{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:26:36Z","timestamp":1762251996833},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Cooperativa de Ensino Superior Polit\u00e9cnico e Universit\u00e1rio (CESPU)","award":["SFRH\/BPD\/36865\/2007"],"award-info":[{"award-number":["SFRH\/BPD\/36865\/2007"]}]},{"name":"CRL","award":["SFRH\/BD\/65387\/2009"],"award-info":[{"award-number":["SFRH\/BD\/65387\/2009"]}]},{"name":"the Faculty of Medicine of Porto University","award":["SFRH\/BD\/65436\/2009"],"award-info":[{"award-number":["SFRH\/BD\/65436\/2009"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.aquatox.2013.10.034","type":"journal-article","created":{"date-parts":[[2013,11,7]],"date-time":"2013-11-07T01:30:13Z","timestamp":1383787813000},"page":"137-143","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Lysine acetylsalicylate increases the safety of a paraquat formulation to freshwater primary producers: A case study with the microalga Chlorella vulgaris"],"prefix":"10.1016","volume":"146","author":[{"given":"Maria Teresa","family":"Baltazar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo Jorge","family":"Dinis-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de Lourdes","family":"Bastos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Alberto","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia","family":"Guilhermino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e9lix","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2013.10.034_bib0005","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1078\/0176-1617-01022","article-title":"Exogenous treatment with salicylic acid leads to increased antioxidant capacity in leaves of barley plants exposed to paraquat","volume":"161","author":"Ananieva","year":"2004","journal-title":"J. Plant. Physiol."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0010","doi-asserted-by":"crossref","first-page":"3252","DOI":"10.2174\/092986711796391552","article-title":"Antioxidant properties and associated mechanisms of salicylates","volume":"18","author":"Baltazar","year":"2011","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0015","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1002\/ps.3412","article-title":"New formulation of paraquat with lysine acetylsalicylate with low mammalian toxicity and effective herbicidal activity","volume":"69","author":"Baltazar","year":"2013","journal-title":"Pest Manage. Sci."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0020","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1476-5381.2012.02017.x","article-title":"Paraquat research: do recent advances in limiting its toxicity make its use safer?","volume":"168","author":"Baltazar","year":"2013","journal-title":"Brit. J. Pharmacol."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0025","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/ps.823","article-title":"Paraquat and sustainable agriculture","volume":"60","author":"Bromilow","year":"2004","journal-title":"Pest Manage. Sci."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0030","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0043-1354(00)00223-2","article-title":"An algal biosensor for the monitoring of water toxicity in estuarine environments","volume":"35","author":"Campanella","year":"2001","journal-title":"Water Res."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0035","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1128\/AEM.52.5.1112-1116.1986","article-title":"Toxicity of paraquat to microorganisms","volume":"52","author":"Carr","year":"1986","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0040","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11738-002-0020-x","article-title":"Activity of salicylic acid on the growth and biochemism of Chlorella vulgaris Beijerinck","volume":"24","author":"Czerpak","year":"2002","journal-title":"Acta. Physiol. Plant."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0045","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1016\/j.chemosphere.2007.09.011","article-title":"Biotransformation of ethinylestradiol by microalgae","volume":"70","author":"Della Greca","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2013.10.034_bib0050","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1399-3054.1980.tb02650.x","article-title":"Effect of some heterocyclic herbicides on Co2 assimilation by spinach-chloroplasts","volume":"49","author":"Diaz","year":"1980","journal-title":"Physiol. Plant."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0055","doi-asserted-by":"crossref","first-page":"S121","DOI":"10.1016\/j.toxlet.2009.06.420","article-title":"Lysine acetylsalicylate elicits full survival of Wistar rats exposed to a lethal dose of paraquat","volume":"189","author":"Dinis-Oliveira","year":"2009","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0060","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.tox.2008.04.014","article-title":"Reactivity of paraquat with sodium salicylate: formation of stable complexes","volume":"249","author":"Dinis-Oliveira","year":"2008","journal-title":"Toxicology"},{"key":"10.1016\/j.aquatox.2013.10.034_bib0065","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1080\/10408440701669959","article-title":"Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment","volume":"38","author":"Dinis-Oliveira","year":"2008","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0070","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.tox.2008.10.015","article-title":"An effective antidote for paraquat poisonings: The treatment with lysine acetylsalicylate","volume":"255","author":"Dinis-Oliveira","year":"2009","journal-title":"Toxicology"},{"key":"10.1016\/j.aquatox.2013.10.034_bib0075","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.freeradbiomed.2007.03.014","article-title":"Sodium salicylate prevents paraquat-induced apoptosis in the rat lung","volume":"43","author":"Dinis-Oliveira","year":"2007","journal-title":"Free Radical Bio. Med."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0080","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/j.freeradbiomed.2006.12.031","article-title":"Full survival of paraquat-exposed rats after treatment with sodium salicylate","volume":"42","author":"Dinis-Oliveira","year":"2007","journal-title":"Free Radical Bio. Med."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0085","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/S0021-9673(00)89326-7","article-title":"Quantitative determination of the herbicide paraquat in human plasma by gas chromatographic and mass spectrometric methods","volume":"139","author":"Draffan","year":"1977","journal-title":"J. Chromatogr."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0090","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.pestbp.2005.03.012","article-title":"Effects of oxidative stress induced by paraquat on wild and cultivated wheats","volume":"83","author":"Ekmekci","year":"2005","journal-title":"Pestic. Biochem. Phys."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0095","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1089\/ars.2013.5278","article-title":"Redox signaling in plants","volume":"18","author":"Foyer","year":"2013","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.aquatox.2013.10.034_bib0100","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.marpolbul.2011.03.030","article-title":"Removal and biodegradation of nonylphenol by different Chlorella species","volume":"63","author":"Gao","year":"2011","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0105","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1897\/04-259R.1","article-title":"Biodegradation of bisphenol a and disappearance of its estrogenic activity by the green alga Chlorella fusca var. vacuolata","volume":"24","author":"Hirooka","year":"2005","journal-title":"Env. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0110","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF00211506","article-title":"The influence of the herbicide paraquat gramaxon on growth and metabolic-activity of 3 chlorophytes","volume":"51","author":"Ibrahim","year":"1990","journal-title":"Water Air Soil Pollut."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0115","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/etc.102","article-title":"Effect assessment of the herbicide paraquat on a green alga using differential gene expression and biochemical biomarkers","volume":"29","author":"Jamers","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0120","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/jexbot\/51.345.685","article-title":"Mechanism of peroxidase actions for salicylic acid-induced generation of active oxygen species and an increase in cytosolic calcium in tobacco cell suspension culture","volume":"51","author":"Kawano","year":"2000","journal-title":"J. Exp. Bot."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0125","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0378-4347(95)00464-5","article-title":"Simultaneous determination of acetylsalicylic acid and salicylic acid in human plasma by high-performance liquid chromatography","volume":"677","author":"Kees","year":"1996","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.aquatox.2013.10.034_bib0130","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0923-0467(95)03060-3","article-title":"Cadmium uptake by unicellular green microalgae","volume":"62","author":"Khoshmanesh","year":"1996","journal-title":"Chem. Eng. J. Biochem. Eng."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0135","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1007\/BF00016484","article-title":"The salicylic acid signal in plants","volume":"26","author":"Klessig","year":"1994","journal-title":"Plants. Mol. Biol."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0140","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1399-3054.2006.00786.x","article-title":"The role of salicylic acid in the glutathione-mediated protection against photooxidative stress in rice","volume":"128","author":"Kusumi","year":"2006","journal-title":"Physiol. Plant"},{"key":"10.1016\/j.aquatox.2013.10.034_bib0145","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.plaphy.2012.11.014","article-title":"Involvement of salicylic acid, glutathione and protein S-thiolation in plant cell death-mediated defence response of Mesembryanthemum crystallinum against Botrytis cinerea","volume":"63","author":"Kuzniak","year":"2013","journal-title":"Plant Physiol. Biochem."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0150","doi-asserted-by":"crossref","first-page":"195","DOI":"10.2166\/wst.2002.0738","article-title":"Removal of pyrene by different microalgal species","volume":"46","author":"Lei","year":"2002","journal-title":"Water Sci. Technol."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0155","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ecoenv.2003.08.023","article-title":"Differential sensitivity of two green algae, Scenedesmus quadricauda and Chlorella vulgaris, to 14 pesticide adjuvants","volume":"58","author":"Ma","year":"2004","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0160","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.ecoenv.2004.12.001","article-title":"Toxicity assessment of 40 herbicides to the green alga Raphidocelis subcapitata","volume":"63","author":"Ma","year":"2006","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0165","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1006\/eesa.2001.2113","article-title":"Toxicity of 40 herbicides to the green alga Chlorella vulgaris","volume":"51","author":"Ma","year":"2002","journal-title":"Ecotoxicol Environ. Saf."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0170","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1002\/bmc.1663","article-title":"Quantification of paraquat in postmortem samples by gas chromatography-ion trap mass spectrometry and review of the literature","volume":"26","author":"Moreira","year":"2012","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0175","first-page":"81","article-title":"Bioremoval and bioreduction of chromium(VI) by the green Microalga, Chlorella vulgaris Beij., isolated from Laguna de Bay, Philippines","volume":"139","author":"Nacorda","year":"2010","journal-title":"Philippine J. Sci."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0180","series-title":"Guideline 201: Freshwater Alga and Cyanobacteria, Growth Inhibition Test","article-title":"OECD guideline for the testing of chemicals","author":"OEDC","year":"2006"},{"key":"10.1016\/j.aquatox.2013.10.034_bib0185","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.envint.2008.06.012","article-title":"Comparison of the sensitivity of different toxicity test endpoints in a microalga exposed to the herbicide paraquat","volume":"35","author":"Prado","year":"2009","journal-title":"Environ. Int."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0190","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1007\/s10646-009-0311-8","article-title":"Inhibitory effects of paraquat on photosynthesis and the response to oxidative stress in Chlorella vulgaris","volume":"18","author":"Qian","year":"2009","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.aquatox.2013.10.034_bib0195","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s001289900422","article-title":"Paraquat toxicity to different green algae","volume":"58","author":"Saenz","year":"1997","journal-title":"Bull. Environ. Contam. Toxicol."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0200","doi-asserted-by":"crossref","first-page":"9764","DOI":"10.1021\/jf0513819","article-title":"Salicylate activity. 1. Protection of plants from paraquat injury","volume":"53","author":"Silverman","year":"2005","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0205","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1365-3180.1966.tb00876.x","article-title":"The fate of paraquat applied to plants","volume":"6","author":"Slade","year":"1966","journal-title":"Weed Res."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0210","first-page":"1","article-title":"The toxicity of paraquat","volume":"7","author":"Smith","year":"1988","journal-title":"Adverse Drug React. Toxicol."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0215","series-title":"Handbook of Phycological Methods: Culture Methods and Growth Measurements","author":"Stein","year":"1973"},{"key":"10.1016\/j.aquatox.2013.10.034_bib0220","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S0025-326X(02)00184-4","article-title":"Removal of tributyltin (TBT) by live and dead microalgal cells","volume":"45","author":"Tam","year":"2002","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0225","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.envint.2010.11.006","article-title":"Health risks from large-scale water pollution: trends in central Asia","volume":"37","author":"Tornqvist","year":"2011","journal-title":"Environ. Int."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0230","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/0734-9750(93)90003-6","article-title":"Bioremoval of heavy-metals by the use of microalgae","volume":"11","author":"Wilde","year":"1993","journal-title":"Biotechnol. Adv."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0235","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1365-313X.2004.02267.x","article-title":"Endogenous salicylic acid protects rice plants from oxidative damage caused by aging as well as biotic and abiotic stress","volume":"40","author":"Yang","year":"2004","journal-title":"Plant J."},{"key":"10.1016\/j.aquatox.2013.10.034_bib0240","series-title":"Biostatistical Analysis","author":"Zar","year":"1996"},{"key":"10.1016\/j.aquatox.2013.10.034_bib0245","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0926-6585(65)90161-5","article-title":"Diquat (I,I\u2019-ethylene-2,2\u2019-dipyridylium dibromide) in photo-reactions of isolated chloroplasts","volume":"109","author":"Zweig","year":"1965","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X13003044?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X13003044?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T09:13:00Z","timestamp":1596791580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X13003044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":49,"alternative-id":["S0166445X13003044"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2013.10.034","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lysine acetylsalicylate increases the safety of a paraquat formulation to freshwater primary producers: A case study with the microalga Chlorella vulgaris","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2013.10.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}