{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T03:58:41Z","timestamp":1779249521256,"version":"3.51.4"},"reference-count":15,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de Bronconeumolog\u00eda"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.arbres.2022.12.001","type":"journal-article","created":{"date-parts":[[2022,12,18]],"date-time":"2022-12-18T17:18:39Z","timestamp":1671383919000},"page":"134-136","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Primary Ciliary Dyskinesia and Bronchiectasis: New Data and Future Challenges"],"prefix":"10.1016","volume":"59","author":[{"given":"Charlotte O.","family":"Pioch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David W.","family":"Connell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amelia","family":"Shoemark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.arbres.2022.12.001_bib0080","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1055\/s-0041-1730919","article-title":"Primary ciliary dyskinesia","volume":"42","author":"Shoemark","year":"2021","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2022.12.001_bib0085","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S2213-2600(21)00453-7","article-title":"The global prevalence and ethnic heterogeneity of primary ciliary dyskinesia gene variants: a genetic database analysis","volume":"10","author":"Hannah","year":"2022","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.arbres.2022.12.001_bib0090","first-page":"49","article-title":"European Respiratory Society guidelines for the diagnosis of primary ciliary dyskinesia","author":"Lucas","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2022.12.001_bib0095","doi-asserted-by":"crossref","first-page":"e24","DOI":"10.1164\/rccm.201805-0819ST","article-title":"Diagnosis of primary ciliary dyskinesia an official American Thoracic Society clinical practice guideline","volume":"197","author":"Shapiro","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2022.12.001_bib0100","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00176-2022","article-title":"Genome sequencing reveals underdiagnosis of primary ciliary dyskinesia in bronchiectasis","author":"Shoemark","year":"2022","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2022.12.001_bib0105","doi-asserted-by":"crossref","first-page":"gaab009","DOI":"10.1093\/molehr\/gaab009","article-title":"Motility of efferent duct cilia aids passage of sperm cells through the male reproductive system","volume":"27","author":"Aprea","year":"2021","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.arbres.2022.12.001_bib0110","doi-asserted-by":"crossref","first-page":"gaab009","DOI":"10.1093\/molehr\/gaab009","article-title":"Motility of efferent duct cilia aids passage of sperm cells through the male reproductive system","volume":"27","author":"Aprea","year":"2021","journal-title":"Mol Hum Reprod"},{"key":"10.1016\/j.arbres.2022.12.001_bib0115","doi-asserted-by":"crossref","first-page":"2002359","DOI":"10.1183\/13993003.02359-2020","article-title":"Topological data analysis reveals genotype\u2013phenotype relationships in primary ciliary dyskinesia","volume":"58","author":"Shoemark","year":"2021","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2022.12.001_bib0120","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1513\/AnnalsATS.202110-1175OC","article-title":"High nasal nitric oxide cilia analyses and genotypes in a retrospective cohort of children with primary ciliary dyskinesia","volume":"19","author":"Legendre","year":"2022","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.arbres.2022.12.001_bib0125","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1513\/AnnalsATS.202106-728OC","article-title":"Limitations of nasal nitric oxide measurement for diagnosis of primary ciliary dyskinesia with normal ultrastructure","volume":"19","author":"Raidt","year":"2022","journal-title":"Ann Am Thorac Soc"},{"key":"10.1016\/j.arbres.2022.12.001_bib0130","doi-asserted-by":"crossref","first-page":"9834","DOI":"10.3390\/ijms22189834","article-title":"Current and future treatments in primary ciliary dyskinesia","volume":"22","author":"Paff","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.arbres.2022.12.001_bib0135","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1001\/jama.2013.1937","article-title":"Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial","volume":"309","author":"Altenburg","year":"2013","journal-title":"JAMA"},{"key":"10.1016\/j.arbres.2022.12.001_bib0140","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S2213-2600(20)30058-8","article-title":"Efficacy and safety of azithromycin maintenance therapy in primary ciliary dyskinesia (BESTCILIA): a multicentre, double-blind, randomised, placebo-controlled phase 3 trial","volume":"8","author":"Kobbernagel","year":"2020","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.arbres.2022.12.001_bib0145","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1056\/NEJMoa2021713","article-title":"Phase 2 trial of the DPP-1 inhibitor brensocatib in bronchiectasis","volume":"383","author":"Chalmers","year":"2020","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arbres.2022.12.001_bib0150","doi-asserted-by":"crossref","first-page":"102134","DOI":"10.1016\/j.pupt.2022.102134","article-title":"Inhaled delivery of a lipid nanoparticle encapsulated messenger RNA encoding a ciliary protein for the treatment of primary ciliary dyskinesia","volume":"75","author":"Woo","year":"2022","journal-title":"Pulm Pharmacol Ther"}],"container-title":["Archivos de Bronconeumolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289622006639?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289622006639?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:42:09Z","timestamp":1759531329000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300289622006639"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0300289622006639"],"URL":"https:\/\/doi.org\/10.1016\/j.arbres.2022.12.001","relation":{},"ISSN":["0300-2896"],"issn-type":[{"value":"0300-2896","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Primary Ciliary Dyskinesia and Bronchiectasis: New Data and Future Challenges","name":"articletitle","label":"Article Title"},{"value":"Archivos de Bronconeumolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arbres.2022.12.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 SEPAR. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}