{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T20:56:11Z","timestamp":1771102571609,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31270548"],"award-info":[{"award-number":["31270548"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21377100"],"award-info":[{"award-number":["21377100"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"crossref","award":["LY15B070009"],"award-info":[{"award-number":["LY15B070009"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Public Beneficial Project of Wenzhou City Sci & Technol Bureau","award":["H20150005"],"award-info":[{"award-number":["H20150005"]}]},{"name":"Public Beneficial Project of Wenzhou City Sci & Technol Bureau","award":["Y20150001"],"award-info":[{"award-number":["Y20150001"]}]},{"name":"Zhejiang Provincial Xinmiao Talent Project","award":["2016R413084"],"award-info":[{"award-number":["2016R413084"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.aquatox.2016.07.009","type":"journal-article","created":{"date-parts":[[2016,7,18]],"date-time":"2016-07-18T11:50:30Z","timestamp":1468842630000},"page":"27-38","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Screening on the differentially expressed miRNAs in zebrafish ( Danio rerio ) exposed to trace \u03b2-diketone antibiotics and their related functions"],"prefix":"10.1016","volume":"178","author":[{"given":"Jieyi","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuhuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuedong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weijun","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongqin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huili","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.aquatox.2016.07.009_bib0005","doi-asserted-by":"crossref","first-page":"8708","DOI":"10.1523\/JNEUROSCI.6565-10.2011","article-title":"Cerebellar-dependent learning in larval zebrafish","volume":"31","author":"Aizenberg","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.aquatox.2016.07.009_bib0010","article-title":"The crucial role and regulations of miRNAs in zebrafish development","author":"Bhattacharya","year":"2016","journal-title":"Protoplasma"},{"issue":"3","key":"10.1016\/j.aquatox.2016.07.009_bib0015","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.envpol.2005.04.021","article-title":"Effects of a mixture of tetracyclines to Lemna gibba and Myriophyllum sibiricum evaluated in aquatic microcosms","volume":"138","author":"Brain","year":"2005","journal-title":"Environ. Pollut."},{"issue":"2","key":"10.1016\/j.aquatox.2016.07.009_bib0020","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1261\/rna.046060.114","article-title":"Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data","volume":"21","author":"Campbell","year":"2015","journal-title":"RNA"},{"issue":"2","key":"10.1016\/j.aquatox.2016.07.009_bib0025","first-page":"68","article-title":"MicroRNA therapeutics: discovering novel targets and developing specific therapy, Perspect","volume":"7","author":"Christopher","year":"2016","journal-title":"Clin. Res."},{"issue":"3","key":"10.1016\/j.aquatox.2016.07.009_bib0030","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1161\/CIRCRESAHA.114.303125","article-title":"MiR-92a: at the heart of lipid-driven endothelial dysfunction","volume":"114","author":"de Winther","year":"2014","journal-title":"Circ. Res."},{"issue":"4","key":"10.1016\/j.aquatox.2016.07.009_bib0035","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/s00244-012-9864-2","article-title":"Combined effects of PFOS and PFOA on zebrafish (Danio rerio) embryos","volume":"64","author":"Ding","year":"2013","journal-title":"Arch. Environ. Contam. Toxicol."},{"issue":"12","key":"10.1016\/j.aquatox.2016.07.009_bib0040","doi-asserted-by":"crossref","first-page":"e0145810","DOI":"10.1371\/journal.pone.0145810","article-title":"Identification of Wnt genes expressed in neural progenitor zones during zebrafish brain development","volume":"10","author":"Duncan","year":"2015","journal-title":"PLoS One"},{"issue":"45","key":"10.1016\/j.aquatox.2016.07.009_bib0045","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1093\/eurheartj\/ehu346","article-title":"MicroRNAs as non-invasive biomarkers of heart transplant rejection","volume":"35","author":"Duong Van Huyen","year":"2014","journal-title":"Eur. Heart J."},{"issue":"1","key":"10.1016\/j.aquatox.2016.07.009_bib0050","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cub.2014.10.055","article-title":"A spinal opsin controls early neural activity and drives a behavioral light response","volume":"25","author":"Friedmann","year":"2015","journal-title":"Curr. Biol."},{"issue":"1","key":"10.1016\/j.aquatox.2016.07.009_bib0055","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.tiv.2012.07.008","article-title":"MiR-183 family regulates chloride intracellular channel 5 expression in inner ear hair cells","volume":"27","author":"Gu","year":"2013","journal-title":"Toxicol. In Vitro"},{"issue":"1","key":"10.1016\/j.aquatox.2016.07.009_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/zeb.2010.0680","article-title":"Observation of miRNA gene expression in zebrafish embryos by in situ hybridization to microRNA primary transcripts","volume":"8","author":"He","year":"2011","journal-title":"Zebrafish"},{"issue":"1","key":"10.1016\/j.aquatox.2016.07.009_bib0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","author":"Huang","year":"2009","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.aquatox.2016.07.009_bib0070","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1007\/s12013-014-0149-4","article-title":"The effects and mechanism of miR-92a and miR-126 on myocardial apoptosis in mouse ischemia-reperfusion model","volume":"70","author":"Jiang","year":"2014","journal-title":"Cell Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.aquatox.2016.07.009_bib0075","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nmeth843","article-title":"In situ detection of miRNAs in animal embryos using LNA-modified oligonucleotide probes","volume":"3","author":"Kloosterman","year":"2006","journal-title":"Nat. Methods"},{"issue":"6","key":"10.1016\/j.aquatox.2016.07.009_bib0080","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1073\/pnas.1016646108","article-title":"miR-96 regulates the progression of differentiation in mammalian cochlear inner and outer hair cells","volume":"108","author":"Kuhn","year":"2011","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.aquatox.2016.07.009_bib0085","doi-asserted-by":"crossref","first-page":"23363","DOI":"10.1038\/srep23363","article-title":"Exploring regulatory networks of miR-96 in the developing inner ear","volume":"6","author":"Lewis","year":"2016","journal-title":"Sci. Rep."},{"issue":"9","key":"10.1016\/j.aquatox.2016.07.009_bib0090","doi-asserted-by":"crossref","first-page":"3254","DOI":"10.1523\/JNEUROSCI.4948-09.2010","article-title":"MicroRNA-183 family members regulate sensorineural fates in the inner ear","volume":"30","author":"Li","year":"2010","journal-title":"J. Neurosci"},{"key":"10.1016\/j.aquatox.2016.07.009_bib0095","article-title":"Immunotoxicity of \u03b2-diketone antibiotic mixtures to zebrafish (Danio rerio) by transcriptome analysis","volume":"4","author":"Li","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.aquatox.2016.07.009_bib0100","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of rela-tive gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"4","key":"10.1016\/j.aquatox.2016.07.009_bib0105","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1038\/nbt.1618","article-title":"Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model","volume":"28","author":"Ma","year":"2010","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.aquatox.2016.07.009_bib0110","doi-asserted-by":"crossref","first-page":"19879","DOI":"10.1038\/srep19879","article-title":"Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons","volume":"6","author":"Malmevik","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.aquatox.2016.07.009_bib0115","doi-asserted-by":"crossref","DOI":"10.1002\/ejhf.517","article-title":"The transcardiac gradient of cardio-microRNAs in the failing heart","author":"Marques","year":"2016","journal-title":"Eur. J. Heart Fail."},{"issue":"6","key":"10.1016\/j.aquatox.2016.07.009_bib0120","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1080\/15287394.2013.865107","article-title":"Individual and mixture toxicity of pharmaceuticals naproxen, carbamazepine, and sulfamethoxazole to Australian striped marsh frog tadpoles (Limnodynastes peronii)","volume":"77","author":"Melvin","year":"2014","journal-title":"J. Toxicol. Environ. Health A"},{"issue":"5","key":"10.1016\/j.aquatox.2016.07.009_bib0125","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.ajhg.2015.03.007","article-title":"Copy-number variation of the glucose transporter gene SLC2A3 and congenital heart defects in the 22q11.2 deletion syndrome","volume":"96","author":"Mlynarski","year":"2015","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.aquatox.2016.07.009_bib0130","doi-asserted-by":"crossref","first-page":"e86176","DOI":"10.1371\/journal.pone.0086176","article-title":"Circadian rhythmicity and light sensitivity of the zebrafish brain","volume":"9","author":"Moore","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.aquatox.2016.07.009_bib0135","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1517\/17425255.2012.674512","article-title":"Fluoroquinolone disposition: identification of the contribution of renal secretory and reabsorptive drug transporters","volume":"8","author":"Mulgaonkar","year":"2012","journal-title":"Expert. Opin. Drug Metab."},{"issue":"52","key":"10.1016\/j.aquatox.2016.07.009_bib0140","doi-asserted-by":"crossref","first-page":"8205","DOI":"10.1016\/j.chroma.2010.10.097","article-title":"Metal ion mediated molecularly imprinted polymer for selective capturing antibiotics containing beta-diketone structure","volume":"1217","author":"Qu","year":"2010","journal-title":"J. Chromatogr. A"},{"issue":"5","key":"10.1016\/j.aquatox.2016.07.009_bib0145","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.devcel.2014.12.013","article-title":"A dicer-miR-107 interaction regulates biogenesis of specific miRNAs crucial for neurogenesis","volume":"32","author":"Ristori","year":"2015","journal-title":"Dev. Cell"},{"issue":"4","key":"10.1016\/j.aquatox.2016.07.009_bib0150","doi-asserted-by":"crossref","first-page":"e1005153","DOI":"10.1371\/journal.pgen.1005153","article-title":"A stress-induced small RNA modulates alpha-rhizobial cell cycle progression","volume":"11","author":"Robledo","year":"2015","journal-title":"PLoS Genet."},{"issue":"6","key":"10.1016\/j.aquatox.2016.07.009_bib0155","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1097\/FJC.0b013e3181f581ba","article-title":"Role of microRNAs in cardiac preconditioning","volume":"56","author":"Salloum","year":"2010","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"5","key":"10.1016\/j.aquatox.2016.07.009_bib0160","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.chemosphere.2006.03.026","article-title":"A global perspective on the use, sales, exposure pathways, occurrence, fate and effects of veterinary antibiotics (VAs) in the environment","volume":"65","author":"Sarmah","year":"2006","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.aquatox.2016.07.009_bib0165","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.3233\/JAD-132144","article-title":"Genome-wide serum microRNA expression profiling identifies serum biomarkers for Alzheimer's disease","volume":"40","author":"Tan","year":"2014","journal-title":"J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.aquatox.2016.07.009_bib0170","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nprot.2007.514","article-title":"High-resolution in situ hybridization to whole-mount zebrafish embryos","volume":"3","author":"Thisse","year":"2008","journal-title":"Nat. Protoc."},{"issue":"3","key":"10.1016\/j.aquatox.2016.07.009_bib0175","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/intimm\/dxv058","article-title":"TANK-binding kinase 1-dependent or \u2fffindependent signaling elicits the cell-type-specific innate immune responses induced by the adenovirus vector","volume":"28","author":"Tsuzuki","year":"2016","journal-title":"Int. Immunol."},{"issue":"1","key":"10.1016\/j.aquatox.2016.07.009_bib0180","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neuroimage.2010.01.086","article-title":"A three-dimensional digital atlas of the zebrafish brain","volume":"51","author":"Ullmann","year":"2010","journal-title":"Neuroimage"},{"issue":"11","key":"10.1016\/j.aquatox.2016.07.009_bib0185","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1016\/j.chemosphere.2009.09.038","article-title":"Adverse effects of enrofloxacin when associated with environmental stress in Tra catfish (Pangasianodon hypophthalmus)","volume":"77","author":"Wang","year":"2009","journal-title":"Chemosphere"},{"issue":"10","key":"10.1016\/j.aquatox.2016.07.009_bib0190","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1002\/tox.21843","article-title":"Toxicity evaluation of \u03b2-diketone antibiotics on the development of embryo-larval zebrafish (Danio rerio)","volume":"29","author":"Wang","year":"2014","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.aquatox.2016.07.009_bib0195","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.chemosphere.2015.10.120","article-title":"Effects of \u03b2-diketone antibiotic mixtures on behavior of zebrafish (Danio rerio)","volume":"144","author":"Wang","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2016.07.009_bib0200","series-title":"The Zebrafish Book: A Guide for the Laboratory Use of Zebrafish (Danio Rerio)","first-page":"267","author":"Westerfield","year":"1995"},{"issue":"3","key":"10.1016\/j.aquatox.2016.07.009_bib0205","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1210\/me.2009-0432","article-title":"MicroRNA-224 is involved in transforming growth factor-beta-mediated mouse granulosa cell proliferation and granulosa cell function by targeting Smad4","volume":"24","author":"Yao","year":"2010","journal-title":"Mol. Endocrinol."},{"issue":"1","key":"10.1016\/j.aquatox.2016.07.009_bib0210","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1093\/toxsci\/kfl078","article-title":"Hepatic gene expression profiling and lipid homeostasis in mice exposed to steatogenic drug, tetracycline","volume":"94","author":"Yin","year":"2006","journal-title":"Toxicol. Sci."},{"issue":"7","key":"10.1016\/j.aquatox.2016.07.009_bib0215","doi-asserted-by":"crossref","first-page":"e102731","DOI":"10.1371\/journal.pone.0102731","article-title":"Toxicological assessment of trace \u03b2-diketone antibiotic mixtures on zebrafish (Danio rerio) by proteomic analysis","volume":"9","author":"Yin","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.aquatox.2016.07.009_bib0220","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.scitotenv.2009.10.049","article-title":"Occurrence of endocrine disrupting compounds, pharmaceuticals, and personal care products in the Han River (Seoul, South Korea)","volume":"408","author":"Yoon","year":"2010","journal-title":"Sci. Total Environ."},{"issue":"6","key":"10.1016\/j.aquatox.2016.07.009_bib0225","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/tox.22087","article-title":"Toxicity assessment of combined fluoroquinolone and tetracycline exposure in zebrafish (Danio rerio)","volume":"31","author":"Zhang","year":"2016","journal-title":"Environ. Toxicol."}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X16301977?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X16301977?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T05:52:30Z","timestamp":1568181150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X16301977"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":45,"alternative-id":["S0166445X16301977"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2016.07.009","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Screening on the differentially expressed miRNAs in zebrafish (Danio rerio) exposed to trace \u03b2-diketone antibiotics and their related functions","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2016.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}