{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:30:40Z","timestamp":1791909040724,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2011,1,1]],"date-time":"2011-01-01T00:00:00Z","timestamp":1293840000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004336","name":"Ministerio de Agricultura, Alimentaci\u00f3n y Medio Ambiente","doi-asserted-by":"publisher","award":["041\/SGTB\/2007\/1.1"],"award-info":[{"award-number":["041\/SGTB\/2007\/1.1"]}],"id":[{"id":"10.13039\/501100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004336","name":"Ministerio de Agricultura, Alimentaci\u00f3n y Medio Ambiente","doi-asserted-by":"publisher","award":["042\/RN08\/03.4"],"award-info":[{"award-number":["042\/RN08\/03.4"]}],"id":[{"id":"10.13039\/501100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004336","name":"Ministerio de Agricultura, Alimentaci\u00f3n y Medio Ambiente","doi-asserted-by":"publisher","award":["CGL2008-01898"],"award-info":[{"award-number":["CGL2008-01898"]}],"id":[{"id":"10.13039\/501100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004336","name":"Ministerio de Agricultura, Alimentaci\u00f3n y Medio Ambiente","doi-asserted-by":"publisher","award":["DE2009-0089"],"award-info":[{"award-number":["DE2009-0089"]}],"id":[{"id":"10.13039\/501100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2011,1]]},"DOI":"10.1016\/j.aquatox.2010.09.004","type":"journal-article","created":{"date-parts":[[2010,9,18]],"date-time":"2010-09-18T04:38:53Z","timestamp":1284784733000},"page":"78-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":73,"title":["Characterization of the multixenobiotic resistance (MXR) mechanism in embryos and larvae of the zebra mussel (Dreissena polymorpha) and studies on its role in tolerance to single and mixture combinations of toxicants"],"prefix":"10.1016","volume":"101","author":[{"given":"Melissa","family":"Faria","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Navarro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Till","family":"Luckenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Pi\u00f1a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Barata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2010.09.004_bib0005","series-title":"Fifth international zebra mussel and other aquatic nuisance organisms conference","first-page":"1","article-title":"Zebra mussel life history","author":"Ackerman","year":"1995"},{"key":"10.1016\/j.aquatox.2010.09.004_bib0010","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1897\/01-386","article-title":"Mixture toxicity and its modelling by quantitative structure \u2013 activity relationships","volume":"22","author":"Altenburger","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0015","series-title":"Standard Methods for the Examination of Water and Wastewater","author":"ASTM","year":"1995"},{"key":"10.1016\/j.aquatox.2010.09.004_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aquatox.2006.01.013","article-title":"Toxicity of binary mixtures of metals and pyrethroid insecticides to Daphnia magna Straus. Implications for multi-substance risks assessment","volume":"78","author":"Barata","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0025","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0166-445X(00)00088-6","article-title":"Multixenobiotic resistance as a cellular defense mechanism in aquatic organisms","volume":"48","author":"Bard","year":"2000","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0030","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0166-445X(99)00011-9","article-title":"The effect of inhibitors of multixenobiotic resistance mechanism on the production of mutagens by Dreissena polymorpha in waters spiked with premutagens","volume":"47","author":"Britvic","year":"1999","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0245","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ejps.2003.07.003","article-title":"The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability","volume":"21","author":"Chan","year":"2004","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0040","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1289\/ehp.99107s6907","article-title":"Pharmaceuticals and personal care products in the environment: agents of subtle change?","volume":"107","author":"Daughton","year":"1999","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0045","series-title":"Methods in Enzymology","doi-asserted-by":"crossref","DOI":"10.1016\/S0076-6879(05)00024-8","article-title":"The genetics of ATP-binding cassette transporters","author":"Dean","year":"2005"},{"key":"10.1016\/j.aquatox.2010.09.004_bib0050","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1152\/physrev.00035.2005","article-title":"Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins","volume":"86","author":"Deeley","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S1095-6433(98)10005-3","article-title":"Use of multidrug transporters as first lines of defense against toxins in aquatic organisms","volume":"120 A","author":"Epel","year":"1998","journal-title":"Comp. Biochem. Physiol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0060","doi-asserted-by":"crossref","first-page":"3914","DOI":"10.1021\/es087187v","article-title":"Efflux transporters: newly appreciated roles in protection against pollutants","volume":"42","author":"Epel","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0065","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1016\/j.scitotenv.2010.02.047","article-title":"Comparative toxicity of single and combined mixtures of selected pollutants among larval stages of the native freshwater mussels (Unio elongatulus) and the invasive zebra mussel (Dreissena polymorpha)","volume":"408","author":"Faria","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0070","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF00744657","article-title":"Molecular analysis of the multidrug transporter","volume":"12","author":"Germann","year":"1993","journal-title":"Cytotechnology"},{"key":"10.1016\/j.aquatox.2010.09.004_bib0075","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/1389200043489199","article-title":"The MRP-related and BCRP\/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation","volume":"5","author":"Haimeur","year":"2004","journal-title":"Curr. Drug Metabol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0080","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0166-445X(02)00050-4","article-title":"Tolerance to biodegraded crude oil in marine invertebrate embryos and larvae is associated with expression of a multixenobiotic resistance transporter","volume":"61","author":"Hamdoun","year":"2002","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0085","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0043-1354(96)00244-8","article-title":"A simplification the bivalve embryogenesis and larval development bioassay method for water quality assessment","volume":"31","author":"His","year":"1997","journal-title":"Water Res."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0250","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/0005-2736(94)90190-2","article-title":"Calcein accumulation as a fluorometric functional assay of the multidrug transporter","volume":"11191","author":"Hollo","year":"1994","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.aquatox.2010.09.004_bib0255","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/10408449209145320","article-title":"The multixenobiotic resistance mechanism in aquatic organisms","volume":"22","author":"Kurelec","year":"1992","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0095","first-page":"855","article-title":"A new type of hazardous chemical: the chemosensitizers of multixenobiotic resistance","volume":"105","author":"Kurelec","year":"1997","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0120","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1289\/ehp.7301","article-title":"Nitromusk and polycyclic musk compounds as long-term inhibitors of cellular xenobiotic defense systems mediated by multidrug transporters","volume":"113","author":"Luckenbach","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0125","doi-asserted-by":"crossref","first-page":"R1919","DOI":"10.1152\/ajpregu.00563.2007","article-title":"ABCB- and ABCC-type transporters confer multixenobiotic resistance and form an environment\u2013tissue barrier in bivalve gills","volume":"294","author":"Luckenbach","year":"2008","journal-title":"Am. J. Physiol. \u2013 Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0130","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3354\/meps238115","article-title":"Identification of six mRNA sequences of genes related to multixenobiotic resistance (MXR) and biotransformation in Mytilus edulis","volume":"238","author":"Ludeking","year":"2002","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0135","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0141-1136(00)00057-X","article-title":"Multidrug resistance in the embryos and larvae of the mussel Mytilus edulis","volume":"50","author":"McFadzen","year":"2000","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0140","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/0014-4827(88)90152-8","article-title":"Use of fluorescent dyes as molecular probes for the study of multidrug resistance","volume":"174","author":"Neyfakh","year":"1988","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0160","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.chemosphere.2006.11.017","article-title":"Identification of multixenobiotic defence mechanism (MXR) background activities in the freshwater bivalve Dreissena polymorpha as reference values for its use as biomarker in contaminated ecosystems","volume":"67","author":"Pain","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2010.09.004_bib0260","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0170","doi-asserted-by":"crossref","first-page":"5010","DOI":"10.1021\/bi973045u","article-title":"Human P-glycoprotein exhibits reduced affinity for substrates during a catalytic transition state","volume":"37","author":"Ramachandra","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.aquatox.2010.09.004_bib0175","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1440-169X.2006.00893.x","article-title":"Increase in multidrug transport activity is associated with oocyte maturation in sea stars","volume":"48","author":"Roepke","year":"2006","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0180","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1152\/physrev.00037.2005","article-title":"Human multidrug resistance ABCB and ABCG transporters: participation in a chemoimmunity defense system","volume":"86","author":"Sarkadi","year":"2006","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0185","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0006-2952(99)00139-2","article-title":"Interaction of the P-glycoprotein multidrug transporter (MDR1) with high affinity peptide chemosensitizers in isolated membranes, reconstituted systems, and intact cells","volume":"58","author":"Sharom","year":"1999","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0190","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.mrfmmm.2004.06.006","article-title":"Emerging contaminants \u2013 pesticides, PPCPs, microbial degradation products and natural substances as inhibitors of multixenobiotic defense in aquatic organisms","volume":"552","author":"Smital","year":"2004","journal-title":"Mutat. Res. \u2013 Fund. Mol. Mech."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0195","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S0166-445X(03)00175-9","article-title":"Inducibility of the P-glycoprotein transport activity in the marine mussel Mytilus galloprovincialis and the freshwater mussel Dreissena polymorpha","volume":"65","author":"Smital","year":"2003","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0200","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/S0141-1136(00)00202-6","article-title":"Inhibition of multixenobiotic resistance mechanism in aquatic organisms by commercially used pesticides","volume":"50","author":"Smital","year":"2000","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0265","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1126\/science.1133609","article-title":"The genome of the sea urchin Strongylocentrotus purpuratus","volume":"314","author":"Sodergren","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.aquatox.2010.09.004_bib0205","doi-asserted-by":"crossref","first-page":"355","DOI":"10.2307\/1542476","article-title":"Multixenobiotic resistance in Urechis-caupo embryos \u2013 protection from environmental toxins","volume":"185","author":"Toomey","year":"1993","journal-title":"Biol. Bull."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0210","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0141-1136(96)87094-2","article-title":"Marine bacteria produce compounds that modulate multixenobiotic transport activity in Urechis caupo embryos","volume":"42","author":"Toomey","year":"1996","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0215","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jtherbio.2007.01.008","article-title":"Effect of temperature on the expression of P-glycoprotein in the zebra mussel, Dreissena polymorpha","volume":"32","author":"Tutundjian","year":"2007","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0220","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/S0380-1330(96)70932-2","article-title":"Evaluation of different phytoplankton for supporting development of zebra mussel larvae (Dreissena polymorpha): the importance of size and polyunsaturated fatty acid content","volume":"22","author":"Vanderploeg","year":"1996","journal-title":"J. Great Lakes Res."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0225","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0048-9697(02)00471-0","article-title":"Inhibition of larval development of the marine copepod Acartia tonsa by four synthetic musk substances","volume":"305","author":"Wollenberger","year":"2003","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0230","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.taap.2007.11.001","article-title":"Development and characterization of P-glycoprotein 1 (Pgp1, ABCB1)-mediated doxorubicin-resistant PLHC-1 hepatoma fish cell line","volume":"227","author":"Zaja","year":"2008","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0235","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.aquatox.2006.12.015","article-title":"Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line","volume":"81","author":"Zaja","year":"2007","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2010.09.004_bib0240","series-title":"Biostatistical Analysis","author":"Zar","year":"1996"}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X10003711?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X10003711?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:49:34Z","timestamp":1759067374000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X10003711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011,1]]}},"alternative-id":["S0166445X10003711"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2010.09.004","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characterization of the multixenobiotic resistance (MXR) mechanism in embryos and larvae of the zebra mussel (Dreissena polymorpha) and studies on its role in tolerance to single and mixture combinations of toxicants","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2010.09.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2010 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}