{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:29:01Z","timestamp":1778315341487,"version":"3.51.4"},"reference-count":48,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de Bronconeumolog\u00eda"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.arbres.2015.02.003","type":"journal-article","created":{"date-parts":[[2015,4,18]],"date-time":"2015-04-18T02:24:31Z","timestamp":1429323871000},"page":"344-349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Tratamiento de la proteinosis alveolar primaria del adulto"],"prefix":"10.1016","volume":"51","author":[{"given":"Jos\u00e9 Antonio","family":"Rodr\u00edguez Portal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arbres.2015.02.003_bib0005","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1056\/NEJM195806052582301","article-title":"Pulmonary alveolar proteinosis","volume":"258","author":"Rosen","year":"1958","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arbres.2015.02.003_bib0010","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1056\/NEJMra023226","article-title":"Pulmonary alveolar proteinosis","volume":"349","author":"Trapnell","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arbres.2015.02.003_bib0015","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1164\/rccm.200708-1271OC","article-title":"Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan","volume":"177","author":"Inoue","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2015.02.003_bib0020","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1164\/rccm.2109105","article-title":"Pulmonary alveolar proteinosis: Progress in the first 44 years","volume":"166","author":"Seymour","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2015.02.003_bib0025","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.clim.2010.02.017","article-title":"The molecular basis of pulmonary alveolar proteinosis","volume":"135","author":"Carey","year":"2010","journal-title":"Clin Immunol"},{"key":"10.1016\/j.arbres.2015.02.003_bib0030","first-page":"L556","article-title":"Aerosolized GM-CSF ameliorates pulmonary alveolar proteinosis in GM-CSF-deficient mice","volume":"276","author":"Reed","year":"1999","journal-title":"Am J Physiol"},{"key":"10.1016\/j.arbres.2015.02.003_bib0035","doi-asserted-by":"crossref","first-page":"9565","DOI":"10.1073\/pnas.92.21.9565","article-title":"Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colonystimulating factor and interleukins 3 and 5","volume":"92","author":"Robb","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.arbres.2015.02.003_bib0040","article-title":"Pulmonary alveolar proteinosis","volume":"63","author":"Bonella","year":"2014","journal-title":"Pneumologia"},{"key":"10.1016\/j.arbres.2015.02.003_bib0045","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1165\/rcmb.2002-0023OC","article-title":"Autoantibodies against granulocyte macrophage colonystimulating factor are diagnostic for pulmonary alveolar proteinosis","volume":"27","author":"Bonfield","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.arbres.2015.02.003_bib0050","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.rmr.2014.08.009","article-title":"Pulmonary alveolar proteinosis","volume":"31","author":"Jouneau","year":"2014","journal-title":"Rev Mal Respir"},{"key":"10.1016\/j.arbres.2015.02.003_bib0055","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/thx.2005.054171","article-title":"Clinical significance of anti-GM-CSF antibodies in idiopathic pulmonary alveolar proteinosis","volume":"61","author":"Lin","year":"2006","journal-title":"Thorax"},{"key":"10.1016\/j.arbres.2015.02.003_bib0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/mgme.1998.2702","article-title":"An SP-B gene mutation responsible for SP-B deficiency in fatal congenital alveolar proteinosis: Evidence for a mutation hotspot in exon 4","volume":"64","author":"Lin","year":"1998","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.arbres.2015.02.003_bib0065","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1146\/annurev.physiol.66.032102.134711","article-title":"Alterations in SP-B and SP-C expression in neonatal lung disease","volume":"66","author":"Nogee","year":"2004","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.arbres.2015.02.003_bib0070","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1164\/rccm.201002-0271OC","article-title":"Hereditary pulmonary alveolar proteinosis: Pathogenesis, presentation, diagnosis, and therapy","volume":"182","author":"Suzuki","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2015.02.003_bib0075","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1183\/09031936.00090610","article-title":"Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations","volume":"37","author":"Suzuki","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2015.02.003_bib0080","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s13023-014-0171-z","article-title":"Characterization of CSF2RA mutation related juvenile pulmonary alveolar proteinosis","volume":"9","author":"Hildebrandt","year":"2014","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.arbres.2015.02.003_bib0085","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/ACI.0000000000000126","article-title":"GATA2 deficiency","volume":"15","author":"Hsu","year":"2015","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.arbres.2015.02.003_bib0090","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.hemonc.2014.09.003","article-title":"Secondary pulmonary alveolar proteinosis in hematologic malignancies","volume":"7","author":"Chaulagain","year":"2014","journal-title":"Hematol Oncol Stem Cell Ther"},{"key":"10.1016\/j.arbres.2015.02.003_bib0095","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.autrev.2014.01.046","article-title":"Autoimmune pulmonary alveolar proteinosis: Clinical course and diagnostic criteria","volume":"13","author":"Ben-Dov","year":"2014","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.arbres.2015.02.003_bib0100","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1111\/j.1440-1843.2012.02274.x","article-title":"Autoimmune pulmonary alveolar proteinosis: Treatment options in year 2013","volume":"18","author":"Leth","year":"2013","journal-title":"Respirology"},{"key":"10.1016\/j.arbres.2015.02.003_bib0105","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1378\/chest.09-2295","article-title":"Whole-lung lavage for pulmonary alveolar proteinosis","volume":"136","author":"Michaud","year":"2009","journal-title":"Chest"},{"key":"10.1016\/j.arbres.2015.02.003_bib0110","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1001\/archinte.1963.03860030173021","article-title":"Pulmonary alveolar proteinosis: A new technique and rationale for treatment","volume":"112","author":"Ramirez","year":"1963","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.arbres.2015.02.003_bib0115","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1378\/chest.125.6.2351","article-title":"Enhanced alveolar clearance with chest percussion therapy and positional changes during whole-lung lavage for alveolar proteinosis","volume":"125","author":"Perez","year":"2004","journal-title":"Chest"},{"key":"10.1016\/j.arbres.2015.02.003_bib0120","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1177\/1753465810378023","article-title":"Therapy options in pulmonary alveolar proteinosis","volume":"4","author":"Luisetti","year":"2010","journal-title":"Ther Adv Respir Dis"},{"key":"10.1016\/j.arbres.2015.02.003_bib0125","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.arbres.2008.02.006","article-title":"Response to inhaled granulocyte-macrophage colony-stimulating factor in a patient with alveolar proteinosis","volume":"45","author":"Rodr\u00edguez Portal","year":"2009","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.arbres.2015.02.003_bib0130","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1136\/thorax.58.7.645","article-title":"GM-CSF and proteinosis","volume":"58","author":"Khanjari","year":"2003","journal-title":"Thorax"},{"key":"10.1016\/j.arbres.2015.02.003_bib0135","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1056\/NEJM199612193352513","article-title":"Efficacy of granulocyte-macrophage colony-stimulating factor in acquired alveolar proteinosis","volume":"335","author":"Seymour","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arbres.2015.02.003_bib0140","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1164\/ajrccm.163.2.2003146","article-title":"Therapeutic efficacy of granulocyte-macrophage colony-stimulating factor in patients with idiopathic acquired alveolar proteinosis","volume":"163","author":"Seymour","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2015.02.003_bib0145","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1164\/ajrccm.161.4.9906044","article-title":"Exogenous granulocytemacrophage colony-stimulating factor administration for pulmonary alveolar proteinosis","volume":"161","author":"Kavuru","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2015.02.003_bib0150","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1006\/clim.2002.5301","article-title":"Anti-GM-CSF titer predicts response to GM-CSF therapy in pulmonary alveolar proteinosis","volume":"105","author":"Bonfield","year":"2002","journal-title":"Clin Immunol"},{"key":"10.1016\/j.arbres.2015.02.003_bib0155","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1378\/chest.130.1.227","article-title":"An open-label trial of granulocyte macrophage colony stimulating factor therapy for moderate symptomatic pulmonary alveolar proteinosis","volume":"130","author":"Venkateshiah","year":"2006","journal-title":"Chest"},{"key":"10.1016\/j.arbres.2015.02.003_bib0160","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1164\/rccm.200906-0978OC","article-title":"Inhaled granulocyte\/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis","volume":"181","author":"Tazawa","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2015.02.003_bib0165","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1183\/09031936.06.00058305","article-title":"Aerosol granulocytemacrophage colony-stimulating factor for pulmonary alveolar proteinosis","volume":"27","author":"Wylam","year":"2006","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2015.02.003_bib0170","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/0167-5699(94)90276-3","article-title":"CD20: A regulator of cell-cycle progression of B lymphocytes","volume":"15","author":"Tedder","year":"1994","journal-title":"Immunol Today"},{"key":"10.1016\/j.arbres.2015.02.003_bib0175","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1002\/art.38788","article-title":"Rituximab for the treatment of relapses in antineutrophil cytoplasmic antibody-associated vasculitis","volume":"66","author":"Miloslavsky","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.arbres.2015.02.003_bib0180","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1465-9921-13-46","article-title":"Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis","volume":"13","author":"Malur","year":"2012","journal-title":"Respir Res"},{"key":"10.1016\/j.arbres.2015.02.003_bib0185","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1183\/09031936.00160908","article-title":"Rituximab therapy in autoinmune pulmonary alveolar proteinosis","volume":"33","author":"Borie","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2015.02.003_bib0190","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1136\/thx.2010.140673","article-title":"Therapeutic effectiveness of rituximab in a patient with unresponsive autoimmune pulmonary alveolar proteinosis","volume":"65","author":"Amital","year":"2010","journal-title":"Thorax"},{"key":"10.1016\/j.arbres.2015.02.003_bib0195","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1183\/09031936.00197710","article-title":"An open-label trial of rituximab therapy in pulmonary alveolar proteinosis","volume":"38","author":"Kavuru","year":"2011","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2015.02.003_bib0200","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1183\/09031936.00097508","article-title":"Plasmapheresis for treatment of pulmonary alveolar proteinosis","volume":"33","author":"Luisetti","year":"2009","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2015.02.003_bib0205","doi-asserted-by":"crossref","DOI":"10.1007\/s00408-014-9678-2","article-title":"A Plasmapheresis Protocol for Refractory Pulmonary Alveolar Proteinosis","author":"Garber","year":"2015","journal-title":"Lung"},{"key":"10.1016\/j.arbres.2015.02.003_bib0210","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00000658-200209000-00003","article-title":"Lung transplantation in children","volume":"236","author":"Huddleston","year":"2002","journal-title":"Ann Surg"},{"key":"10.1016\/j.arbres.2015.02.003_bib0215","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1378\/chest.111.5.1457","article-title":"Recurrent alveolar proteinosis following double lung transplantation","volume":"111","author":"Parker","year":"1997","journal-title":"Chest"},{"key":"10.1016\/j.arbres.2015.02.003_bib0220","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1191\/1479972306cd101rs","article-title":"Pulmonary alveolar proteinosis","volume":"3","author":"Ioachimescu","year":"2006","journal-title":"Chron Respir Dis"},{"key":"10.1016\/j.arbres.2015.02.003_bib0225","first-page":"980","article-title":"Pulmonary alveolar proteinosis","volume":"93","author":"Robertson","year":"1965","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.arbres.2015.02.003_bib0230","article-title":"Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis","volume":"20","author":"Happle","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.arbres.2015.02.003_bib0235","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/nature13807","article-title":"Pulmonary macrophage transplantation therapy","volume":"514","author":"Suzuki","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.arbres.2015.02.003_bib0240","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1055\/s-0032-1325160","article-title":"Pulmonary alveolar proteinosis","volume":"33","author":"Wang","year":"2012","journal-title":"Semin Respir Crit Care Med"}],"container-title":["Archivos de Bronconeumolog\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289615000757?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289615000757?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,9,23]],"date-time":"2018-09-23T11:56:47Z","timestamp":1537703807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300289615000757"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":48,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0300289615000757"],"URL":"https:\/\/doi.org\/10.1016\/j.arbres.2015.02.003","relation":{},"ISSN":["0300-2896"],"issn-type":[{"value":"0300-2896","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tratamiento de la proteinosis alveolar primaria del adulto","name":"articletitle","label":"Article Title"},{"value":"Archivos de Bronconeumolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arbres.2015.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 SEPAR. Published by Elsevier Espa\u00f1a, S.L. All rights reserved.","name":"copyright","label":"Copyright"}]}}