{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:32:37Z","timestamp":1793583157629,"version":"4.5.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2018,6]]},"DOI":"10.1016\/j.aquatox.2018.03.034","type":"journal-article","created":{"date-parts":[[2018,3,29]],"date-time":"2018-03-29T14:52:10Z","timestamp":1522335130000},"page":"188-198","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"special_numbering":"C","title":["Bioactive extracellular compounds produced by the dinoflagellate Alexandrium minutum are highly detrimental for oysters"],"prefix":"10.1016","volume":"199","author":[{"given":"J.","family":"Castrec","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Soudant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Payton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Miner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5885-467X","authenticated-orcid":false,"given":"C.","family":"Lambert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Le Go\u00efc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Huvet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Quillien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Boullot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Amzil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"H\u00e9garet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fabioux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2018.03.034_bib0005","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.aquatox.2017.07.001","article-title":"The paralytic shellfish toxin, saxitoxin, enters the cytoplasm and induces apoptosis of oyster immune cells through a caspase-dependent pathway","volume":"190","author":"Abi-Khalil","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0010","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1146\/annurev-marine-120308-081121","article-title":"Progress in understanding harmful algal blooms (HABs): Paradigm shifts and new technologies for research, monitoring and management","volume":"4","author":"Anderson","year":"2012","journal-title":"Annu. Rev. Mar. Sci."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0015","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.hal.2011.10.012","article-title":"The globally distributed genus Alexandrium: Multifaceted roles in marine ecosystems and impacts on human health","volume":"14","author":"Anderson","year":"2012","journal-title":"Harmful Algae"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0020","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S0022-0981(98)00120-8","article-title":"Comparison of allelopathic properties in three toxic Alexandrium species","volume":"232","author":"Arzul","year":"1999","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0025","first-page":"417","article-title":"Experimental study of the effects of a toxic microalgal diet on feeding of the oyster Crassostrea gigas Thunberg","volume":"12","author":"Bardouil","year":"1993","journal-title":"J. Shellfish Res."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0030","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1002\/lno.10240","article-title":"In situ spawning in a marine broadcast spawner, the Pacific oyster Crassostrea gigas: timing and environmental triggers","volume":"61","author":"Bernard","year":"2016","journal-title":"Limnol. Oceanogr"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0035","first-page":"397","article-title":"Inferential statistical methods for estimating and comparing cosinor parameters","volume":"9","author":"Bingham","year":"1982","journal-title":"Chronobiologia"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0040","first-page":"173","volume":"15","author":"Bodoy","year":"1986"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0045","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.aquatox.2017.01.009","article-title":"Effects of bioactive extracellular compounds and paralytic shellfish toxins produced by Alexandrium minutum on growth and behaviour of juvenile great scallops Pecten maximus","volume":"184","author":"Borcier","year":"2017","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0050","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S0990-7440(03)00080-9","article-title":"Paralytic shellfish poison accumulation yields and feeding time activity in the Pacific oyster (Crassostrea gigas) and king scallop (Pecten maximus)","volume":"16","author":"Bougrier","year":"2003","journal-title":"Aquat. Living Resour."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0055","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3390\/md15010021","article-title":"Molecular characterization of voltage-gated sodium channels and their relations with paralytic shellfish toxin bioaccumulation in the Pacific oyster Crassostrea gigas","volume":"15","author":"Boullot","year":"2017","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0060","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/10641269891314294","article-title":"Paralytic shellfish toxins in bivalve molluscs: occurrence, transfer kinetics, and biotransformation","volume":"6","author":"Bricelj","year":"1998","journal-title":"Rev. Fish. Sci."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0065","series-title":"Toxic Phytoplankton Blooms in the Sea","first-page":"371","article-title":"Growth of the blue mussel Mytilus edulis on toxic Alexandrium fundyense and effects of gut passage on dinoflagellate cells","author":"Bricelj","year":"1993"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0070","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0300-9084(00)01174-3","article-title":"Molecular mechanisms of neurotoxin action on voltage-gated sodium channels","volume":"82","author":"Cest\u00e8le","year":"2000","journal-title":"Biochimie"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0075","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00227-007-0693-1","article-title":"Influence of the parasite worm Polydora sp. on the behaviour of the oyster Crassostrea gigas: a study of the respiratory impact and associated oxidative stress","volume":"152","author":"Chambon","year":"2007","journal-title":"Mar. Biol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0080","first-page":"4","article-title":"The Bay of Brest (France), a new risky site for toxic Alexandrium minutum blooms and PSP shellfish contamination","volume":"51","author":"Chapelle","year":"2015","journal-title":"Harmful Algae News"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0085","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev-arplant-042110-103759","article-title":"The cryptochromes: blue light photoreceptors in plants and animals","volume":"62","author":"Chaves","year":"2011","journal-title":"Annu. Rev. Plant Biol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0090","series-title":"Effect of PSP-toxins producing dinoflagellates upon molluscan shellfish feeding behaviour: An assessment of the toxins role. Post-Doctoral Report","author":"Contreras","year":"2011"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0095","doi-asserted-by":"crossref","first-page":"e0160935","DOI":"10.1371\/journal.pone.0160935","article-title":"Short-term behavioural responses of the great scallop Pecten maximus exposed to the toxic alga Alexandrium minutum measured by accelerometry and passive acoustics","volume":"11","author":"Coquereau","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0100","doi-asserted-by":"crossref","first-page":"e46594","DOI":"10.1371\/journal.pone.0046594","article-title":"Reactive oxygen species in unstimulated hemocytes of the Pacific oyster Crassostrea gigas: a mitochondrial involvement","volume":"7","author":"Donaghy","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0105","first-page":"1","article-title":"Scientific opinion of the panel on contaminants in the food chain on a request from the European Commission on marine biotoxins in shellfish: summary on regulated marine biotoxins","volume":"1306","author":"EFSA Journalournal","year":"2009","journal-title":"EFSA J."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0110","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.hal.2003.08.004","article-title":"Evidence for the production of a novel proteinaceous hemolytic exotoxin by dinoflagellate Alexandrium taylori","volume":"3","author":"Emura","year":"2004","journal-title":"Harmful Algae"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0115","series-title":"Toxic Marine Phytoplankton","first-page":"132","article-title":"Effects of Gyrodinium cf. aureolum on Pecten maximus (post larvae, juveniles and adults)","author":"Erard-Le Denn","year":"1990"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0120","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1007\/s00227-010-1418-4","article-title":"Effects of induced paralysis on hemocytes and tissues of the giant lions-paw scallop by paralyzing shellfish poison","volume":"157","author":"Estrada","year":"2010","journal-title":"Mar. Biol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0125","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1016\/j.imbio.2014.07.006","article-title":"Apoptosis of hemocytes from lions-paw scallop Nodipecten subnodosus induced with paralyzing shellfish poison from Gymnodinium catenatum","volume":"219","author":"Estrada","year":"2014","journal-title":"Immunobiology"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0130","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.toxicon.2009.12.013","article-title":"Paralytic shellfish poisoning: seafood safety and human health perspectives","volume":"56","author":"Etheridge","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0022-0981(92)90121-P","article-title":"Occurrence of agglutinins in the pallial cavity mucus of oysters","volume":"162","author":"Fisher","year":"1992","journal-title":"J. Exp. Mar. Biol. Ecol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0140","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3354\/ame035045","article-title":"Allelopathy in Alexandrium spp.: effect on a natural plankton community and on algal monocultures","volume":"35","author":"Fistarol","year":"2004","journal-title":"Aquat. Microb. Ecol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0145","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3354\/ame01570","article-title":"Reactive oxygen species are linked to the toxicity of the dinoflagellate Alexandrium spp. to protists","volume":"66","author":"Flores","year":"2012","journal-title":"Aquat. Microb. Ecol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0150","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00227-008-0917-z","article-title":"Deleterious effects of a nonPST bioactive compound(s) from Alexandrium tamarense on bivalve hemocytes","volume":"154","author":"Ford","year":"2008","journal-title":"Mar. Biol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0155","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.hal.2008.02.006","article-title":"Experimental exposure of the blue mussel (Mytilus edulis, L.) to the toxic dinoflagellate Alexandrium fundyense: histopathology, immune responses, and recovery","volume":"7","author":"Galimany","year":"2008","journal-title":"Harmful Algae"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0160","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1051\/alr:2008010","article-title":"Detoxification of Pacific oyster Crassostrea gigas fed on diets of Skeletonema costatum with and without silt, following PSP contamination by Alexandrium minutum","volume":"21","author":"Gu\u00e9guen","year":"2008","journal-title":"Aquat. Living Resour."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0165","doi-asserted-by":"crossref","first-page":"234","DOI":"10.2216\/i0031-8884-32-3-234.1","article-title":"Stichochrysis immobilis is a diatom, not a chrysophyte","volume":"32","author":"Guillard","year":"1993","journal-title":"Phycologia"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0170","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s10565-011-9186-6","article-title":"In vitro interactions between several species of harmful algae and haemocytes of bivalve molluscs","volume":"27","author":"H\u00e9garet","year":"2011","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0175","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.hal.2010.01.003","article-title":"Effects of Alexandrium minutum exposure on nutrition-related processes and reproductive output in oysters Crassostrea gigas","volume":"9","author":"Haberkorn","year":"2010","journal-title":"Harmful Algae"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0180","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.aquatox.2009.12.006","article-title":"Effects of Alexandrium minutum exposure upon physiological and hematological variables of diploid and triploid oysters, Crassostrea gigas","volume":"97","author":"Haberkorn","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0185","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.marpolbul.2011.03.034","article-title":"Relationship between valve activity, microalgae concentration in the water and toxin accumulation in the digestive gland of the Pacific oyster Crassostrea gigas exposed to Alexandrium minutum","volume":"62","author":"Haberkorn","year":"2011","journal-title":"Mar. Pollut. Bull."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0190","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1146\/annurev.ph.31.030169.003331","article-title":"Chronobiology","volume":"31","author":"Halberg","year":"1969","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0195","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0006-3495(86)83690-6","article-title":"Saxitoxin and tetrodotoxin. Electrostatic effects on sodium channel gating current in crayfish axons","volume":"49","author":"Heggeness","year":"1986","journal-title":"Biophys. J."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0200","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.aquaculture.2016.01.001","article-title":"Influence of gametogenesis pattern and sex on paralytic shellfish toxin levels in triploid Pacific oyster Crassostrea gigas exposed to a natural bloom of Alexandrium minutum","volume":"455","author":"Hermabessiere","year":"2016","journal-title":"Aquaculture"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5047\/absm.2010.00301.0001","article-title":"Paralytic shellfish poisoning toxins: biochemistry and origin","volume":"3","author":"Kodama","year":"2010","journal-title":"Aqua-Biosci. Monogr."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0210","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1051\/alr:2007015","article-title":"Viability, growth and toxicity of Alexandrium catenella and Alexandrium minutum (Dinophyceae) following ingestion and gut passage in the oyster Crassostrea gigas","volume":"20","author":"Laabir","year":"2007","journal-title":"Aquat. Living Resour."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0215","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S1050-4648(02)00160-2","article-title":"Measurement of Crassostrea gigas hemocyte oxidative metabolism by flow cytometry and the inhibiting capacity of pathogenic vibrios","volume":"15","author":"Lambert","year":"2003","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0220","series-title":"Aquaculture","article-title":"Non-PSTs producing Alexandrium minutum have deleterious effects on Crassostrea gigas haemocytes or spermatozoa, in vitro, and allelopathic effects on Chaetoceros neogracile","author":"Lambert","year":"2013"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0225","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.aquatox.2014.05.002","article-title":"Physiological responses of Manila clams Venerupis (=Ruditapes) philippinarum with varying parasite Perkinsus olseni burden to toxic algal Alexandrium ostenfeldii exposure","volume":"154","author":"Lassudrie","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0230","first-page":"409","article-title":"Ecophysiological study of toxic Alexandrium spp. effects on the oyster Crassostrea gigas","author":"Lassus","year":"1996","journal-title":"Harmful Toxic Algal Blooms"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0235","first-page":"211","article-title":"Effect of a continuous supply of the toxic dinoflagellate Alexandrium minutum Halim on the feeding behavior of the Pacific oyster (Crassostrea gigas Thunberg)","volume":"18","author":"Lassus","year":"1999","journal-title":"J. Shellfish Res."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0240","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1051\/alr:2004012","article-title":"Paralytic shellfish poison outbreaks in the Penz\u00e9 estuary: environmental factors affecting toxin uptake in the oyster, Crassostrea gigas","volume":"17","author":"Lassus","year":"2004","journal-title":"Aquat. Living Resour."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0245","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1051\/alr:2007016","article-title":"Modelling the accumulation of PSP toxins in Thau Lagoon oysters (Crassostrea gigas) from trials using mixed cultures of Alexandrium catenella and Thalassiosira weissflogii","volume":"20","author":"Lassus","year":"2007","journal-title":"Aquat. Living Resour."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0250","article-title":"Toxic and Harmful Microalgae of the World Ocean\/Micro-algues Toxiques Et Nuisibles De l\u2019oc\u00e9an Mondial","author":"Lassus","year":"2016"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0255","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1080\/01926230290105721","article-title":"Fixation of testes and eyes using a modified Davidson\u2019s fluid: comparison with Bouin\u2019s fluid and conventional Davidson\u2019s fluid","volume":"30","author":"Latendresse","year":"2002","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0260","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00248-011-9889-5","article-title":"A new insight into allelopathic effects of Alexandrium minutum on photosynthesis and respiration of the diatom Chaetoceros neogracile revealed by photosynthetic-performance analysis and flow cytometry","volume":"62","author":"Lelong","year":"2011","journal-title":"Microb. Ecol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0265","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.hal.2015.09.001","article-title":"Fish gill damage by the dinoflagellate Alexandrium catenella from Chilean fjords: synergistic action of ROS and PUFA","volume":"49","author":"Mardones","year":"2015","journal-title":"Harmful Algae"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0270","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1128\/AEM.65.1.45-52.1999","article-title":"Enumeration of marine viruses in culture and natural samples by flow cytometry","volume":"65","author":"Marie","year":"1999","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0275","doi-asserted-by":"crossref","first-page":"857","DOI":"10.3109\/07420528.2012.699126","article-title":"Evidence for a plastic dual circadian rhythm in the oyster Crassostrea gigas","volume":"29","author":"Mat","year":"2012","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0280","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.aquatox.2013.07.008","article-title":"Genetic and genotoxic impacts in the oyster Crassostrea gigas exposed to the harmful alga Alexandrium minutum","volume":"140\u2013141","author":"Mat","year":"2013","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0285","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.hal.2013.03.003","article-title":"Effects of the dinoflagellate Alexandrium minutum and its toxin (saxitoxin) on the functional activity and gene expression of Crassostrea gigas hemocytes","volume":"26","author":"Mello","year":"2013","journal-title":"Harmful Algae"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0290","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3354\/meps152175","article-title":"Feeding physiology of Cerastoderma edule in response to a wide range of seston concentrations","volume":"152","author":"Navarro","year":"1997","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0295","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/BF00392742","article-title":"Ichthyotoxicity found in cultured media of Protogonyaulax spp","volume":"92","author":"Ogata","year":"1986","journal-title":"Mar. Biol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0300","first-page":"7","article-title":"Remodeling of the cycling transcriptome of the oyster Crassostrea gigas by the harmful algae Alexandrium minutum","author":"Payton","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0305","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s10126-017-9761-9","article-title":"Trojan horse strategy for non-invasive interference of clock gene in the oyster Crassostrea gigas","volume":"19","author":"Payton","year":"2017","journal-title":"Mar. Biotechnol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0310","doi-asserted-by":"crossref","first-page":"e0169790","DOI":"10.1371\/journal.pone.0169790","article-title":"Identification of the molecular clockwork of the oyster Crassostrea gigas","volume":"12","author":"Perrigault","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0315","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.toxicon.2017.12.050","article-title":"Sources of paralytic shellfish toxin accumulation variability in the Pacific oyster Crassostrea gigas","volume":"144","author":"Pousse","year":"2018","journal-title":"Toxicon"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0320","first-page":"263","article-title":"Molecular taxonomy in 2D: a novel ITS2 rRNA sequence-structure approach guides the description of the oysters\u2019 subfamily Saccostreinae and the genus Magallana (Bivalvia: Ostreidae)","volume":"179","author":"Salvi","year":"2017","journal-title":"Zool. J. Linn. Soc."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0325","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/0166-445X(87)90024-5","article-title":"The effects of the toxic dinoflagellate Protogonyaulax tamarensis on the feeding and behaviour of bivalve molluscs","volume":"10","author":"Shumway","year":"1987","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0330","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3354\/meps230047","article-title":"Toxic effects of Alexandrium spp. on heterotrophic dinoflagellates: an allelochemical defence mechanism independent of PSP-toxin content","volume":"230","author":"Tillmann","year":"2002","journal-title":"Mar. Ecol. Prog. Ser."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0335","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/plankt\/fbm034","article-title":"On the allelochemical potency of the marine dinoflagellate Alexandrium ostenfeldii against heterotrophic and autotrophic protists","volume":"29","author":"Tillmann","year":"2007","journal-title":"J. Plankton Res."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0340","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.hal.2007.05.009","article-title":"Allelochemical interactions and short-term effects of the dinoflagellate Alexandrium on selected photoautotrophic and heterotrophic protists","volume":"7","author":"Tillmann","year":"2008","journal-title":"Harmful Algae"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0345","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.hal.2009.03.005","article-title":"Intra-population clonal variability in allelochemical potency of the toxigenic dinoflagellate Alexandrium tamarense","volume":"8","author":"Tillmann","year":"2009","journal-title":"Harmful Algae"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0350","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.hal.2015.11.004","article-title":"Bioactive compounds of marine dinoflagellate isolates from western Greenland and their phylogenetic association within the genus Alexandrium","volume":"51","author":"Tillmann","year":"2016","journal-title":"Harmful Algae"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0355","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1002\/etc.5620220432","article-title":"Estimation of potential and limits of bivalve closure response to detect contaminants: application to cadmium","volume":"22","author":"Tran","year":"2003","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0360","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.aquaculture.2009.10.030","article-title":"Behavioral responses of Crassostrea gigas exposed to the harmful algae Alexandrium minutum","volume":"298","author":"Tran","year":"2010","journal-title":"Aquaculture"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0365","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/07420528.2011.565897","article-title":"Field chronobiology of a molluscan bivalve: how the moon and sun cycles interact to drive oyster activity rhythms","volume":"28","author":"Tran","year":"2011","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0370","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.aquatox.2014.10.023","article-title":"The toxic dinoflagellate Alexandrium minutum disrupts daily rhythmic activities at gene transcription, physiological and behavioral levels in the oyster Crassostrea gigas","volume":"158","author":"Tran","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0375","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.3390\/md8072185","article-title":"Neurotoxic alkaloids: saxitoxin and its analogs","volume":"8","author":"Wiese","year":"2010","journal-title":"Mar. Drugs"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0380","series-title":"Toxic Phytoplankton Blooms in the Sea","first-page":"447","article-title":"Detrimental effects of a Prorocentrum isolate upon hard clams and bay scallops in laboratory feeding studies","author":"Wikfors","year":"1993"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0385","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0990-7440(99)80029-1","article-title":"Effect of the PSP-causing dinoflagellate, Alexandrium sp. on the initial feeding response of Crassostrea gigas","volume":"11","author":"Wildish","year":"1998","journal-title":"Aquat. Living Resour."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0390","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.hal.2010.08.001","article-title":"Allelopathic effects of Alexandrium spp on Prorocentrum donghaiense","volume":"10","author":"Yang","year":"2010","journal-title":"Harmful Algae"},{"key":"10.1016\/j.aquatox.2018.03.034_bib0395","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1111\/j.1461-0248.2009.01343.x","article-title":"Evidence for the adaptive significance of circadian rhythms","volume":"12","author":"Yerushalmi","year":"2009","journal-title":"Ecol. Lett."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0400","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.algal.2016.04.019","article-title":"Molecular exploration of algal interaction between the diatom Phaeodactylum tricornutum and the dinoflagellate Alexandrium tamarense","volume":"17","author":"Zheng","year":"2016","journal-title":"Algal Res."},{"key":"10.1016\/j.aquatox.2018.03.034_bib0405","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/nn0702-616","article-title":"Short circuiting the circadian clock","volume":"5","author":"Van Den Pol","year":"2002","journal-title":"Nat. Neurosci."}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X18301267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X18301267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:51:36Z","timestamp":1759067496000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X18301267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6]]},"references-count":81,"alternative-id":["S0166445X18301267"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2018.03.034","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bioactive extracellular compounds produced by the dinoflagellate Alexandrium minutum are highly detrimental for oysters","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2018.03.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}