{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:50:23Z","timestamp":1790607023694,"version":"4.1.0"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004257","name":"Helse Vest","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004257","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.archger.2021.104459","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T19:15:50Z","timestamp":1624562150000},"page":"104459","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Polypharmacy is associated with functional decline in Alzheimer's disease and Lewy body dementia"],"prefix":"10.1016","volume":"96","author":[{"given":"Miguel Germ\u00e1n","family":"Borda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicol\u00e1s","family":"Castellanos-Perilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego Alejandro","family":"Tovar-Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragnhild","family":"Oesterhus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hogne","family":"Soennesyn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.archger.2021.104459_bib0001","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1159\/000165917","article-title":"Frequency and case identification of dementia with Lewy bodies using the revised consensus criteria","volume":"26","author":"Aarsland","year":"2008","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"key":"10.1016\/j.archger.2021.104459_bib0002","first-page":"542","volume":"21","author":"Bayliss","year":"2020","journal-title":"The optimize patient- and family-centered, primary care-based deprescribing intervention for older adults with dementia or mild cognitive impairment and multiple chronic conditions: Study protocol for a pragmatic cluster randomized controlled trial"},{"key":"10.1016\/j.archger.2021.104459_bib0003","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1111\/j.1525-1497.2001.10918.x","article-title":"Functional status: The six vital sign","volume":"16","author":"Bierman","year":"2001","journal-title":"Journal of General Internal Medicine"},{"key":"10.1016\/j.archger.2021.104459_bib0004","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1111\/jgs.16709","article-title":"Neuropsychiatric symptoms and functional decline in Alzheimer's disease and Lewy body dementia","volume":"68","author":"Borda","year":"2020","journal-title":"Journal of the American Geriatrics Society"},{"issue":"4","key":"10.1016\/j.archger.2021.104459_bib0006","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.3233\/JAD-200961","article-title":"Association of malnutrition with functional and cognitive trajectories in people living with dementia: A five-year follow-up study","volume":"79","author":"Borda","year":"2021","journal-title":"Journal of Alzheimers Disease"},{"issue":"6","key":"10.1016\/j.archger.2021.104459_bib0007","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1002\/gps.5494","article-title":"Benzodiazepines and antidepressants: Effects on cognitive and functional decline in Alzheimer's disease and Lewy body dementia","volume":"36","author":"Borda","year":"2020","journal-title":"International Journal of Geriatric Psychiatry"},{"issue":"6","key":"10.1016\/j.archger.2021.104459_bib0008","doi-asserted-by":"crossref","first-page":"357","DOI":"10.2217\/nmt-2020-0039","article-title":"Hippocampal subfields and decline in activities of daily living in Alzheimer's disease and dementia with Lewy bodies","volume":"10","author":"Borda","year":"2020","journal-title":"Neurodegenerative Disease Management"},{"key":"10.1016\/j.archger.2021.104459_bib0009","article-title":"What works for whom in the management of diabetes in people living with dementia: A realist review","volume":"15","author":"Bunn","year":"2017","journal-title":"BMC Medicine [Electronic Resource]"},{"key":"10.1016\/j.archger.2021.104459_bib0010","first-page":"2308","volume":"44","author":"Cummings","year":"1994"},{"key":"10.1016\/j.archger.2021.104459_bib0011","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-029172","article-title":"Potentially inappropriate prescribing in dementia: A state-of-the-art review since 2007","volume":"10","author":"Delgado","year":"2020","journal-title":"BMJ Open"},{"key":"10.1016\/j.archger.2021.104459_bib0012","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1007\/s00228-019-02721-1","article-title":"Polypharmacy patterns in the last year of life in patients with dementia","volume":"75","author":"Denholm","year":"2019","journal-title":"European Journal of Clinical Pharmacology"},{"key":"10.1016\/j.archger.2021.104459_bib0013","first-page":"1376","volume":"394","author":"Dent","year":"2019"},{"key":"10.1016\/j.archger.2021.104459_bib0014","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1002\/mds.21507","article-title":"Clinical diagnostic criteria for dementia associated with Parkinson's disease","volume":"22","author":"Emre","year":"2007","journal-title":"Movement Disorders"},{"key":"10.1016\/j.archger.2021.104459_bib0015","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"Mini-Mental State\" A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"Journal of Psychiatric Research"},{"key":"10.1016\/j.archger.2021.104459_bib0016","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/ageing\/afm116","article-title":"Inappropriate prescribing in an acutely ill population of elderly patients as determined by Beers' Criteria","volume":"37","author":"Gallagher","year":"2008","journal-title":"Age and Ageing"},{"key":"10.1016\/j.archger.2021.104459_bib0017","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/gerona\/gly078","article-title":"The impact of dementia diagnosis on patterns of potentially inappropriate medication use among older adults","volume":"73","author":"Gnjidic","year":"2018","journal-title":"Journals of Gerontology. Series A, Biological Sciences and Medical Sciences"},{"key":"10.1016\/j.archger.2021.104459_bib0018","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/bcp.13590","article-title":"The relationship between frailty and polypharmacy in older people: A systematic review","volume":"84","author":"Guti\u00e9rrez-Valencia","year":"2018","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.archger.2021.104459_bib0019","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/pds.2116","article-title":"Association of polypharmacy with nutritional status, functional ability and cognitive capacity over a three-year period in an elderly population","volume":"20","author":"Jyrkk\u00e4","year":"2011","journal-title":"Pharmacoepidemiology and Drug Safety"},{"key":"10.1016\/j.archger.2021.104459_bib0020","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1007\/s11606-019-05106-3","article-title":"The association between polypharmacy and physical function in older adults: A systematic review","volume":"34","author":"Katsimpris","year":"2019","journal-title":"Journal of General Internal Medicine"},{"key":"10.1016\/j.archger.2021.104459_bib0021","doi-asserted-by":"crossref","DOI":"10.1177\/2042098620933741","article-title":"An overview of prevalence, determinants and health outcomes of polypharmacy","volume":"11","author":"Khezrian","year":"2020","journal-title":"Therapeutic Advances in Drug Safety"},{"key":"10.1016\/j.archger.2021.104459_bib0022","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3233\/JAD-170905","article-title":"Polypharmacy and potentially inappropriate medication in people with dementia: a nationwide study","volume":"63","author":"Kristensen","year":"2018","journal-title":"Journal of Alzheimers Disease"},{"key":"10.1016\/j.archger.2021.104459_bib0023","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1177\/2374373517727532","article-title":"Towards a more patient-centered approach to medication safety","volume":"5","author":"Lee","year":"2018","journal-title":"Journal of Patient Experience"},{"key":"10.1016\/j.archger.2021.104459_bib0024","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1532-5415.1968.tb02103.x","article-title":"Cumulative illness rating scale","volume":"16","author":"Linn","year":"1968","journal-title":"Journal of the American Geriatrics Society"},{"key":"10.1016\/j.archger.2021.104459_bib0025","volume":"24","author":"Linn","year":"1988"},{"key":"10.1016\/j.archger.2021.104459_bib0026","first-page":"2673","volume":"390","author":"Livingston","year":"2017"},{"key":"10.1016\/j.archger.2021.104459_bib0027","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1186\/s12889-019-7762-5","article-title":"Consequences of chronic diseases and other limitations associated with old age - a scoping review","volume":"19","author":"Maresova","year":"2019","journal-title":"BMC Public Health [Electronic Resource]"},{"key":"10.1016\/j.archger.2021.104459_bib0028","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/s12877-017-0621-2","article-title":"What is polypharmacy? A systematic review of definitions","volume":"17","author":"Masnoon","year":"2017","journal-title":"BMC Geriatrics"},{"key":"10.1016\/j.archger.2021.104459_bib0029","first-page":"88","volume":"89","author":"McKeith","year":"2017","journal-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB consortium"},{"key":"10.1016\/j.archger.2021.104459_bib0030","first-page":"939","volume":"34","author":"McKhann","year":"1984","journal-title":"Clinical diagnosis of Alzheimer's disease: Report of the nincds-adrda work group under the auspices of department of health and human services task force on Alzheimer's disease"},{"key":"10.1016\/j.archger.2021.104459_bib0031","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1007\/s00228-018-2446-0","article-title":"Potentially inappropriate medication in the elderly: A systematic review of validated explicit criteria","volume":"74","author":"Motter","year":"2018","journal-title":"European Journal of Clinical Pharmacology"},{"key":"10.1016\/j.archger.2021.104459_bib0032","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.exger.2018.02.011","article-title":"Polypharmacy in people with dementia: Associations with adverse health outcomes","volume":"106","author":"Mueller","year":"2018","journal-title":"Experimental Gerontology"},{"key":"10.1016\/j.archger.2021.104459_bib0033","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/ggi.12217","article-title":"Comprehensive geriatric assessment in elderly patients with dementia","volume":"15","author":"Namioka","year":"2015","journal-title":"Geriatrics & Gerontology International"},{"key":"10.1016\/j.archger.2021.104459_bib0034","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/gps.4456","article-title":"Potentially inappropriate medications and drug-drug interactions in home-dwelling people with mild dementia","volume":"32","author":"Oesterhus","year":"2017","journal-title":"International Journal of Geriatric Psychiatry"},{"key":"10.1016\/j.archger.2021.104459_bib0035","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1080\/17512433.2020.1697676","article-title":"STOPP\/START criteria for potentially inappropriate medications\/potential prescribing omissions in older people: Origin and progress","volume":"13","author":"O'Mahony","year":"2020","journal-title":"Expert Review of Clinical Pharmacology"},{"key":"10.1016\/j.archger.2021.104459_bib0036","first-page":"1","article-title":"Deprescribing in older people","volume":"81","author":"O'Mahony","year":"2020","journal-title":"British Journal of Hospital Medicine"},{"key":"10.1016\/j.archger.2021.104459_bib0037","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/jppr.1403","article-title":"Medication use to manage comorbidities for people with dementia: A systematic review","volume":"48","author":"Page","year":"2018","journal-title":"Journal of Pharmacy Practice and Research"},{"key":"10.1016\/j.archger.2021.104459_bib0038","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s41999-018-0124-5","article-title":"Association of polypharmacy and hyperpolypharmacy with frailty states: A systematic review and meta-analysis","volume":"10","author":"Palmer","year":"2019","journal-title":"European Geriatric Medicine"},{"key":"10.1016\/j.archger.2021.104459_bib0039","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1177\/2042098616670798","article-title":"Polypharmacy and inappropriate medication use in patients with dementia: An underresearched problem","volume":"8","author":"Parsons","year":"2017","journal-title":"Therapeutic Advances in Drug Safety"},{"key":"10.1016\/j.archger.2021.104459_bib0040","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1001\/jama.2008.892","article-title":"Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States","volume":"300","author":"Qato","year":"2008","journal-title":"Jama"},{"key":"10.1016\/j.archger.2021.104459_bib0041","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.jgo.2013.04.002","article-title":"Improved targeting of cancer care for older patients: A systematic review of the utility of comprehensive geriatric assessment","volume":"4","author":"Ramjaun","year":"2013","journal-title":"Journal of Geriatric Oncology"},{"key":"10.1016\/j.archger.2021.104459_bib0042","article-title":"Interventions to improve the appropriate use of polypharmacy for older people","volume":"9","author":"Rankin","year":"2018","journal-title":"Cochrane Database of Systematic Reviews (Online)"},{"key":"10.1016\/j.archger.2021.104459_bib0043","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1111\/jgs.15317","article-title":"Associations between polypharmacy and cognitive and physical capability: A British birth cohort study","volume":"66","author":"Rawle","year":"2018","journal-title":"Journal of the American Geriatrics Society"},{"key":"10.1016\/j.archger.2021.104459_bib0044","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000437093","article-title":"The reliability and validity of the norwegian version of the quality of life in late-stage dementia scale","volume":"40","author":"R\u00f8en","year":"2015","journal-title":"Dementia and Geriatric Cognitive Disorders"},{"key":"10.1016\/j.archger.2021.104459_bib0045","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010357","article-title":"Cognitive decline in dementia with Lewy bodies: A 5-year prospective cohort study","volume":"6","author":"Rongve","year":"2016","journal-title":"BMJ Open"},{"key":"10.1016\/j.archger.2021.104459_bib0046","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/jhm.2614","article-title":"Medications associated with geriatric syndromes and their prevalence in older hospitalized adults discharged to skilled nursing facilities","volume":"11","author":"Saraf","year":"2016","journal-title":"Journal of Hospital Medicine"},{"key":"10.1016\/j.archger.2021.104459_bib0047","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1001\/archneur.62.10.1601","article-title":"Delusions and hallucinations are associated with worse outcome in Alzheimer disease","volume":"62","author":"Scarmeas","year":"2005","journal-title":"Archives of Neurology"},{"key":"10.1016\/j.archger.2021.104459_bib0048","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.3233\/JAD-170274","article-title":"Accuracy of clinical diagnosis of dementia with Lewy bodies versus neuropathology","volume":"59","author":"Skogseth","year":"2017","journal-title":"Journal of Alzheimers Disease"},{"key":"10.1016\/j.archger.2021.104459_bib0049","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1192\/bjp.180.3.270","article-title":"Islington study of dementia subtypes in the community","volume":"180","author":"Stevens","year":"2002","journal-title":"British Journal of Psychiatry"},{"key":"10.1016\/j.archger.2021.104459_bib0050","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1001\/jamainternmed.2014.4103","article-title":"Use of medications of questionable benefit in advanced dementia","volume":"174","author":"Tjia","year":"2014","journal-title":"JAMA Internal Medicine"},{"key":"10.1016\/j.archger.2021.104459_bib0051","article-title":"Declining use of potentially inappropriate medication in people with dementia from 2000 to 2015: A repeated cross-sectional nationwide register-based study","author":"Underlien Kristensen","year":"2021","journal-title":"Journal of Alzheimers Disease"},{"key":"10.1016\/j.archger.2021.104459_bib0052","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1002\/gps.4933","article-title":"Course of neuropsychiatric symptoms in dementia: 5-year longitudinal study","volume":"33","author":"Vik-Mo","year":"2018","journal-title":"International Journal of Geriatric Psychiatry"},{"key":"10.1016\/j.archger.2021.104459_bib0053","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2318-14-19","article-title":"The treatment of hypertension in people with dementia: A systematic review of observational studies","volume":"14","author":"Welsh","year":"2014","journal-title":"BMC Geriatrics"},{"key":"10.1016\/j.archger.2021.104459_bib0054","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/ijcp.12313","article-title":"Comprehensive geriatric assessment\u2013a guide for the non-specialist","volume":"68","author":"Welsh","year":"2014","journal-title":"International Journal of Clinical Practice"},{"key":"10.1016\/j.archger.2021.104459_bib0055","unstructured":"WHO, (2014). Collaborating centre for drug statistics methodology."}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494321001229?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494321001229?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:08:32Z","timestamp":1759090112000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494321001229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":54,"alternative-id":["S0167494321001229"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2021.104459","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Polypharmacy is associated with functional decline in Alzheimer's disease and Lewy body dementia","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2021.104459","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104459"}}