{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:05:56Z","timestamp":1788897956824,"version":"build-2803163510"},"reference-count":40,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de Bronconeumolog\u00eda"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.arbres.2025.01.002","type":"journal-article","created":{"date-parts":[[2025,1,6]],"date-time":"2025-01-06T17:02:15Z","timestamp":1736182935000},"page":"417-426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sputum Microbiota Correlates With Metabolome and Clinical Outcomes in Asthma\u2013Bronchiectasis Overlap"],"prefix":"10.1016","volume":"61","author":[{"given":"Xiao-xian","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-feng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-hui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-ming","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui-xia","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen-hong","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lai-jian","family":"Cen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui-min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-xin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-jie","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arbres.2025.01.002_bib0205","series-title":"Global strategy for asthma management and prevention","year":"2018"},{"issue":"4","key":"10.1016\/j.arbres.2025.01.002_bib0210","first-page":"311","article-title":"Expert consensus on the diagnosis and treatment of adult bronchiectasis in China","volume":"44","author":"Bronchiectasis Expert Consensus Writing Group","year":"2021","journal-title":"Chin J Tubere Respir Dis"},{"issue":"11","key":"10.1016\/j.arbres.2025.01.002_bib0215","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1080\/02770903.2023.2203743","article-title":"Does asthma\u2013bronchiectasis overlap syndrome (ABOS) really exist?","volume":"60","author":"Tiotiu","year":"2023","journal-title":"J Asthma"},{"issue":"10","key":"10.1016\/j.arbres.2025.01.002_bib0220","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1080\/02770903.2020.1784194","article-title":"How does comorbid bronchiectasis affect asthmatic patients? A meta-analysis","volume":"58","author":"Lan","year":"2021","journal-title":"J Asthma"},{"issue":"10","key":"10.1016\/j.arbres.2025.01.002_bib0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaip.2022.05.026","article-title":"Clinical deterioration and lung function change in patients with concomitant asthma and bronchiectasis","volume":"10","author":"Kim","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"3","key":"10.1016\/j.arbres.2025.01.002_bib0230","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1080\/02770903.2020.1857395","article-title":"Impact of asthma on bronchiectasis severity and risk of exacerbations","volume":"59","author":"Ferri","year":"2022","journal-title":"J Asthma"},{"issue":"Suppl. 1","key":"10.1016\/j.arbres.2025.01.002_bib0235","first-page":"1","article-title":"British Thoracic Society Guideline for bronchiectasis in adults","volume":"74","author":"Hill","year":"2019","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.arbres.2025.01.002_bib0240","doi-asserted-by":"crossref","first-page":"e12331","DOI":"10.1002\/clt2.12331","article-title":"Bacteria and viruses and clinical outcomes of asthma\u2013bronchiectasis overlap syndrome: a cohort study","volume":"14","author":"Zhang","year":"2024","journal-title":"Clin Transl Allergy"},{"issue":"4","key":"10.1016\/j.arbres.2025.01.002_bib0245","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1164\/rccm.202110-2241OC","article-title":"Lung microbiota and metabolites collectively associate with clinical outcomes in milder stage chronic obstructive pulmonary disease","volume":"206","author":"Madapoosi","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"10.1016\/j.arbres.2025.01.002_bib0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2010.10.048","article-title":"Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma","volume":"127","author":"Huang","year":"2011","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"10.1016\/j.arbres.2025.01.002_bib0255","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jaci.2015.05.044","article-title":"The airway microbiome in patients with severe asthma: associations with disease features and severity","volume":"136","author":"Huang","year":"2015","journal-title":"J Allergy Clin Immunol"},{"issue":"9","key":"10.1016\/j.arbres.2025.01.002_bib0260","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.5588\/ijtld.18.0037","article-title":"Proteobacteria community compositions correlate with bronchiectasis severity","volume":"22","author":"Guan","year":"2018","journal-title":"Int J Tuberc Lung Dis"},{"issue":"8","key":"10.1016\/j.arbres.2025.01.002_bib0265","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/S2213-2600(20)30557-9","article-title":"The sputum microbiome and clinical outcomes in patients with bronchiectasis: a prospective observational study","volume":"9","author":"Dicker","year":"2021","journal-title":"Lancet Respir Med"},{"issue":"1","key":"10.1016\/j.arbres.2025.01.002_bib0270","doi-asserted-by":"crossref","first-page":"6871","DOI":"10.1038\/s41598-019-42862-y","article-title":"A longitudinal characterization of the non-cystic fibrosis bronchiectasis airway microbiome","volume":"9","author":"Woo","year":"2019","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.arbres.2025.01.002_bib0275","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1038\/s41591-021-01289-7","article-title":"Integrative microbiomics in bronchiectasis exacerbations","volume":"27","author":"Mac Aog\u00e1in","year":"2021","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.arbres.2025.01.002_bib0280","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1038\/s41564-022-01196-8","article-title":"Multi-omics analyses of airway host\u2013microbe interactions in chronic obstructive pulmonary disease identify potential therapeutic interventions","volume":"7","author":"Yan","year":"2022","journal-title":"Nat Microbiol"},{"issue":"1","key":"10.1016\/j.arbres.2025.01.002_bib0285","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaci.2017.03.044","article-title":"Inflammatory phenotypes in patients with severe asthma are associated with distinct airway microbiology","volume":"141","author":"Taylor","year":"2018","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"10.1016\/j.arbres.2025.01.002_bib0290","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1164\/rccm.202108-1889OC","article-title":"Characterization of eosinophilic bronchiectasis: a European Multicohort Study","volume":"205","author":"Shoemark","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"10.1016\/j.arbres.2025.01.002_bib0295","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S2213-2600(21)00277-0","article-title":"Criteria and definitions for the radiological and clinical diagnosis of bronchiectasis in adults for use in clinical trials: international consensus recommendations","volume":"10","author":"Aliberti","year":"2022","journal-title":"Lancet Respir Med"},{"issue":"2","key":"10.1016\/j.arbres.2025.01.002_bib0300","doi-asserted-by":"crossref","first-page":"261","DOI":"10.2214\/ajr.165.2.7618537","article-title":"CT findings in bronchiectasis: limited value in distinguishing between idiopathic and specific types","volume":"165","author":"Reiff","year":"1995","journal-title":"Am J Roentgenol"},{"issue":"5","key":"10.1016\/j.arbres.2025.01.002_bib0305","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1164\/rccm.201309-1575OC","article-title":"The bronchiectasis severity index: an international derivation and validation study","volume":"189","author":"Chalmers","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.arbres.2025.01.002_bib0310","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2147\/COPD.S121943","article-title":"Predicting high risk of exacerbations in bronchiectasis: the E-FACED score","volume":"12","author":"Martinez-Garcia","year":"2017","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"issue":"6","key":"10.1016\/j.arbres.2025.01.002_bib0315","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01289-2017","article-title":"Standardised classification of the aetiology of bronchiectasis using an objective algorithm","volume":"50","author":"Ara\u00fajo","year":"2017","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2025.01.002_bib0320","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jaci.2014.06.035","article-title":"Biological clustering supports both \u201cDutch\u201d and \u201cBritish\u201d hypotheses of asthma and chronic obstructive pulmonary disease","volume":"135","author":"Ghebre","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.arbres.2025.01.002_bib0325","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1440-1843.2006.00784.x","article-title":"Inflammatory subtypes in asthma: assessment and identification using induced sputum","volume":"11","author":"Simpson","year":"2006","journal-title":"Respirology"},{"issue":"6","key":"10.1016\/j.arbres.2025.01.002_bib0330","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1378\/chest.14-1961","article-title":"The role of viral infection in pulmonary exacerbations of bronchiectasis in adults: a prospective study","volume":"147","author":"Gao","year":"2015","journal-title":"Chest"},{"issue":"8","key":"10.1016\/j.arbres.2025.01.002_bib0335","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/s41587-019-0209-9","article-title":"Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2","volume":"37","author":"Bolyen","year":"2019","journal-title":"Nat Biotechnol"},{"issue":"12","key":"10.1016\/j.arbres.2025.01.002_bib0340","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"issue":"12","key":"10.1016\/j.arbres.2025.01.002_bib0345","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1164\/rccm.202009-3448OC","article-title":"Inflammatory endotype-associated airway microbiome in chronic obstructive pulmonary disease clinical stability and exacerbations: a multicohort longitudinal analysis","volume":"203","author":"Wang","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"10.1016\/j.arbres.2025.01.002_bib0350","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1002687","article-title":"Inferring correlation networks from genomic survey data","volume":"8","author":"Friedman","year":"2012","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.arbres.2025.01.002_bib0355","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.3389\/fmicb.2017.02224","article-title":"Microbiome datasets are compositional: and this is not optional","volume":"8","author":"Gloor","year":"2017","journal-title":"Front Microbiol"},{"issue":"1","key":"10.1016\/j.arbres.2025.01.002_bib0360","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1002\/imt2.85","article-title":"OmicStudio: a composable bioinformatics cloud platform with real-time feedback that can generate high-quality graphs for publication","volume":"2","author":"Lyu","year":"2023","journal-title":"Imeta"},{"issue":"10","key":"10.1016\/j.arbres.2025.01.002_bib0365","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/S2213-2600(18)30510-1","article-title":"Functional effects of the microbiota in chronic respiratory disease","volume":"7","author":"Budden","year":"2019","journal-title":"Lancet Respir Med"},{"issue":"10","key":"10.1016\/j.arbres.2025.01.002_bib0370","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1136\/thoraxjnl-2020-216475","article-title":"Dysregulation of prostaglandins, leukotrienes and lipoxin A(4) in bronchiectasis","volume":"77","author":"Bedi","year":"2022","journal-title":"Thorax"},{"issue":"1","key":"10.1016\/j.arbres.2025.01.002_bib0375","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41392-020-00443-w","article-title":"Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets","volume":"6","author":"Wang","year":"2021","journal-title":"Signal Transduct Target Ther"},{"issue":"5","key":"10.1016\/j.arbres.2025.01.002_bib0380","doi-asserted-by":"crossref","first-page":"684","DOI":"10.4168\/aair.2021.13.5.684","article-title":"Arachidonic acid 15-lipoxygenase: effects of its expression metabolites, and genetic and epigenetic variations on airway inflammation","volume":"13","author":"Xu","year":"2021","journal-title":"Allergy Asthma Immunol Res"},{"issue":"4","key":"10.1016\/j.arbres.2025.01.002_bib0385","doi-asserted-by":"crossref","first-page":"e0152724","DOI":"10.1371\/journal.pone.0152724","article-title":"Airway microbiota in severe asthma and relationship to asthma severity and phenotypes","volume":"11","author":"Zhang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.arbres.2025.01.002_bib0390","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.rmed.2017.08.016","article-title":"Sputum microbiota in severe asthma patients: relationship to eosinophilic inflammation","volume":"131","author":"Li","year":"2017","journal-title":"Respir Med"},{"issue":"4","key":"10.1016\/j.arbres.2025.01.002_bib0395","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1164\/rccm.202108-1943OC","article-title":"Endotyping chronic obstructive pulmonary disease bronchiectasis, and the \u201cchronic obstructive pulmonary disease-bronchiectasis association\u201d","volume":"206","author":"Huang","year":"2022","journal-title":"Am J Respir Crit Care Med"},{"issue":"9","key":"10.1016\/j.arbres.2025.01.002_bib0400","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1164\/rccm.201908-1550OC","article-title":"Inhaled steroids, circulating eosinophils chronic airway infection, and pneumonia risk in chronic obstructive pulmonary disease. A network analysis","volume":"201","author":"Martinez-Garcia","year":"2020","journal-title":"Am J Respir Crit Care Med"}],"container-title":["Archivos de Bronconeumolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289625000067?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289625000067?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T16:54:14Z","timestamp":1751388854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300289625000067"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":40,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0300289625000067"],"URL":"https:\/\/doi.org\/10.1016\/j.arbres.2025.01.002","relation":{},"ISSN":["0300-2896"],"issn-type":[{"value":"0300-2896","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sputum Microbiota Correlates With Metabolome and Clinical Outcomes in Asthma\u2013Bronchiectasis Overlap","name":"articletitle","label":"Article Title"},{"value":"Archivos de Bronconeumolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arbres.2025.01.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 SEPAR. Published by Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}