{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T04:30:57Z","timestamp":1791261057384,"version":"4.1.0"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Research Grants Council of the Hong Kong Special Administrative Region, China"},{"DOI":"10.13039\/100007567","name":"City University of Hong Kong","doi-asserted-by":"crossref","award":["7004660"],"award-info":[{"award-number":["7004660"]}],"id":[{"id":"10.13039\/100007567","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100013263","name":"State Key Laboratory in Marine Pollution","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100013263","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aquatic Toxicology"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.aquatox.2018.07.019","type":"journal-article","created":{"date-parts":[[2018,7,31]],"date-time":"2018-07-31T12:25:22Z","timestamp":1533039922000},"page":"95-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"special_numbering":"C","title":["Sex-specific immunomodulatory action of the environmental estrogen 17\u03b1-ethynylestradiol alongside with reproductive impairment in fish"],"prefix":"10.1016","volume":"203","author":[{"given":"Roy R.","family":"Ye","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7882-629X","authenticated-orcid":false,"given":"Drew R.","family":"Peterson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Ichi","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1783-1295","authenticated-orcid":false,"given":"Helmut","family":"Segner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7294-6829","authenticated-orcid":false,"given":"Frauke","family":"Seemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doris W.T.","family":"Au","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.aquatox.2018.07.019_bib0005","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.envint.2014.04.011","article-title":"Occurrence of 17\u03b1-ethynylestradiol (EE2) in the environment and effect on exposed biota: a review","volume":"69","author":"Aris","year":"2014","journal-title":"Environ. Int."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0010","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.chemosphere.2015.08.078","article-title":"Reproductive effects in fathead minnows (Pimphales promelas) following a 21 d exposure to 17\u03b1-ethinylestradiol","volume":"144","author":"Armstrong","year":"2016","journal-title":"Chemosphere"},{"issue":"5","key":"10.1016\/j.aquatox.2018.07.019_bib0015","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.marpolbul.2011.05.014","article-title":"The marine medaka Oryzias melastigma\u2013a potential marine fish model for innate immune study","volume":"63","author":"Bo","year":"2011","journal-title":"Mar. Pollut. Bull."},{"issue":"2","key":"10.1016\/j.aquatox.2018.07.019_bib0020","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.cbd.2012.02.005","article-title":"Identification of differentially expressed genes and quantitative expression of complement genes in the liver of marine medaka Oryzias melastigma challenged with Vibrio parahaemolyticus","volume":"7","author":"Bo","year":"2012","journal-title":"Comp. Biochem. Physiol. Part D Genomics Proteomics"},{"issue":"4","key":"10.1016\/j.aquatox.2018.07.019_bib0025","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.fsi.2008.03.017","article-title":"Modulation of the immune system of fish by their environment","volume":"25","author":"Bowden","year":"2008","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0030","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.fsi.2016.09.006","article-title":"Estrogen regulation of gene expression in the teleost fish immune system","volume":"58","author":"Burgos-Aceves","year":"2016","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.aquatox.2018.07.019_bib0035","doi-asserted-by":"crossref","first-page":"376","DOI":"10.2533\/chimia.2008.376","article-title":"Estrogenic endocrine disruption in Switzerland: assessment of fish exposure and effects","volume":"62","author":"Burkhardt-Holm","year":"2008","journal-title":"CHIMIA. Int. J. Chem."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0040","doi-asserted-by":"crossref","first-page":"40981","DOI":"10.1038\/srep40981","article-title":"Understanding the dynamics of toll-like receptor 5 response to flagellin and its regulation by estradiol","volume":"7","author":"Caballero","year":"2017","journal-title":"Sci. Rep."},{"issue":"15-16","key":"10.1016\/j.aquatox.2018.07.019_bib0045","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1016\/j.molimm.2011.07.001","article-title":"Dietary intake of 17\u03b1-ethinylestradiol promotes leukocytes infiltration in the gonad of the hermaphrodite gilthead seabream","volume":"48","author":"Cabas","year":"2011","journal-title":"Mol. Immunol."},{"issue":"3","key":"10.1016\/j.aquatox.2018.07.019_bib0050","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1016\/j.dci.2011.09.011","article-title":"17\u03b1-ethynylestradiol alters the immune response of the teleost gilthead seabream (Sparus aurata L.) both in vivo and in vitro","volume":"36","author":"Cabas","year":"2012","journal-title":"Dev. Comp. Immunol."},{"issue":"8","key":"10.1016\/j.aquatox.2018.07.019_bib0055","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.chemosphere.2006.08.003","article-title":"Biologically directed environmental monitoring, fate, and transport of estrogenic endocrine disrupting compounds in water: a review","volume":"65","author":"Campbell","year":"2006","journal-title":"Chemosphere"},{"issue":"4","key":"10.1016\/j.aquatox.2018.07.019_bib0060","doi-asserted-by":"crossref","first-page":"932","DOI":"10.3390\/ijms19040932","article-title":"Immune-specific expression and estrogenic regulation of the four estrogen receptor isoforms in female rainbow trout (Oncorhynchus mykiss)","volume":"19","author":"Casanova-Nakayama","year":"2018","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.aquatox.2018.07.019_bib0065","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/jfb.12164","article-title":"Expression profile of oestrogen receptors and oestrogen\u2010related receptors is organ specific and sex dependent: the Japanese medaka Oryzias latipes model","volume":"83","author":"Cheung","year":"2013","journal-title":"J. Fish Biol."},{"issue":"3","key":"10.1016\/j.aquatox.2018.07.019_bib0070","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.fsi.2007.01.015","article-title":"Effect of sex-steroid hormones, testosterone and estradiol, on humoral immune parameters of gilthead seabream","volume":"23","author":"Cuesta","year":"2007","journal-title":"Fish Shellfish Immunol."},{"issue":"3-4","key":"10.1016\/j.aquatox.2018.07.019_bib0075","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.aquatox.2011.06.022","article-title":"Effects of in vivo chronic hydrocarbons pollution on sanitary status and immune system in sea bass (Dicentrarchus labrax L.)","volume":"105","author":"Danion","year":"2011","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.fsi.2017.09.020","article-title":"Modification of the plasma complement protein profile by exogenous estrogens is indicative of a compromised immune competence in marine medaka (Oryzias melastigma)","author":"Dong","year":"2017","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0085","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.aquatox.2015.01.009","article-title":"Severe intersex is predictive of poor fertilization success in populations of rainbow darter (Etheostoma caeruleum)","volume":"160","author":"Fuzzen","year":"2015","journal-title":"Aquat. Toxicol."},{"issue":"4","key":"10.1016\/j.aquatox.2018.07.019_bib0090","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.bbi.2007.10.005","article-title":"Sex differences in the recognition of and innate antiviral responses to Seoul virus in Norway rats","volume":"22","author":"Hannah","year":"2008","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.aquatox.2018.07.019_bib0095","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/j.gene.2012.09.060","article-title":"Estrogen regulates iron homeostasis through governing hepatic hepcidin expression via an estrogen response element","volume":"511","author":"Hou","year":"2012","journal-title":"Gene"},{"issue":"5-6","key":"10.1016\/j.aquatox.2018.07.019_bib0100","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.fsi.2010.02.009","article-title":"Effect of endocrine disrupting chemicals on the transcription of genes related to the innate immune system in the early developmental stage of zebrafish (Danio rerio)","volume":"28","author":"Jin","year":"2010","journal-title":"Fish Shellfish Immunol."},{"issue":"3","key":"10.1016\/j.aquatox.2018.07.019_bib0105","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/etc.5620210302","article-title":"The potential for estradiol and ethinylestradiol degradation in English rivers","volume":"21","author":"J\u00fcrgens","year":"2002","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0110","doi-asserted-by":"crossref","DOI":"10.1111\/1755-0998.12769","article-title":"The genome of the marine medaka Oryzias melastigma","author":"Kim","year":"2018","journal-title":"Mol. Ecol. Resour."},{"issue":"1","key":"10.1016\/j.aquatox.2018.07.019_bib0115","doi-asserted-by":"crossref","DOI":"10.1038\/msb4100039","article-title":"Robustness trade\u2010offs and host\u2013microbial symbiosis in the immune system","volume":"2","author":"Kitano","year":"2006","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0120","volume":"3","author":"Kleinbaum","year":"2010"},{"issue":"2","key":"10.1016\/j.aquatox.2018.07.019_bib0125","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.cellimm.2015.01.018","article-title":"Estrogen receptors regulate innate immune cells and signaling pathways","volume":"294","author":"Kovats","year":"2015","journal-title":"Cell. Immunol."},{"issue":"2","key":"10.1016\/j.aquatox.2018.07.019_bib0130","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0951-8320(94)90010-8","article-title":"Proportional hazards model: a review","volume":"44","author":"Kumar","year":"1994","journal-title":"Reliab. Eng. Syst. Saf."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0135","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.ygcen.2015.11.021","article-title":"Three nuclear and two membrane estrogen receptors in basal teleosts, Anguilla sp.: identification, evolutionary history and differential expression regulation","volume":"235","author":"Lafont","year":"2016","journal-title":"Gen. Comp. Endocrinol."},{"issue":"6","key":"10.1016\/j.aquatox.2018.07.019_bib0140","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1002\/etc.5620200610","article-title":"Effects of the synthetic estrogen 17\u03b1-ethinylestradiol on the life-cycle of the fathead minnow (Pimephales promelas)","volume":"20","author":"L\u00e4nge","year":"2001","journal-title":"Environ. Toxicol. Chem."},{"issue":"2","key":"10.1016\/j.aquatox.2018.07.019_bib0145","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/gcen.2000.7593","article-title":"Differential in vitro suppressive effects of steroids on leukocyte phagocytosis in two teleosts, tilapia and common carp","volume":"121","author":"Law","year":"2001","journal-title":"Gen. Comp. Endocrinol."},{"issue":"12","key":"10.1016\/j.aquatox.2018.07.019_bib0150","doi-asserted-by":"crossref","first-page":"e408","DOI":"10.1038\/emm.2017.207","article-title":"Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression","volume":"49","author":"Lee","year":"2017","journal-title":"Exp. Mol. Med."},{"issue":"1","key":"10.1016\/j.aquatox.2018.07.019_bib0155","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.chemosphere.2009.02.035","article-title":"Levels of six estrogens in water and sediment from three rivers in Tianjin area, China","volume":"76","author":"Lei","year":"2009","journal-title":"Chemosphere"},{"issue":"1","key":"10.1016\/j.aquatox.2018.07.019_bib0160","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1477-7827-3-74","article-title":"17Beta-estradiol suppresses TLR3-induced cytokine and chemokine production in endometrial epithelial cells","volume":"3","author":"Lesmeister","year":"2005","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"8","key":"10.1016\/j.aquatox.2018.07.019_bib0165","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.dci.2011.03.015","article-title":"Estrogen-responsive genes in macrophages of the bony fish gilthead seabream: a transcriptomic approach","volume":"35","author":"Liarte","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"2","key":"10.1016\/j.aquatox.2018.07.019_bib0170","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.chemosphere.2004.10.051","article-title":"Bioaccumulation of 14 C-17\u03b1-ethinylestradiol by the aquatic oligochaete Lumbriculus variegatus in spiked artificial sediment","volume":"59","author":"Liebig","year":"2005","journal-title":"Chemosphere"},{"issue":"12","key":"10.1016\/j.aquatox.2018.07.019_bib0175","doi-asserted-by":"crossref","first-page":"3754","DOI":"10.1016\/j.watres.2012.04.006","article-title":"Steroids in a typical swine farm and their release into the environment","volume":"46","author":"Liu","year":"2012","journal-title":"Water Res."},{"issue":"4","key":"10.1016\/j.aquatox.2018.07.019_bib0180","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212 \u0394\u0394CT method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"3","key":"10.1016\/j.aquatox.2018.07.019_bib0185","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.it.2013.10.006","article-title":"SeXX matters in immunity","volume":"35","author":"Markle","year":"2014","journal-title":"Trends Immunol."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0190","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.aquatox.2014.10.003","article-title":"Influence of short-term exposure to low levels of 17\u03b1-ethynylestradiol on expression of genes involved in immunity and on immune parameters in rainbow trout, Oncorhynchus mykiss","volume":"157","author":"Massart","year":"2014","journal-title":"Aquat. Toxicol."},{"issue":"1-3","key":"10.1016\/j.aquatox.2018.07.019_bib0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.scitotenv.2004.12.070","article-title":"Review of evidence: are endocrine-disrupting chemicals in the aquatic environment impacting fish populations?","volume":"343","author":"Mills","year":"2005","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0200","series-title":"Water Quality Guidelines for Pharmaceutically-active Compounds (PhACs): 17\u03b1-ethinylestradiol (EE2)","author":"Nagpal","year":"2009"},{"issue":"7399","key":"10.1016\/j.aquatox.2018.07.019_bib0205","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/485441a","article-title":"Environmental science: the hidden costs of flexible fertility","volume":"485","author":"Owen","year":"2012","journal-title":"Nature"},{"issue":"8","key":"10.1016\/j.aquatox.2018.07.019_bib0210","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1210\/en.2005-0284","article-title":"A yin-yang effect between sex chromosome complement and sex hormones on the immune response","volume":"146","author":"Palaszynski","year":"2005","journal-title":"Endocrinology"},{"issue":"12","key":"10.1016\/j.aquatox.2018.07.019_bib0215","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1016\/j.dci.2011.03.006","article-title":"Toll-like receptors in bony fish: from genomics to function","volume":"35","author":"Palti","year":"2011","journal-title":"Dev. Comp. Immunol."},{"issue":"11","key":"10.1016\/j.aquatox.2018.07.019_bib0220","doi-asserted-by":"crossref","first-page":"7806","DOI":"10.1074\/jbc.M008922200","article-title":"Hepcidin, a urinary antimicrobial peptide synthesized in the liver","volume":"276","author":"Park","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0225","series-title":"PhD Thesis","first-page":"203","article-title":"Environmental estrogen induced multigenerational (F1-F4) reproductive and immune impairments in fish","author":"Peterson","year":"2018"},{"issue":"6","key":"10.1016\/j.aquatox.2018.07.019_bib0230","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.dci.2004.10.007","article-title":"Pathogenesis and inflammatory response to Edwardsiella tarda infection in the zebrafish","volume":"29","author":"Pressley","year":"2005","journal-title":"Dev. Comp. Immunol."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0235","first-page":"1","article-title":"20 Years of fish immunotoxicology\u2013what we know and where we are","author":"Rehberger","year":"2017","journal-title":"Crit. Rev. Toxicol."},{"issue":"2","key":"10.1016\/j.aquatox.2018.07.019_bib0240","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0166-445X(02)00079-6","article-title":"Effects of sewage effluent and ethynyl oestradiol upon molecular markers of oestrogenic exposure, maturation and reproductive success in the sand goby (Pomatoschistus minutus, Pallas)","volume":"62","author":"Robinson","year":"2003","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0245","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yhbeh.2016.11.017","article-title":"Sex differences in immune responses: hormonal effects, antagonistic selection, and evolutionary consequences","volume":"88","author":"Roved","year":"2017","journal-title":"Horm. Behav."},{"issue":"9","key":"10.1016\/j.aquatox.2018.07.019_bib0250","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1080\/15287390701236470","article-title":"Concentration-and time-dependent effects of the synthetic estrogen, 17\u03b1-ethinylestradiol, on reproductive capabilities of the zebrafish, Danio rerio","volume":"70","author":"Sch\u00e4fers","year":"2007","journal-title":"J. Toxicol. Environ. Health Part A"},{"issue":"1-2","key":"10.1016\/j.aquatox.2018.07.019_bib0255","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0378-4274(02)00043-7","article-title":"Determination of vitellogenin kinetics in male fathead minnows (Pimephales promelas)","volume":"131","author":"Schmid","year":"2002","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0260","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.marenvres.2013.03.003","article-title":"17\u03b2-estradiol induces changes in cytokine levels in head kidney and blood of juvenile sea bass (Dicentrarchus labrax, L., 1758)","volume":"87","author":"Seemann","year":"2013","journal-title":"Mar. Environ. Res."},{"issue":"6","key":"10.1016\/j.aquatox.2018.07.019_bib0265","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/jat.3215","article-title":"Sensitive periods for 17\u03b2\u2010estradiol exposure during immune system development in sea bass head kidney","volume":"36","author":"Seemann","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0270","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.cbpc.2017.03.010","article-title":"The development of cellular immune defence in marine medaka Oryzias melastigma","volume":"199","author":"Seemann","year":"2017","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0275","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.ygcen.2013.05.015","article-title":"Impact of environmental estrogens on Yfish considering the diversity of estrogen signaling","volume":"191","author":"Segner","year":"2013","journal-title":"Gen. Comp. Endocrinol."},{"issue":"8","key":"10.1016\/j.aquatox.2018.07.019_bib0280","first-page":"2232","article-title":"Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge","volume":"269","author":"Shike","year":"2002","journal-title":"FEBS J."},{"issue":"6","key":"10.1016\/j.aquatox.2018.07.019_bib0285","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1007\/s11356-012-0737-z","article-title":"A time-course study of immune response in Japanese flounder Paralichthys olivaceus exposed to heavy oil","volume":"19","author":"Song","year":"2012","journal-title":"Environ. Sci. Pollut. Res. - Int."},{"issue":"4-5","key":"10.1016\/j.aquatox.2018.07.019_bib0290","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.fsi.2011.02.020","article-title":"Ontogenetic expression and 17\u03b2-estradiol regulation of immune-related genes in early life stages of Japanese medaka (Oryzias latipes)","volume":"30","author":"Sun","year":"2011","journal-title":"Fish Shellfish Immunol."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0295","series-title":"R: a Language and Environment for Statistical Computing","author":"R. Core Team","year":"2013"},{"issue":"1","key":"10.1016\/j.aquatox.2018.07.019_bib0300","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0048-9697(98)00334-9","article-title":"Behavior and occurrence of estrogens in municipal sewage treatment plants\u2014I. Investigations in Germany, Canada and Brazil","volume":"225","author":"Ternes","year":"1999","journal-title":"Sci. Total Environ."},{"issue":"8","key":"10.1016\/j.aquatox.2018.07.019_bib0305","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1897\/08-642.1","article-title":"Effect of 17\u03b2\u2010estradiol on the immunocompetence of japanese sea bass (Lateolabrax Japonicus)","volume":"28","author":"Thilagam","year":"2009","journal-title":"Environ. Toxicol. Chem."},{"issue":"6","key":"10.1016\/j.aquatox.2018.07.019_bib0310","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1021\/es0201348","article-title":"Relative potencies and combination effects of steroidal estrogens in fish","volume":"37","author":"Thorpe","year":"2003","journal-title":"Environ. Sci. Technol."},{"issue":"5","key":"10.1016\/j.aquatox.2018.07.019_bib0315","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0145-305X(94)90003-5","article-title":"Estradiol increases susceptibility of goldfish to Trypanosoma danilewskyi","volume":"18","author":"Wang","year":"1994","journal-title":"Dev. Comp. Immunol."},{"issue":"6","key":"10.1016\/j.aquatox.2018.07.019_bib0320","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.peptides.2010.02.025","article-title":"Antiviral activity by fish antimicrobial peptides of epinecidin-1 and hepcidin 1\u20135 against nervous necrosis virus in medaka","volume":"31","author":"Wang","year":"2010","journal-title":"Peptides"},{"issue":"1","key":"10.1016\/j.aquatox.2018.07.019_bib0325","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.fsi.2011.04.007","article-title":"17Beta-estradiol affects the response of complement components and survival of rainbow trout (Oncorhynchus mykiss) challenged by bacterial infection","volume":"31","author":"Wenger","year":"2011","journal-title":"Fish Shellfish Immunol."},{"issue":"5","key":"10.1016\/j.aquatox.2018.07.019_bib0330","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1007\/s10126-012-9473-0","article-title":"Estrogen modulates hepatic gene expression and survival of rainbow trout infected with pathogenic bacteria Yersinia ruckeri","volume":"14","author":"Wenger","year":"2012","journal-title":"Mar. Biotechnol."},{"issue":"5406","key":"10.1016\/j.aquatox.2018.07.019_bib0335","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1126\/science.283.5406.1277","article-title":"A gender gap in autoimmunity: task force on gender, multiple sclerosis and autoimmunity","volume":"283","author":"Whitacre","year":"1999","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.aquatox.2018.07.019_bib0340","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1007\/s00436-008-1044-y","article-title":"Effect of tricaine methanesulfonate on survival and reproduction of the fish ectoparasite Ichthyophthirius multifiliis","volume":"103","author":"Xu","year":"2008","journal-title":"Parasitol. Res."},{"issue":"7","key":"10.1016\/j.aquatox.2018.07.019_bib0345","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1210\/en.2011-2045","article-title":"17\u03b2-Estradiol inhibits iron hormone hepcidin through an estrogen responsive element half-site","volume":"153","author":"Yang","year":"2012","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.aquatox.2018.07.019_bib0350","doi-asserted-by":"crossref","first-page":"2477","DOI":"10.1007\/s11356-012-0887-z","article-title":"Gender-specific modulation of immune system complement gene expression in marine medaka Oryzias melastigma following dietary exposure of BDE-47","volume":"19","author":"Ye","year":"2012","journal-title":"Environ. Sci. Pollut. Res. - Int."},{"issue":"36","key":"10.1016\/j.aquatox.2018.07.019_bib0355","doi-asserted-by":"crossref","first-page":"27687","DOI":"10.1007\/s11356-016-7208-x","article-title":"Immune competence assessment in marine medaka (Orzyias melastigma)\u2014a holistic approach for immunotoxicology","volume":"24","author":"Ye","year":"2017","journal-title":"Environ. Sci. Pollut. Res. - Int."},{"issue":"15","key":"10.1016\/j.aquatox.2018.07.019_bib0360","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1016\/S0043-1354(03)00261-6","article-title":"Sorption and degradation of selected five endocrine disrupting chemicals in aquifer material","volume":"37","author":"Ying","year":"2003","journal-title":"Water Res."},{"key":"10.1016\/j.aquatox.2018.07.019_bib0365","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.envint.2014.04.011","article-title":"Occurrence of 17 \u03b1 -ethynylestradiol (EE2) in the environment and effect on exposed biota : a review","volume":"69","author":"Zaharin","year":"2014","journal-title":"Environ. Int."},{"issue":"1","key":"10.1016\/j.aquatox.2018.07.019_bib0370","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1021\/es0619298","article-title":"Sorption of selected endocrine disrupting chemicals to different aquatic colloids","volume":"41","author":"Zhou","year":"2007","journal-title":"Environ. Sci. Technol."}],"container-title":["Aquatic Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X18304971?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166445X18304971?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:50:38Z","timestamp":1759067438000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166445X18304971"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":74,"alternative-id":["S0166445X18304971"],"URL":"https:\/\/doi.org\/10.1016\/j.aquatox.2018.07.019","relation":{},"ISSN":["0166-445X"],"issn-type":[{"value":"0166-445X","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-specific immunomodulatory action of the environmental estrogen 17\u03b1-ethynylestradiol alongside with reproductive impairment in fish","name":"articletitle","label":"Article Title"},{"value":"Aquatic Toxicology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.aquatox.2018.07.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}