{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:23:41Z","timestamp":1761989021276,"version":"build-2065373602"},"reference-count":38,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T00:00:00Z","timestamp":1488326400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de Bronconeumolog\u00eda"],"published-print":{"date-parts":[[2017,3]]},"DOI":"10.1016\/j.arbres.2016.09.014","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T21:00:32Z","timestamp":1482872432000},"page":"120-127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Valor pron\u00f3stico del pH en el condensado de aire exhalado y de la fracci\u00f3n exhalada de \u00f3xido n\u00edtrico en la enfermedad pulmonar intersticial asociada a esclerosis sist\u00e9mica"],"prefix":"10.1016","volume":"53","author":[{"given":"Alfredo","family":"Guillen-del Castillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"S\u00e1nchez-Vidaurre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen P.","family":"Sime\u00f3n-Aznar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda J.","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Fonollosa-Pla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arbres.2016.09.014_bib0195","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1056\/NEJMra0806188","article-title":"Scleroderma","volume":"360","author":"Gabrielli","year":"2009","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arbres.2016.09.014_bib0200","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1136\/ard.2006.066068","article-title":"Changes in causes of death in systemic sclerosis, 1972-2002","volume":"66","author":"Steen","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.arbres.2016.09.014_bib0205","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1183\/09059180.00005512","article-title":"Scleroderma lung disease","volume":"22","author":"Solomon","year":"2013","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.arbres.2016.09.014_bib0210","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1164\/rccm.200706-877OC","article-title":"Interstitial lung disease in systemic sclerosis: A simple staging system","volume":"177","author":"Goh","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2016.09.014_bib0215","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3899\/jrheum.120725","article-title":"Serum interleukin 6 is predictive of early functional decline and mortality in interstitial lung disease associated with systemic sclerosis","volume":"40","author":"De Lauretis","year":"2013","journal-title":"J Rheumatol"},{"key":"10.1016\/j.arbres.2016.09.014_bib0220","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1097\/BOR.0b013e3283126985","article-title":"Scleroderma lung disease: Evolving understanding in light of newer studies","volume":"20","author":"Antoniou","year":"2008","journal-title":"Curr Opin Rheumatol"},{"issue":"Suppl 5","key":"10.1016\/j.arbres.2016.09.014_bib0225","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1093\/rheumatology\/ken272","article-title":"Histopathology and bronchoalveolar lavage","volume":"47","author":"Silver","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.arbres.2016.09.014_bib0230","doi-asserted-by":"crossref","first-page":"2005","DOI":"10.1002\/art.22696","article-title":"Bronchoalveolar lavage cellular profiles in patients with systemic sclerosis-associated interstitial lung disease are not predictive of disease progression","volume":"56","author":"Goh","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.arbres.2016.09.014_bib0235","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00011-007-7136-9","article-title":"Cytokine concentrations in exhaled breath condensates in systemic sclerosis","volume":"57","author":"Edme","year":"2008","journal-title":"Inflamm Res"},{"key":"10.1016\/j.arbres.2016.09.014_bib0240","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1093\/rheumatology\/keq271","article-title":"Increased cysteinyl-leukotrienes and 8-isoprostane in exhaled breath condensate from systemic sclerosis patients","volume":"49","author":"Tufvesson","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.arbres.2016.09.014_bib0245","first-page":"S5","article-title":"Increased alveolar nitric oxide in early systemic sclerosis","volume":"28","author":"Wuttge","year":"2010","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.arbres.2016.09.014_bib0250","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1136\/thoraxjnl-2011-200499","article-title":"Alveolar concentration of nitric oxide predicts pulmonary function deterioration in scleroderma","volume":"67","author":"Tiev","year":"2012","journal-title":"Thorax"},{"key":"10.1016\/j.arbres.2016.09.014_bib0255","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.arbr.2011.11.005","article-title":"Latent pulmonary inflammation in patients with systemic sclerosis","volume":"48","author":"Sanchez-Vidaurre","year":"2012","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.arbres.2016.09.014_bib0260","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: An American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"Van den Hoogen","year":"2013","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.arbres.2016.09.014_bib0265","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1136\/ard.2008.096677","article-title":"EULAR recommendations for the treatment of systemic sclerosis: A report from the EULAR Scleroderma Trials and Research group (EUSTAR)","volume":"68","author":"Kowal-Bielecka","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.arbres.2016.09.014_bib0270","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1136\/annrheumdis-2013-203301","article-title":"Evidence-based detection of pulmonary arterial hypertension in systemic sclerosis: The DETECT study","volume":"73","author":"Coghlan","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.arbres.2016.09.014_bib0275","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1183\/13993003.01032-2015","volume":"46","author":"Galie","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2016.09.014_bib0280","doi-asserted-by":"crossref","first-page":"e1728","DOI":"10.1097\/MD.0000000000001728","article-title":"Registry of the Spanish Network for Systemic Sclerosis: Survival, prognostic factors, and causes of death","volume":"94","author":"Simeon-Aznar","year":"2015","journal-title":"Medicine"},{"key":"10.1016\/j.arbres.2016.09.014_bib0285","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1183\/09031936.05.00034505","article-title":"General considerations for lung function testing","volume":"26","author":"Miller","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2016.09.014_bib0290","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1164\/rccm.200406-710ST","article-title":"ATS\/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005","volume":"171","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2016.09.014_bib0295","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1378\/chest.06-1335","article-title":"Portable exhaled nitric oxide measurement: Comparison with the gold standard technique","volume":"131","author":"Menzies","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.arbres.2016.09.014_bib0300","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1183\/09031936.05.00029705","article-title":"Exhaled breath condensate: Methodological recommendations and unresolved questions","volume":"26","author":"Horvath","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2016.09.014_bib0305","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1164\/ajrccm.161.3.9911005","article-title":"Endogenous airway acidification. Implications for asthma pathophysiology","volume":"161","author":"Hunt","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2016.09.014_bib0310","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1164\/rccm.200111-068OC","article-title":"pH in expired breath condensate of patients with inflammatory airway diseases","volume":"165","author":"Kostikas","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2016.09.014_bib0315","doi-asserted-by":"crossref","first-page":"016004","DOI":"10.1088\/1752-7155\/6\/1\/016004","article-title":"Exhaled breath condensate (EBC) biomarkers in pulmonary fibrosis","volume":"6","author":"Chow","year":"2012","journal-title":"J Breath Res"},{"key":"10.1016\/j.arbres.2016.09.014_bib0320","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.rmed.2009.04.009","article-title":"Exhaled breath condensate biomarkers in asbestos-related lung disorders","volume":"103","author":"Chow","year":"2009","journal-title":"Respir Med"},{"key":"10.1016\/j.arbres.2016.09.014_bib0325","series-title":"New Perspectives in Monitoring Lung Inflammation: Analysis of Exhaled Breath Condensate","first-page":"73","article-title":"Measurement of exhaled breath condensate pH: Implications for pathophysiology and monitoring of inflammatory airway diseases","author":"Gaston","year":"2005"},{"key":"10.1016\/j.arbres.2016.09.014_bib0330","series-title":"New Perspectives in Monitoring Lung Inflammation: Analysis of Exhaled Breath Condensate","first-page":"11","article-title":"Analysis of exhaled breath condensate: Methodological issues","author":"Montuschi","year":"2005"},{"key":"10.1016\/j.arbres.2016.09.014_bib0335","doi-asserted-by":"crossref","first-page":"R111","DOI":"10.1186\/ar2766","article-title":"Bronchoalveoloar lavage fluid cytokines and chemokines as markers and predictors for the outcome of interstitial lung disease in systemic sclerosis patients","volume":"11","author":"Schmidt","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.arbres.2016.09.014_bib0340","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1152\/japplphysiol.00950.2003","article-title":"Modeling pulmonary nitric oxide exchange","volume":"96","author":"George","year":"2004","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.arbres.2016.09.014_bib0345","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1152\/jappl.1998.85.2.653","article-title":"A two-compartment model of pulmonary nitric oxide exchange dynamics","volume":"85","author":"Tsoukias","year":"1998","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.arbres.2016.09.014_bib0350","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1378\/chest.119.5.1449","article-title":"Exhaled nitric oxide is elevated in patients with progressive systemic sclerosis without interstitial lung disease","volume":"119","author":"Moodley","year":"2001","journal-title":"Chest"},{"key":"10.1016\/j.arbres.2016.09.014_bib0355","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1378\/chest.06-2929","article-title":"Exhaled nitric oxide levels in systemic sclerosis with and without pulmonary involvement","volume":"132","author":"Malerba","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.arbres.2016.09.014_bib0360","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1183\/09031936.00129806","article-title":"Severity of scleroderma lung disease is related to alveolar concentration of nitric oxide","volume":"30","author":"Tiev","year":"2007","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2016.09.014_bib0365","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1164\/rccm.2104003","article-title":"Partitioning of alveolar and conducting airway nitric oxide in scleroderma lung disease","volume":"165","author":"Girgis","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2016.09.014_bib0370","first-page":"547","article-title":"Increased nitric oxide in exhaled air in patients with systemic sclerosis","volume":"16","author":"Fajac","year":"1998","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.arbres.2016.09.014_bib0375","doi-asserted-by":"crossref","first-page":"017111","DOI":"10.1088\/1752-7155\/7\/1\/017111","article-title":"Carbon monoxide in exhaled breath testing and therapeutics","volume":"7","author":"Ryter","year":"2013","journal-title":"J Breath Res"},{"key":"10.1016\/j.arbres.2016.09.014_bib0380","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1046\/j.1475-097X.2003.00482.x","article-title":"The single breath transfer factor (Tl,co) and the transfer coefficient (Kco): A window onto the pulmonary microcirculation","volume":"23","author":"Hughes","year":"2003","journal-title":"Clin Physiol Funct Imaging"}],"container-title":["Archivos de Bronconeumolog\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289616302599?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289616302599?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:36:43Z","timestamp":1759531003000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300289616302599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["S0300289616302599"],"URL":"https:\/\/doi.org\/10.1016\/j.arbres.2016.09.014","relation":{},"ISSN":["0300-2896"],"issn-type":[{"type":"print","value":"0300-2896"}],"subject":[],"published":{"date-parts":[[2017,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Valor pron\u00f3stico del pH en el condensado de aire exhalado y de la fracci\u00f3n exhalada de \u00f3xido n\u00edtrico en la enfermedad pulmonar intersticial asociada a esclerosis sist\u00e9mica","name":"articletitle","label":"Article Title"},{"value":"Archivos de Bronconeumolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arbres.2016.09.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 SEPAR. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}