{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T21:33:26Z","timestamp":1792359206976,"version":"4.4.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["58\\u20131950\\u20130-014"],"award-info":[{"award-number":["58\\u20131950\\u20130-014"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","award":["0-014"],"award-info":[{"award-number":["0-014"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01 AG050499"],"award-info":[{"award-number":["U01 AG050499"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007154","name":"Wake Forest University","doi-asserted-by":"publisher","award":["1 P30 AG21332"],"award-info":[{"award-number":["1 P30 AG21332"]}],"id":[{"id":"10.13039\/100007154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007921","name":"University of Pittsburgh","doi-asserted-by":"publisher","award":["P30 AG024827"],"award-info":[{"award-number":["P30 AG024827"]}],"id":[{"id":"10.13039\/100007921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008090","name":"Tufts University","doi-asserted-by":"publisher","award":["1P30AG031679"],"award-info":[{"award-number":["1P30AG031679"]}],"id":[{"id":"10.13039\/100008090","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.archger.2020.104131","type":"journal-article","created":{"date-parts":[[2020,5,30]],"date-time":"2020-05-30T06:11:44Z","timestamp":1590819104000},"page":"104131","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: The ENRGISE Pilot study"],"prefix":"10.1016","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1549-6451","authenticated-orcid":false,"given":"Carlo","family":"Custodero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen D.","family":"Anton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P.","family":"Beavers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert T.","family":"Mankowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"McDermott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger A.","family":"Fielding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne B.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-2420","authenticated-orcid":false,"given":"Russel P.","family":"Tracy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen B.","family":"Kritchevsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter T.","family":"Ambrosius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Pahor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd M.","family":"Manini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.archger.2020.104131_bib0005","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1065874","article-title":"Identification of ubiquitin ligases required for skeletal muscle atrophy","volume":"294","author":"Bodine","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.archger.2020.104131_bib0010","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/gerona\/gln038","article-title":"Chronic inflammation is associated with low physical function in older adults across multiple comorbidities","volume":"64","author":"Brinkley","year":"2009","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.archger.2020.104131_bib0015","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/jcsm.12134","article-title":"Systemic inflammation, body composition, and physical performance in old community-dwellers","volume":"8","author":"Calvani","year":"2017","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"key":"10.1016\/j.archger.2020.104131_bib0020","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/gerona\/59.3.M242","article-title":"Inflammatory markers and physical performance in older persons: The InCHIANTI study","volume":"59","author":"Cesari","year":"2004","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.archger.2020.104131_bib0025","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.arr.2008.07.002","article-title":"Molecular inflammation: Underpinnings of aging and age-related diseases","volume":"8","author":"Chung","year":"2009","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.archger.2020.104131_bib0030","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1532-5415.1999.tb01583.x","article-title":"Serum IL-6 level and the development of disability in older persons","volume":"47","author":"Ferrucci","year":"1999","journal-title":"Journal of the American Geriatrics Society"},{"key":"10.1016\/j.archger.2020.104131_bib0035","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1046\/j.1532-5415.2002.50605.x","article-title":"Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels","volume":"50","author":"Ferrucci","year":"2002","journal-title":"Journal of the American Geriatrics Society"},{"key":"10.1016\/j.archger.2020.104131_bib0040","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1093\/gerona\/glw240","article-title":"Chronic inflammation: Accelerator of biological aging","volume":"72","author":"Fougere","year":"2017","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.archger.2020.104131_bib0045","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.tem.2016.09.005","article-title":"Inflammaging and\u2019 Garb-aging\u2019","volume":"28","author":"Franceschi","year":"2017","journal-title":"Trends in Endocrinology and Metabolism"},{"key":"10.1016\/j.archger.2020.104131_bib0050","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1093\/gerona\/61.10.1059","article-title":"The loss of skeletal muscle strength, mass, and quality in older adults: The health, aging and body composition study","volume":"61","author":"Goodpaster","year":"2006","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.archger.2020.104131_bib0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev.pu.17.050196.000325","article-title":"Disability as a public health outcome in the aging population","volume":"17","author":"Guralnik","year":"1996","journal-title":"Annual Review of Public Health"},{"key":"10.1016\/j.archger.2020.104131_bib0060","doi-asserted-by":"crossref","first-page":"M85","DOI":"10.1093\/geronj\/49.2.M85","article-title":"A short physical performance battery assessing lower extremity function: Association with self-reported disability and prediction of mortality and nursing home admission","volume":"49","author":"Guralnik","year":"1994","journal-title":"Journal of Gerontology"},{"key":"10.1016\/j.archger.2020.104131_bib0065","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1152\/japplphysiol.01026.2004","article-title":"IL-6-induced skeletal muscle atrophy","volume":"98","author":"Haddad","year":"2005","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.archger.2020.104131_bib0070","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2519\/jospt.1992.16.5.215","article-title":"Measurement of grip strength: Validity and reliability of the sphygmomanometer and jamar grip dynamometer","volume":"16","author":"Hamilton","year":"1992","journal-title":"Journal of Orthopaedic and Sports Physical Therapy"},{"key":"10.1016\/j.archger.2020.104131_bib0075","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/gerona\/glr055","article-title":"Absolute strength and loss of strength as predictors of mobility decline in older adults: The InCHIANTI study","volume":"67","author":"Hicks","year":"2012","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.archger.2020.104131_bib0080","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/gerona\/glp005","article-title":"Association between inflammatory components and physical function in the health, aging, and body composition study: A principal component analysis approach","volume":"64","author":"Hsu","year":"2009","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.archger.2020.104131_bib0085","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/jgs.12840","article-title":"Muscle strength and physical performance as predictors of mortality, hospitalization, and disability in the oldest old","volume":"62","author":"Legrand","year":"2014","journal-title":"Journal of the American Geriatrics Society"},{"key":"10.1016\/j.archger.2020.104131_bib0090","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1161\/01.CIR.102.14.1690","article-title":"Cardiac-specific overexpression of tumor necrosis factor-alpha causes oxidative stress and contractile dysfunction in mouse diaphragm","volume":"102","author":"Li","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.archger.2020.104131_bib0095","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/gerona\/61.6.575","article-title":"Interleukin-6 in aging and chronic disease: A magnificent pathway","volume":"61","author":"Maggio","year":"2006","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.archger.2020.104131_bib0100","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/gerona\/glr010","article-title":"Dynapenia and aging: An update","volume":"67","author":"Manini","year":"2012","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.archger.2020.104131_bib0105","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1111\/jgs.14965","article-title":"ENabling reduction of low-grade inflammation in SEniors Pilot Study: Concept, rationale, and design","volume":"65","author":"Manini","year":"2017","journal-title":"Journal of the American Geriatrics Society"},{"key":"10.1016\/j.archger.2020.104131_bib0110","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1001\/jama.295.17.2018","article-title":"Association of long-distance corridor walk performance with mortality, cardiovascular disease, mobility limitation, and disability","volume":"295","author":"Newman","year":"2006","journal-title":"JAMA"},{"key":"10.1016\/j.archger.2020.104131_bib0115","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1093\/ajcp\/102.6.802","article-title":"Variability of plasma IL-6 and crosslinked fibrin dimers over time in community dwelling elderly subjects","volume":"102","author":"Rao","year":"1994","journal-title":"American Journal of Clinical Pathology"},{"key":"10.1016\/j.archger.2020.104131_bib0120","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/00005768-200103000-00006","article-title":"Nitric oxide, reactive oxygen species, and skeletal muscle contraction","volume":"33","author":"Reid","year":"2001","journal-title":"Medicine and Science in Sports and Exercise"},{"key":"10.1016\/j.archger.2020.104131_bib0125","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1164\/rccm.2202005","article-title":"Respiratory and limb muscle weakness induced by tumor necrosis factor-alpha: Involvement of muscle myofilaments","volume":"166","author":"Reid","year":"2002","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"issue":"526","key":"10.1016\/j.archger.2020.104131_bib0130","first-page":"e529","article-title":"Inflammatory markers and loss of muscle mass (sarcopenia) and strength","volume":"119","author":"Schaap","year":"2006","journal-title":"American Journal of Medicine"},{"key":"10.1016\/j.archger.2020.104131_bib0135","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1152\/japplphysiol.01138.2006","article-title":"Free radical-mediated skeletal muscle dysfunction in inflammatory conditions","volume":"102","author":"Supinski","year":"2007","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.archger.2020.104131_bib0140","doi-asserted-by":"crossref","first-page":"M709","DOI":"10.1093\/gerona\/55.12.M709","article-title":"Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging","volume":"55","author":"Taaffe","year":"2000","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.archger.2020.104131_bib0145","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1007\/BF00643739","article-title":"Static and dynamic assessment of the biodex dynamometer","volume":"62","author":"Taylor","year":"1991","journal-title":"European Journal of Applied Physiology and Occupational Physiology"},{"key":"10.1016\/j.archger.2020.104131_bib0150","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1093\/gerona\/glr099","article-title":"Inflammatory markers and gait speed decline in older adults","volume":"66","author":"Verghese","year":"2011","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.archger.2020.104131_bib0155","doi-asserted-by":"crossref","first-page":"M326","DOI":"10.1093\/gerona\/57.5.M326","article-title":"Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: The Health ABC Study","volume":"57","author":"Visser","year":"2002","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.archger.2020.104131_bib0160","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jot.2017.05.006","article-title":"Inflammation and age-associated skeletal muscle deterioration (sarcopaenia)","volume":"10","author":"Wang","year":"2017","journal-title":"Journal of Orthopaedic Translation"},{"key":"10.1016\/j.archger.2020.104131_bib0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.arr.2017.01.006","article-title":"Frailty and sarcopenia: The potential role of an aged immune system","volume":"36","author":"Wilson","year":"2017","journal-title":"Ageing Research Reviews"},{"key":"10.1016\/j.archger.2020.104131_bib0170","doi-asserted-by":"crossref","first-page":"S146","DOI":"10.1093\/geronb\/60.3.S146","article-title":"Further evidence for the importance of subclinical functional limitation and subclinical disability assessment in gerontology and geriatrics","volume":"60","author":"Wolinsky","year":"2005","journal-title":"Journals of Gerontology. Series B, Psychological Sciences and Social Sciences"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494320301254?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494320301254?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T21:34:04Z","timestamp":1778535244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494320301254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":34,"alternative-id":["S0167494320301254"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2020.104131","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The relationship between interleukin-6 levels and physical performance in mobility-limited older adults with chronic low-grade inflammation: The ENRGISE Pilot study","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2020.104131","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104131"}}