{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:49:57Z","timestamp":1792525797436,"version":"4.5.0"},"reference-count":86,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.aquatox.2014.08.014","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T21:36:14Z","timestamp":1409952974000},"page":"269-273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":55,"special_numbering":"C","title":["Aquatic toxicology of fluoxetine: Understanding the knowns and the unknowns"],"prefix":"10.1016","volume":"156","author":[{"given":"Adam Michael","family":"Stewart","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Grossman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caio","family":"Maximino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis Broock","family":"Rosemberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Echevarria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan V.","family":"Kalueff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2014.08.014_bib0005","doi-asserted-by":"crossref","first-page":"e103232","DOI":"10.1371\/journal.pone.0103232","article-title":"Diazepam and fluoxetine decrease the stress response in zebrafish","volume":"9","author":"Abreu","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0010","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ygcen.2009.04.007","article-title":"Ontogeny of the corticotropin-releasing factor system in zebrafish","volume":"164","author":"Alderman","year":"2009","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0015","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1093\/ilar.47.2.124","article-title":"Behavioral phenotyping of transgenic and knockout mice: practical concerns and potential pitfalls","volume":"47","author":"Bailey","year":"2006","journal-title":"ILAR J.\/Natl. Res. Council, Instit. Lab. Animal Resources"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0020","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0733-8619(05)70338-8","article-title":"Myoglobinuria, malignant hyperthermia, neuroleptic malignant syndrome and serotonin syndrome","volume":"15","author":"Bertorini","year":"1997","journal-title":"Neurol. Clin."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0025","doi-asserted-by":"crossref","first-page":"e36931","DOI":"10.1371\/journal.pone.0036931","article-title":"Measures of anxiety in zebrafish (Danio rerio): dissociation of black\/white preference and novel tank test","volume":"7","author":"Blaser","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0030","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.aquatox.2014.01.007","article-title":"Fish on Prozac (and Zoloft): ten years later","volume":"151","author":"Brooks","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0035","doi-asserted-by":"crossref","first-page":"153","DOI":"10.3389\/fphar.2014.00153","article-title":"Discovering novel neuroactive drugs through high-throughput behavior-based chemical screening in the zebrafish","volume":"5","author":"Bruni","year":"2014","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0040","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1038\/nprot.2010.140","article-title":"Measuring behavioral and endocrine responses to novelty stress in adult zebrafish","volume":"5","author":"Cachat","year":"2010","journal-title":"Nat. Protocols"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0045","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1038\/nprot.2010.140","article-title":"Measuring behavioral and endocrine responses to novelty stress in adult zebrafish","volume":"5","author":"Cachat","year":"2010","journal-title":"Nat. Prot."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0050","doi-asserted-by":"crossref","first-page":"e17597","DOI":"10.1371\/journal.pone.0017597","article-title":"Three-dimensional neurophenotyping of adult zebrafish behavior","volume":"6","author":"Cachat","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0055","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s00726-013-1658-y","article-title":"Chronic and acute alcohol administration induced neurochemical changes in the brain: comparison of distinct zebrafish populations","volume":"46","author":"Chatterjee","year":"2014","journal-title":"Amino Acids"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0060","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cbpa.2006.11.011","article-title":"Chronic administration of fluoxetine alters locomotor behavior, but does not potentiate the locomotor stimulating effects of CRH in juvenile Chinook salmon (Oncorhynchus tshawytscha)","volume":"147","author":"Clements","year":"2007","journal-title":"Comp. Biochem. Physiol. Part A, Mol. Integrat. Physiol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2014.05.014","article-title":"Zebrafish and conditioned place preference: a translational model of drug reward","author":"Collier","year":"2014","journal-title":"Progr. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0070","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1126\/science.284.5420.1670","article-title":"Genetics of mouse behavior: interactions with laboratory environment","volume":"284","author":"Crabbe","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0075","first-page":"140","article-title":"Behavioral phenotyping of rodents","volume":"53","author":"Crawley","year":"2003","journal-title":"Comp. Med."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0080","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.neuron.2008.03.001","article-title":"Behavioral phenotyping strategies for mutant mice","volume":"57","author":"Crawley","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0085","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.physbeh.2012.06.007","article-title":"Fluoxetine alters behavioral consistency of aggression and courtship in male Siamese fighting fish, Betta splendens","volume":"107","author":"Dzieweczynski","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0090","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.pnpbp.2011.01.020","article-title":"Assessing attention in the zebrafish: are we there yet?","volume":"35","author":"Echevarria","year":"2011","journal-title":"Progr. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0095","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1515\/rns.2011.010","article-title":"Alcohol-induced behavior change in zebrafish models","volume":"22","author":"Echevarria","year":"2011","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0100","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbr.2009.06.022","article-title":"Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish","volume":"205","author":"Egan","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0105","first-page":"62","article-title":"From pharmacogenetics to pharmacogenomics: the way toward the personalization of antidepressant treatment","volume":"59","author":"Fabbri","year":"2014","journal-title":"Canad. J. Psychiatry. Revue canadienne de psychiatrie"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0110","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.aquatox.2005.09.009","article-title":"Ecotoxicology of human pharmaceuticals","volume":"76","author":"Fent","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0115","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1016\/j.marpolbul.2011.07.011","article-title":"Can pharmaceuticals interfere with the synthesis of active androgens in male fish? An in vitro study","volume":"62","author":"Fernandes","year":"2011","journal-title":"Marine Pollut. Bull."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0120","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3389\/fnbeh.2012.00068","article-title":"A zebrafish model of glucocorticoid resistance shows serotonergic modulation of the stress response","volume":"6","author":"Griffiths","year":"2012","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0125","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.bbr.2010.05.039","article-title":"Characterization of behavioral and endocrine effects of LSD on zebrafish","volume":"214","author":"Grossman","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0130","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.bbr.2013.08.045","article-title":"Animal models of the serotonin syndrome: a systematic review","volume":"256","author":"Haberzettl","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2014.03.008","article-title":"Serotonergic modulation of zebrafish behavior: towards a paradox","author":"Herculano","year":"2014","journal-title":"Progr. Neuro-psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2014.01.022","article-title":"Gaining translational momentum: more zebrafish models for neuroscience research","author":"Kalueff","year":"2014","journal-title":"Progr. neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0145","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1089\/zeb.2012.0861","article-title":"Towards a comprehensive catalog of zebrafish behavior 1.0 and beyond","volume":"10","author":"Kalueff","year":"2013","journal-title":"Zebrafish"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0150","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.neuint.2007.08.015","article-title":"Perspectives on genetic animal models of serotonin toxicity","volume":"52","author":"Kalueff","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0155","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.neubiorev.2009.08.003","article-title":"Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes","volume":"34","author":"Kalueff","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0160","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tips.2013.12.002","article-title":"Zebrafish as an emerging model for studying complex brain disorders","volume":"35","author":"Kalueff","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2007.01.023","article-title":"What's wrong with my mouse model?. Advances and strategies in animal modeling of anxiety and depression","volume":"179","author":"Kalueff","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2466\/02.13.PR0.110.1.51-62","article-title":"Decreased aggressive and locomotor behaviors in Betta splendens after exposure to fluoxetine","volume":"110","author":"Kohlert","year":"2012","journal-title":"Psychol. Rep."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0175","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nchembio.307","article-title":"Rapid behavior-based identification of neuroactive small molecules in the zebrafish","volume":"6","author":"Kokel","year":"2010","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0180","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/bfgp\/eln040","article-title":"Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish","volume":"7","author":"Kokel","year":"2008","journal-title":"Briefings Funct. Genom. Proteomics"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0185","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/B978-0-12-381320-6.00022-9","article-title":"Using the zebrafish photomotor response for psychotropic drug screening","volume":"105","author":"Kokel","year":"2011","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0190","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.tibtech.2012.05.001","article-title":"Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology","volume":"30","author":"Kokel","year":"2012","journal-title":"Trends Biotechnol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0195","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1038\/nchembio.732","article-title":"Chemical informatics and target identification in a zebrafish phenotypic screen","volume":"8","author":"Laggner","year":"2012","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0200","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.chemosphere.2010.12.026","article-title":"Distribution of antidepressants and their metabolites in brook trout exposed to municipal wastewaters before and after ozone treatment\u2014evidence of biological effects","volume":"83","author":"Lajeunesse","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ntt.2013.11.001","article-title":"Strain dependent neurochemical changes induced by embryonic alcohol exposure in zebrafish","volume":"41","author":"Mahabir","year":"2014","journal-title":"Neurotoxicol. Teratol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0210","doi-asserted-by":"crossref","first-page":"e103943","DOI":"10.1371\/journal.pone.0103943","article-title":"Fingerprinting of psychoactive drugs in zebrafish anxiety-like behaviors","volume":"9","author":"Maximino","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0215","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.pnpbp.2011.01.006","article-title":"Pharmacological analysis of zebrafish (Danio rerio) scototaxis","volume":"35","author":"Maximino","year":"2011","journal-title":"Progr. Neuro-psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0220","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2010.01.031","article-title":"Parametric analyses of anxiety in zebrafish scototaxis","volume":"210","author":"Maximino","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0225","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1089\/zeb.2010.0669","article-title":"A review of monoaminergic neuropsychopharmacology in zebrafish","volume":"7","author":"Maximino","year":"2010","journal-title":"Zebrafish"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2014.07.003","article-title":"Fluoxetine and WAY 100,635 dissociate increases in scototaxis and analgesia induced by conspecific alarm substance in zebrafish (Danio rerio Hamilton 1822)","author":"Maximino","year":"2014","journal-title":"Pharmacol., Biochem. Behav."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0235","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuropharm.2013.03.006","article-title":"Role of serotonin in zebrafish (Danio rerio) anxiety: relationship with serotonin levels and effect of buspirone, WAY 100635, SB 224289, fluoxetine and para-chlorophenylalanine (pCPA) in two behavioral models","volume":"71","author":"Maximino","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0240","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1111\/gbb.12047","article-title":"Behavioral and neurochemical changes in the zebrafish leopard strain","volume":"12","author":"Maximino","year":"2013","journal-title":"Genes, Brain Behav."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0245","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.aquatox.2010.08.016","article-title":"Waterborne fluoxetine disrupts the reproductive axis in sexually mature male goldfish Carassius auratus","volume":"100","author":"Mennigen","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0250","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.aquatox.2010.07.022","article-title":"Waterborne fluoxetine disrupts feeding and energy metabolism in the goldfish Carassius auratus","volume":"100","author":"Mennigen","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0255","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/10937404.2011.578559","article-title":"Pharmaceuticals as neuroendocrine disruptors: lessons learned from fish on Prozac","volume":"14","author":"Mennigen","year":"2011","journal-title":"J. Toxicol. Environ. Health Part B, Crit. Rev."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0260","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.aquatox.2009.10.015","article-title":"Fluoxetine treatment affects nitrogen waste excretion and osmoregulation in a marine teleost fish","volume":"95","author":"Morando","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0265","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/nrn2284","article-title":"Targeting the murine serotonin transporter: insights into human neurobiology","volume":"9","author":"Murphy","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0270","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1021\/cn400090q","article-title":"Perspectives on zebrafish models of hallucinogenic drugs and related psychotropic compounds","volume":"4","author":"Neelkantan","year":"2013","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2014.03.003","article-title":"Aquatic blues: modeling depression and antidepressant action in zebrafish","author":"Nguyen","year":"2014","journal-title":"Progr. Neuro-psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0280","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.physbeh.2012.01.017","article-title":"Strain dependent gene expression and neurochemical levels in the brain of zebrafish: focus on a few alcohol related targets","volume":"107","author":"Pan","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0285","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.pbb.2013.03.013","article-title":"iPhone(R) applications as versatile video tracking tools to analyze behavior in zebrafish (Danio rerio)","volume":"106","author":"Pittman","year":"2013","journal-title":"Pharmacol., Biochem. Behav."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0290","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.physbeh.2013.10.023","article-title":"Startle response memory and hippocampal changes in adult zebrafish pharmacologically-induced to exhibit anxiety\/depression-like behaviors","volume":"123","author":"Pittman","year":"2014","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0295","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1897\/08-561.1","article-title":"Occurrence of pharmaceuticals and personal care products in fish: results of a national pilot study in the United States","volume":"28","author":"Ramirez","year":"2009","journal-title":"Environ. Toxicol. Chem.\/SETAC"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0300","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.bbr.2011.11.041","article-title":"On the edge: pharmacological evidence for anxiety-related behavior in zebrafish larvae","volume":"228","author":"Richendrfer","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0305","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1126\/science.1183090","article-title":"Zebrafish behavioral profiling links drugs to biological targets and rest\/wake regulation","volume":"327","author":"Rihel","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0310","doi-asserted-by":"crossref","first-page":"e19397","DOI":"10.1371\/journal.pone.0019397","article-title":"Differences in spatio-temporal behavior of zebrafish in the open tank paradigm after a short-period confinement into dark and bright environments","volume":"6","author":"Rosemberg","year":"2011","journal-title":"PloS One"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0315","first-page":"43","article-title":"Zebrafish behavior in novel environments: effects of acute exposure to anxiolytic compounds and choice of Danio rerio line","volume":"23","author":"Sackerman","year":"2010","journal-title":"Int. J. Comp. Psychol.\/ISCP; sponsored by the International Society for Comparative Psychology and the University of Calabria"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0320","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1021\/es9022706","article-title":"Antidepressant pharmaceuticals in two U.S. effluent-impacted streams: occurrence and fate in water and sediment, and selective uptake in fish neural tissue","volume":"44","author":"Schultz","year":"2010","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0325","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.aquatox.2011.03.011","article-title":"Selective uptake and biological consequences of environmentally relevant antidepressant pharmaceutical exposures on male fathead minnows","volume":"104","author":"Schultz","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0330","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.scitotenv.2014.04.131","article-title":"A one-year follow-up analysis of antidepressants in Portuguese wastewaters: occurrence and fate, seasonal influence, and risk assessment","volume":"490","author":"Silva","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0335","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/FBP.0b013e328345f758","article-title":"Behavioral effects of MDMA (\u2019ecstasy\u2019) on adult zebrafish","volume":"22","author":"Stewart","year":"2011","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0340","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1016\/j.pnpbp.2010.11.035","article-title":"Pharmacological modulation of anxiety-like phenotypes in adult zebrafish behavioral models","volume":"35","author":"Stewart","year":"2011","journal-title":"Progr. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0345","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.tins.2014.02.011","article-title":"Zebrafish models for translational neuroscience research: from tank to bedside","volume":"37","author":"Stewart","year":"2014","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0350","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.neuint.2013.02.018","article-title":"Perspectives on experimental models of serotonin syndrome in zebrafish","volume":"62","author":"Stewart","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2013.12.024","article-title":"Developing better and more valid animal models of brain disorders","author":"Stewart","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0360","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1517\/17460441.2014.857309","article-title":"Anxiolytic drug discovery: what are the novel approaches and how can we improve them?","volume":"9","author":"Stewart","year":"2014","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0430","doi-asserted-by":"crossref","DOI":"10.1038\/mp.2014.128","article-title":"Molecular psychiatry of zebrafish","author":"Stewart","year":"2015","journal-title":"Mol. Psychiatry."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0365","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.aquatox.2013.12.010","article-title":"The apparently very variable potency of the anti-depressant fluoxetine","volume":"151","author":"Sumpter","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0370","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.aquatox.2013.11.021","article-title":"Are some invertebrates exquisitely sensitive to the human pharmaceutical fluoxetine?","volume":"146","author":"Sumpter","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0375","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1089\/zeb.2013.0952","article-title":"Back to basics: searching for a comprehensive framework for exploring individual differences in zebrafish (danio rerio) behavior","volume":"11","author":"Toms","year":"2014","journal-title":"Zebrafish"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0380","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.bbr.2013.09.040","article-title":"Individual differences in activity levels in zebrafish (Danio rerio)","volume":"257","author":"Tran","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0385","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/neu.10173","article-title":"Different data from different labs: lessons from studies of gene-environment interaction","volume":"54","author":"Wahlsten","year":"2003","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0390","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.aquatox.2013.10.012","article-title":"Environmental concentrations of the selective serotonin reuptake inhibitor fluoxetine impact specific behaviors involved in reproduction, feeding and predator avoidance in the fish Pimephales promelas (fathead minnow)","volume":"151","author":"Weinberger","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0395","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1080\/03601234.2012.607767","article-title":"Fluoxetine effects on sheepshead minnow (Cyprinodon variegatus) locomotor activity","volume":"47","author":"Winder","year":"2012","journal-title":"J. Environ. Sci. Health Part. B, Pesticides, Food Contam. Agric. Wastes"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0400","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.bbr.2009.12.023","article-title":"Analyzing habituation responses to novelty in zebrafish (Danio rerio)","volume":"208","author":"Wong","year":"2010","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0405","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/1471-2164-14-348","article-title":"Behavioral and neurogenomic transcriptome changes in wild-derived zebrafish with fluoxetine treatment","volume":"14","author":"Wong","year":"2013","journal-title":"BMC Genom."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0410","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1601-1848.2001.00006.x","article-title":"Behavioral phenotyping enhanced--beyond (environmental) standardization","volume":"1","author":"Wurbel","year":"2002","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.aquatox.2014.08.014_bib0415","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/syn.20830","article-title":"A behavioral and molecular analysis of ketamine in zebrafish","volume":"65","author":"Zakhary","year":"2011","journal-title":"Synapse"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0420","article-title":"An affective disorder in zebrafish with mutation of the glucocorticoid receptor","author":"Ziv","year":"2012","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.aquatox.2014.08.014_bib0425","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/mp.2012.64","article-title":"An affective disorder in zebrafish with mutation of the glucocorticoid receptor","volume":"18","author":"Ziv","year":"2013","journal-title":"Mol. Psychiatry"}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X14002793?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X14002793?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T14:31:35Z","timestamp":1565793095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X14002793"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":86,"alternative-id":["S0166445X14002793"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2014.08.014","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aquatic toxicology of fluoxetine: Understanding the knowns and the unknowns","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2014.08.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}