{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:32:41Z","timestamp":1787905961661,"version":"build-2784847793"},"reference-count":22,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.es","elsevier.es","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archivos de Bronconeumolog\u00eda"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.arbres.2025.11.011","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:17:57Z","timestamp":1764721077000},"page":"474-480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Inside GEMA 5.5: Expert Insights on the Latest Changes in Asthma Management"],"prefix":"10.1016","volume":"62","author":[{"given":"Carlos","family":"Almonacid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santiago","family":"Quirce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"del Cuvillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Valverde-Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Plaza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.arbres.2025.11.011_bib0115","series-title":"Global Initiative for Asthma \u2013 GINA","author":"GINA Strategy Report","year":"2025"},{"key":"10.1016\/j.arbres.2025.11.011_bib0120","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.arbres.2024.04.002","article-title":"Spanish Consensus on Remission in Asthma (REMAS)","volume":"60","author":"\u00c1lvarez-Guti\u00e9rrez","year":"2024","journal-title":"Arch Bronconeumol"},{"key":"10.1016\/j.arbres.2025.11.011_bib0125","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S2213-2600(24)00299-6","article-title":"Treating eosinophilic exacerbations of asthma and COPD with benralizumab (ABRA): a double-blind, double-dummy, active placebo-controlled randomised trial","volume":"13","author":"Ramakrishnan","year":"2025","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.arbres.2025.11.011_bib0130","doi-asserted-by":"crossref","first-page":"S31","DOI":"10.1016\/j.jaip.2021.10.011","article-title":"A practical guide to implementing SMART in asthma management","volume":"10","author":"Reddel","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.arbres.2025.11.011_bib0135","series-title":"GEMA 5.5. Gu\u00eda Espa\u00f1ola para el Manejo del Asma","year":"2025"},{"key":"10.1016\/j.arbres.2025.11.011_bib0140","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1002\/ppul.27171","article-title":"Once or consecutive administration of inhaled salbutamol in children with acute asthma exacerbation: Is an additional dose beneficial?","volume":"59","author":"\u00d6zdemir","year":"2024","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.arbres.2025.11.011_bib0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.pupt.2024.102333","article-title":"Triple inhaled therapy in asthma: beliefs, behaviours and doubts","volume":"87","author":"Bagnasco","year":"2024","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.arbres.2025.11.011_bib0150","doi-asserted-by":"crossref","first-page":"5885","DOI":"10.4103\/jfmpc.jfmpc_1082_24","article-title":"Results from a UK consensus about the optimal prescribing of medium strength triple therapy in uncontrolled adult asthma patients in the NHS","volume":"13","author":"Russell","year":"2024","journal-title":"J Family Med Prim Care"},{"key":"10.1016\/j.arbres.2025.11.011_bib0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e31186","article-title":"Differences in the effectiveness of single, dual, and triple inhaled corticosteroid therapy for reducing future risk of severe asthma exacerbation: a systematic review and network meta-analysis","volume":"10","author":"Yamasaki","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.arbres.2025.11.011_bib0160","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1056\/NEJMoa2414482","article-title":"Tezepelumab in adults with severe chronic rhinosinusitis with nasal polyps","volume":"392","author":"Lipworth","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arbres.2025.11.011_bib0165","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(25)00197-7","article-title":"Efficacy and safety of twice per year depemokimab in chronic rhinosinusitis with nasal polyps (ANCHOR-1 and ANCHOR-2): phase 3, randomised, double-blind, parallel trials","volume":"405","author":"Gevaert","year":"2025","journal-title":"Lancet"},{"key":"10.1016\/j.arbres.2025.11.011_bib0170","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.3390\/jcm12185846","article-title":"Severe asthma and biological therapies: now and the future","volume":"12","author":"Sardon-Prado","year":"2023","journal-title":"J Clin Med"},{"key":"10.1016\/j.arbres.2025.11.011_bib0175","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1056\/NEJMoa2406673","article-title":"Twice-yearly depemokimab in severe asthma with an eosinophilic phenotype","volume":"391","author":"Jackson","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arbres.2025.11.011_bib0180","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/S2213-2600(24)00362-X","article-title":"Effect of dupilumab on exhaled nitric oxide, mucus plugs, and functional respiratory imaging in patients with type 2 asthma (VESTIGE): a randomised, double-blind, placebo-controlled, phase 4 trial","volume":"13","author":"Castro","year":"2025","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.arbres.2025.11.011_bib0185","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1111\/all.15792","article-title":"Dupilumab sustains efficacy in patients with moderate-to-severe type 2 asthma regardless of inhaled corticosteroids dose","volume":"78","author":"Pavord","year":"2023","journal-title":"Allergy"},{"key":"10.1016\/j.arbres.2025.11.011_bib0190","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S2213-2600(23)00303-X","article-title":"Assessment of long-term safety and efficacy of dupilumab in children with asthma (LIBERTY ASTHMA EXCURSION): an open-label extension study","volume":"12","author":"Bacharier","year":"2024","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.arbres.2025.11.011_bib0195","doi-asserted-by":"crossref","first-page":"2976","DOI":"10.1002\/ppul.27167","article-title":"Dupilumab 200mg was efficacious in children (6-11 years) with moderate-to-severe asthma for up to 2 years: EXCURSION open-label extension study","volume":"59","author":"Phipatanakul","year":"2024","journal-title":"Pediatr Pulmonol"},{"key":"10.1016\/j.arbres.2025.11.011_bib0200","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00061-2024","article-title":"Revised ISHAM-ABPA working group clinical practice guidelines for diagnosing, classifying and treating allergic bronchopulmonary aspergillosis\/mycoses","volume":"63","author":"Agarwal","year":"2024","journal-title":"Eur Respir J"},{"key":"10.1016\/j.arbres.2025.11.011_bib0205","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00408-024-00717-y","article-title":"Efficacy of biologics in patients with allergic bronchopulmonary aspergillosis: a systematic review and meta-analysis","volume":"202","author":"Chen","year":"2024","journal-title":"Lung"},{"key":"10.1016\/j.arbres.2025.11.011_bib0210","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1056\/NEJMoa2311155","article-title":"Benralizumab versus mepolizumab for eosinophilic granulomatosis with polyangiitis","volume":"390","author":"Wechsler","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.arbres.2025.11.011_bib0215","doi-asserted-by":"crossref","DOI":"10.1111\/eci.14333","article-title":"Efficacy and safety of benralizumab in eosinophilic granulomatosis with polyangiitis: a meta-analysis of eight studies","volume":"55","author":"Spataro","year":"2025","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.arbres.2025.11.011_bib0220","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.jaip.2024.01.006","article-title":"Long-term effectiveness of benralizumab in eosinophilic granulomatosis with polyangiitis","volume":"12","author":"Nanzer","year":"2024","journal-title":"J Allergy Clin Immunol Pract"}],"container-title":["Archivos de Bronconeumolog\u00eda"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289625004181?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0300289625004181?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T14:31:30Z","timestamp":1783175490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0300289625004181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":22,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0300289625004181"],"URL":"https:\/\/doi.org\/10.1016\/j.arbres.2025.11.011","relation":{},"ISSN":["0300-2896"],"issn-type":[{"value":"0300-2896","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inside GEMA 5.5: Expert Insights on the Latest Changes in Asthma Management","name":"articletitle","label":"Article Title"},{"value":"Archivos de Bronconeumolog\u00eda","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.arbres.2025.11.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 SEPAR. Published by Elsevier Espa\u00f1a, S.L.U. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}