dependently recruits B cells to inhibit the AAV redosing","volume":"33","author":"Xu","year":"2025","journal-title":"Mol Ther, Methods Clin Dev"},{"key":"10.1016\/j.apsb.2026.04.001_bib21","doi-asserted-by":"crossref","first-page":"eabd3438","DOI":"10.1126\/scitranslmed.abd3438","article-title":"Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses","volume":"13","author":"Chan","year":"2021","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.apsb.2026.04.001_bib22","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS\u2013STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.apsb.2026.04.001_bib23","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/j.tcb.2022.11.001","article-title":"Cellular functions of cGAS\u2013STING signaling","volume":"33","author":"Chen","year":"2023","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.apsb.2026.04.001_bib24","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.omtm.2019.05.012","article-title":"Enhancement of adeno-associated virus-mediated gene therapy using hydroxychloroquine in murine and human tissues","volume":"14","author":"Chandler","year":"2019","journal-title":"Mol Ther, Methods Clin Dev"},{"key":"10.1016\/j.apsb.2026.04.001_bib25","doi-asserted-by":"crossref","first-page":"3694","DOI":"10.1038\/s41467-025-58778-3","article-title":"AAV vectors trigger DNA damage response-dependent pro-inflammatory signalling in human iPSC-derived CNS models and mouse brain","volume":"16","author":"Costa-Verdera","year":"2025","journal-title":"Nat Commun"},{"key":"10.1016\/j.apsb.2026.04.001_bib26","doi-asserted-by":"crossref","first-page":"2492","DOI":"10.1016\/j.immuni.2023.10.001","article-title":"SMPDL3A is a cGAMP-degrading enzyme induced by LXR-mediated lipid metabolism to restrict cGAS\u2013STING DNA sensing","volume":"56","author":"Hou","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2026.04.001_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2024.115363","article-title":"Adeno-associated virus vector delivery to the brain: technology advancements and clinical applications","volume":"211","author":"Ye","year":"2024","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.apsb.2026.04.001_bib28","doi-asserted-by":"crossref","first-page":"E40","DOI":"10.1212\/WNL.0000000000012952","article-title":"Safety of AADC gene therapy for moderately advanced Parkinson disease three-year outcomes from the PD-1101 trial","volume":"98","author":"Christine","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.apsb.2026.04.001_bib29","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1038\/ni.3558","article-title":"Regulation and function of the cGAS\u2013STING pathway of cytosolic DNA sensing","volume":"17","author":"Chen","year":"2016","journal-title":"Nat Immunol"},{"key":"10.1016\/j.apsb.2026.04.001_bib30","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1016\/j.immuni.2024.02.019","article-title":"New frontiers in the cGAS\u2013STING intracellular DNA-sensing pathway","volume":"57","author":"Dvorkin","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2026.04.001_bib31","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.1016\/j.apsb.2024.05.012","article-title":"Mitophagy and cGAS\u2013STING crosstalk in neuroinflammation","volume":"14","author":"Zhou","year":"2024","journal-title":"Acta Pharm Sin B"},{"key":"10.1016\/j.apsb.2026.04.001_bib32","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP\u2013AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.apsb.2026.04.001_bib33","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.neuron.2023.10.014","article-title":"STING signaling in the brain: molecular threats, signaling activities, and therapeutic challenges","volume":"112","author":"Yang","year":"2024","journal-title":"Neuron"},{"key":"10.1016\/j.apsb.2026.04.001_bib34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.immuni.2020.05.013","article-title":"Structures and mechanisms in the cGAS\u2013STING innate immunity pathway","volume":"53","author":"Zhang","year":"2020","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2026.04.001_bib35","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.it.2024.08.008","article-title":"Emerging roles of astrocytes as immune effectors in the central nervous system","volume":"45","author":"Fisher","year":"2024","journal-title":"Trends Immunol"},{"key":"10.1016\/j.apsb.2026.04.001_bib36","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1038\/s41577-020-00487-7","article-title":"Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders","volume":"21","author":"Zengeler","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.apsb.2026.04.001_bib37","article-title":"Targeting the cGAS\u2013STING pathway inhibits peripheral T-cell lymphoma progression and enhances the chemotherapeutic efficacy","volume":"11","author":"Lu","year":"2024","journal-title":"Adv Sci"},{"key":"10.1016\/j.apsb.2026.04.001_bib38","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2022110597","article-title":"DNA sensing via the cGAS\/STING pathway activates the immunoproteasome and adaptive T-cell immunity","volume":"42","author":"Wang","year":"2023","journal-title":"EMBO J"},{"key":"10.1016\/j.apsb.2026.04.001_bib39","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1038\/s41592-022-01547-7","article-title":"Directed evolution of adeno-associated virus for efficient gene delivery to microglia","volume":"19","author":"Lin","year":"2022","journal-title":"Nat Methods"},{"key":"10.1016\/j.apsb.2026.04.001_bib40","doi-asserted-by":"crossref","first-page":"33734","DOI":"10.1021\/acsnano.5c00694","article-title":"Biomimetic nanoregulators mediated tyrosine hydroxylase mRNA and stimulator of interferon genes antagonist codelivery for synergistic therapy on Parkinson's disease","volume":"19","author":"Yang","year":"2025","journal-title":"ACS Nano"},{"key":"10.1016\/j.apsb.2026.04.001_bib41","article-title":"Microglia-specific transduction via AAV11 armed with IBA1 promoter and miRNA-9 targeting sequences","author":"Luo","year":"2024","journal-title":"bioRxiv"},{"key":"10.1016\/j.apsb.2026.04.001_bib42","doi-asserted-by":"crossref","first-page":"eadr1015","DOI":"10.1126\/science.adr1015","article-title":"Microglia replacement halts the progression of microgliopathy in mice and humans","volume":"389","author":"Wu","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.apsb.2026.04.001_bib43","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/s41586-018-0287-8","article-title":"Targeting STING with covalent small-molecule inhibitors","volume":"559","author":"Haag","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2026.04.001_bib44","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/s41586-023-06373-1","article-title":"cGAS\u2013STING drives ageing-related inflammation and neurodegeneration","volume":"620","author":"Gulen","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.apsb.2026.04.001_bib45","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.cell.2020.09.020","article-title":"TDP-43 triggers mitochondrial DNA release via mPTP to activate cGAS\/STING in ALS","volume":"183","author":"Yu","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2026.04.001_bib46","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/s43587-022-00337-2","article-title":"Activation of innate immune cGAS\u2013STING pathway contributes to Alzheimer's pathogenesis in 5xFAD mice","volume":"3","author":"Xie","year":"2023","journal-title":"Nat Aging"},{"key":"10.1016\/j.apsb.2026.04.001_bib47","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1073\/pnas.1821000116","article-title":"AAV-regulatory sequences are correlated with ocular toxicity","volume":"116","author":"Xiong","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.apsb.2026.04.001_bib48","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/s41573-019-0012-9","article-title":"Adeno-associated virus vector as a platform for gene therapy delivery","volume":"18","author":"Wang","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.apsb.2026.04.001_bib49","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1016\/j.ymthe.2025.03.037","article-title":"The curious case of AAV immunology","volume":"33","author":"Keeler","year":"2025","journal-title":"Mol Ther"},{"key":"10.1016\/j.apsb.2026.04.001_bib50","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1182\/bloodadvances.2021006419","article-title":"Fatal thrombotic microangiopathy case following adeno-associated viral gene therapy","volume":"6","author":"Guillou","year":"2022","journal-title":"Blood Adv"},{"key":"10.1016\/j.apsb.2026.04.001_bib51","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41576-019-0205-4","article-title":"Engineering adeno-associated virus vectors for gene therapy","volume":"21","author":"Li","year":"2020","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.apsb.2026.04.001_bib52","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41583-020-0263-9","article-title":"Immune cell regulation of glia during CNS injury and disease","volume":"21","author":"Greenhalgh","year":"2020","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.apsb.2026.04.001_bib53","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/s41583-020-0263-9","article-title":"Immune cell regulation of glia during CNS injury and disease","volume":"21","author":"Greenhalgh","year":"2020","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.apsb.2026.04.001_bib54","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.omtm.2020.10.003","article-title":"In situ detection of adeno-associated viral vector genomes with SABER-FISH","volume":"19","author":"Wang","year":"2020","journal-title":"Mol Ther, Methods Clin Dev"},{"key":"10.1016\/j.apsb.2026.04.001_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2024.114122","article-title":"HSV-1 employs UL56 to antagonize expression and function of cGAMP channels","volume":"43","author":"Blest","year":"2024","journal-title":"Cell Rep"},{"key":"10.1016\/j.apsb.2026.04.001_bib56","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1150705","article-title":"cGAMP the travelling messenger","volume":"14","author":"Blest","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.apsb.2026.04.001_bib57","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.immuni.2024.12.002","article-title":"Structures of ATP-binding cassette transporter ABCC1 reveal the molecular basis of cyclic dinucleotide cGAMP export","volume":"58","author":"Shinde","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2026.04.001_bib58","doi-asserted-by":"crossref","first-page":"4043","DOI":"10.1016\/j.cell.2024.05.031","article-title":"STING orchestrates the neuronal inflammatory stress response in multiple sclerosis","volume":"187","author":"Woo","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.apsb.2026.04.001_bib59","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.immuni.2024.11.017","article-title":"The cGAS\u2013STING pathway activates transcription factor TFEB to stimulate lysosome biogenesis and pathogen clearance","volume":"58","author":"Xu","year":"2025","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2026.04.001_bib60","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1126\/science.adf8974","article-title":"Human STING is a proton channel","volume":"381","author":"Liu","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.apsb.2026.04.001_bib61","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1016\/j.immuni.2023.11.001","article-title":"Nuclear localization of STING1 competes with canonical signaling to activate AHR for commensal and intestinal homeostasis","volume":"56","author":"Zhang","year":"2023","journal-title":"Immunity"},{"key":"10.1016\/j.apsb.2026.04.001_bib62","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41419-020-2248-z","article-title":"Inhibition of AIM2 inflammasome activation alleviates GSDMD-induced pyroptosis in early brain injury after subarachnoid haemorrhage","volume":"11","author":"Yuan","year":"2020","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.apsb.2026.04.001_bib63","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/ni.2237","article-title":"Regulation of inflammasome signaling","volume":"13","author":"Rathinam","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.apsb.2026.04.001_bib64","doi-asserted-by":"crossref","first-page":"E517","DOI":"10.1073\/pnas.1218933110","article-title":"Human retinal gene therapy for Leber congenital amaurosis shows advancing retinal degeneration despite enduring visual improvement","volume":"110","author":"Cideciyan","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2026.04.001_bib65","article-title":"Endothelial retargeting of AAV9 in vivo","volume":"9","author":"Bozoglu","year":"2022","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.apsb.2026.04.001_bib66","doi-asserted-by":"crossref","first-page":"5785","DOI":"10.1073\/pnas.1821000116","article-title":"AAV cis-regulatory sequences are correlated with ocular toxicity","volume":"116","author":"Xiong","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.apsb.2026.04.001_bib67","first-page":"13","article-title":"Activation of Piezo 1 in the pathogenesis of glaucoma","volume":"2","author":"Chen","year":"2025","journal-title":"NPT"},{"key":"10.1016\/j.apsb.2026.04.001_bib68","doi-asserted-by":"crossref","first-page":"6459","DOI":"10.1182\/blood-2010-10-314518","article-title":"The genome of self-complementary adeno-associated viral vectors increases toll-like receptor 9-dependent innate immune responses in the liver","volume":"117","author":"Martino","year":"2011","journal-title":"Blood"}],"container-title":["Acta Pharmaceutica Sinica B"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383526002364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2211383526002364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T22:52:18Z","timestamp":1785970338000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2211383526002364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":68,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2211383526002364"],"URL":"https:\/\/doi.org\/10.1016\/j.apsb.2026.04.001","relation":{},"ISSN":["2211-3835"],"issn-type":[{"value":"2211-3835","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Attenuating AAV-triggered innate immunity in the adult mouse nervous system via cGAS\u2013STING pathway inhibition","name":"articletitle","label":"Article Title"},{"value":"Acta Pharmaceutica Sinica B","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.apsb.2026.04.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V. on behalf of Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences.","name":"copyright","label":"Copyright"}]}}