{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T12:20:48Z","timestamp":1792758048132,"version":"4.5.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.aquatox.2017.10.002","type":"journal-article","created":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T07:45:34Z","timestamp":1507794334000},"page":"128-135","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"special_numbering":"C","title":["Endocrine disruptors affect larval zebrafish behavior: Testing potential mechanisms and comparisons of behavioral sensitivity to alternative biomarkers"],"prefix":"10.1016","volume":"193","author":[{"given":"Thomas W.K.","family":"Fraser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdolrahman","family":"Khezri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Lewandowska-Sabat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Ropstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2017.10.002_bib0005","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s10695-005-8246-3","article-title":"Evaluation of a 40day assay for testing endocrine disrupters: effects of an anti-estrogen and an aromatase inhibitor on sex ratio and vitellogenin concentrations in juvenile zebrafish (Danio rerio)","volume":"30","author":"Andersen","year":"2004","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0010","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1111\/1471-0528.12681","article-title":"Attention deficit hyperactivity disorder and autism spectrum disorder in children born to mothers with thyroid dysfunction: a Danish nationwide cohort study","volume":"121","author":"Andersen","year":"2014","journal-title":"BJOG"},{"key":"10.1016\/j.aquatox.2017.10.002_bib0015","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1289\/ehp.011091063","article-title":"Antiandrogenic pesticides disrupt sexual characteristics in the adult male guppy Poecilia reticulata","volume":"109","author":"Baatrup","year":"2001","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0020","doi-asserted-by":"crossref","first-page":"A104","DOI":"10.1289\/ehp.1205448","article-title":"The impact of endocrine disruption a consensus statement on the state of the science","volume":"121","author":"Bergman","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0025","doi-asserted-by":"crossref","first-page":"40905","DOI":"10.1038\/srep40905","article-title":"Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish","volume":"7","author":"Best","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0030","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1289\/ehp.0900979","article-title":"Prenatal bisphenol A exposure and early childhood behaviour","volume":"117","author":"Braun","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0035","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fnins.2016.00112","article-title":"Estrogenic effects of several BPA analogs in the developing zebrafish brain","volume":"10","author":"Cano-Nicolau","year":"2016","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0040","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.taap.2016.05.019","article-title":"Several synthetic progestins disrupt the glial cell specific-brain aromatase expression in developing zebrafish","volume":"305","author":"Cano-Nicolau","year":"2016","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0045","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1007\/s11356-014-3974-5","article-title":"Bisphenol A, nonylphenols, benzophenones, and benzotriazoles in soils, groundwater, surface water, sediments, and food: a review","volume":"22","author":"Careghini","year":"2015","journal-title":"Environ. Sci. Pollut. Res."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0050","doi-asserted-by":"crossref","first-page":"181","DOI":"10.2108\/zsj.29.181","article-title":"Changes in thyroid hormone levels during zebrafish development","volume":"29","author":"Chang","year":"2012","journal-title":"Zoolog. Sci."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0055","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1289\/ehp.93101378","article-title":"Developmental effects of endocrine-disrupting chemicals in wildlife and humans","volume":"101","author":"Colborn","year":"1993","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0060","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.aquatox.2008.12.001","article-title":"Effects of the synthetic estrogen, 17\u03b1-ethinylestradiol, on aggression and courtship behavior in male zebrafish (Danio rerio)","volume":"91","author":"Colman","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0065","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0378-4274(01)00451-9","article-title":"Effect of organotins on human aromatase activity in vitro","volume":"126","author":"Cooke","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0070","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1021\/es405313r","article-title":"Identification of synthetic steroids in river water downstream from pharmaceutical manufacture discharges based on a bioanalytical approach and passive sampling","volume":"48","author":"Cruesot","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0075","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ygcen.2010.03.003","article-title":"An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 a-ethinylestradiol in zebrafish (Danio rerio)","volume":"167","author":"De Wit","year":"2010","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0080","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.yhbeh.2010.06.016","article-title":"Behavioral and physiological responses of a wild teleost fish to cortisol and androgen manipulation during parental care","volume":"58","author":"Dey","year":"2010","journal-title":"Horm. Behav."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0085","series-title":"Pesticides in Ground Water Database \u2013 A Compilation of Monitoring Studies: 1971\u20131991","author":"EPA","year":"1992"},{"key":"10.1016\/j.aquatox.2017.10.002_bib0090","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.bbr.2009.06.022","article-title":"Understanding behavioral and physiological phenotypes of stress and anxiety in zebrafish","volume":"205","author":"Egan","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0095","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1677\/joe.0.1750597","article-title":"Influence of maternal hyperthyroidism in the rat on the expression of neuronal and astrocytic cytoskeletal proteins in fetal brain","volume":"175","author":"Evans","year":"2002","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.reprotox.2015.04.012","article-title":"Comparative analysis of goitrogenic effects of phenylthiourea and methimazole in zebrafish embryos","volume":"57","author":"Fetter","year":"2015","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0105","doi-asserted-by":"crossref","first-page":"11789","DOI":"10.1021\/acs.est.5b01034","article-title":"Identification and characterization of androgen-responsive genes in zebrafish embryos","volume":"49","author":"Fetter","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0110","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.toxlet.2017.05.021","article-title":"Toxin induced behavioural aberrations in larval zebrafish are dependent on minor methodological alterations","volume":"276","author":"Fraser","year":"2017","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0115","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/S0043-1354(01)00367-0","article-title":"Occurrence of phthalates and bisphenol A and F in the environment","volume":"36","author":"Fromme","year":"2002","journal-title":"Water Res."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0120","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/j.1365-2826.2011.02229.x","article-title":"Endocrine disrupters: a review of some sources, effects, and mechanisms of actions on behaviour and neuroendocrine systems","volume":"24","author":"Frye","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0125","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/j.chemosphere.2012.01.002","article-title":"Distribution of bisphenol-A, triclosan and n-nonylphenol in human adipose tissue, liver and brain","volume":"87","author":"Geens","year":"2012","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2017.10.002_bib0130","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0378-4274(02)00041-3","article-title":"Occurrence, fate, and removal of pharmaceutical residues in the aquatic environment: a review of recent research data","volume":"131","author":"Heberer","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0135","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3390\/ijms18020291","article-title":"A mixture of persistant organic pollutants and perfluorooctanesulfonic acid induces similar behavioural responses, but different gene expression profiles in zebrafish larvae","volume":"18","author":"Khezri","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0140","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.aquatox.2016.03.021","article-title":"Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture","volume":"175","author":"Kinch","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0145","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.chemosphere.2016.11.053","article-title":"Behavioural effect of low-dose BPA on male zebrafish: tuning of male mating competition and female mating preference during courtship process","volume":"169","author":"Li","year":"2017","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2017.10.002_bib0150","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.aquatox.2015.07.015","article-title":"Zebrafish sex differentiation and gonad development after exposure to 17\u03b1-ethinylestradiol, fadrozole and their binary mixture: a stereological study","volume":"166","author":"Luzio","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0155","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1093\/toxsci\/kfj136","article-title":"Brain cytochrome P450 aromatase gene isoforms and activity levels in Atlantic salmon after waterborne exposure to nominal environmental concentrations of the pharmaceutical ethynylestradiol and antifoulant tributyltin","volume":"91","author":"Lyssimachou","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0160","doi-asserted-by":"crossref","first-page":"e43850","DOI":"10.1371\/journal.pone.0043850","article-title":"Evaluation of 14 organic solvents and carriers for screening application in zebrafish embryos and larvae","volume":"7","author":"Maes","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.aquatox.2017.10.002_bib0165","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1095\/biolreprod.108.073643","article-title":"Androgens upregulate cyp19a1b (aromatase B) gene expression in the brain of zebrafish (Danio rerio) through estrogen receptors","volume":"80","author":"Mouriec","year":"2009","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0170","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1093\/toxsci\/kfv044","article-title":"Advanced morphological-behavioral test platform reveals neurodevelopmental defects in embryonic zebrafish exposed to comprehensive suite of halogenated and organophosphate flame retardants","volume":"145","author":"Noyes","year":"2015","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0175","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.envres.2006.06.002","article-title":"Sexual dimorphic responses in wildlife exposed to endocrine disrupting chemicals","volume":"104","author":"Orlando","year":"2007","journal-title":"Environ. Res."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0180","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1289\/ehp.1104492","article-title":"Prenatal bisphenol A exposure and child behavior in an inner-city cohort","volume":"120","author":"Perera","year":"2012","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0185","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.aquatox.2013.05.020","article-title":"Anti-androgens act jointly in suppressing spiggin concentrations in androgen-primed female three-spined sticklebacks \u2013prediction of combined effects by concentration addition","volume":"140\u2013141","author":"Pottinger","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0190","doi-asserted-by":"crossref","first-page":"6844","DOI":"10.1021\/es9012454","article-title":"Simple, rapid zebrafish larva bioassay for assessing the potential of chemical pollutants and drugs to disrupt thyroid gland function","volume":"43","author":"Rald\u00faa","year":"2009","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0195","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1007\/s10646-013-1054-0","article-title":"A study of parabens and bisphenol A in surface water and fish brain tissue from the Greater Pittsburgh Area","volume":"22","author":"Renz","year":"2013","journal-title":"Ecotoxicology"},{"key":"10.1016\/j.aquatox.2017.10.002_bib0200","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0018-506X(77)90045-9","article-title":"The effect of an androgen inhibitor on behavior and testicular morphology in the stickleback Gasterosteus aculeatus","volume":"9","author":"Rouse","year":"1977","journal-title":"Horm. Behav."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0205","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.tox.2011.11.001","article-title":"Neurodevelopmental low-dose bisphenol A exposure leads to early life-stage hyperactivity and learning deficits in adult zebrafish","volume":"291","author":"Saili","year":"2012","journal-title":"Toxicology"},{"key":"10.1016\/j.aquatox.2017.10.002_bib0210","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.pneurobio.2013.09.004","article-title":"Revisiting the roles of progesterone and allopregnanolone in the nervous system: resurgence of the progesterone receptors","volume":"113","author":"Schumacher","year":"2014","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0215","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.aquatox.2008.07.016","article-title":"The model anti-androgen flutamide suppresses the expression of typical male stickleback reproductive behaviour","volume":"90","author":"Sebire","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0220","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.reprotox.2011.06.121","article-title":"Zebrafish embryos as an alternative to animal experiments \u2013 a commentary on the definition of the onset of protected life stages in animal welfare regulations","volume":"33","author":"Str\u00e4hle","year":"2012","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0225","doi-asserted-by":"crossref","first-page":"7525","DOI":"10.1021\/es202248h","article-title":"Zebrafish eleutheroembryos provide a suitable vertebrate model for screening chemicals that impair thyroid hormone synthesis","volume":"45","author":"Thienpoint","year":"2011","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0230","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1897\/08-653.1","article-title":"Altered gene expression in the brain and ovaries of zebrafish (Danio rerio) exposed to the aromatase inhibitor fadrozole: microarray analysis and hypothesis generation","volume":"28","author":"Villeneuve","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0235","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1007\/s11064-007-9339-4","article-title":"Gender differences in the effects of prenatal stress on brain development and behaviour","volume":"32","author":"Weinstock","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0240","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/S1001-0742(09)60272-2","article-title":"Effects of chronic exposure to nonylphenol on locomotor activity and social behavior in zebrafish (Danio rerio)","volume":"22","author":"Xia","year":"2010","journal-title":"J. Environ. Sci."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0245","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ecoenv.2015.09.029","article-title":"Bisphenol A and other bisphenol analogues including BPS and BPF in surface water samples from Japan China, Korea and India","volume":"122","author":"Yamazaki","year":"2015","journal-title":"Ecotoxicol. Environ. Safe."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0250","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.anbehav.2004.01.005","article-title":"Abnormal behaviours induced by chemical pollution: a review of the evidence and new challenges","volume":"68","author":"Zala","year":"2004","journal-title":"Anim. Behav."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0255","doi-asserted-by":"crossref","first-page":"10155","DOI":"10.1021\/acs.est.5b02226","article-title":"Environmental progestins progesterone and drospirenone alter the circadian rhythm network in zebrafish (Danio rerio)","volume":"49","author":"Zhao","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2017.10.002_bib0260","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1021\/es405584f","article-title":"Transcriptional and physiological responses induced by binary mixtures of drospirenone and progesterone in zebrafish (Danio rerio)","volume":"48","author":"Zucchi","year":"2014","journal-title":"Environ. Sci. Technol."}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X17302801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X17302801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T20:11:33Z","timestamp":1575403893000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X17302801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":52,"alternative-id":["S0166445X17302801"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2017.10.002","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endocrine disruptors affect larval zebrafish behavior: Testing potential mechanisms and comparisons of behavioral sensitivity to alternative biomarkers","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2017.10.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}