{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:52:20Z","timestamp":1759539140738,"version":"build-2065373602"},"reference-count":15,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de Bronconeumolog\u00eda"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.arbres.2020.01.024","type":"journal-article","created":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T01:59:20Z","timestamp":1584410360000},"page":"151-153","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Nuevos enfoques en investigaci\u00f3n de la infecci\u00f3n tuberculosa latente"],"prefix":"10.1016","volume":"57","author":[{"given":"Patricio","family":"Escalante","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Arias-Guill\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Jos\u00e9","family":"Palacios Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arbres.2020.01.024_bib0080","unstructured":"World Health Organization. Global tuberculosis report 2019. Geneva: WHO; 2019 [consultado 17 Oct 2019]. Disponible en: https:\/\/www.who.int\/tb\/publications\/global_report\/en\/"},{"key":"10.1016\/j.arbres.2020.01.024_bib0085","doi-asserted-by":"crossref","first-page":"20130437","DOI":"10.1098\/rstb.2013.0437","article-title":"The ongoing challenge of latent tuberculosis","volume":"369","author":"Esmail","year":"2014","journal-title":"Philos Trans R Soc Lond B Biol Sci."},{"key":"10.1016\/j.arbres.2020.01.024_bib0090","first-page":"74","article-title":"New perspectives in latent tuberculosis infection","volume":"56","author":"Arias-Guillen","year":"2019","journal-title":"Arch Bronconeumol."},{"key":"10.1016\/j.arbres.2020.01.024_bib0095","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/resp.13272","article-title":"Update on tuberculosis biomarkers: From correlates of risk, to correlates of active disease and of cure from disease","volume":"23","author":"Goletti","year":"2018","journal-title":"Respirology."},{"key":"10.1016\/j.arbres.2020.01.024_bib0100","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1183\/09031936.00120908","article-title":"LTBI: Latent tuberculosis infection or lasting immune responses to M. tuberculosis? A TBNET consensus statement","volume":"33","author":"Mack","year":"2009","journal-title":"Eur Respir J."},{"key":"10.1016\/j.arbres.2020.01.024_bib0105","doi-asserted-by":"crossref","first-page":"13980","DOI":"10.1073\/pnas.0901720106","article-title":"Epidemiological benefits of more-effective tuberculosis vaccines, drugs, and diagnostics","volume":"106","author":"Abu-Raddad","year":"2009","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.arbres.2020.01.024_bib0110","doi-asserted-by":"crossref","first-page":"1800946","DOI":"10.1183\/13993003.00946-2018","article-title":"An evaluation framework for new tests that predict progression from tuberculosis infection to clinical disease","volume":"52","author":"Kik","year":"2018","journal-title":"Eur Respir J."},{"key":"10.1016\/j.arbres.2020.01.024_bib0115","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.chest.2017.04.161","article-title":"Improving the diagnosis of latent TB infection: Tools for TB elimination?","volume":"151","author":"Schluger","year":"2017","journal-title":"Chest."},{"key":"10.1016\/j.arbres.2020.01.024_bib0120","doi-asserted-by":"crossref","first-page":"E5636","DOI":"10.1073\/pnas.1611987113","article-title":"CD4+ T-cell-independent mechanisms suppress reactivation of latent tuberculosis in a macaque model of HIV coinfection","volume":"113","author":"Foreman","year":"2016","journal-title":"Proc Natl Acad Sci U S A."},{"key":"10.1016\/j.arbres.2020.01.024_bib0125","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/mi.2017.60","article-title":"Defective positioning in granulomas but not lung-homing limits CD4 T-cell interactions with Mycobacterium tuberculosis-infected macrophages in rhesus macaques","volume":"11","author":"Kauffman","year":"2018","journal-title":"Mucosal Immunol."},{"key":"10.1016\/j.arbres.2020.01.024_bib0130","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1038\/s41586-018-0439-x","article-title":"A multi-cohort study of the immune factors associated with M. tuberculosis infection outcomes","volume":"560","author":"Roy Chowdhury","year":"2018","journal-title":"Nature."},{"key":"10.1016\/j.arbres.2020.01.024_bib0135","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1164\/rccm.201903-0646OC","article-title":"Isoniazid and rifapentine treatment eradicates persistent Mycobacterium tuberculosis in macaques","volume":"201","author":"Foreman","year":"2020","journal-title":"Am J Respir Crit Care Med."},{"key":"10.1016\/j.arbres.2020.01.024_bib0140","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1111\/j.1440-1843.2010.01751.x","article-title":"Treatment of latent tuberculosis infection: An update","volume":"15","author":"Lobue","year":"2010","journal-title":"Respirology."},{"key":"10.1016\/j.arbres.2020.01.024_bib0145","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1164\/rccm.201412-2141OC","article-title":"Combinatorial immunoprofiling in latent tuberculosis infection toward better risk stratification","volume":"192","author":"Escalante","year":"2015","journal-title":"Am J Respir Crit Care Med."},{"key":"10.1016\/j.arbres.2020.01.024_bib0150","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1086\/499311","article-title":"Effect of treatment of latent tuberculosis infection on the T cell response to Mycobacterium tuberculosis antigens","volume":"193","author":"Wilkinson","year":"2006","journal-title":"J Infect Dis."}],"container-title":["Archivos de Bronconeumolog\u00eda"],"original-title":[],"language":"es","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289620300569?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289620300569?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:39:21Z","timestamp":1759531161000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300289620300569"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["S0300289620300569"],"URL":"https:\/\/doi.org\/10.1016\/j.arbres.2020.01.024","relation":{},"ISSN":["0300-2896"],"issn-type":[{"type":"print","value":"0300-2896"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nuevos enfoques en investigaci\u00f3n de la infecci\u00f3n tuberculosa latente","name":"articletitle","label":"Article Title"},{"value":"Archivos de Bronconeumolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arbres.2020.01.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 SEPAR. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}