{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T00:52:53Z","timestamp":1759539173593,"version":"build-2065373602"},"reference-count":17,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de Bronconeumolog\u00eda"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.arbres.2022.06.005","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T11:10:09Z","timestamp":1656760209000},"page":"837-839","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Increased Blood Eosinophil Count Is Related to Less Daily Physical Activity in Patients With Chronic Obstructive Pulmonary Disease"],"prefix":"10.1016","volume":"58","author":[{"given":"Ra\u00fal","family":"Galera","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Mergelina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Casitas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabet","family":"Mart\u00ednez-Cer\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Garc\u00eda R\u00edo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arbres.2022.06.005_bib0090","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1164\/rccm.202009-3533SO","article-title":"Global initiative for the diagnosis. Management, and prevention of chronic obstructive lung disease. The 2020 GOLD science committee report on COVID-19 and chronic obstructive pulmonary disease","volume":"203","author":"Halpin","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2022.06.005_bib0095","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.arbres.2021.03.005","article-title":"Spanish COPD Guidelines (GesEPOC) 2021: updated pharmacological treatment of stable COPD","volume":"58","author":"Miravitlles","year":"2022","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.arbres.2022.06.005_bib0100","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1164\/rccm.201108-1553OC","article-title":"Blood eosinophils to direct corticosteroid treatment of exacerbations of chronic obstructive pulmonary disease: a randomized placebo-controlled trial","volume":"186","author":"Bafadhel","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2022.06.005_bib0105","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1164\/rccm.201509-1869OC","article-title":"Blood eosinophils and exacerbations in chronic obstructive pulmonary disease. The Copenhagen general population study","volume":"193","author":"Vedel-Krogh","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2022.06.005_bib0110","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1164\/ajrccm.160.6.9811041","article-title":"Asthma attacks with eosinophilia predict mortality from chronic obstructive pulmonary disease in a general population sample","volume":"160","author":"Hospers","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2022.06.005_bib0115","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.rmed.2013.03.007","article-title":"Characterisation of the overlap COPD-asthma phenotype. Focus on physical activity and health status","volume":"107","author":"Miravitlles","year":"2013","journal-title":"Respir Med"},{"key":"10.1016\/j.arbres.2022.06.005_bib0120","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1164\/rccm.200812-1873OC","article-title":"Daily physical activity in patients with chronic obstructive pulmonary disease is mainly associated with dynamic hyperinflation","volume":"180","author":"Garcia-Rio","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2022.06.005_bib0125","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1249\/MSS.0000000000001859","article-title":"Physical activity is associated with attenuated disease progression in chronic obstructive pulmonary disease","volume":"51","author":"Demeyer","year":"2019","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.arbres.2022.06.005_bib0130","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1183\/09031936.00023214","article-title":"Changes in physical activity and all-cause mortality in COPD","volume":"44","author":"Vaes","year":"2014","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2022.06.005_bib0135","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"Miller","year":"2005","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2022.06.005_bib0140","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1183\/09031936.00080312","article-title":"Multi-ethnic reference values for spirometry for the 3-95-yr age range: the global lung function 2012 equations","volume":"40","author":"Quanjer","year":"2012","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2022.06.005_bib0145","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1186\/1471-2466-14-209","article-title":"Aclidinium improves exercise endurance, dyspnea, lung hyperinflation, and physical activity in patients with COPD: a randomized, placebo-controlled, crossover trial","volume":"14","author":"Beeh","year":"2014","journal-title":"BMC Pulm Med"},{"key":"10.1016\/j.arbres.2022.06.005_bib0150","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01162-2017","article-title":"Prevalence of persistent blood eosinophilia: relation to outcomes in patients with COPD","volume":"50","author":"Casanova","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2022.06.005_bib0155","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S2213-2600(17)30432-0","article-title":"Association of sputum and blood eosinophil concentrations with clinical measures of COPD severity: an analysis of the SPIROMICS cohort","volume":"5","author":"Hastie","year":"2017","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.arbres.2022.06.005_bib0160","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1152\/japplphysiol.01615.2011","article-title":"Effect of incremental exercise on airway and systemic inflammation in patients with COPD","volume":"112","author":"Davidson","year":"2012","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.arbres.2022.06.005_bib0165","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1186\/s12966-019-0863-9","article-title":"The effects of small-scale physical and social environmental interventions on walking behaviour among Dutch older adults living in deprived neighbourhoods: results from the quasi-experimental NEW.ROADS study","volume":"16","author":"Prins","year":"2019","journal-title":"Int J Behav Nutr Phys Act"},{"key":"10.1016\/j.arbres.2022.06.005_bib0170","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s12026-014-8517-0","article-title":"Effects of stress on immune function: the good, the bad, and the beautiful","volume":"58","author":"Dhabhar","year":"2014","journal-title":"Immunol Res"}],"container-title":["Archivos de Bronconeumolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289622004823?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289622004823?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:42:27Z","timestamp":1759531347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300289622004823"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":17,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["S0300289622004823"],"URL":"https:\/\/doi.org\/10.1016\/j.arbres.2022.06.005","relation":{},"ISSN":["0300-2896"],"issn-type":[{"type":"print","value":"0300-2896"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Increased Blood Eosinophil Count Is Related to Less Daily Physical Activity in Patients With Chronic Obstructive Pulmonary Disease","name":"articletitle","label":"Article Title"},{"value":"Archivos de Bronconeumolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arbres.2022.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 SEPAR. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}