{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T20:52:43Z","timestamp":1759179163377},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["aggjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.archger.2014.04.005","type":"journal-article","created":{"date-parts":[[2014,5,9]],"date-time":"2014-05-09T23:33:30Z","timestamp":1399678410000},"page":"491-495","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["High prevalence of aspirin resistance in elderly patients with cardiovascular disease (CVD) and hyperhomocysteinaemia"],"prefix":"10.1016","volume":"59","author":[{"given":"Huaxin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuying","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoli","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoliang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yixin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingpo","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianfeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenxiu","family":"Leng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.archger.2014.04.005_bib0005","doi-asserted-by":"crossref","first-page":"911","DOI":"10.3949\/ccjm.77a.10036","article-title":"The homocysteine hypothesis: Still relevant to the prevention and treatment of cardiovascular disease?","volume":"77","author":"Abraham","year":"2010","journal-title":"Cleveland Clinic Journal of Medicine"},{"key":"10.1016\/j.archger.2014.04.005_bib0010","article-title":"High frequency of aspirin resistance in patients with nephrotic syndrome","author":"Akoglu","year":"2011","journal-title":"Nephrology, Dialysis, Transplantation"},{"key":"10.1016\/j.archger.2014.04.005_bib0015","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/S0049-3848(02)00405-X","article-title":"Aspirin non-responsiveness as measured by PFA-100 in patients with coronary artery disease","volume":"108","author":"Andersen","year":"2002","journal-title":"Thrombosis Research"},{"issue":"Suppl 1","key":"10.1016\/j.archger.2014.04.005_bib0020","doi-asserted-by":"crossref","first-page":"S56","DOI":"10.1038\/sj.cdd.4401451","article-title":"Role of hyperhomocysteinemia in endothelial dysfunction and atherothrombotic disease","volume":"11","author":"Austin","year":"2004","journal-title":"Cell Death and Differentiation"},{"key":"10.1016\/j.archger.2014.04.005_bib0025","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.thromres.2011.07.001","article-title":"Interaction between homocysteine and lipoprotein(a) increases the prevalence of coronary artery disease\/myocardial infarction in women: A case\u2013control study","volume":"129","author":"Balogh","year":"2012","journal-title":"Thrombosis Research"},{"key":"10.1016\/j.archger.2014.04.005_bib0030","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1186\/2193-1801-2-423","article-title":"Relationship between total homocysteine, total cholesterol and creatinine levels in overt hypothyroid patients","volume":"2","author":"Bamashmoos","year":"2013","journal-title":"Springerplus"},{"key":"10.1016\/j.archger.2014.04.005_bib0035","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1007\/s11239-011-0550-4","article-title":"Hyper-homocysteinemia: A novel risk factor or a powerful marker for cardiovascular diseases?. Pathogenetic and therapeutical uncertainties","volume":"32","author":"Cacciapuoti","year":"2011","journal-title":"Journal of Thrombosis and Thrombolysis"},{"key":"10.1016\/j.archger.2014.04.005_bib0040","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1001\/jama.288.16.2015","article-title":"Homocysteine and risk of ischemic heart disease and stroke: a meta-analysis","volume":"288","author":"Collaboration","year":"2002","journal-title":"Journal of the American Medical Association"},{"key":"10.1016\/j.archger.2014.04.005_bib0045","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1055\/s-2000-8469","article-title":"Homocysteine, coagulation, platelet function, and thrombosis","volume":"26","author":"Coppola","year":"2000","journal-title":"Seminars in Thrombosis and Hemostasis"},{"issue":"2","key":"10.1016\/j.archger.2014.04.005_bib0050","doi-asserted-by":"crossref","first-page":"e16473","DOI":"10.1371\/journal.pone.0016473","article-title":"Reconciling the Evidence on Serum Homocysteine and Ischaemic Heart Disease: A meta-analysis","volume":"6","author":"David","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.archger.2014.04.005_bib0055","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.2337\/diacare.24.10.1805","article-title":"The relationship among homocysteine, creatinine clearance, and albuminuria in patients with type 2 diabetes","author":"Davies","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.archger.2014.04.005_bib0060","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.2337\/db07-0707","article-title":"The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: An analysis from the aspirin-induced platelet effect (ASPECT) study","volume":"56","author":"DiChiara","year":"2007","journal-title":"Diabetes"},{"key":"10.1016\/j.archger.2014.04.005_bib0065","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1096\/fasebj.11.13.9367351","article-title":"Acute methionine load-induced hyperhomocysteinemia enhances platelet aggregation, thromboxane biosynthesis, and macrophage-derived tissue factor activity in rats","volume":"11","author":"Durand","year":"1997","journal-title":"FASEB Journal"},{"key":"10.1016\/j.archger.2014.04.005_bib0070","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/j.jacc.2007.11.080","article-title":"The role of aspirin in cardiovascular prevention: Implications of aspirin resistance","volume":"51","author":"Gasparyan","year":"2008","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.archger.2014.04.005_bib0075","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1017\/S0007114507691958","article-title":"Homocysteine increases the risk of mortality in elderly individuals","volume":"97","author":"Gonzalez","year":"2007","journal-title":"British Journal of Nutrition"},{"key":"10.1016\/j.archger.2014.04.005_bib0080","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1161\/CIRCULATIONAHA.106.675587","article-title":"U.S. Evaluation of dose-related effects of aspirin on platelet function: Results from the Aspirin-Induced Platelet Effect (ASPECT) study","volume":"115","author":"Gurbel","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.archger.2014.04.005_bib0085","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1001\/archinte.166.17.1842","article-title":"Impact of medication therapy discontinuation on mortality after myocardial infarction","volume":"166","author":"Ho","year":"2006","journal-title":"Archives of Internal Medicine"},{"key":"10.1016\/j.archger.2014.04.005_bib0090","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1538-7836.2006.02275.x","article-title":"Enhanced platelet activation in hyperhomocysteinemic individuals","volume":"5","author":"Holven","year":"2007","journal-title":"Journal of Thrombosis and Haemostasis"},{"key":"10.1016\/j.archger.2014.04.005_bib0095","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.ijcard.2006.10.025","article-title":"The frequency of aspirin resistance and its risk factors in patients with metabolic syndrome","volume":"115","author":"Kahraman","year":"2007","journal-title":"International Journal of Cardiology"},{"key":"10.1016\/j.archger.2014.04.005_bib0100","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1093\/eurheartj\/ehm226","article-title":"A comparison of six major platelet function tests to determine the prevalence of aspirin resistance in patients with stable coronary artery disease","volume":"28","author":"Lordkipanidze","year":"2007","journal-title":"European Heart Journal"},{"key":"10.1016\/j.archger.2014.04.005_bib0105","doi-asserted-by":"crossref","first-page":"185","DOI":"10.18388\/abp.2012_2137","article-title":"The disturbance of hemostasis induced by hyperhomocysteinemia; the role of antioxidants","volume":"59","author":"Malinowska","year":"2012","journal-title":"Acta Biochimica Polonica"},{"key":"10.1016\/j.archger.2014.04.005_bib0110","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1111\/j.1751-7176.2010.00307.x","article-title":"Aspirin resistance in hypertensive patients","volume":"12","author":"Ozben","year":"2010","journal-title":"Journal of Clinical Hypertension (Greenwich)"},{"key":"10.1016\/j.archger.2014.04.005_bib0115","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.jvs.2010.08.029","article-title":"Variability and persistence of aspirin response in lower extremity peripheral arterial disease patients","volume":"53","author":"Saunders","year":"2011","journal-title":"Journal of Vascular Surgery"},{"key":"10.1016\/j.archger.2014.04.005_bib0120","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1479-5876-6-46","article-title":"Non-compliance is the predominant cause of aspirin resistance in chronic coronary arterial disease patients","volume":"6","author":"Schwartz","year":"2008","journal-title":"Journal of Translational Medicine"},{"key":"10.1016\/j.archger.2014.04.005_bib0125","doi-asserted-by":"crossref","first-page":"1726S","DOI":"10.1093\/jn\/136.6.1726S","article-title":"The many facets of hyperhomocysteinemia: Studies from the Framingham cohorts","volume":"136","author":"Selhub","year":"2006","journal-title":"Journal of Nutrition"},{"key":"10.1016\/j.archger.2014.04.005_bib0130","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.niox.2008.11.005","article-title":"Homocysteine decreases platelet NO level via protein kinase C activation","volume":"20","author":"Signorello","year":"2009","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.archger.2014.04.005_bib0135","doi-asserted-by":"crossref","first-page":"636","DOI":"10.5301\/JN.2011.6259","article-title":"Aspirin resistance in patients with chronic renal failure","volume":"24","author":"Tanrikulu","year":"2011","journal-title":"Nephrol"},{"key":"10.1016\/j.archger.2014.04.005_bib0140","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jacc.2011.05.028","article-title":"Homocysteine and reclassification of cardiovascular disease risk","volume":"58","author":"Veeranna","year":"2011","journal-title":"Journal of the American College of Cardiology"},{"key":"10.1016\/j.archger.2014.04.005_bib0145","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1160\/TH05-04-0889","article-title":"Effect of compliance and dosage adaptation of long term aspirin on platelet function with PFA-100 in patients after myocardial infarction","volume":"94","author":"von Pape","year":"2005","journal-title":"Thrombosis and Haemostasis"},{"key":"10.1016\/j.archger.2014.04.005_bib0150","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1136\/bmj.325.7374.1202","article-title":"Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis","volume":"325","author":"Wald","year":"2002","journal-title":"BMJ"},{"key":"10.1016\/j.archger.2014.04.005_bib0155","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1161\/CIRCULATIONAHA.109.866889","article-title":"Hyperhomocysteinemia promotes inflammatory monocyte generation and accelerates atherosclerosis in transgenic cystathionine beta-synthase-deficient mice","volume":"120","author":"Zhang","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.archger.2014.04.005_bib0160","first-page":"727","article-title":"Resistance to acetylsalicylic acid in patients after ischemic stroke","volume":"118","author":"Zytkiewicz","year":"2008","journal-title":"Polskie Archiwum Medycyny Wewnetrznej"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016749431400051X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016749431400051X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,10]],"date-time":"2019-08-10T06:31:10Z","timestamp":1565418670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016749431400051X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["S016749431400051X"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2014.04.005","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High prevalence of aspirin resistance in elderly patients with cardiovascular disease (CVD) and hyperhomocysteinaemia","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2014.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ireland Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}