{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T23:44:56Z","timestamp":1794008696892,"version":"4.8.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Innovative Medicines Initiative Joint Undertaking under iPiE","award":["n\u00b0 115735"],"award-info":[{"award-number":["n\u00b0 115735"]}],"id":[{"id":"https:\/\/ror.org\/019af4n30","id-type":"ROR","asserted-by":"crossref"}]},{"name":"European Union's Seventh Framework Programme","award":["FP7\/2007-2013"],"award-info":[{"award-number":["FP7\/2007-2013"]}]},{"name":"EFPIA companies\u2019"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.aquatox.2018.05.020","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T13:02:20Z","timestamp":1527512540000},"page":"129-137","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":63,"special_numbering":"C","title":["Influence of pH on the uptake and toxicity of \u03b2-blockers in embryos of zebrafish, Danio rerio"],"prefix":"10.1016","volume":"201","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5097-8811","authenticated-orcid":false,"given":"Lisa","family":"Bittner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabet","family":"Teixido","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Seiwert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5304-706X","authenticated-orcid":false,"given":"Beate I.","family":"Escher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Kl\u00fcver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2018.05.020_bib0005","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1002\/cne.22278","article-title":"Regional distribution and cellular localization of b2-adrenoceptors in the adult zebrafish brain (Danio rerio)","volume":"518","author":"Ampatzis","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0010","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/etc.3579","article-title":"Zebrafish embryo tolerance to environmental stress factors-concentration-dose response analysis of oxygen limitation, pH, and UV-light irradiation","volume":"36","author":"Andrade","year":"2017","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0015","doi-asserted-by":"crossref","first-page":"8211","DOI":"10.1021\/es072658j","article-title":"Repeating history: pharmaceuticals in the environment","volume":"41","author":"Ankley","year":"2007","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0020","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/j.1749-6632.2009.04451.x","article-title":"Timing of the functional diversification of a- and b-adrenoceptors in fish and other vertebrates","volume":"1163","author":"Aris-Brosou","year":"2009","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0025","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/etc.2020","article-title":"Development and evaluation of a mechanistic bioconcentration model for ionogenic organic chemicals in fish","volume":"32","author":"Armitage","year":"2013","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0030","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1002\/etc.3680","article-title":"Assessing the bioaccumulation potential of ionizable organic compounds: current knowledge and research priorities","volume":"36","author":"Armitage","year":"2017","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0035","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1139\/a06-005","article-title":"A review of bioconcentration factor (BCF) and bioaccumulation factor (BAF) assessments for organic chemicals in aquatic organisms","volume":"14","author":"Arnot","year":"2006","journal-title":"Environ. Rev."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0040","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1023\/A:1011954332221","article-title":"pH-metric logP 10. Determination of liposomal membrane-water partition coefficients of lonizable drugs","volume":"15","author":"Avdeef","year":"1998","journal-title":"Pharm. Res."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0045","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1016\/j.tetlet.2007.03.085","article-title":"Potentiometric determination of octanol\u2013water and liposome\u2013water partition coefficients (logP) of ionizable organic compounds","volume":"48","author":"Barzanti","year":"2007","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0050","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1039\/C7EM00099E","article-title":"Baseline toxicity and ion-trapping models to describe the pH-dependence of bacterial toxicity of pharmaceuticals","volume":"19","author":"Baumer","year":"2017","journal-title":"Environ. Sci. Processes Impacts"},{"key":"10.1016\/j.aquatox.2018.05.020_bib0055","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.watres.2017.02.036","article-title":"Two novel real time cell-based assays quantify beta-blocker and NSAID specific effects in effluents of municipal wastewater treatment plants","volume":"115","author":"Bernhard","year":"2017","journal-title":"Water Res."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0060","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0378-5173(87)90152-9","article-title":"Thermodynamics of partitioning of \u03b2-blockers in the n-octanol- buffer and liposome systems","volume":"36","author":"Betageri","year":"1987","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0065","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.watres.2014.08.040","article-title":"Influence of pH-dependent aquatic toxicity of ionizable pharmaceuticals on risk assessments over environmental pH ranges","volume":"72","author":"Bostr\u00f6m","year":"2015","journal-title":"Water Res."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0070","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.aquatox.2014.10.008","article-title":"Influence of the perivitelline space on the quantification of internal concentrations of chemicals in eggs of zebrafish embryos (Danio rerio)","volume":"157","author":"Brox","year":"2014","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0075","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1007\/s00216-014-7929-y","article-title":"A quantitative HPLC-MS\/MS method for studying internal concentrations and toxicokinetics of 34 polar analytes in zebrafish (Danio rerio) embryos","volume":"406","author":"Brox","year":"2014","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0080","doi-asserted-by":"crossref","first-page":"10264","DOI":"10.1021\/acs.est.6b04325","article-title":"Toxicokinetics of polar chemicals in zebrafish embryo (Danio rerio): influence of physicochemical properties and of biological processes","volume":"50","author":"Brox","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0085","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1002\/etc.3460","article-title":"Micropollutants in European rivers: a mode of action survey to support the development of effect-based tools for water monitoring","volume":"35","author":"Busch","year":"2016","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0090","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1897\/05-359R.1","article-title":"Uptake and elimination of ionizable organic chemicals at fish gills: II. Observed and predicted effects of pH, alkalinity, and chemical properties","volume":"25","author":"Erickson","year":"2006","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0095","doi-asserted-by":"crossref","first-page":"7402","DOI":"10.1021\/es052572v","article-title":"Comparative ecotoxicological hazard assessment of b-blockers and their human metabolites using a mode-of-action-based test battery and a QSAR approach","volume":"40","author":"Escher","year":"2006","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0100","doi-asserted-by":"crossref","first-page":"455a","DOI":"10.1021\/es0406740","article-title":"Internal exposure: linking bioavailability to effects","volume":"38","author":"Escher","year":"2004","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0105","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0166-445X(94)00067-Z","article-title":"pH-dependent sorption, bioconcentration and algal toxicity of sulfonylurea herbicides","volume":"31","author":"Fahl","year":"1995","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0110","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/0043-1354(94)00349-C","article-title":"Bioaccumulation and bioavailability of tributyltin chloride: influence of pH and humic acids","volume":"29","author":"Fent","year":"1995","journal-title":"Water Res."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0115","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.ecoenv.2004.10.015","article-title":"Development of a zebrafish 4-day embryo-larval bioassay to assess toxicity of chemicals","volume":"63","author":"Fraysse","year":"2006","journal-title":"Ecotoxicol. Environ Saf."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0120","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1021\/ie50391a022","article-title":"Toxicity of sodium pentachlorophenate and pentachlorophenol to Fish","volume":"34","author":"Goodnight","year":"1942","journal-title":"Ind. Eng. Chem."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0125","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ecoenv.2017.03.032","article-title":"Chronic exposure to the beta-blocker metoprolol reduces growth and alters gene expression of gonadotropins and vitellogenin in Nile tilapia (Oreochromis niloticus)","volume":"141","author":"Gr\u00f6ner","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0130","doi-asserted-by":"crossref","first-page":"5807","DOI":"10.1021\/es8005173","article-title":"Evolutionary conservation of human drug targets in organisms used for environmental risk assessments","volume":"42","author":"Gunnarsson","year":"2008","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0135","series-title":"Exploring QSAR: Hydrophobic, Electronic, and Steric Constants","author":"Hansch","year":"1995"},{"key":"10.1016\/j.aquatox.2018.05.020_bib0140","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/s00244-002-1182-7","article-title":"Toxicity of select b adrenergic receptor-blocking pharmaceuticals (b-blockers) on aquatic organisms","volume":"43","author":"Huggett","year":"2002","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0145","first-page":"49","article-title":"Ernest Overton\u2019s contribution to the cell membrane concept: a centennial appreciation","volume":"12","author":"Kleinzeller","year":"1997","journal-title":"News Physiol. Sci."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0150","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.chemosphere.2016.08.079","article-title":"Development of a general baseline toxicity QSAR model for the fish embryo acute toxicity test","volume":"164","author":"Kl\u00fcver","year":"2016","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2018.05.020_bib0155","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1023\/A:1011923103938","article-title":"Towards the predictability of drug-lipid membrane interactions: the pH-dependent affinity of propanolol to phosphatidylinositol containing liposomes","volume":"15","author":"Kr\u00e4mer","year":"1998","journal-title":"Pharm. Res."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0160","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/jez.672","article-title":"\u03b2-blockers as endocrine disruptors: the potential effects of human \u03b2-blockers on aquatic organisms","volume":"315A","author":"Massarsky","year":"2011","journal-title":"J. Exp. Zool. Part A Ecol. Genet. Physiol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0165","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.aquatox.2015.06.011","article-title":"Differential sensitivity in embryonic stages of the zebrafsih (Danio rerio): the role of toxicokinetics for stage-specific susceptibility for azinos-methyl lethal effects","volume":"166","author":"Massei","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0170","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.cbpb.2015.10.009","article-title":"Behavioral and biochemical adjustments of the zebrafish Danio rerio exposed to the \u03b2-blocker propranolol","volume":"199","author":"Mitchell","year":"2016","journal-title":"Comp. Biochem. Physiol. B Biochem. Mol. Biol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0175","first-page":"38","article-title":"DarT: Teh embryo test with the zebrafish Danio rerio - a general model in ecotoxicology and toxicology","volume":"19","author":"Nagel","year":"2002","journal-title":"Altern. Anim. Exp."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0180","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1016\/j.chemosphere.2007.06.089","article-title":"The effects of pH on fluoxetine in Japanese medaka (Oryzias latipes): acute toxicity in fish larvae and bioaccumulation in juvenile fish","volume":"70","author":"Nakamura","year":"2008","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2018.05.020_bib0185","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.aquatox.2010.10.008","article-title":"The pH-dependent toxicity of basic pharmaceuticals in the green algae Scenedesmus vacuolatus can be explained with a toxicokinetic ion-trapping model","volume":"101","author":"Neuwoehner","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0190","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1177\/106002807801200906","article-title":"pKa values of medicinal compounds in pharmacy practice","volume":"12","author":"Newton","year":"1978","journal-title":"Drug Intell. Clin. Pharm."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0195","doi-asserted-by":"crossref","first-page":"R526","DOI":"10.1152\/ajpregu.00146.2003","article-title":"Activity of the unique \u03b2-adrenergic Na+\/H+ exchanger in trout erythrocytes is controlled by a novel \u03b23-AR subtype","volume":"285","author":"Nickerson","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0200","series-title":"Test No. 236: Fish Embryo Acute Toxicity (FET) Test","author":"OECD","year":"2013"},{"key":"10.1016\/j.aquatox.2018.05.020_bib0205","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.scitotenv.2015.02.104","article-title":"Characterization of pharmaceuticals and personal care products in hospital effluent and waste water influent\/effluent by direct-injection LC-MS-MS","volume":"518-519","author":"Oliveira","year":"2015","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0210","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.aquatox.2007.02.007","article-title":"Comparative physiology, pharmacology and toxicology of \u03b2-blockers: mammals versus fish","volume":"82","author":"Owen","year":"2007","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0215","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.aquatox.2009.05.009","article-title":"Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry","volume":"93","author":"Owen","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0220","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jpba.2012.08.009","article-title":"Evaluation of fluorescence anisotropy to assess drug\u2013lipid membrane partitioning","volume":"71","author":"Pallicer","year":"2012","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0225","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1002\/etc.391","article-title":"The effect of pH on the uptake and toxicity of the bivalent weak base chloroquine tested on Salix viminalis and Daphnia magna","volume":"30","author":"Rendal","year":"2011","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0230","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/BF01054858","article-title":"Influence of pH on the toxicity of substituted phenols to fish","volume":"10","author":"Saarikoski","year":"1981","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0235","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/0147-6513(82)90032-X","article-title":"Relation between physicochemical properties of phenols and their toxicity and accumulation in fish","volume":"6","author":"Saarikoski","year":"1982","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0240","doi-asserted-by":"crossref","first-page":"L86","DOI":"10.1529\/biophysj.106.084343","article-title":"A new model of weak acid permeation through membranes revisited: does overton still rule?","volume":"90","author":"Saparov","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0245","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.yrtph.2014.06.004","article-title":"Extensive review of fish embryo acute toxicities for the prediction of GHS acute systemic toxicity categories","volume":"69","author":"Scholz","year":"2014","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"4","key":"10.1016\/j.aquatox.2018.05.020_bib0250","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/etc.4090","article-title":"Meta-analysis of Fish early life stage tests \u2013 association of toxic ratios and acute-to-chronic ratios with modes of action","volume":"37","author":"Scholz","year":"2018","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0255","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1242\/jeb.02117","article-title":"Development of the sympatho-vagal balance in the cardiovascular system in zebrafish (Danio rerio) characterized by power spectrum and classical signal analysis","volume":"209","author":"Schwerte","year":"2006","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0260","doi-asserted-by":"crossref","first-page":"2254","DOI":"10.1016\/j.bbamem.2016.03.032","article-title":"Permeability across lipid membranes","volume":"1858","author":"Shinoda","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.aquatox.2018.05.020_bib0265","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1242\/jeb.052803","article-title":"In vivo and in vitro assessment of cardiac b-adrenergic receptors in larval zebrafish (Danio rerio)","volume":"214","author":"Steele","year":"2011","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0270","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/BF01054993","article-title":"Effect of pH on the accumulation kinetics of pentachlorophenol in goldfish","volume":"19","author":"Stehly","year":"1990","journal-title":"Arch. Environ. Contam. Toxicol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0275","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.scitotenv.2014.07.111","article-title":"The sub-lethal effects and tissue concentration of the human pharmaceutical atenolol in rainbow trout (Oncorhynchus mykiss)","volume":"497","author":"Steinbach","year":"2014","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0280","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1002\/tox.21867","article-title":"Toxicity and enantiospecific differences of two b-blockers, propranolol and metoprolol, in the embryos and larvae of zebrafish (Danio rerio)","volume":"29","author":"Sun","year":"2013","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0285","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1007\/s00216-006-1033-x","article-title":"Ultrastructural effects of pharmaceuticals (carbamazepine, clofibric acid, metoprolol, diclofenac) in rainbow trout (Oncorhynchus mykiss) and common carp (Cyprinus carpio)","volume":"387","author":"Triebskorn","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0290","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0742-8413(90)90096-R","article-title":"The influence of pH on the accumulation of tri-n-butyltin chloride and triphenyltin chloride in carp","volume":"95","author":"Tsuda","year":"1990","journal-title":"Comp. Biochem. Physiol. Part C: Comp. Pharmacol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0295","doi-asserted-by":"crossref","first-page":"2685","DOI":"10.1897\/08-546.1","article-title":"Aquatic toxicity of sertraline to Pimephales promelas at environmentally relevant surface water pH","volume":"28","author":"Valenti","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0300","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/0045-6535(92)90280-5","article-title":"Classifying environmental pollutants","volume":"25","author":"Verhaar","year":"1992","journal-title":"Chemosphere"},{"key":"10.1016\/j.aquatox.2018.05.020_bib0305","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.gene.2009.06.005","article-title":"Zebrafish \u03b2-adrenergic receptor mRNA expression and control of pigmentation","volume":"446","author":"Wang","year":"2009","journal-title":"Gene"},{"key":"10.1016\/j.aquatox.2018.05.020_bib0310","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.ydbio.2009.04.035","article-title":"Development of zebrafish swimbladder: the requirement of hedgehog signaling in specification and organization of the three tissue layers","volume":"331","author":"Winata","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0315","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.aquatox.2007.11.017","article-title":"Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas)","volume":"86","author":"Winter","year":"2008","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0320","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.scitotenv.2012.09.060","article-title":"pH-dependent aquatic criteria for 2,4-dichlorophenol, 2,4,6-trichlorophenol and pentachlorophenol","volume":"441","author":"Xing","year":"2012","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0325","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.aquatox.2015.02.016","article-title":"Dioxin inhibition of swim bladder development in zebrafish: Is it secondary to heart failure?","volume":"162","author":"Yue","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.05.020_bib0330","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ecoenv.2016.09.023","article-title":"pH-dependent ecological risk assessment of pentachlorophenol in Taihu Lake and Liaohe River","volume":"135","author":"Zheng","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X18301152?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X18301152?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T11:46:23Z","timestamp":1589888783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X18301152"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":66,"alternative-id":["S0166445X18301152"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2018.05.020","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Influence of pH on the uptake and toxicity of \u03b2-blockers in embryos of zebrafish, Danio rerio","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2018.05.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}