{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:08:24Z","timestamp":1790428104616,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","issue":"3-4","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.aquatox.2011.07.009","type":"journal-article","created":{"date-parts":[[2011,7,23]],"date-time":"2011-07-23T12:47:58Z","timestamp":1311425278000},"page":"378-384","source":"Crossref","is-referenced-by-count":14,"title":["Brain cytochrome P450 aromatase activity in roach (Rutilus rutilus): Seasonal variations and impact of environmental contaminants"],"prefix":"10.1016","volume":"105","author":[{"given":"Perrine","family":"Geraudie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Hinfray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Gerbron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Porcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Brion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Minier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2011.07.009_bib0005","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1365-2826.1994.tb00621.x","article-title":"Distribution of estrogen receptor-immunoreactive cells in the brain of the rainbow trout (Oncorhynchus mykiss)","volume":"6","author":"Anglade","year":"1994","journal-title":"J. Neuroendocrinol."},{"issue":"6","key":"10.1016\/j.aquatox.2011.07.009_bib0010","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nrn846","article-title":"Oestrogen as a neuroprotective hormone","volume":"3","author":"Behl","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0015","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.mce.2004.01.006","article-title":"Cloning, sequence analysis, tissue distribution, and sex-specific expression of the neural form of P450 aromatase in juvenile sea bass (Dicentrarchus labrax)","volume":"219","author":"Blazquez","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0020","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ygcen.2008.06.001","article-title":"Sex-related changes in estrogen receptors and aromatase gene expression and enzymatic activity during early development and sex differentiation in the European sea bass (Dicentrarchus labrax)","volume":"158","author":"Blazquez","year":"2008","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0025","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0030","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.aquatox.2006.06.014","article-title":"Evidence of genotoxicity related to high PAH content of sediments in the upper part of the Seine estuary (Normandy), France","volume":"79","author":"Cachot","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0035","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0048-9697(99)00480-5","article-title":"Towards an integrative approach in environmental contamination and toxicology","volume":"247","author":"Cajaraville","year":"2000","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0040","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0960-0760(01)00147-9","article-title":"Differential tissue distribution, developmental programming, estrogen regulation and promoter characteristics of cyp19 genes in teleost fish","volume":"79","author":"Callard","year":"2001","journal-title":"J. Steroid Biochem. Mol. Biol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0045","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ygcen.2007.03.005","article-title":"Interference of endocrine disrupting chemicals with aromatase CYP19 expression or activity, and consequences for reproduction of teleost fish","volume":"155","author":"Cheshenko","year":"2008","journal-title":"Gen. Comp. Endocrinol."},{"issue":"2","key":"10.1016\/j.aquatox.2011.07.009_bib0050","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1095\/biolreprod.109.076331","article-title":"Porcine hypothalamic aromatase cytochrome P450: isoform characterization, sex-dependent activity, regional expression, and regulation by enzyme inhibition in neonatal boars","volume":"81","author":"Corbin","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0055","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.yfrne.2010.01.003","article-title":"Aromatase in the brain of teleost fish: expression, regulation and putative functions","volume":"31","author":"Diotel","year":"2010","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0060","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.ygcen.2007.05.018","article-title":"Local expression of CYP19A1 and CYP19A2 in developing and adult killifish (Fundulus heteroclitus)","volume":"155","author":"Dong","year":"2008","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0065","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1006\/taap.1997.8307","article-title":"Effects of some persistent halogenated environmental contaminants on aromatase (CYP19) activity in the human choriocarcinoma cell line JEG-3","volume":"148","author":"Drenth","year":"1998","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0075","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/gcen.1997.6891","article-title":"Immunolocalization of aromatase and androgen receptor positive neurons in the goldfish brain","volume":"106","author":"Gelinas","year":"1997","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0080","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0303-7207(98)00015-X","article-title":"Isolation of a goldfish brain cytochrome P450 aromatase cDNA: mRNA expression during the seasonal cycle and after steroid treatment","volume":"138","author":"Gelinas","year":"1998","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0085","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/s10695-009-9351-5","article-title":"Roach (Rutilus rutilus) reproduction: a study of biochemical and histological parameters in a low contaminated site","volume":"36","author":"Geraudie","year":"2010","journal-title":"Fish. Physiol. Biochem."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0090","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1017\/S003118200999151X","article-title":"Endocrine effects of the tapeworm Ligula intestinalis in its teleost host, the roach (Rutilus rutilus)","volume":"137","author":"Geraudie","year":"2010","journal-title":"Parasitology"},{"key":"10.1016\/j.aquatox.2011.07.009_bib0095","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0016-6480(03)00086-8","article-title":"Aromatase activity in the European sea bass (Dicentrarchus labrax L.) brain. Distribution and changes in relation to age, sex, and the annual reproductive cycle","volume":"132","author":"Gonzalez","year":"2003","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0100","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.aquatox.2004.12.007","article-title":"Isolation and characterization of two cytochrome P450 aromatase forms in killifish (Fundulus heteroclitus): differential expression in fish from polluted and unpolluted environments","volume":"71","author":"Greytak","year":"2004","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.aquatox.2011.07.009_bib0105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ygcen.2006.02.005","article-title":"Inhibition of cytochrome P450 brain aromatase reduces two male specific sexual behaviours in the male Endler guppy (Poecilia reticulata)","volume":"147","author":"Hallgren","year":"2006","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0110","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0166-445X(02)00011-5","article-title":"Exposure to exogenous 17\u03b2-estradiol disrupts P450aromB mRNA expression in the brain and gonad of adult fathead minnows (Pimephales promelas)","volume":"60","author":"Halm","year":"2002","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0115","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.aquatox.2004.12.008","article-title":"Parasitism in fish \u2013 an endocrine modulator of ecological relevance?","volume":"72","author":"Hecker","year":"2005","journal-title":"Aquat. Toxicol."},{"issue":"3","key":"10.1016\/j.aquatox.2011.07.009_bib0120","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.chemosphere.2006.05.046","article-title":"Suppression of aromatase activity in the population of bream (Abramis brama) from the river Elbe Germany","volume":"66","author":"Hecker","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2011.07.009_bib0125","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.cbpc.2006.09.002","article-title":"Inhibition of rainbow trout (Oncorhynchus mykiss) P450 aromatase activities in brain and ovarian microsomes by various environmental substances","volume":"144","author":"Hinfray","year":"2006","journal-title":"Comp. Biochem. Physiol. C-Toxicol. Pharmacol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0130","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/tox.20203","article-title":"Brain and gonadal aromatase as potential targets of endocrine disrupting chemicals in a model species, the zebrafish (Danio rerio)","volume":"21","author":"Hinfray","year":"2006","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0135","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1016\/j.scitotenv.2010.01.003","article-title":"Endocrine disruption in wild population of chub (Leuciscus cephalus) in contaminated French streams","volume":"408","author":"Hinfray","year":"2010","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0145","doi-asserted-by":"crossref","first-page":"3155","DOI":"10.1002\/dvdy.21344","article-title":"The zebrafish, brain-specific, aromatase cyp19a2 is neither expressed nor distributed in a sexually dimorphic manner during sexual differentiation","volume":"236","author":"Kallivretaki","year":"2007","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0150","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S1096-4959(01)00319-0","article-title":"Estrogen and xenoestrogens upregulate the brain aromatase isoform (P450aromB) and perturb markers of early development in zebrafish (Danio rerio)","volume":"129","author":"Kishida","year":"2001","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0280","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1093\/toxsci\/kfn151","article-title":"Altered sexual development in roach (Rutilus rutilus) exposed to environmental concentrations of the pharmaceutical 17a-ethinylestradiol and associated expression dynamics of aromatases and estrogen receptors","volume":"106","author":"Lange","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0155","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.taap.2003.12.012","article-title":"First evidence of endocrine disruption in feral carp from the Ebro River","volume":"196","author":"Lavado","year":"2004","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0160","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1002\/mrd.20892","article-title":"Characterization of a cis-acting element involved in cell-specific expression of the zebrafish brain aromatase gene","volume":"75","author":"Le Page","year":"2008","journal-title":"Mol. Reprod. Dev."},{"issue":"1","key":"10.1016\/j.aquatox.2011.07.009_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-0173(96)00002-1","article-title":"Review of brain aromatase cytochrome P450","volume":"22","author":"Lephart","year":"1996","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0170","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.anireprosci.2006.05.015","article-title":"Seasonal changes of serum sex steroids concentration and aromatase activity of gonad and brain in red-spotted grouper (Epinephelus akaara)","volume":"99","author":"Li","year":"2007","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0175","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.yhbeh.2009.09.002","article-title":"Rapid steroid influences on visually guided sexual behavior in male goldfish","volume":"56","author":"Lord","year":"2009","journal-title":"Horm. Behav."},{"issue":"2","key":"10.1016\/j.aquatox.2011.07.009_bib0180","first-page":"256","article-title":"Estrogenic response of wild roach from the Seine River (France)","volume":"32","author":"Maltret-Geraudie","year":"2008","journal-title":"Cybium"},{"key":"10.1016\/j.aquatox.2011.07.009_bib0185","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/cne.20497","article-title":"Expression and estrogen-dependent regulation of the zebrafish brain aromatase gene","volume":"485","author":"Menuet","year":"2005","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0190","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1051\/analusis:2000280801","article-title":"An investigation of the incidence of intersex fish in Seine-Maritime and Sussex regions","volume":"28","author":"Minier","year":"2000","journal-title":"Analysis"},{"key":"10.1016\/j.aquatox.2011.07.009_bib0195","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1897\/05-161R.1","article-title":"A pollution monitoring pilot study involving chemical analysis and biomarker measurements in the Seine estuary using zebra mussels (Dreissena polymorpha)","volume":"25","author":"Minier","year":"2006","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0200","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3354\/meps322143","article-title":"Multixenobiotic resistance protein expression in Mytilus edulis, Mytilus galloprovinciallis and Crassostrea gigas from the French coasts","volume":"322","author":"Minier","year":"2006","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0205","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0141-1136(93)90030-4","article-title":"Inhibition of ovarian microsomal aromatase and follicular oestradiol secretion by imidazole fungicides in rainbow trout","volume":"35","author":"Monod","year":"1993","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0210","article-title":"In vivo biomarkers of estrogenicity: limitation of interpretation in wild environment","author":"Nadzialek","year":"2010","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0215","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1006\/taap.2001.9194","article-title":"Evidence for endocrine disruption in perch (Perca fluviatilis) in a remote Swedish lake in the vicinity of a public refuse dump","volume":"174","author":"Noaksson","year":"2001","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0220","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0016-6480(03)00267-3","article-title":"Altered steroid metabolism in several teleost species exposed to endocrine disrupting substances in refuse dump leachate","volume":"134","author":"Noaksson","year":"2003","journal-title":"Gen. Comp. Endocrinol."},{"issue":"Suppl. 3","key":"10.1016\/j.aquatox.2011.07.009_bib0225","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1289\/ehp.02110s3429","article-title":"Aromatase activity in the ovary and brain of the eastern mosquitofish (Gambusia holbrooki) exposed to paper mill effluent","volume":"101","author":"Orlando","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0230","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1210\/endo-122-4-1349","article-title":"Changes in brain aromatase and 5a-reductase activities correlate significantly with seasonal reproductive cycles in goldfish (Carassius auratus)","volume":"122","author":"Pasmanik","year":"1988","journal-title":"Endocrinology"},{"key":"10.1016\/j.aquatox.2011.07.009_bib0235","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.chemosphere.2007.04.082","article-title":"Profiles of environmental and endogenous estrogens in the zebra mussel (Dreissena polymorpha)","volume":"69","author":"Peck","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2011.07.009_bib0240","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.envint.2007.11.003","article-title":"Biomarker responses in wild three-spined stickleback (Gasterosteus aculeatus L.) as a useful tool for freshwater biomonitoring: A multiparametric approach","volume":"34","author":"Sanchez","year":"2008","journal-title":"Environ. Int."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0250","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0960-0760(01)00120-0","article-title":"Promoter characteristics of two cyp19 genes differentially expressed in the brain and ovary of teleost fish","volume":"78","author":"Tchoudakova","year":"2001","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"17","key":"10.1016\/j.aquatox.2011.07.009_bib0255","doi-asserted-by":"crossref","first-page":"5364","DOI":"10.1016\/S0021-9258(20)79735-8","article-title":"Utilization of oxygen and reduced nicotinamide adenine dinucleotide phosphate by human placental microsomes during aromatization of androstenedione","volume":"219","author":"Thompson","year":"1974","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0260","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/jez.1090","article-title":"Developmental expression of cytochrome P450 aromatase genes (CYP19a and CYP19b) in zebrafish fry (Danio rerio)","volume":"290","author":"Trant","year":"2001","journal-title":"J. Exp. Zool."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0265","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/etc.5620180234","article-title":"An in vivo testing system for endocrine disruptors in fish early life stages using induction of vitellogenin","volume":"18","author":"Tyler","year":"1999","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0270","first-page":"235","article-title":"The Roach (Rutilus rutilus) as a sentinel for assessing endocrine disruption","volume":"14","author":"Tyler","year":"2007","journal-title":"Environ. Sci."},{"key":"10.1016\/j.aquatox.2011.07.009_bib0275","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.aquatox.2005.10.016","article-title":"Relationship between brain and ovary aromatase activity and isoform-specific aromatase mRNA, expression in the fathead minnow (Pimephales promelas)","volume":"76","author":"Villeneuve","year":"2006","journal-title":"Aquat. Toxicol."}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X11002074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X11002074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,28]],"date-time":"2021-11-28T16:00:43Z","timestamp":1638115243000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X11002074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":53,"journal-issue":{"issue":"3-4","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0166445X11002074"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2011.07.009","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}