{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:18:51Z","timestamp":1790194731803,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de Bronconeumolog\u00eda"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.arbres.2018.07.002","type":"journal-article","created":{"date-parts":[[2018,8,16]],"date-time":"2018-08-16T10:06:53Z","timestamp":1534414013000},"page":"81-87","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"title":["Prognostic Value of Frequent Exacerbations in Bronchiectasis: The Relationship With Disease Severity"],"prefix":"10.1016","volume":"55","author":[{"given":"Miguel \u00c1ngel","family":"Martinez-Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Athanazio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgina","family":"Gramblicka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Corso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cavalcanti Lundgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Fernandes de Figueiredo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Arancibia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samia","family":"Rached","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Gir\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"M\u00e1iz Carro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"de la Rosa Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concepci\u00f3n","family":"Prados","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casilda","family":"Olveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arbres.2018.07.002_bib0155","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/15412550902766934","article-title":"Phenotypes of adult bronchiectasis: onset of productive cough in childhood and adulthood","volume":"6","author":"King","year":"2009","journal-title":"COPD"},{"key":"10.1016\/j.arbres.2018.07.002_bib0160","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1513\/AnnalsATS.201510-678OC","article-title":"The multiple faces of non-cystic fibrosis bronchiectasis: a cluster analysis approach","volume":"13","author":"Mart\u00ednez-Garc\u00eda","year":"2016","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.arbres.2018.07.002_bib0165","doi-asserted-by":"crossref","first-page":"1113","DOI":"10.1183\/13993003.01899-2015","article-title":"Clinical phenotypes in adult patients with bronchiectasis","volume":"47","author":"Aliberti","year":"2016","journal-title":"Eur Respir J"},{"issue":"Suppl. 1","key":"10.1016\/j.arbres.2018.07.002_bib0170","doi-asserted-by":"crossref","first-page":"S12","DOI":"10.1080\/15412555.2017.1286171","article-title":"Bronchiectasis: phenotyping a complex disease","volume":"14","author":"Chalmers","year":"2017","journal-title":"COPD"},{"key":"10.1016\/j.arbres.2018.07.002_bib0175","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/S0140-6736(12)60953-2","article-title":"Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial","volume":"380","author":"Wong","year":"2012","journal-title":"Lancet"},{"key":"10.1016\/j.arbres.2018.07.002_bib0180","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1001\/jama.2013.2290","article-title":"Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial","volume":"309","author":"Serisier","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.arbres.2018.07.002_bib0185","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1001\/jama.2013.1937","article-title":"Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial","volume":"309","author":"Altenburg","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.arbres.2018.07.002_bib0190","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1164\/rccm.201312-2208OC","article-title":"Inhaled colistin in patients with bronchiectasis and chronic Pseudomonas aeruginosa infection","volume":"189","author":"Haworth","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2018.07.002_bib0195","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S2213-2600(14)70165-1","article-title":"Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): two randomised double-blind, placebo-controlled phase 3 trials","volume":"2","author":"Barker","year":"2014","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.arbres.2018.07.002_bib0200","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02053-2017","article-title":"RESPIRE 2 a phase III placebo-controlled randomised trial of ciprofloxacin dry poder for inhalation in non-cystic fibrosis bronchiectasis","volume":"51","author":"Aksamit","year":"2018","journal-title":"Eur Resp J"},{"key":"10.1016\/j.arbres.2018.07.002_bib0205","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/rccm.201309-1575OC","article-title":"The bronchiectasis severity index: an international derivation and validation study","volume":"189","author":"Chalmers","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2018.07.002_bib0210","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1136\/thoraxjnl-2016-208481","article-title":"Multidimensional severity assessment in bronchiectasis: an analysis of seven European cohorts","volume":"71","author":"McDonnell","year":"2016","journal-title":"Thorax"},{"key":"10.1016\/j.arbres.2018.07.002_bib0215","doi-asserted-by":"crossref","first-page":"e0175171","DOI":"10.1371\/journal.pone.0175171","article-title":"Comparison of two prognostic scores (BSI and FACED) in a Spanish cohort of adult patients with bronchiectasis and improvement of the FACED predictive capacity for exacerbations","volume":"12","author":"Rosales-Mayor","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.arbres.2018.07.002_bib0220","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12890-017-0417-3","article-title":"Latin America validation of FACED score in patients with bronchiectasis: an analysis of six cohorts","volume":"17","author":"Athanazio","year":"2017","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.arbres.2018.07.002_bib0225","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2147\/COPD.S121943","article-title":"Predicting high risk of exacerbations in bronchiectasis: the E-FACED score","volume":"12","author":"Martinez-Garcia","year":"2017","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.arbres.2018.07.002_bib0230","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1378\/chest.128.2.739","article-title":"Quality-of-life determinants in patients with clinically stable bronchiectasis","volume":"128","author":"Mart\u00ednez-Garc\u00eda","year":"2005","journal-title":"Chest"},{"key":"10.1016\/j.arbres.2018.07.002_bib0235","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12931-015-0167-9","article-title":"Lung function, symptoms and inflammation during exacerbations of non-cystic fibrosis bronchiectasis: a prospective observational cohort study","volume":"16","author":"Brill","year":"2015","journal-title":"Respir Res"},{"key":"10.1016\/j.arbres.2018.07.002_bib0240","first-page":"1602","article-title":"A comprehensive analysis of the Impact of Pseudomonas aeruginosa colonization on prognosis in adult bronchiectasis","volume":"12","author":"Finch","year":"2015","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.arbres.2018.07.002_bib0245","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1378\/chest.07-0490","article-title":"Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis","volume":"132","author":"Mart\u00ednez-Garc\u00eda","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.arbres.2018.07.002_bib0250","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1164\/rccm.201605-1027OC","article-title":"Neutrophil elastase activity is associated with exacerbations and lung function decline in bronchiectasis","volume":"195","author":"Chalmers","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2018.07.002_bib0255","article-title":"Annual direct medical costs of bronchiectasis treatment: Impact of severity, exacerbations, chronic bronchial infection and COPD coexistence","volume":"12","author":"De la Rosa","year":"2016","journal-title":"Chron Respir Dis"},{"key":"10.1016\/j.arbres.2018.07.002_bib0260","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1378\/chest.10-0099","article-title":"Trends and burden of bronchiectasis-associated hospitalizations in the United States, 1993\u20132006","volume":"138","author":"Seitz","year":"2010","journal-title":"Chest"},{"key":"10.1016\/j.arbres.2018.07.002_bib0265","doi-asserted-by":"crossref","first-page":"e71109","DOI":"10.1371\/journal.pone.0071109","article-title":"Bronchiectasis-associated hospitalizations in Germany, 2005\u20132011: a population-based study of disease burden and trends","volume":"8","author":"Ringshausen","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.arbres.2018.07.002_bib0270","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.rmed.2010.02.022","article-title":"Trends in bronchiectasis mortality in England and Wales","volume":"104","author":"Roberts","year":"2010","journal-title":"Resp Med"},{"key":"10.1016\/j.arbres.2018.07.002_bib0275","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1164\/rccm.201711-2202OC","article-title":"Characterization of the \u201cfrequent exacerbation phenotype\u201d in bronchiectasis","volume":"197","author":"Chalmers","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2018.07.002_bib0280","unstructured":"Global Strategy for the diagnosis, management and prevention of chronic obstructive lung disease. Report 2017. Available from: https:\/\/www.goldcopd.org\/gold-2017-global-strategy-diagnosis-management-prevention-copd\/ (accessed 21-9-17)."},{"key":"10.1016\/j.arbres.2018.07.002_bib0285","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00004728-198206000-00001","article-title":"Computed tomography of bronchiectasis","volume":"6","author":"Naidich","year":"1982","journal-title":"J Comput Assist Tomogr"},{"key":"10.1016\/j.arbres.2018.07.002_bib0290","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1183\/09031936.00026313","article-title":"Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score","volume":"43","author":"Martinez-Garcia","year":"2014","journal-title":"Eur Resp J"},{"key":"10.1016\/j.arbres.2018.07.002_bib0295","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1183\/13993003.01312-2015","article-title":"Predicting mortality in bronchiectasis using bronchiectasis severity index and FACED scores: a 19-year cohort study","volume":"47","author":"Ellis","year":"2016","journal-title":"Eur Resp J"},{"key":"10.1016\/j.arbres.2018.07.002_bib0300","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00051-2017","article-title":"Pulmonary exacerbation in adults with bronchiectasis: a consensus definition for clinical research","volume":"49","author":"Hill","year":"2017","journal-title":"Eur Resp J"}],"container-title":["Archivos de Bronconeumolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289618302916?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289618302916?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:37:26Z","timestamp":1759531046000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300289618302916"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0300289618302916"],"URL":"https:\/\/doi.org\/10.1016\/j.arbres.2018.07.002","relation":{},"ISSN":["0300-2896"],"issn-type":[{"value":"0300-2896","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic Value of Frequent Exacerbations in Bronchiectasis: The Relationship With Disease Severity","name":"articletitle","label":"Article Title"},{"value":"Archivos de Bronconeumolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arbres.2018.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 SEPAR. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}