{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T07:37:56Z","timestamp":1792309076636,"version":"4.4.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,4,1]],"date-time":"2009-04-01T00:00:00Z","timestamp":1238544000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1016\/j.aquatox.2008.12.007","type":"journal-article","created":{"date-parts":[[2008,12,28]],"date-time":"2008-12-28T04:48:52Z","timestamp":1230439732000},"page":"65-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":123,"title":["Cadmium detoxification strategies in two phytoplankton species: Metal binding by newly synthesized thiolated peptides and metal sequestration in granules"],"prefix":"10.1016","volume":"92","author":[{"given":"Michel","family":"Lavoie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Le Faucheur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claude","family":"Fortin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.C.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2008.12.007_bib1","doi-asserted-by":"crossref","first-page":"658","DOI":"10.4319\/lo.1995.40.4.0658","article-title":"Phytochelatin production in marine algae. 2. Induction by various metals","volume":"40","author":"Ahner","year":"1995","journal-title":"Limnol. Oceanogr."},{"key":"10.1016\/j.aquatox.2008.12.007_bib2","doi-asserted-by":"crossref","first-page":"649","DOI":"10.4319\/lo.1995.40.4.0649","article-title":"Phytochelatin production in marine algae. 1. An interspecies comparison","volume":"40","author":"Ahner","year":"1995","journal-title":"Limnol. Oceanogr."},{"key":"10.1016\/j.aquatox.2008.12.007_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3354\/meps232093","article-title":"Glutathione and other low molecular weight thiols in marine phytoplankton under metal stress","volume":"232","author":"Ahner","year":"2002","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.aquatox.2008.12.007_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/tox.20149","article-title":"Significance of physicochemical forms of storage in microalgae in predicting copper transfer to filter-feeding oysters (Crassostrea gigas)","volume":"21","author":"Amiard-Triquet","year":"2006","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib5","first-page":"189","article-title":"Metal bioavailability to phytoplankton\u2014applicability of the biotic ligand model","volume":"133","author":"Campbell","year":"2002","journal-title":"Comp. Biochem. Phys. C"},{"key":"10.1016\/j.aquatox.2008.12.007_bib6","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1126\/science.1138375","article-title":"Exploring cells with a centrifuge","volume":"189","author":"De Duve","year":"1975","journal-title":"Science"},{"key":"10.1016\/j.aquatox.2008.12.007_bib7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s10534-005-1245-0","article-title":"Cadmium toxicity in plants: is there any analogy to its carcinogenic effect in mammalian cells?","volume":"18","author":"Deckert","year":"2005","journal-title":"BioMetals"},{"key":"10.1016\/j.aquatox.2008.12.007_bib8","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.4319\/lo.2004.49.5.1754","article-title":"Novel copper-binding nitrogen-rich thiols produced and exuded by Emiliania huxleyi","volume":"49","author":"Dupont","year":"2004","journal-title":"Limnol. Oceanogr."},{"key":"10.1016\/j.aquatox.2008.12.007_bib9","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s002440010165","article-title":"Determination of cadmium partitioning in microalgae and oysters: contribution to the assessment of trophic transfer","volume":"40","author":"Ettajani","year":"2001","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib10","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1002\/etc.5620191123","article-title":"Silver uptake by the green alga Chlamydomonas reinhardtii in relation to chemical speciation: influence of chloride","volume":"19","author":"Fortin","year":"2000","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2008.12.007_bib11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1007\/BF00425162","article-title":"Algae sequester heavy metals via synthesis of phytochelatin complexes","volume":"150","author":"Gekeler","year":"1988","journal-title":"Arch. Microbiol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib12","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.aquatox.2005.12.001","article-title":"Sub-cellular partitioning of cadmium, copper, nickel and zinc in indigenous yellow perch (Perca flavescens) sampled along a polymetallic gradient","volume":"77","author":"Gigu\u00e8re","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib13","series-title":"Biological Centrifugation","author":"Graham","year":"2001"},{"key":"10.1016\/j.aquatox.2008.12.007_bib14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1104\/pp.98.1.127","article-title":"Heavy metal-activated synthesis of peptides in Chlamydomonas reinhardtii","volume":"98","author":"Howe","year":"1992","journal-title":"Plant Physiol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib15","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0168-9452(01)00501-5","article-title":"Cadmium sequestration in Chlamydomonas reinhardtii","volume":"161","author":"Hu","year":"2001","journal-title":"Plant Sci."},{"key":"10.1016\/j.aquatox.2008.12.007_bib16","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1111\/j.1438-8677.1992.tb00284.x","article-title":"Gamma-glutamylcysteinylserine\u2014a new homolog of glutathione in plants of the family Poacea","volume":"105","author":"Klapheck","year":"1992","journal-title":"Bot. Acta"},{"key":"10.1016\/j.aquatox.2008.12.007_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0031-9422(96)00514-6","article-title":"The formation of Cd-phytochelatin complexes in plant cell cultures","volume":"44","author":"Kneer","year":"1997","journal-title":"Phytochemistry"},{"key":"10.1016\/j.aquatox.2008.12.007_bib18","unstructured":"Lavoie, M., Bernier, J., Fortin, C., Campbell, P.G.C. Cell homogenization and subcellular fractionation in two phytoplankton algae: implication for the assessment of metal subcellular distributions. Limnol. Oceanogr. Methods, in press."},{"key":"10.1016\/j.aquatox.2008.12.007_bib19","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1897\/04-394R.1","article-title":"Phytochelatin induction, cadmium accumulation and algal sensitivity to free cadmium ion in Scenedesmus vacuolatus","volume":"24","author":"Le Faucheur","year":"2005","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2008.12.007_bib20","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0044-328X(82)80002-0","article-title":"Localization of cadmium in Fucus vesiculosus by X-ray microanalysis","volume":"105","author":"Lignell","year":"1982","journal-title":"Z. Pflanzenphysiol. Bd."},{"key":"10.1016\/j.aquatox.2008.12.007_bib21","series-title":"Metal Speciation and Bioavailability in Aquatic Systems","first-page":"479","article-title":"Metal detoxification in aquatic organisms","author":"Mason","year":"1995"},{"key":"10.1016\/j.aquatox.2008.12.007_bib22","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1399-3054.1977.tb04882.x","article-title":"Cadmium accumulation by the marine red alga Porphyra umbilicalis","volume":"41","author":"McLean","year":"1977","journal-title":"Physiol. Plant"},{"key":"10.1016\/j.aquatox.2008.12.007_bib23","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1034\/j.1399-3054.2002.1150214.x","article-title":"Cadmium accumulation in the chloroplast of Euglena gracilis","volume":"115","author":"Mendoza-Cozatl","year":"2002","journal-title":"Physiol. Plant"},{"key":"10.1016\/j.aquatox.2008.12.007_bib24","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1021\/es0613963","article-title":"Predicting copper toxicity with its intracellular or subcellular concentration and the thiol synthesis in a marine diatom","volume":"41","author":"Miao","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib25","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0141-1136(01)00093-9","article-title":"Synthesis and stability of phytochelatins induced by cadmium and lead in the marine diatom Phaeodactylum tricornutum","volume":"52","author":"Morelli","year":"2001","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.aquatox.2008.12.007_bib26","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S0176-1617(96)80178-7","article-title":"Subcellular distribution of cadmium in the unicellular green alga Chlamydomonas reinhardtii","volume":"149","author":"Nagel","year":"1996","journal-title":"J. Plant Physiol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib27","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0168-6496(03)00049-7","article-title":"Ultrastructural changes in Chlamydomonas acidophila (Chlorophyta) induced by heavy metals and polyphosphate metabolism","volume":"44","author":"Nishikawa","year":"2003","journal-title":"FEMS Microb. Ecol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib28","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.plantsci.2005.08.025","article-title":"Polyphosphate metabolism in an acidophilic alga Chlamydomonas acidophila KT-1 (Chlorophyta) under phosphate stress","volume":"170","author":"Nishikawa","year":"2006","journal-title":"Plant Sci."},{"key":"10.1016\/j.aquatox.2008.12.007_bib29","unstructured":"NIST, 2004. NIST critical stability constants of metal complexes database, in: Martell, A.E., Smith, R.M., Motekaitis, R.J. (Eds.), Standard Reference Database 46. National Institute of Standards and Technology, Gaithersburg, MD."},{"key":"10.1016\/j.aquatox.2008.12.007_bib30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1046\/j.1529-8817.1999.3520293.x","article-title":"Effects of cadmium toxicity on growth and elemental composition of marine phytoplankton","volume":"35","author":"Payne","year":"1999","journal-title":"J. Phycol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemosphere.2005.11.024","article-title":"Heavy metal detoxification in eukaryotic microalgae","volume":"64","author":"Perales-Vela","year":"2006","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2008.12.007_bib32","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1002\/etc.5620200927","article-title":"Class III metallothioneins in response to cadmium toxicity in the marine microalga Tetraselmis suecica (Kylin) Butch.","volume":"20","author":"P\u00e9rez-Rama","year":"2001","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2008.12.007_bib33","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1139\/f99-102","article-title":"Effets des m\u00e9taux (Ag, Cd, Cu) sur la composition biochimique et compartimentation de ces m\u00e9taux chez deux microalgues Skeletonema costatum et Tetraselmis suecica","volume":"56","author":"Perrein-Ettajani","year":"1999","journal-title":"Can. J. Fish Aquat. Sci."},{"key":"10.1016\/j.aquatox.2008.12.007_bib34","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1104\/pp.109.4.1141","article-title":"Phytochelatins and related peptides\u2014structure, biosynthesis, and function","volume":"109","author":"Rauser","year":"1995","journal-title":"Plant Physiol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib35","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1104\/pp.104.048579","article-title":"Update on phytochelatin synthase. Weeds, worms, and more. Papain's long-lost cousin, phytochelatin synthase","volume":"136","author":"Rea","year":"2004","journal-title":"Plant Physiol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF00993642","article-title":"HPLC analysis of nonprotein thiols in planktonic diatoms: pool size, redox state and response to copper and cadmium exposure","volume":"127","author":"Rijstenbil","year":"1996","journal-title":"Mar. Biol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib37","doi-asserted-by":"crossref","first-page":"46196","DOI":"10.1074\/jbc.M105268200","article-title":"The polyphosphate bodies of Chlamydomonas reinhardtii possess a proton-pumping pyrophosphatase and are similar to acidocalcisomes","volume":"276","author":"Ruiz","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.aquatox.2008.12.007_bib38","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/0198-9715(92)90053-T","article-title":"MINEQL+: a software environment for chemical equilibrium modeling","volume":"16","author":"Schecher","year":"1992","journal-title":"Comput. Environ. Urban Syst."},{"key":"10.1016\/j.aquatox.2008.12.007_bib39","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2216\/i0031-8884-15-2-155.1","article-title":"Cadmium-induced ultrastructural changes in mitochondria of freshwater green algae","volume":"15","author":"Silverberg","year":"1976","journal-title":"Phycologia"},{"key":"10.1016\/j.aquatox.2008.12.007_bib40","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1039\/c39910001129","article-title":"Evidence for discrete Cd(SCys)4 units in cadmium phytochelatin complexes from EXAFS spectroscopy","volume":"16","author":"Strasdeit","year":"1991","journal-title":"J. Chem. Soc. Chem. Commun."},{"key":"10.1016\/j.aquatox.2008.12.007_bib41","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0166-445X(97)00034-9","article-title":"Long-chain class III metallothioneins as a mechanism of cadmium tolerance in the marine diatom Phaeodactylum tricornutum Bohlin","volume":"39","author":"Torres","year":"1997","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib42","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3354\/meps138245","article-title":"Cadmium toxicity and zinc limitation in centric diatoms of the genus Thalassiosira","volume":"138","author":"Tortell","year":"1996","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.aquatox.2008.12.007_bib43","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/BF00203803","article-title":"Ultrastructural changes in Dunaliella minuta following acute and chronic exposure to copper and cadmium","volume":"23","author":"Visviki","year":"1992","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib44","first-page":"149","article-title":"Acute and chronic exposure of Dunaliella salina and Chlamydomonas bullosa to copper and cadmium: effects on growth","volume":"26","author":"Visviki","year":"1994","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.aquatox.2008.12.007_bib45","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3354\/meps249183","article-title":"Subcellular compartmentalization of Cd and Zn in two bivalves. I. Significance of metal-sensitive fractions (MSF) and biological detoxified metal (BDM)","volume":"249","author":"Wallace","year":"2003","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.aquatox.2008.12.007_bib46","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/BF02182157","article-title":"Identification of toxic metals in affected algal cells in assays of wastewaters","volume":"6","author":"Wong","year":"1994","journal-title":"J. Appl. Phycol."}],"updated-by":[{"DOI":"10.1016\/j.aquatox.2010.09.015","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2011,1,17]],"date-time":"2011-01-17T00:00:00Z","timestamp":1295222400000}}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X08004128?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X08004128?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:45:21Z","timestamp":1759067121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X08004128"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,4]]},"references-count":46,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["S0166445X08004128"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2008.12.007","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2009,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cadmium detoxification strategies in two phytoplankton species: Metal binding by newly synthesized thiolated peptides and metal sequestration in granules","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2008.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}