{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:03:08Z","timestamp":1782183788149,"version":"3.54.5"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2007,8,1]],"date-time":"2007-08-01T00:00:00Z","timestamp":1185926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1016\/j.aquatox.2007.02.023","type":"journal-article","created":{"date-parts":[[2007,6,18]],"date-time":"2007-06-18T03:32:29Z","timestamp":1182137549000},"page":"255-267","source":"Crossref","is-referenced-by-count":43,"title":["Interactive effects of metals in mixtures on bioaccumulation in the amphipod Hyalella azteca"],"prefix":"10.1016","volume":"84","author":[{"given":"W.P.","family":"Norwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Borgmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.G.","family":"Dixon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2007.02.023_bib1","series-title":"Metal Metabolism in Aquatic Environments. Chap. 11","first-page":"351","article-title":"Influence of ecological factors on accumulation of metal mixtures","author":"Amiard-Triquet","year":"1998"},{"key":"10.1016\/j.aquatox.2007.02.023_bib2","unstructured":"ANZECC, ARMCANZ., 2000. Australian and New Zealand Guidelines for Fresh and Marine Water Quality."},{"key":"10.1016\/j.aquatox.2007.02.023_bib3","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/BF01059166","article-title":"Chronic effects of inorganic and organic mercury on Daphnia magna: toxicity, accumulation and loss","volume":"11","author":"Biesinger","year":"1982","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.aquatox.2007.02.023_bib4","unstructured":"Borgmann, U., Dixon, D.G., Norwood, W.P., 2000. Metal bioavailability and toxicity in sediments from lakes near Rouyn-Noranda and identification of the cause of toxicity. Environment Canada, Burlington, NWRI Contribution Number 00-066, 1\u201319."},{"key":"10.1016\/j.aquatox.2007.02.023_bib5","first-page":"1055","article-title":"Identification of the toxic agent in metal-contaminated sediments from Manitouwadge Lake, Ontario, using toxicity-accumulation relationships in Hyalella azteca","volume":"54","author":"Borgmann","year":"1997","journal-title":"Can. J. Fish Aquat. Sci."},{"key":"10.1016\/j.aquatox.2007.02.023_bib6","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1139\/f01-048","article-title":"Identifying cause in sediment assessments: bioavailability and the sediment quality triad","volume":"58","author":"Borgmann","year":"2001","journal-title":"Can. J. Fish Aquat. Sci."},{"issue":"8","key":"10.1016\/j.aquatox.2007.02.023_bib7","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1139\/cjfas-56-8-1494","article-title":"Assessing the toxicity of lead in sediments to Hyalella azteca: the significance of bioaccumulation and dissolved metal","volume":"56","author":"Borgmann","year":"1999","journal-title":"Can. J. Fish Aquat. Sci."},{"key":"10.1016\/j.aquatox.2007.02.023_bib8","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1139\/f91-124","article-title":"Relationship between chronic toxicity and bioaccumulation of cadmium in Hyalella azteca","volume":"48","author":"Borgmann","year":"1991","journal-title":"Can. J. Fish Aquat. Sci."},{"key":"10.1016\/j.aquatox.2007.02.023_bib9","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF00008374","article-title":"Accumulation, regulation and toxicity of copper, zinc, lead and mercury in Hyalella azteca","volume":"259","author":"Borgmann","year":"1993","journal-title":"Hydrobiologia"},{"key":"10.1016\/j.aquatox.2007.02.023_bib10","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.envpol.2004.02.010","article-title":"Re-evaluation of metal bioaccumulation and chronic toxicity in Hyalella azteca using saturation curves and the biotic ligand model","volume":"131","author":"Borgmann","year":"2004","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.aquatox.2007.02.023_bib11","series-title":"Canadian Environmental Quality Guidelines","author":"Canadian Council of Ministers of the Environment (CCME)","year":"1999"},{"key":"10.1016\/j.aquatox.2007.02.023_bib12","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1002\/etc.5620201034","article-title":"Biotic ligand model of the acute toxicity of metals. 1. Technical basis","volume":"20","author":"Di Toro","year":"2001","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2007.02.023_bib13","unstructured":"European Inland Fisheries Advisory Commission, 1987. Water quality criteria for European freshwater fish. Report on combined effects on freshwater fish and other aquatic life of mixtures of toxicants in waters, vol. 37, Food and Agriculture Organization of the United Nations, pp. ix\u201375."},{"issue":"12","key":"10.1016\/j.aquatox.2007.02.023_bib14","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1002\/etc.5620141224","article-title":"A residue-based toxicokinetic model for pulse-exposure toxicity in aquatic systems","volume":"14","author":"Hickie","year":"1995","journal-title":"Environ. Toxicol. Chem."},{"issue":"1","key":"10.1016\/j.aquatox.2007.02.023_bib15","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.envpol.2004.01.014","article-title":"Assessment of water quality and toxicity of polluted Rivers Fez and Seboun in the region of Fez (Morocco)","volume":"131","author":"Koukal","year":"2004","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.aquatox.2007.02.023_bib16","series-title":"The Chemical Kinetics of Enzyme Action","author":"Laidler","year":"1973"},{"key":"10.1016\/j.aquatox.2007.02.023_bib17","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1002\/etc.5620111205","article-title":"Toxicokinetics in aquatic systems: model comparisons and use in hazard assessment","volume":"11","author":"Landrum","year":"1992","journal-title":"Environ. Toxicol. Chem. (Annu. Rev.)"},{"key":"10.1016\/j.aquatox.2007.02.023_bib18","first-page":"2212","article-title":"Bioaccumulation kinetics and toxicity of lead in Hyalella azteca (Crustacea, Amphipoda)","volume":"53","author":"MacLean","year":"1996","journal-title":"Can. J. Fish Aquat. Sci."},{"key":"10.1016\/j.aquatox.2007.02.023_bib19","first-page":"183","article-title":"Toxicant body residues: Implications for aquatic bioassays with some organic chemicals","volume":"vol. 1124","author":"McCarty","year":"1991"},{"key":"10.1016\/j.aquatox.2007.02.023_bib20","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF00350012","article-title":"Differential sensitivity of marine infaunal amphipods to tributyltin","volume":"116","author":"Meador","year":"1993","journal-title":"Mar. Biol."},{"issue":"5","key":"10.1016\/j.aquatox.2007.02.023_bib21","first-page":"976","article-title":"Effect of gut clearance on metal body concentrations in Hyalella azteca","volume":"18","author":"Neumann","year":"1999","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2007.02.023_bib22","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.envpol.2005.11.041","article-title":"Saturation models of arsenic, cobalt, chromium and manganese bioaccumulation by Hyalella azteca","volume":"143","author":"Norwood","year":"2006","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.aquatox.2007.02.023_bib23","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.envpol.2006.07.017","article-title":"Chronic toxicity of arsenic, cobalt, chromium and manganese to Hyalella azteca in relation to exposure and bioaccumulation","volume":"147","author":"Norwood","year":"2007","journal-title":"Environ. Pollut."},{"issue":"4","key":"10.1016\/j.aquatox.2007.02.023_bib24","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1080\/713610010","article-title":"Effects of metal mixtures on aquatic biota: A review of observations and methods","volume":"9","author":"Norwood","year":"2003","journal-title":"Hum. Ecol. Risk Assess."},{"key":"10.1016\/j.aquatox.2007.02.023_bib25","first-page":"3","article-title":"The biotic ligand model: a historical overview","volume":"133","author":"Paquin","year":"2002","journal-title":"Comp. Biochem. Physiol., Part C"},{"issue":"2\/3","key":"10.1016\/j.aquatox.2007.02.023_bib26","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0048-9697(98)00232-0","article-title":"Modelling metal interactions at fish gills","volume":"219","author":"Playle","year":"1998","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2007.02.023_bib27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.aquatox.2004.01.017","article-title":"Using multiple metal-gill binding models and the toxic unit concept to help reconcile multiple-metal toxicity results","volume":"67","author":"Playle","year":"2004","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2007.02.023_bib28","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S0269-7491(01)00130-0","article-title":"Toxicity of uranium mine receiving waters to early life stage fathead minnows (Pimephales promelas) in the laboratory","volume":"116","author":"Pyle","year":"2002","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.aquatox.2007.02.023_bib29","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ecoenv.2003.12.002","article-title":"Toxic metals in aquatic plants surviving in surface water polluted by copper mining industry","volume":"59","author":"Samecka-Cymerman","year":"2004","journal-title":"Ecotox. Environ. Saf."},{"key":"10.1016\/j.aquatox.2007.02.023_bib30","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1071\/EN04076","article-title":"Predicting the bioavailability of metals and metal complexes: critical review of the biotic ligand model","author":"Slaveykova","year":"2005","journal-title":"Environ. Chem."},{"key":"10.1016\/j.aquatox.2007.02.023_bib31","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1139\/f88-202","article-title":"Multivariate analysis of correlations between environmental parameters and cadmium concentrations in Hyalella azteca (Crustacea: Amphipoda) from central Ontario lakes","volume":"45","author":"Stephenson","year":"1988","journal-title":"Can. J. Fish Aquat. Sci."},{"key":"10.1016\/j.aquatox.2007.02.023_bib32","unstructured":"U.S. EPA., 2006. MINTEQA2: A Geochemical Assessment Model for Environmental Systems. Version 4.03, revised May 2006, computer program, Athens, Georgia 30605, U.S.A."}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X07002305?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X07002305?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,6]],"date-time":"2019-01-06T15:52:01Z","timestamp":1546789921000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X07002305"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["S0166445X07002305"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2007.02.023","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}