{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T12:14:18Z","timestamp":1789820058090,"version":"4.0.1"},"reference-count":13,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de Bronconeumolog\u00eda"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.arbres.2022.12.008","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T11:13:17Z","timestamp":1671793997000},"page":"139-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Biologics in Bronchiectasis: A Future Treatment?"],"prefix":"10.1016","volume":"59","author":[{"given":"Mattia","family":"Nigro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Simonetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel \u00c1ngel","family":"Mart\u00ednez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Aliberti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arbres.2022.12.008_bib0070","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S2213-2600(21)00277-0","article-title":"Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations","volume":"10","author":"Aliberti","year":"2022","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.arbres.2022.12.008_bib0075","doi-asserted-by":"crossref","first-page":"180108","DOI":"10.1183\/16000617.0108-2018","article-title":"A systematic review of pharmacotherapeutic clinical trial end-points for bronchiectasis in adults","volume":"28","author":"Crichton","year":"2019","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.arbres.2022.12.008_bib0080","doi-asserted-by":"crossref","first-page":"1801269","DOI":"10.1183\/13993003.01269-2018","article-title":"Treatable traits in bronchiectasis","volume":"52","author":"Boaventura","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2022.12.008_bib0085","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/S0140-6736(18)31767-7","article-title":"Advances in bronchiectasis: endotyping, genetics, microbiome, and disease heterogeneity","volume":"392","author":"Flume","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.arbres.2022.12.008_bib0090","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S2213-2600(20)30504-X","article-title":"Neutrophil extracellular traps, disease severity, and antibiotic response in bronchiectasis: an international, observational, multicohort study","volume":"9","author":"Keir","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.arbres.2022.12.008_bib0095","doi-asserted-by":"crossref","first-page":"772","DOI":"10.3390\/biomedicines9070772","article-title":"T2-high endotype and response to biological treatments in patients with bronchiectasis","volume":"9","author":"Oriano","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.arbres.2022.12.008_bib0100","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1164\/rccm.202108-1889OC","article-title":"Characterization of eosinophilic bronchiectasis: a European multicohort study","volume":"205","author":"Shoemark","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2022.12.008_bib0105","doi-asserted-by":"crossref","first-page":"106127","DOI":"10.1016\/j.rmed.2020.106127","article-title":"Role of inhaled corticosteroids in reducing exacerbations in bronchiectasis patients with blood eosinophilia pooled post-hoc analysis of 2 randomized clinical trials","volume":"172","author":"Martinez-Garcia","year":"2020","journal-title":"Respir Med"},{"key":"10.1016\/j.arbres.2022.12.008_bib0110","article-title":"Blood eosinophils do not predict inhaled budesonide response in bronchiectasis","volume":"56","author":"Aliberti","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2022.12.008_bib0115","doi-asserted-by":"crossref","first-page":"83","DOI":"10.2147\/JAA.S196200","article-title":"Severe uncontrolled asthma with bronchiectasis: a pilot study of an emerging phenotype that responds to mepolizumab","volume":"12","author":"Carpagnano","year":"2019","journal-title":"J Asthma Allergy"},{"key":"10.1016\/j.arbres.2022.12.008_bib0120","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01333-2019","article-title":"Anti-IL5 and anti-IL5R\u03b1 therapy for clinically significant bronchiectasis with eosinophilic endotype: a case series","volume":"55","author":"Rademacher","year":"2020","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2022.12.008_bib0125","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/mmy\/myw109","article-title":"Bronchiectasis and Aspergillus: how are they linked?","volume":"55","author":"De Soyza","year":"2017","journal-title":"Med Mycol"},{"key":"10.1016\/j.arbres.2022.12.008_bib0130","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00328-2018","article-title":"The overlap between bronchiectasis and chronic airway diseases: state of the art and future directions","volume":"52","author":"Polverino","year":"2018","journal-title":"Eur Respir J"}],"container-title":["Archivos de Bronconeumolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289622006718?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289622006718?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T22:41:51Z","timestamp":1759531311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300289622006718"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0300289622006718"],"URL":"https:\/\/doi.org\/10.1016\/j.arbres.2022.12.008","relation":{},"ISSN":["0300-2896"],"issn-type":[{"value":"0300-2896","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Biologics in Bronchiectasis: A Future Treatment?","name":"articletitle","label":"Article Title"},{"value":"Archivos de Bronconeumolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arbres.2022.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 SEPAR. Published by Elsevier Espa\u00f1a, S.L.U. All rights reserved.","name":"copyright","label":"Copyright"}]}}