{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T08:09:45Z","timestamp":1772784585837,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Major State Basic Research Development Program","award":["2008CB418102"],"award-info":[{"award-number":["2008CB418102"]}]},{"name":"Nanjing University Talent Development Foundation"},{"name":"National Nature Science Foundation of China (NSFC)","award":["20890113"],"award-info":[{"award-number":["20890113"]}]},{"name":"National Nature Science Foundation of China (NSFC)","award":["31000249"],"award-info":[{"award-number":["31000249"]}]},{"name":"National Science and Engineering Research Council of Canada"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.aquatox.2012.04.001","type":"journal-article","created":{"date-parts":[[2012,4,10]],"date-time":"2012-04-10T20:00:20Z","timestamp":1334088020000},"page":"108-115","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Characterization of a bystander effect induced by the endocrine-disrupting chemical 6-propyl-2-thiouracil in zebrafish embryos"],"prefix":"10.1016","volume":"118-119","author":[{"given":"Chunsheng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingsheng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongyong","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Giesy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianghua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangyu","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2012.04.001_bib0005","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1093\/toxsci\/kfp227","article-title":"Dynamic nature of alterations in the endocrine system of fathead minnows exposed to the fungicide prochloraz","volume":"112","author":"Ankley","year":"2009","journal-title":"Toxicological Sciences"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0010","first-page":"11","article-title":"Chemical induction of the bystander effect in normal human lymphoblastoid cells","volume":"676","author":"Asur","year":"2009","journal-title":"Radiation Research"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0015","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1093\/mutage\/geq003","article-title":"Bystander effects induced by chemicals and ionizing radiation: evaluation of changes in gene expression of downstream MAPK targets","volume":"25","author":"Asur","year":"2010","journal-title":"Mutagenesis"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0020","doi-asserted-by":"crossref","first-page":"26","DOI":"10.2307\/1543442","article-title":"Field observations of intraspecific agonistic behaviour of two crayfish species, Orconectes rusticus and Orconectes virilis, in different habitats","volume":"205","author":"Bergman","year":"2003","journal-title":"Biological Bulletin"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0025","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1111\/j.1600-0749.2004.00166.x","article-title":"Melicular cloning, gene expression in albino mutants and gene knockdown studies of tyrosinase mRNA in rainbow trout","volume":"17","author":"Boonanuntanasarn","year":"2004","journal-title":"Pigment Cell Research"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2148-7-74","article-title":"Evolution of pigment synthesis pathway by gene and genome duplication in fish","volume":"7","author":"Braasch","year":"2007","journal-title":"BMC Evolutionary Biology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0035","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s004270000125","article-title":"Tyrosinase gene expression in zebrafish embryos","volume":"211","author":"Camp","year":"2001","journal-title":"Development Genes and Evolution"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0040","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1600-0749.2007.00365.x","article-title":"Zebrafish as a new model for phenotype-based screening of melanogenic regulatory compounds","volume":"20","author":"Choi","year":"2007","journal-title":"Pigment Cell Research"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0045","doi-asserted-by":"crossref","first-page":"8829","DOI":"10.1021\/es101535f","article-title":"Radioadaptive response induced by alpha-particle-induced stress communicated in vivo between zebrafish embryos","volume":"44","author":"Choi","year":"2010","journal-title":"Environmental Science & Technology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0050","first-page":"1","article-title":"DNA damaging bystander signalling from stem cells, cancer cells and fibroblasts after Cr (VI) exposure and its dependence on telomerase","volume":"683","author":"Cogan","year":"2010","journal-title":"Radiation Research"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0055","first-page":"938","article-title":"Dietary uptake efficiency of 2,2\u2032,4,4\u2032,5,5\u2032-hexachlorobiphenyl in yellow perch and rainbow trout: role of dietary and body lipids","volume":"18","author":"Dabrowska","year":"1999","journal-title":"Environmental Toxicology and Chemistry"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0060","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1681\/ASN.2004090754","article-title":"Kidney development and disease in the zebrafish","volume":"16","author":"Drummond","year":"2005","journal-title":"Journal of the American Society of Nephrology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0065","first-page":"511","article-title":"Demonstration of tyrosinase in the adult bovine uveal tract and retinal pigment epithelium","volume":"17","author":"Dryja","year":"1978","journal-title":"Investigative Ophthalmology Visual Science"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0070","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/S0031-9384(97)00347-8","article-title":"Chemical communication, aggression, and conspecific recognition in the fish Nile tilapia","volume":"62","author":"Giaquinto","year":"1997","journal-title":"Physiology and Behavior"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0075","series-title":"Multispecies Toxicity Testing","article-title":"Replicability of aquatic multispecies test systems","author":"Giesy","year":"1985"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0080","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.ecoenv.2006.06.012","article-title":"The H295R system for evaluation of endocrine-disrupting effects","volume":"65","author":"Gracia","year":"2006","journal-title":"Ecotoxicology and Environmental Safety"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0085","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1530\/rep.0.1220857","article-title":"Alterations in the development of the reproductive and endocrine systems of wildlife exposed to endocrine disrupting contaminants","volume":"122","author":"Guillette","year":"2001","journal-title":"Reproduction"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0090","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0167-4889(98)00176-1","article-title":"Effects of lithium on pigmentation in the embryonic zebrafish","volume":"1449","author":"Jin","year":"1999","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0095","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1242\/jeb.01564","article-title":"Development of oxygen sensing in the gills of zebrafish","volume":"208","author":"Jonz","year":"2005","journal-title":"Journal of Experimental Biology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0100","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1002\/pmic.201000442","article-title":"Protein expression profiling in the zebrafish (Danio rerio) embryos exposed to the microcystin-LR","volume":"11","author":"Li","year":"2011","journal-title":"Proteomics"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0105","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1139\/f82-005","article-title":"Chemical communication in fish","volume":"39","author":"Liley","year":"1982","journal-title":"Canadian Journal of Fisheries and Aquatic Sciences"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0110","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.aquatox.2009.04.005","article-title":"Waterborne exposure to fluorotelomer alcohol 6:2 FTOH alters plasma sex hormone and gene transcription in the hypothalamic-pituitary-gonadal (HPG) axis of zebrafish","volume":"93","author":"Liu","year":"2009","journal-title":"Aquatic Toxicology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0115","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.aquatox.2009.09.012","article-title":"Endocrine disruption and reproductive impairment in zebrafish by exposure to 8:2 fluorotelomer alcohol","volume":"96","author":"Liu","year":"2010","journal-title":"Aquatic Toxicology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0120","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.taap.2010.06.016","article-title":"Effects of fluorotelomer alcohol 8:2 FTOH on steroidogenesis in H295R cells: targeting the cAMP signalling cascade","volume":"247","author":"Liu","year":"2010","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0125","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1021\/es102659p","article-title":"Effects of prochloraz or propylthiouracil on the cross-talk between the HPG, HPA, and HPT axes in zebrafish","volume":"45","author":"Liu","year":"2011","journal-title":"Environmental Science and Technology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0130","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/dvdy.22220","article-title":"Reiterative use of the notch signal during zebrafish intrahepatic biliary development","volume":"239","author":"Lorent","year":"2010","journal-title":"Developmental Dynamics"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0135","doi-asserted-by":"crossref","first-page":"6859","DOI":"10.1021\/es061099y","article-title":"Communication of radiation-induced stress or bystander signals between fish in vivo","volume":"40","author":"Mothersill","year":"2006","journal-title":"Environmental Science & Technology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0140","doi-asserted-by":"crossref","first-page":"3382","DOI":"10.1021\/es062978n","article-title":"Characterization of a radiation-induced stress response communicated in vivo between zebrafish","volume":"41","author":"Mothersill","year":"2007","journal-title":"Environmental Science & Technology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0145","doi-asserted-by":"crossref","first-page":"3335","DOI":"10.1021\/es8035219","article-title":"Communication of radiation-induced signals in vivo between DNA repair deficient and proficient medaka (Oryzias latipes)","volume":"43","author":"Mothersill","year":"2009","journal-title":"Environmental Science & Technology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0150","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/etc.376","article-title":"Predicting chemical impacts on vertebrate endocrine systems","volume":"30","author":"Nichols","year":"2011","journal-title":"Environmental Toxicology and Chemistry"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0155","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/j.yhbeh.2010.08.002","article-title":"Short-term exposure to a synthetic estrogen disrupts mating dynamics in a pipefish","volume":"58","author":"Partridge","year":"2010","journal-title":"Hormones and Behavior"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0160","doi-asserted-by":"crossref","first-page":"12965","DOI":"10.1073\/pnas.97.24.12965","article-title":"Small molecule developmental screens reveal the logic and timing of vertebrate development","volume":"21","author":"Peterson","year":"2000","journal-title":"Proceedings of the National Academy of ciences of the United States of America"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0165","doi-asserted-by":"crossref","DOI":"10.1139\/f93-290","article-title":"Copper and cadmium binding to fish gills: modification by dissolved organic carbon and synthesis ligands","volume":"50","author":"Playle","year":"1993","journal-title":"Canadian Journal of Fisheries and Aquatic Sciences"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0170","doi-asserted-by":"crossref","first-page":"S550","DOI":"10.1016\/j.taap.2004.12.024","article-title":"Bystander effects, genomic instability, adaptive response, and cancer risk assessment for radiation and chemical exposures","volume":"207","author":"Preston","year":"2005","journal-title":"Toxicology and Applied Pharmacology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0175","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1089\/zeb.2008.0551","article-title":"Pigments, patterns, and fish behaviour","volume":"5","author":"Price","year":"2008","journal-title":"Zebrafish"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0180","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.mce.2006.04.002","article-title":"Female sexual maturation and reproduction after prepubertal exposure to estrogens and endocrine disrupting chemicals: a review of rodent and human data","volume":"254","author":"Rasier","year":"2006","journal-title":"Molecular and Cellular Endocrinology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0185","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1023\/A:1007517720723","article-title":"Studying visual cues in fish behaviour: a review of ethological techniques","volume":"56","author":"Rowland","year":"1999","journal-title":"Environmental Biology of Fishes"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0190","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.yhbeh.2009.01.006","article-title":"Disruption of sexual selection in sand gobies (Pomatoschistus minutus) by 17\u03b1-ethinyl estradiol and endocrine disruptor","volume":"55","author":"Saaristo","year":"2009","journal-title":"Hormones and Behavior"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0195","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.yhbeh.2009.06.010","article-title":"Sand goby (Pomatoschistus minutus) males exposed to an endocrine disrupting chemical fail in nest and mate competition","volume":"56","author":"Saaristo","year":"2009","journal-title":"Hormones and Behavior"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0200","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.aquatox.2009.12.015","article-title":"An endocrine disrupting chemical changes courtship and parental care in the sand goby","volume":"97","author":"Saaristo","year":"2010","journal-title":"Aquatic Toxicology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0205","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.ydbio.2005.06.001","article-title":"A mutation in the silver gene leads to defects in melanosome biogenesis and alterations in the visual system in the zebrafish mutant fading vision","volume":"284","author":"Schonthaler","year":"2005","journal-title":"Developmental Biology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0210","doi-asserted-by":"crossref","first-page":"4171","DOI":"10.1002\/pmic.200700573","article-title":"Evidence for a protective response by the gill proteome of rainbow trout exposed to X-ray induced bystander signals","volume":"7","author":"Smith","year":"2007","journal-title":"Proteomics"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0215","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1080\/10408440802116496","article-title":"Effects of atrazine on fish, amphibians and aquatic reptiles: a critical review","volume":"38","author":"Solomon","year":"2008","journal-title":"Critical Reviews in Toxicology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0220","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1897\/1551-5028(2000)019<2298:PEOCCE>2.3.CO;2","article-title":"Physiological effects of chronic copper exposure to rainbow trout (Oncorhynchus mykiss) in hard and soft water: evaluation of chronic indicators","volume":"19","author":"Taylor","year":"2000","journal-title":"Environmental Toxicology and Chemistry"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0225","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s10126-006-5116-7","article-title":"Integration of double-fluorescence expression vectors into zebrafish genome for the selection of site-directed knockout\/knockin","volume":"8","author":"Wu","year":"2006","journal-title":"Marine Biotechnology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0230","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1021\/es048679k","article-title":"Quantitative RT-PCR methods for evaluating toxicant-induced effects on steroidogenesis using the H295R cell line","volume":"39","author":"Zhang","year":"2005","journal-title":"Environmental Science & Technology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0235","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.aquatox.2008.04.009","article-title":"Real-time PCR array to study effects of chemicals on the hypothalamic-pituitary-gonadal axis of the Japanese medaka","volume":"88","author":"Zhang","year":"2008","journal-title":"Aquatic Toxicology"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0240","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1897\/08-082.1","article-title":"Time-dependent transcriptional profiles of genes of the hypothalamic-pituitary-gonadal axis in medaka (Oryzias latipes) exposed to fadrozole and 17beta-trenbolone","volume":"27","author":"Zhang","year":"2008","journal-title":"Environmental Toxicology and Chemistry"},{"key":"10.1016\/j.aquatox.2012.04.001_bib0245","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1021\/es800591t","article-title":"Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole","volume":"42","author":"Zhang","year":"2008","journal-title":"Environmental Science and Technology"}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X12001282?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X12001282?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T04:56:52Z","timestamp":1537592212000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X12001282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":49,"alternative-id":["S0166445X12001282"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2012.04.001","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}