{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T02:14:56Z","timestamp":1790820896150,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Discovery Grant from the Natural Science and Engineering Research Council of Canada"},{"DOI":"10.13039\/501100000045","name":"Western Economic Diversification Canada","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100000045","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.aquatox.2014.10.019","type":"journal-article","created":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T16:16:46Z","timestamp":1414858606000},"page":"14-21","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"special_numbering":"C","title":["A mixture of the novel brominated flame retardants TBPH and TBB affects fecundity and transcript profiles of the HPGL-axis in Japanese medaka"],"prefix":"10.1016","volume":"158","author":[{"given":"David M.V.","family":"Saunders","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Podaima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garry","family":"Codling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John. P.","family":"Giesy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Wiseman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2014.10.019_bib0005","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/j.chemosphere.2012.03.100","article-title":"Occurrence of alternative flame retardants in indoor dust from New Zealand: Indoor sources and human exposure assessment","volume":"88","author":"Ali","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2014.10.019_bib0010","first-page":"1","article-title":"Differential biomarker gene and protein expressions in nonylphenol and estradiol-17\u03b2 treated juvenile rainbow trout (Oncorhynchus mykiss)","volume":"129","author":"Arukwe","year":"2001","journal-title":"Comp. Biochem. Physiol. C: Toxicol. Pharmacol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0015","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1002\/etc.94","article-title":"Accumulation and DNA damage in fathead minnows (Pimephales promelas) exposed to 2 brominated flame-retardant mixtures, Firemaster\u00ae 550 and Firemaster\u00ae BZ-54","volume":"29","author":"Bearr","year":"2010","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0010201","article-title":"DEHP impairs zebrafish reproduction by affecting critical factors in oogenesis","volume":"5","author":"Carnevali","year":"2010","journal-title":"PLoS ONE"},{"key":"10.1016\/j.aquatox.2014.10.019_bib0025","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.envint.2010.11.007","article-title":"Novel brominated flame retardants: a review of their analysis, environmental fate and behaviour","volume":"37","author":"Covaci","year":"2011","journal-title":"Environ. Int."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0030","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1006\/taap.1994.1200","article-title":"Di-(2-ethylhexyl) phthalate suppresses estradiol and ovulation in cycling rats","volume":"128","author":"Davis","year":"1994","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0035","first-page":"241","article-title":"Emerging brominated flame retardants in the environment","volume":"16","author":"De Wit","year":"2011","journal-title":"Environ. Chem."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0040","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.ygcen.2005.04.003","article-title":"Cloning of a second form of activin-betaA cDNA and regulation of activin-betaA subunits and activin type II receptor mRNA expression by gonadotropin in the zebrafish ovary","volume":"143","author":"DiMuccio","year":"2005","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0045","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.aquatox.2014.02.009","article-title":"Identification and expression of aryl hydrocarbon receptors (AhR1 and AhR2) provide insight in an evolutionary context regarding sensitivity of white sturgeon (Acipenser transmontanus) to dioxin-like compounds","volume":"150","author":"Doering","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0050","doi-asserted-by":"crossref","first-page":"9735","DOI":"10.1021\/es302099f","article-title":"Novel flame retardants in urban-feeding ring-billed gulls from the St. Lawrence River, Canada","volume":"46","author":"Gentes","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0055","doi-asserted-by":"crossref","first-page":"9701","DOI":"10.1021\/es3019258","article-title":"Transcriptional responses of the brain\u2013gonad\u2013liver axis of fathead minnows exposed to untreated and ozone-treated oil sands process-affected water","volume":"46","author":"He","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0060","series-title":"Use of Accelerated Solvent Extraction With In-Cell Cleanup to Eliminate Sample Cleanup During Sample Preparation","author":"Kettle","year":"2013"},{"key":"10.1016\/j.aquatox.2014.10.019_bib0065","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/S0160-4120(02)00058-2","article-title":"Inhibition of oocyte development in Japanese medaka (Oryzias latipes) exposed to di-2-ethylhexyl phthalate","volume":"28","author":"Kim","year":"2002","journal-title":"Environ. Int."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0070","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1677\/joe.1.06684","article-title":"Changes in mRNAs encoding steroidogenic acute regulatory protein, steroidogenic enzymes and receptors for gonadotropins during spermatogenesis in rainbow trout testes","volume":"189","author":"Kusakabe","year":"2006","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0075","doi-asserted-by":"crossref","first-page":"6944","DOI":"10.1021\/es901408t","article-title":"Hexabromocyclododecanes (HBCDs) and polybrominated diphenyl ethers (PBDEs) and detection of two novel flame retardants in marine mammals from Hong Kong, South China","volume":"43","author":"Lam","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0080","series-title":"BFR2010 Workshop","article-title":"New flame retardants in the global atmosphere under the GAPS network","author":"Lee","year":"2010"},{"key":"10.1016\/j.aquatox.2014.10.019_bib0085","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1016\/j.chemosphere.2013.06.025","article-title":"Effects of estrone on the early life stages and expression of vitellogenin and estrogen receptor genes of Japanese medaka (Oryzias latipes)","volume":"93","author":"Lei","year":"2013","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2014.10.019_bib0090","first-page":"104","article-title":"Effects of TDCPP or TPP on gene transcriptions and hormones of HPG axis, and their consequences on reproduction in adult zebrafish (Danio rerio)","volume":"134\u2013135","author":"Liu","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0095","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1021\/es203251f","article-title":"2-Ethylhexyl tetrabromobenzoate and bis(2-ethylhexyl) tetrabromophthalate flame retardants in the great lakes atmosphere","volume":"46","author":"Ma","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0105","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.toxlet.2012.11.025","article-title":"Biological impact of phthalates","volume":"217","author":"Mankidy","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0100","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.toxlet.2013.10.018","article-title":"Effects of novel brominated flame retardants on steroidogenesis in primary porcine testicular cells","volume":"224","author":"Mankidy","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0110","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.mce.2007.10.013","article-title":"Auto-regulation of estrogen receptor subtypes and gene expression profiling of 17\u03b2-estradiol action in the neuroendocrine axis of male goldfish","volume":"283","author":"Marlatt","year":"2008","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0115","doi-asserted-by":"crossref","first-page":"6793","DOI":"10.1021\/es201850n","article-title":"Polybrominated diphenyl ethers vs alternate brominated flame retardants and dechloranes from east Asia to the Arctic","volume":"45","author":"Moller","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0120","series-title":"Test No. 229: Fish Short Term Reproductive Assay","author":"OECD","year":"2012"},{"key":"10.1016\/j.aquatox.2014.10.019_bib0125","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.aquatox.2014.05.022","article-title":"Atrazine reduces reproduction in Japanese medaka (Oryzias latipes)","volume":"154","author":"Papoulias","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0130","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/jbt.21439","article-title":"Accumulation and endocrine disrupting effects of the flame retardant mixture Firemaster\u00ae 550 in rats: an exploratory assessment","volume":"27","author":"Patisaul","year":"2013","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0135","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1016\/S0015-0282(02)04389-3","article-title":"Role of environmental estrogens in the deterioration of male factor fertility","volume":"78","author":"Rozati","year":"2002","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0140","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.mce.2003.12.007","article-title":"Differential expression of largemouth bass (Micropterus salmoides) estrogen receptor isotypes alpha, beta, and gamma by estradiol","volume":"218","author":"Sabo-Attwood","year":"2004","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0145","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.toxlet.2013.09.009","article-title":"In vitro endocrine disruption and TCDD-like effects of three novel brominated flame retardants: TBPH, TBB, & TBCO","volume":"223","author":"Saunders","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0150","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.1021\/es801070p","article-title":"Alternate and new brominated flame retardants detected in U.S. house dust","volume":"42","author":"Stapleton","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0155","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1021\/es061739x","article-title":"A graphical systems model to facilitate hypothesis-driven ecotoxicogenomics research on the teleost brain\u2013pituitary\u2013gonadal axis","volume":"41","author":"Villeneuve","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0160","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.tox.2004.07.016","article-title":"Lifelong exposure to di-(2-ethylhexyl)-phthalate induces tumors in liver and testes of Sprague-Dawley rats","volume":"206","author":"Voss","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.aquatox.2014.10.019_bib0165","doi-asserted-by":"crossref","first-page":"8729","DOI":"10.1021\/es102287q","article-title":"Interconversion of hydroxylated and methoxylated polybrominated diphenyl ethers in Japanese medaka","volume":"44","author":"Wan","year":"2012","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0170","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1002\/etc.2261","article-title":"Endocrine disrupting by di-(2-ethylhexyl)-phthalate (DEHP) in Chinese rare minnow (Gobiocypris rarus)","volume":"32","author":"Wang","year":"2013","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0175","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.aquatox.2004.12.011","article-title":"Short-term effects of endocrine-disrupting chemicals on the expression of estrogen-responsive genes in male medaka (Oryzias latipes)","volume":"72","author":"Yamaguchi","year":"2005","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0180","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.aquatox.2013.10.025","article-title":"Exposure to DEHP and MEHP from hatching to adulthood causes reproductive dysfunction and endocrine disruption in marine medaka (Oryzias melastigma)","volume":"146","author":"Ye","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0185","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1021\/es404093n","article-title":"Bridging the gap from screening assays to estrogenic effects in fish: potential roles of multiple estrogen receptor subtypes","volume":"48","author":"Yost","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0205","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/toxsci\/kfl161","article-title":"Development and validation of endogenous reference genes for expression profiling of medaka (Oryzias latipes) exposed to endocrine disrupting chemicals by quantitative real-time RT-PCR","volume":"95","author":"Zhang","year":"2007","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0190","doi-asserted-by":"crossref","first-page":"6762","DOI":"10.1021\/es800591t","article-title":"Response of the medaka HPG axis PCR Array and reproduction to prochloraz and ketoconazole","volume":"42","author":"Zhang","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0195","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1897\/08-082.1","article-title":"Time-dependent transcriptional profiles of genes of the hypothalamic-pituitary-gonadal axis in medaka (Oryzias latipes) exposed to fadrozole and 17\u03b2-trenbolone","volume":"27","author":"Zhang","year":"2008","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2014.10.019_bib0200","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.aquatox.2008.04.009","article-title":"Real-time PCR array to study effects of chemicals on the hypothalamic\u2013pituitary\u2013gonadal axis of the Japanese medaka","volume":"88","author":"Zhang","year":"2008","journal-title":"Aquat. Toxicol."}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X14003221?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X14003221?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T02:24:26Z","timestamp":1538101466000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X14003221"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":41,"alternative-id":["S0166445X14003221"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2014.10.019","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A mixture of the novel brominated flame retardants TBPH and TBB affects fecundity and transcript profiles of the HPGL-axis in Japanese medaka","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2014.10.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}