{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T19:03:03Z","timestamp":1789844583876,"version":"4.0.1"},"reference-count":91,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"CAPES (Coordination of Improvement of Higher Education Personnel)"},{"name":"Oceanographic Institute of the University of S\u00e3o Paulo"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2015,1]]},"DOI":"10.1016\/j.aquatox.2014.11.008","type":"journal-article","created":{"date-parts":[[2014,11,22]],"date-time":"2014-11-22T19:41:02Z","timestamp":1416685262000},"page":"218-229","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"special_numbering":"C","title":["Genotoxicity, potential cytotoxicity and cell uptake of titanium dioxide nanoparticles in the marine fish Trachinotus carolinus (Linnaeus, 1766)"],"prefix":"10.1016","volume":"158","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6628-4294","authenticated-orcid":false,"given":"Caroline P.","family":"Vignardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio M.","family":"Hasue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscila V.","family":"Sart\u00f3rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Cardoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex S.D.","family":"Machado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.A.C.R.","family":"Passos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais C.A.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana M.","family":"Nucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thiago L.R.","family":"Hewer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ii-Sei","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ngan V.","family":"Phan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2014.11.008_bib0005","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s11192-012-0903-6","article-title":"Capturing new developments in an emerging technology: an updated search strategy for identifying nanotechnology research outputs","volume":"95","author":"Arora","year":"2012","journal-title":"Scientometrics"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0010","first-page":"351","article-title":"Induction of micronuclei and other nuclear abnormalities in European minnow Phoxinus phoxinus and mollie Poecilia latipinna: an assessment of the fish micronucleus test","volume":"95","author":"Ayllon","year":"2000","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0015","doi-asserted-by":"crossref","first-page":"S99","DOI":"10.1016\/j.aquatox.2006.02.022","article-title":"Investigation of micronuclei and other nuclear abnormalities in peripheral blood and kidney of marine fish treated with crude oil","volume":"78","author":"Barsiene","year":"2006","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0020","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1577\/1548-8659(1971)100<486:FHOJPT>2.0.CO;2","article-title":"Food habits of juvenile pompano (Trachinotus carolinus) in Louisiana","volume":"100","author":"Bellinger","year":"1971","journal-title":"Trans. Am. Fish. Soc."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0025","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1007\/s00216-009-3261-3","article-title":"Genotoxic potential of TiO2 on bottlenose dolphin leukocytes","volume":"396","author":"Bernardeschi","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0030","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.aquatox.2013.12.021","article-title":"Dietary cdse\/zns quantum dot exposure in estuarine fish: bioavailability, oxidative stress responses, reproduction, and maternal transfer","volume":"148","author":"Blickley","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0035","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.envint.2008.04.002","article-title":"Immunotoxicity of carbon black nanoparticles to blue mussel hemocytes","volume":"34","author":"Canesi","year":"2008","journal-title":"Environ. Int."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0040","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.aquatox.2010.04.009","article-title":"Biomarkers in Mytilus galloprovincialis exposed to suspensions of selected nanoparticles (nano carbon black, c60 fullerene, nano-TiO2, nano-SiO2)","volume":"100","author":"Canesi","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0045","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1139\/f90-237","article-title":"Assessment of the piscine micronucleus test as an in situ biological indicator of chemical contaminant effects","volume":"47","author":"Carrasco","year":"1990","journal-title":"Can. J. Fish. Aquat. Sci."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0050","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.trac.2008.06.004","article-title":"Distribution and potential toxicity of engineered inorganic nanoparticles and carbon nanostructures in biological systems","volume":"27","author":"Casals","year":"2008","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0055","first-page":"81","article-title":"Micronuclei, nuclear lesions and interphase silver-stained nucleolar organizer regions (AgNORs) as cyto-genotoxicity indicators in Oreochromis niloticus exposed to textile mill effluent","volume":"538","author":"\u00c7ava","year":"2003","journal-title":"Most"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0060","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/jat.1414","article-title":"In vivo acute toxicity of titanium dioxide nanoparticles to mice after intraperitioneal injection","volume":"29","author":"Chen","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0065","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.yexcr.2004.12.021","article-title":"Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles","volume":"305","author":"Chen","year":"2005","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0070","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.watres.2003.10.029","article-title":"Linear correlation between inactivation of E. coli and OH radical concentration in TiO2 photocatalytic disinfection","volume":"38","author":"Cho","year":"2004","journal-title":"Water Res."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0075","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.scitotenv.2013.06.022","article-title":"Fish exposure to nano-TiO2 under different experimental conditions: methodological aspects for nanoecotoxicology investigations","volume":"463-464","author":"Clemente","year":"2013","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0080","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/jbm.a.32976","article-title":"Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles","volume":"96","author":"Cui","year":"2011","journal-title":"J. Biomed. Mater. Res. Part A"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0085","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00204-007-0253-y","article-title":"Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats","volume":"82","author":"Fabian","year":"2008","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0090","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00216-008-2458-1","article-title":"Ecotoxicity and analysis of nanomaterials in the aquatic environment","volume":"393","author":"Farr\u00e9","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0095","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.aquatox.2007.07.009","article-title":"Toxicity of titanium dioxide nanoparticles to rainbow trout (Oncorhynchus mykiss): gill injury, oxidative stress, and other physiological effects","volume":"84","author":"Federici","year":"2007","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0100","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1016\/j.envpol.2009.11.013","article-title":"Sublethal toxicity of nano-titanium dioxide and carbon nanotubes in a sediment dwelling marine polychaete","volume":"158","author":"Galloway","year":"2010","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0105","first-page":"25","article-title":"Sensitivity and variability of visual scoring in the comet assay. Results of an inter-laboratory scoring exercise with the use of silver staining","volume":"556","author":"Garc\u00eda","year":"2004","journal-title":"Mutat. Res."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0110","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1289\/ehp.8006","article-title":"Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells","volume":"113","author":"Geiser","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0115","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1021\/tx200334k","article-title":"Distinctive toxicity of TiO2 rutile\/anatase mixed phase nanoparticles on Caco-2 cells","volume":"25","author":"Gerloff","year":"2012","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0120","series-title":"Comet Assay for Detecting DNA Damage and Repair in Individual Cells","author":"Gontijo","year":"2003"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0125","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1080\/17435390802596456","article-title":"The effect of zinc oxide and titanium dioxide nanoparticles in the Comet assay with UVA photoactivation of human sperm and lymphocytes","volume":"3","author":"Gopalan","year":"2003","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0130","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1743-8977-7-37","article-title":"Impact of agglomeration state of nano- and submicron sized gold particles on pulmonary inflammation","volume":"7","author":"Gosens","year":"2010","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0135","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/etc.709","article-title":"Effects of chronic nanoparticulate silver exposure to adult and juvenile sheepshead minnows (Cyprinodon variegatus)","volume":"31","author":"Griffitt","year":"2012","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0140","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.tox.2005.05.007","article-title":"Ultrafine titanium dioxide particles in the absence of photoactivation can induce oxidative damage to human bronchial epithelial cells","volume":"213","author":"Gurr","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0145","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.toxlet.2010.02.022","article-title":"Intracellular distribution, geno- and cytotoxic effects of nanosized titanium dioxide particles in the anatase crystal phase on human nasal mucosa cells","volume":"195","author":"Hackenberg","year":"2010","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0150","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/17435390902788078","article-title":"Acute and chronic toxicity of nano-scale TiO2 particles to freshwater fish, cladocerans, and green algae, and effects of organic and inorganic substrate on TiO2 toxicity","volume":"3","author":"Hall","year":"2009","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0155","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s10646-008-0205-1","article-title":"Manufactured nanoparticles: their uptake and effects on fish: a mechanistic analysis","volume":"17","author":"Handy","year":"2008","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0160","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1016\/S1001-0742(08)62440-7","article-title":"Effect of sub-acute exposure to TiO2 nanoparticles on oxidative stress and histopathological changes in Juvenile Carp (Cyprinus carpio)","volume":"21","author":"Hao","year":"2009","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0165","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0378-4274(98)00312-9","article-title":"Carcinogenicity of metal compounds: possible role of DNA repair inhibition","volume":"102-103","author":"Hartwig","year":"1998","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0170","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0044-8486(99)00140-4","article-title":"The daily feeding rhythm to demand feeders and the effects of timed meal-feeding on the growth of juvenile Florida pompano, Trachinotus carolinus","volume":"180","author":"Heilman","year":"1999","journal-title":"Aquaculture"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0175","series-title":"A Laboratory Companion for General and Comparative Physiology","author":"Hoar","year":"1967"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0180","series-title":"Fishes of the Gulf of Mexico, Texas, Lousiana, and Adjacent Waters","author":"Hoese","year":"1977"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nnano.2008.110","article-title":"Trophic transfer of nanoparticles in a simplified invertebrate food web","volume":"3","author":"Holbrook","year":"2008","journal-title":"Nat. Nanotechnol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0190","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.taap.2009.08.013","article-title":"Disturbed mitotic progression and genome segregation are involved in cell transformation mediated by nano-TiO2 long-term exposure","volume":"241","author":"Huang","year":"2009","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0195","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1016\/j.scitotenv.2011.03.040","article-title":"An assessment of the fate, behaviour and environmental risk associated with sunscreen TiO2 nanoparticles in UK field scenarios","volume":"409","author":"Johnson","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0200","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/1743-8977-6-33","article-title":"Identification of the mechanisms that drive the toxicity of TiO2 particulates: the contribution of physicochemical characteristics","volume":"6","author":"Johnston","year":"2009","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0205","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.aquatox.2013.07.003","article-title":"Bioaccumulation of silver nanoparticles in rainbow trout (Oncorhynchus mykiss): influence of concentration and salinity","volume":"140-141","author":"Joo","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0210","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ecoenv.2010.10.017","article-title":"Effects of nanosized titanium dioxide on innate immune system of fathead minnow (Pimephales promelas rafinesque, 1820)","volume":"74","author":"Jovanovil\u0107","year":"2011","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0215","doi-asserted-by":"crossref","first-page":"501","DOI":"10.3109\/17435390.2011.587903","article-title":"Titanium dioxide nanoparticles exhibit genotoxicity and impair DNA repair activity in a549 cells","volume":"6","author":"Jugan","year":"2012","journal-title":"Nanotoxicology"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0220","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.envpol.2008.08.004","article-title":"Synthetic TiO2 nanoparticle emission from exterior facades into the aquatic environment","volume":"156","author":"Kaegi","year":"2008","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0225","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/jps.10575","article-title":"Effect of relative humidity on the photocatalytic activity of titanium dioxide and photostability of famotidine","volume":"93","author":"Kakinoki","year":"2004","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0230","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/em.20399","article-title":"Titanium dioxide nanoparticles trigger p53-mediated damage response in peripheral blood lymphocytes","volume":"49","author":"Kang","year":"2008","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0235","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1021\/tx800064j","article-title":"Copper oxide nanoparticles are highly toxic: a comparison between metal oxide nanoparticles and carbon nanotubes","volume":"21","author":"Karlsson","year":"2008","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0240","doi-asserted-by":"crossref","first-page":"6757","DOI":"10.1021\/es901102n","article-title":"Titanium nanomaterial removal and release from wastewater treatment plants","volume":"43","author":"Kiser","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0245","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1897\/08-090.1","article-title":"Nanomaterials in the environment: fate, bioavailability and effects","volume":"27","author":"Klaine","year":"2008","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0250","series-title":"X-ray Diffraction Procedures. For Polycrystalline and Amorphous Materials","author":"Klug","year":"1962"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0255","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/0043-1354(94)90220-8","article-title":"Measurements in situ of concentration and size distribution of colloidal matter in deep groundwaters by photon correlation spectroscopy","volume":"28","author":"Ledin","year":"1994","journal-title":"Water Res."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0260","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1897\/05-278R.1","article-title":"Daphnia magna mortality when exposed to titanium dioxide and fullerene (C60) nanoparticles","volume":"25","author":"Lovern","year":"2006","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0265","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.1016\/j.envpol.2009.05.047","article-title":"The algal toxicity of silver engineered nanoparticles and detoxification by exopolymeric substances","volume":"157","author":"Miao","year":"2009","journal-title":"Environ. Pollut."},{"issue":"1","key":"10.1016\/j.aquatox.2014.11.008_bib0270","doi-asserted-by":"crossref","first-page":"e30321","DOI":"10.1371\/journal.pone.0030321","article-title":"Tio2 nanoparticles are phototoxic to marine phytoplankton","volume":"7","author":"Miller","year":"2012","journal-title":"PLoS ONE"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0275","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ejps.2006.06.003","article-title":"Doxorubicin encapsulation and diffusional release from stable, polymeric, hydrogel nanoparticles","volume":"29","author":"Missirlis","year":"2006","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0280","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1021\/es7029637","article-title":"Exposure modeling of engineered nanoparticles in the environment","volume":"42","author":"Mueller","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0285","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1021\/ar300022h","article-title":"Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening","volume":"46","author":"Nel","year":"2013","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0290","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1743-8977-2-8","article-title":"Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy","volume":"2","author":"Oberd\u00f6rster","year":"2005","journal-title":"Part Fibre Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0295","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s13273-011-0010-4","article-title":"Comparison of cellular effects of titanium dioxide nanoparticles with different photocatalytic potential in human keratinocyte, hacat cells","volume":"7","author":"Park","year":"2011","journal-title":"Mol. Cell. Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0300","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.chemosphere.2010.10.068","article-title":"The toxicity of titanium dioxide nanopowder to early life stages of the japanese medaka (Oryzias latipes)","volume":"82","author":"Paterson","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0305","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1002\/jat.1454","article-title":"Energy dispersive X-ray analysis of titanium dioxide nanoparticle distribution after intravenous and subcutaneous injection in mice","volume":"29","author":"Patri","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0310","first-page":"209","article-title":"Biomonitoring of the genotoxic potential (micronucleus and erythrocyte nuclear abnormalities assay) of the Admiralty Bay water surrounding the Brazilian Antarctic Research Station \u201cComandante Ferraz,\u201d King George Island","volume":"30","author":"Phan","year":"2006","journal-title":"Polar Biol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.canlet.2004.12.002","article-title":"Expression of base excision DNA repair genes as a biomarker of oxidative DNA damage","volume":"229","author":"Powell","year":"2005","journal-title":"Cancer Lett."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0320","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02114669","article-title":"Bioenergetics of fishes in a high-energy surf-zone","volume":"106","author":"Preez","year":"1990","journal-title":"Mar. Biol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0325","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1289\/ehp.02110797","article-title":"Evidence that ultrafine titanium dioxide induces micronuclei and apoptosis in Syrian hamster embryo fibroblasts","volume":"110","author":"Rahman","year":"2002","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0330","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1007\/s10646-009-0357-7","article-title":"Dietary exposure to titanium dioxide nanoparticles in rainbow trout, (Oncorhynchus mykiss): no effect on growth, but subtle biochemical disturbances in the brain","volume":"18","author":"Ramsden","year":"2009","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0335","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.mrfmmm.2007.12.010","article-title":"Hydroxyl radicals (*OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells","volume":"640","author":"Reeves","year":"2008","journal-title":"Mutat. Res."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0340","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.apcatb.2010.06.001","article-title":"Silver-TiO2 nanocomposites: synthesis and harmful algae bloom UV-photoelimination","volume":"98","author":"Rodr\u00edguez-Gonz\u00e1lez","year":"2010","journal-title":"Appl. Catal. B: Environ."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0345","first-page":"1","article-title":"Occurrence and treatment of monogenoides in fingerlings of florida pompano (Trachinotus carolinus) cultivated experimentally in the north area of the state of S\u00e3o Paulo","volume":"16","author":"Sanches","year":"2007","journal-title":"Rev. Bras. Parasitol. Vet"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0350","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1080\/08958370701496202","article-title":"Genotoxicity of poorly soluble particles","volume":"19","author":"Schins","year":"2007","journal-title":"Inhalation Toxicol."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0355","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/toxsci\/kfp064","article-title":"High doses of intravenously administered titanium dioxide nanoparticles accumulate in the kidneys of rainbow trout but with no observable impairment of renal function","volume":"109","author":"Scown","year":"2009","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0360","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.tiv.2010.11.008","article-title":"ROS-mediated genotoxicity induced by titanium dioxide nanoparticles in human epidermal cells","volume":"25","author":"Shukla","year":"2011","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0365","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1016\/j.biomaterials.2009.04.009","article-title":"Nanogenotoxicology: the DNA damaging potential of engineered nanomaterials","volume":"30","author":"Singh","year":"2009","journal-title":"Biomaterials"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0370","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0014-4827(88)90265-0","article-title":"A simple technique for quantitation of low level of DNA damage in individual cells","volume":"175","author":"Singh","year":"1988","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0375","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1021\/nn1034857","article-title":"Nanomaterials in the environment: from materials to high-throughput screening to organisms","volume":"5","author":"Thomas","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0380","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1098-2280(2000)35:3<206::AID-EM8>3.0.CO;2-J","article-title":"Single cell gel\/comet assay: guidelines for in vitro and in vivo genetic toxicology testing","volume":"35","author":"Tice","year":"2000","journal-title":"Environ. Mol. Mutagen."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0385","doi-asserted-by":"crossref","first-page":"8784","DOI":"10.1158\/0008-5472.CAN-09-2496","article-title":"Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice","volume":"69","author":"Trouiller","year":"2009","journal-title":"Cancer Res."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0390","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1007\/s10646-008-0226-9","article-title":"Genotoxic and cytotoxic potential of titanium dioxide (TiO2) nanoparticles on fish cells in vitro","volume":"17","author":"Vevers","year":"2008","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0395","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.chemosphere.2010.12.069","article-title":"Disruption of zebrafish (Danio rerio) reproduction upon chronic exposure to TiO2 nanoparticles","volume":"83","author":"Wang","year":"2011","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0400","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.marenvres.2009.05.002","article-title":"Marine aggregates facilitate ingestion of nanoparticles by suspension-feeding bivalves","volume":"68","author":"Ward","year":"2009","journal-title":"Mar. Environ. Res."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0405","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1679\/aohc.46.173","article-title":"The fine structure of lamellated nerve endings found in the rat gingiva","volume":"46","author":"Watanabe","year":"1983","journal-title":"Arch. Histol. Jpn."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0410","series-title":"Proceedings of the Fifth International Asian Interchange Workshop","article-title":"Aquaculture of the Florida pompano (Trachinotus carolinus) and other jacks (family Carangidae) in the western Atlantic, Gulf of Mexico, and Caribbean Basin: status and potential","author":"Watanabe","year":"1995"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0415","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1383-5718(02)00070-0","article-title":"A modified neutral comet assay: elimination of lysis at high temperature and validation of the assay with anti-single-stranded DNA antibody","volume":"518","author":"Wojew\u00f3dzka","year":"2002","journal-title":"Mutat. Res."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0420","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s00216-009-3249-z","article-title":"Toxicities of nano zinc oxide to five marine organisms: influences of aggregate size and ion solubility","volume":"396","author":"Wong","year":"2010","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0425","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.scitotenv.2011.01.015","article-title":"Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: acute toxicity, oxidative stress and oxidative damage","volume":"409","author":"Xiong","year":"2011","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2014.11.008_bib0430","series-title":"Biostatistical Analysis","author":"Zar","year":"1996"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0435","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.3748\/wjg.v10.i21.3191","article-title":"Photocatalytic killing effect of TiO2 nanoparticles on ls-174-t human colon carcinoma cells","volume":"10","author":"Zhang","year":"2004","journal-title":"World J. Gastroenterol"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0440","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.1021\/nn3010087","article-title":"Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation","volume":"6","author":"Zhang","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0445","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.chemosphere.2006.09.003","article-title":"Enhanced bioaccumulation of cadmium in carp in the presence of titanium dioxide nanoparticles","volume":"67","author":"Zhang","year":"2007","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0450","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1016\/j.chemosphere.2010.03.022","article-title":"Trophic transfer of TiO2 nanoparticles from Daphnia to zebrafish in a simplified freshwater food chain","volume":"79","author":"Zhu","year":"2010","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2014.11.008_bib0455","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/10934520701792779","article-title":"Comparative toxicity of several metal oxide nanoparticle aqueous suspensions to Zebrafish (Danio rerio) early developmental stage","volume":"43","author":"Zhu","year":"2008","journal-title":"J. Environ. Sci. Health A: Toxic\/Hazard. Subst. Environ. Eng."}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X14003440?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X14003440?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T09:30:46Z","timestamp":1538040646000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X14003440"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1]]},"references-count":91,"alternative-id":["S0166445X14003440"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2014.11.008","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2015,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genotoxicity, potential cytotoxicity and cell uptake of titanium dioxide nanoparticles in the marine fish Trachinotus carolinus (Linnaeus, 1766)","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2014.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}