{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:36:11Z","timestamp":1787240171699,"version":"build-2736575974"},"reference-count":22,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T00:00:00Z","timestamp":1277942400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001823","name":"Ministerstvo \u0160kolstv\u00ed, Ml\u00e1de\u017ee a T\u011blov\u00fdchovy","doi-asserted-by":"publisher","award":["MSM 0021620817"],"award-info":[{"award-number":["MSM 0021620817"]}],"id":[{"id":"10.13039\/501100001823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["IGA MZ 8830-4"],"award-info":[{"award-number":["IGA MZ 8830-4"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009647","name":"Ministry of Health","doi-asserted-by":"publisher","award":["00064165"],"award-info":[{"award-number":["00064165"]}],"id":[{"id":"10.13039\/100009647","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1016\/j.archger.2009.06.006","type":"journal-article","created":{"date-parts":[[2009,7,18]],"date-time":"2009-07-18T05:09:14Z","timestamp":1247893754000},"page":"e1-e6","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6)"],"prefix":"10.1016","volume":"51","author":[{"given":"Martin","family":"Sedl\u00e1\u0159","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Kudrnov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Erhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanislav","family":"Tr\u010da","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Kvasni\u010dka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zden\u011bk","family":"Kr\u0161ka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji\u0159\u00ed","family":"Mazoch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Mal\u00edkov\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miroslav","family":"Zeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ale\u0161","family":"Linhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.archger.2009.06.006_bib1","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/BF02877699","article-title":"Relationships between markers of inflammation, severity of injury, and clinical outcomes in hemorrhagic shock","volume":"24","author":"Akkose","year":"2007","journal-title":"Adv. Ther."},{"key":"10.1016\/j.archger.2009.06.006_bib2","first-page":"253","article-title":"The release of interleukin-1 beta (IL-1) precedes that of interleukin 6 (IL-6) in patients undergoing major surgery","volume":"10","author":"Baigrie","year":"1991","journal-title":"Lymphokine Cytokine Res."},{"key":"10.1016\/j.archger.2009.06.006_bib3","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1159\/000104400","article-title":"Immune modulation after total hip surgery. A prospective ex vivo study","volume":"39","author":"Bastian","year":"2007","journal-title":"Eur. Surg. Res."},{"key":"10.1016\/j.archger.2009.06.006_bib4","doi-asserted-by":"crossref","first-page":"M420","DOI":"10.1093\/gerona\/62.4.420","article-title":"Cytokines and C-reactive protein production in hip fracture operated elderly patients","volume":"62","author":"Beloosesky","year":"2007","journal-title":"J. Gerontol. A: Biol. Sci. Med. Sci."},{"key":"10.1016\/j.archger.2009.06.006_bib5","first-page":"193","article-title":"Acute phase reaction in severe trauma","volume":"2","author":"Br\u00edza","year":"2002","journal-title":"Sb. L\u00e9k."},{"key":"10.1016\/j.archger.2009.06.006_bib6","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/00365510600889635","article-title":"Systemic and local cytokine patterns during total hip surgery","volume":"66","author":"Clementsen","year":"2006","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"10.1016\/j.archger.2009.06.006_bib7","first-page":"22","article-title":"Serial estimation of interleukin 6 as a measure of systemic disease in rheumatoid arthritis","volume":"19","author":"Dasgupta","year":"1992","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.archger.2009.06.006_bib8","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1080\/03009740701250785","article-title":"Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells","volume":"36","author":"Doss","year":"2007","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.archger.2009.06.006_bib9","first-page":"128","article-title":"Effects of gender difference in early cytokine levels in trauma patients","volume":"108","author":"Ertan","year":"2007","journal-title":"Bratisl. Lek. Listy"},{"key":"10.1016\/j.archger.2009.06.006_bib10","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1210\/jcem.86.3.7305","article-title":"Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women","volume":"86","author":"Fernandez-Real","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"Suppl. 2","key":"10.1016\/j.archger.2009.06.006_bib11","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/ar1917","article-title":"Interleukin-6 and chronic inflammation","volume":"8","author":"Gabay","year":"2006","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.archger.2009.06.006_bib12","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.surg.2006.01.018","article-title":"Increased plasma interleukin 6 concentrations and exaggerated adipose tissue interleukin 6 content in severely obese patients after operative trauma","volume":"140","author":"Gletsu","year":"2006","journal-title":"Surgery"},{"key":"10.1016\/j.archger.2009.06.006_bib13","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1006\/cyto.2000.0675","article-title":"Changes in plasma IL-1beta, TNFalpha and IL-6 after total hip replacement surgery in general or regional anaesthesia","volume":"12","author":"H\u00f8gevold","year":"2000","journal-title":"Cytokine"},{"key":"10.1016\/j.archger.2009.06.006_bib14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/S0020-1383(97)00057-0","article-title":"Plasma cytokines and endotoxin levels in patients with severe injury and their relationship with organ damage","volume":"28","author":"Jiang","year":"1997","journal-title":"Injury"},{"key":"10.1016\/j.archger.2009.06.006_bib15","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1471-4906(02)00013-3","article-title":"IL-6 a regulator of the transition from neutrophil to monocyte recruitment during inflammation","volume":"24","author":"Kaplanski","year":"2003","journal-title":"Trends Immunol."},{"key":"10.1016\/j.archger.2009.06.006_bib16","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1291\/hypres.30.541","article-title":"Plasma interleukin-6 and tumor necrosis factor-alpha can predict coronary endothelial dysfunction in hypertensive patients","volume":"30","author":"Naya","year":"2007","journal-title":"Hypertens. Res."},{"key":"10.1016\/j.archger.2009.06.006_bib17","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1080\/17453670610013006","article-title":"C-reactive protein as a parameter of surgical trauma: CRP response after different types of surgery in 349 hip fractures","volume":"77","author":"Neumaier","year":"2006","journal-title":"Acta Orthop."},{"key":"10.1016\/j.archger.2009.06.006_bib18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1074-7613(00)80334-9","article-title":"Role of IL-6 and its soluble receptor in induction of chemokines and leukocyte recruitment","volume":"6","author":"Romano","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.archger.2009.06.006_bib19","first-page":"541","article-title":"Serum interleukin-6 and C reactive protein responses in patients after laparoscopic or conventional cholecystectomy","volume":"158","author":"Roumen","year":"1992","journal-title":"Eur. J. Surg."},{"key":"10.1016\/j.archger.2009.06.006_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/1043-4666(94)90040-X","article-title":"Elevation of circulating interleukin 6 after surgery: factors influencing the serum level","volume":"6","author":"Sakamoto","year":"1994","journal-title":"Cytokine"},{"key":"10.1016\/j.archger.2009.06.006_bib21","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.joca.2007.05.023","article-title":"Inflammatory response in patients undergoing hip surgery due to osteoarthrosis or different types of hip fractures","volume":"16","author":"Sedl\u00e1\u0159","year":"2008","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.archger.2009.06.006_bib22","first-page":"1396","article-title":"The early second hit in trauma management augments the proinflammatory immune response to multiple injuries","volume":"62","author":"Tschoeke","year":"2007","journal-title":"J. Trauma"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494309001496?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494309001496?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:02:02Z","timestamp":1759089722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494309001496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010,7]]}},"alternative-id":["S0167494309001496"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2009.06.006","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Older age and type of surgery predict the early inflammatory response to hip trauma mediated by interleukin-6 (IL-6)","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2009.06.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}