{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:36:49Z","timestamp":1772120209780,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Programa Operativo de Empleo Juvenil"},{"name":"European Social Fund Investing in your future (ESF) and ERDF","award":["PEJD-2018-PRE\/BMD-8237"],"award-info":[{"award-number":["PEJD-2018-PRE\/BMD-8237"]}]},{"name":"Rio Hortega","award":["CM19\/00069"],"award-info":[{"award-number":["CM19\/00069"]}]}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de Bronconeumolog\u00eda"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.arbres.2020.05.034","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T17:49:09Z","timestamp":1593539349000},"page":"681-689","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Core Microbiota in Central Lung Cancer With Streptococcal Enrichment as a Possible Diagnostic Marker"],"prefix":"10.1016","volume":"57","author":[{"given":"Salvador","family":"Bello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 J.","family":"Vengoechea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuel","family":"Ponce-Alonso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana L.","family":"Figueredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Minchol\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Rezusta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Gamb\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Manuel","family":"Pastor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"family":"Javier\u00a0Galeano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rosa","family":"del Campo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arbres.2020.05.034_bib0175","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3389\/fped.2019.00393","article-title":"Lower airway microbiota","volume":"7","author":"Pulvirenti","year":"2019","journal-title":"Front Pediatr"},{"key":"10.1016\/j.arbres.2020.05.034_bib0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.arbr.2020.01.003","article-title":"The lower airway microbiome and lung cancer","author":"Garc\u00eda-Pach\u00f3n","year":"2020","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0185","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.arbres.2019.04.012","article-title":"Lung cancer and microbiome","volume":"56","author":"Garrido-Mart\u00edn","year":"2020","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0190","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.canlet.2017.11.036","article-title":"Interplay between the lung microbiome and lung cancer","volume":"415","author":"Mao","year":"2018","journal-title":"Cancer Lett"},{"key":"10.1016\/j.arbres.2020.05.034_bib0195","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.12659\/MSM.915332","article-title":"Preliminary study of microbiota diversity in saliva and bronchoalveolar lavage fluid from patients with primary bronchogenic carcinoma","volume":"25","author":"Wang","year":"2019","journal-title":"Med Sci Monit"},{"key":"10.1016\/j.arbres.2020.05.034_bib0200","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1002\/ijc.31098","article-title":"Difference of lower airway microbiome in bilateral protected specimen brush between lung cancer patients with unilateral lobar masses and control subjects","volume":"142","author":"Liu","year":"2018","journal-title":"Int J Cancer"},{"key":"10.1016\/j.arbres.2020.05.034_bib0205","first-page":"1775","article-title":"Lung tissue microbial profile in lung cancer is distinct from emphysema","volume":"8","author":"Liu","year":"2018","journal-title":"Am J Cancer Res"},{"key":"10.1016\/j.arbres.2020.05.034_bib0210","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13059-018-1501-6","article-title":"Interaction between the microbiome and TP53 in human lung cancer","volume":"19","author":"Greathouse","year":"2018","journal-title":"Genome Biol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0215","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.3389\/fmicb.2019.01050","article-title":"Gut microbiota shapes the efficiency of cancer therapy","volume":"10","author":"Ma","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0220","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3389\/fmicb.2018.00614","article-title":"Significance of Streptococcus gallolyticus subsp. gallolyticus association with colorectal cancer","volume":"9","author":"Pasquereau-Kotula","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0225","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/bioinformatics\/btt086","article-title":"QUAST: quality assessment tool for genome assemblies","volume":"29","author":"Gurevich","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.arbres.2020.05.034_bib0230","doi-asserted-by":"crossref","first-page":"e40863","DOI":"10.1371\/journal.pone.0040863","article-title":"primers for the DNA-based identification of Ascomycetes and Basidiomycetes in environmental samples","volume":"7","author":"Toju","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.arbres.2020.05.034_bib0235","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0240","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0245","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrc.2017.13","article-title":"Microbiota: a key orchestrator of cancer therapy","volume":"17","author":"Roy","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.arbres.2020.05.034_bib0250","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1186\/s13059-016-1021-1","article-title":"Characterizing human lung tissue microbiota and its relationship to epidemiological and clinical features","volume":"17","author":"Yu","year":"2016","journal-title":"Genome Biol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0255","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1146\/annurev-physiol-021115-105238","article-title":"The microbiome and the respiratory tract","volume":"78","author":"Dickson","year":"2016","journal-title":"Annu Rev Physiol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0260","doi-asserted-by":"crossref","first-page":"525","DOI":"10.7861\/clinmedicine.17-6-525","article-title":"The lung microbiome in health and disease","volume":"17","author":"Moffatt","year":"2017","journal-title":"Clin Med (Lond)"},{"key":"10.1016\/j.arbres.2020.05.034_bib0265","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1164\/rccm.201104-0655OC","article-title":"Topographical continuity of bacterial populations in the healthy human respiratory tract","volume":"184","author":"Charlson","year":"2011","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2020.05.034_bib0270","doi-asserted-by":"crossref","first-page":"e0177062","DOI":"10.1371\/journal.pone.0177062","article-title":"A pilot study using metagenomic sequencing of the sputum microbiome suggests potential bacterial biomarkers for lung cancer","volume":"12","author":"Cameron","year":"2017","journal-title":"PLOS ONE"},{"key":"10.1016\/j.arbres.2020.05.034_bib0275","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1164\/rccm.201710-2118OC","article-title":"Airway microbiota is associated with up-regulation of the PI3K pathway in lung cancer","volume":"198","author":"Tsay","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2020.05.034_bib0280","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1158\/1055-9965.EPI-18-0966","article-title":"The microbiome in lung cancer tissue and recurrence-free survival","volume":"28","author":"Peters","year":"2019","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.arbres.2020.05.034_bib0285","doi-asserted-by":"crossref","first-page":"16031","DOI":"10.1038\/nmicrobiol.2016.31","article-title":"Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype","volume":"1","author":"Segal","year":"2016","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0290","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/em.21878","article-title":"The potential role of lung microbiota in lung cancer attributed to household coal burning exposures","volume":"55","author":"Hosgood","year":"2014","journal-title":"Environ Mol Mutagen"},{"key":"10.1016\/j.arbres.2020.05.034_bib0295","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3389\/fmicb.2018.00603","article-title":"The road to infection: host\u2013microbe interactions defining the pathogenicity of Streptococcus bovis\/Streptococcus equinus complex members","volume":"9","author":"Jans","year":"2018","journal-title":"Front Microbiol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0300","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1111\/sji.12636","article-title":"The regulatory role of the oral commensal Streptococcus mitis on human monocytes","volume":"87","author":"Engen","year":"2018","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0305","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/imm.12764","article-title":"Lung-resident \u03b3\u03b4 T cells and their roles in lung diseases","volume":"151","author":"Cheng","year":"2017","journal-title":"Immunology"},{"key":"10.1016\/j.arbres.2020.05.034_bib0310","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2018.12.040","article-title":"Commensal microbiota promote lung cancer development via \u03b3\u03b4 T cells","volume":"176","author":"Jin","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.arbres.2020.05.034_bib0315","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.3389\/fmicb.2016.02169","article-title":"Mycobiome in the lower respiratory tract \u2013 a clinical perspective","volume":"7","author":"Krause","year":"2017","journal-title":"Front Microbiol"},{"key":"10.1016\/j.arbres.2020.05.034_bib0320","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1164\/rccm.201210-1913OC","article-title":"Comparison of the respiratory microbiome in healthy nonsmokers and smokers","volume":"187","author":"Morris","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2020.05.034_bib0325","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1164\/rccm.201702-0441OC","article-title":"Lung microbiota is related to smoking status and to development of acute respiratory distress syndrome in critically ill trauma patients","volume":"197","author":"Panzer","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2020.05.034_bib0330","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S2213-2600(18)30510-1","article-title":"Functional effects of the microbiota in chronic respiratory disease","volume":"7","author":"Budden","year":"2019","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.arbres.2020.05.034_bib0335","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s40168-017-0381-4","article-title":"The lung tissue microbiota of mild and moderate chronic obstructive pulmonary disease","volume":"6","author":"Pragman","year":"2018","journal-title":"Microbiome"},{"key":"10.1016\/j.arbres.2020.05.034_bib0340","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1164\/rccm.201103-0430OC","article-title":"Lung cancer in patients with COPD: incidence and predicting factors","volume":"184","author":"de Torres","year":"2011","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Archivos de Bronconeumolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289620301927?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289620301927?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:40:06Z","timestamp":1759531206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300289620301927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["S0300289620301927"],"URL":"https:\/\/doi.org\/10.1016\/j.arbres.2020.05.034","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-17856\/v1","asserted-by":"object"}]},"ISSN":["0300-2896"],"issn-type":[{"value":"0300-2896","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Core Microbiota in Central Lung Cancer With Streptococcal Enrichment as a Possible Diagnostic Marker","name":"articletitle","label":"Article Title"},{"value":"Archivos de Bronconeumolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arbres.2020.05.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 SEPAR. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}