{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T04:12:47Z","timestamp":1776485567061,"version":"3.51.2"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.archger.2022.104661","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T18:10:02Z","timestamp":1645294202000},"page":"104661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Frailty and outcomes in older adults with non-valvular atrial fibrillation from the ANAFIE registry"],"prefix":"10.1016","volume":"101","author":[{"given":"Masahiro","family":"Akishita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Suzuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Akao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotsugu","family":"Atarashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Ikeda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Koretsune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Okumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wataru","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Tsutsui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yasaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takenori","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Teramukai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Kimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiyuki","family":"Morishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Takita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.archger.2022.104661_bib0001","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1186\/s12913-016-1360-3","article-title":"Associations of frailty with health care costs\u2013results of the ESTHER cohort study","volume":"16","author":"Bock","year":"2016","journal-title":"BMC Health Services Research"},{"key":"10.1016\/j.archger.2022.104661_bib0002","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jamda.2015.12.016","article-title":"Frailty: An emerging public health priority","volume":"17","author":"Cesari","year":"2016","journal-title":"Journal of the American Medical Directors Association"},{"key":"10.1016\/j.archger.2022.104661_bib0003","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1111\/ggi.12360","article-title":"Relationships between each category of 25-item frailty risk assessment (Kihon Checklist) and newly certified older adults under long-term care insurance: A 24-month follow-up study in a rural community in Japan","volume":"15","author":"Fukutomi","year":"2015","journal-title":"Geriatrics & Gerontology International"},{"key":"10.1016\/j.archger.2022.104661_bib0004","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jamda.2014.12.008","article-title":"Thromboembolic prevention in frail elderly patients with atrial fibrillation: A practical algorithm","volume":"16","author":"Granziera","year":"2015","journal-title":"Journal of the American Medical Directors Association"},{"key":"10.1016\/j.archger.2022.104661_bib0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11739-018-1938-3","article-title":"Influence of frailty on anticoagulant prescription and clinical outcomes after 1-year follow-up in hospitalised older patients with atrial fibrillation","volume":"14","author":"Gull\u00f3n","year":"2019","journal-title":"Internal and Emergency Medicine"},{"key":"10.1016\/j.archger.2022.104661_bib0006","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1253\/circj.CJ-14-1245","article-title":"Low body weight is associated with the incidence of stroke in atrial fibrillation patients - Insight from the Fushimi AF Registry","volume":"79","author":"Hamatani","year":"2015","journal-title":"Circulation Journal"},{"key":"10.1016\/j.archger.2022.104661_bib0007","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/S0140-6736(19)31786-6","article-title":"Frailty: Implications for clinical practice and public health","volume":"394","author":"Hoogendijk","year":"2019","journal-title":"Lancet"},{"key":"10.1016\/j.archger.2022.104661_bib0008","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jjcc.2018.02.018","article-title":"Prospective observational study in elderly patients with non-valvular atrial fibrillation: Rationale and design of the All Nippon AF In the Elderly (ANAFIE) Registry","volume":"72","author":"Inoue","year":"2018","journal-title":"Journal of Cardiology"},{"key":"10.1016\/j.archger.2022.104661_bib0009","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.archger.2016.12.001","article-title":"Clinical implication of frailty assessment in older patients with atrial fibrillation","volume":"70","author":"Kim","year":"2017","journal-title":"Archives of Gerontology and Geriatrics"},{"key":"10.1016\/j.archger.2022.104661_bib0010","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.je.2016.09.008","article-title":"Prevalence of frailty in Japan: A systematic review and meta-analysis","volume":"27","author":"Kojima","year":"2017","journal-title":"Journal of Epidemiology"},{"key":"10.1016\/j.archger.2022.104661_bib0011","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.jamda.2015.06.025","article-title":"Prevalence of frailty in nursing homes: A systematic review and meta-analysis","volume":"16","author":"Kojima","year":"2015","journal-title":"Journal of the American Medical Directors Association"},{"key":"10.1016\/j.archger.2022.104661_bib0012","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1080\/09638288.2016.1212282","article-title":"Frailty as a predictor of disabilities among community-dwelling older people: A systematic review and meta-analysis","volume":"39","author":"Kojima","year":"2017","journal-title":"Disability and Rehabilitation"},{"key":"10.1016\/j.archger.2022.104661_bib0013","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jamda.2018.04.006","article-title":"Frailty defined by FRAIL Scale as a predictor of mortality: A systematic review and meta-analysis","volume":"19","author":"Kojima","year":"2018","journal-title":"Journal of the American Medical Directors Association"},{"key":"10.1016\/j.archger.2022.104661_bib0014","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1253\/circj.CJ-19-0094","article-title":"Baseline demographics and clinical characteristics in the All Nippon AF in the Elderly (ANAFIE) Registry","volume":"83","author":"Koretsune","year":"2019","journal-title":"Circulation Journal"},{"key":"10.1016\/j.archger.2022.104661_bib0015","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/ggi.14331","article-title":"Relationship between the Kihon Checklist and all-cause hospitalization among community-dwelling older adults","volume":"22","author":"Koyama","year":"2021","journal-title":"Geriatrics & Gerontology International"},{"key":"10.1016\/j.archger.2022.104661_bib0016","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jamda.2017.03.015","article-title":"Integrated care: Enhancing the role of the primary health care professional in preventing functional decline: A systematic review","volume":"18","author":"Morley","year":"2017","journal-title":"Journal of the American Medical Directors Association"},{"key":"10.1016\/j.archger.2022.104661_bib0017","doi-asserted-by":"crossref","DOI":"10.1016\/j.archger.2021.104519","article-title":"Bidirectional relationship between insomnia and frailty in older adults: A 2-year longitudinal study","volume":"97","author":"Nemoto","year":"2021","journal-title":"Archives of Gerontology and Geriatrics"},{"key":"10.1016\/j.archger.2022.104661_bib0018","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.8398","article-title":"Global incidence of frailty and prefrailty among community-dwelling older adults: A systematic review and meta-analysis","volume":"2","author":"Ofori-Asenso","year":"2019","journal-title":"JAMA Network Open"},{"key":"10.1016\/j.archger.2022.104661_bib0019","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/geriatrics5010017","article-title":"Frailty confers high mortality risk across different populations: Evidence from an overview of systematic reviews and meta-analyses","volume":"5","author":"Ofori-Asenso","year":"2020","journal-title":"Geriatrics (Basel)"},{"key":"10.1016\/j.archger.2022.104661_bib0020","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1253\/circj.CJ-20-0373","article-title":"Impact of frailty on bleeding events related to anticoagulation therapy in patients with atrial fibrillation","volume":"85","author":"Ohta","year":"2021","journal-title":"Circulation Journal"},{"key":"10.1016\/j.archger.2022.104661_bib0021","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2020.2881","article-title":"Risk factors associated with ischemic stroke in japanese patients with nonvalvular atrial fibrillation","volume":"3","author":"Okumura","year":"2020","journal-title":"JAMA Network Open"},{"key":"10.1016\/j.archger.2022.104661_bib0022","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.018557","article-title":"Association between frailty and atrial fibrillation in older adults: The Framingham Heart Study Offspring Cohort","volume":"10","author":"Orkaby","year":"2021","journal-title":"Journal of the American Heart Association"},{"key":"10.1016\/j.archger.2022.104661_bib0023","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1093\/gerona\/glv228","article-title":"Characterizing frailty status in the systolic Blood Pressure Intervention Trial","volume":"71","author":"Pajewski","year":"2016","journal-title":"The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences Sc"},{"key":"10.1016\/j.archger.2022.104661_bib0024","first-page":"17","article-title":"Comparison of the measurement properties of the functional independence and difficulty scale with the Barthel index in community-dwelling elderly people in Japan","volume":"28","author":"Saito","year":"2016","journal-title":"Aging Clinical and Experimental Research"},{"key":"10.1016\/j.archger.2022.104661_bib0025","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/ggi.12543","article-title":"Validity of the Kihon Checklist for assessing frailty status","volume":"16","author":"Satake","year":"2016","journal-title":"Geriatrics & Gerontology International"},{"key":"10.1016\/j.archger.2022.104661_bib0026","doi-asserted-by":"crossref","first-page":"39","DOI":"10.2165\/11319540-000000000-00000","article-title":"Reasons for undertreatment with oral anticoagulants in frail geriatric outpatients with atrial fibrillation: A prospective, descriptive study","volume":"27","author":"Tulner","year":"2010","journal-title":"Drugs & Aging"},{"key":"10.1016\/j.archger.2022.104661_bib0027","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejim.2018.04.018","article-title":"Frailty and atrial fibrillation: A systematic review","volume":"56","author":"Villani","year":"2018","journal-title":"European Journal of Internal Medicine"},{"key":"10.1016\/j.archger.2022.104661_bib0028","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/ageing\/afy180","article-title":"Management of atrial fibrillation for older people with frailty: A systematic review and meta-analysis","volume":"48","author":"Wilkinson","year":"2019","journal-title":"Age and Ageing"},{"key":"10.1016\/j.archger.2022.104661_bib0029","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1186\/s12916-020-01870-w","article-title":"Clinical outcomes in patients with atrial fibrillation and frailty: Insights from the ENGAGE AF-TIMI 48 trial","volume":"18","author":"Wilkinson","year":"2020","journal-title":"BMC Medicine"},{"key":"10.1016\/j.archger.2022.104661_bib0030","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1161\/01.STR.22.8.983","article-title":"Atrial fibrillation as an independent risk factor for stroke: The Framingham Study","volume":"22","author":"Wolf","year":"1991","journal-title":"Stroke"},{"key":"10.1016\/j.archger.2022.104661_bib0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cger.2010.08.009","article-title":"The frailty syndrome: Definition and natural history","volume":"27","author":"Xue","year":"2011","journal-title":"Clinics in Geriatric Medicine"},{"key":"10.1016\/j.archger.2022.104661_bib0032","article-title":"Two-year outcomes of more than 30 000 elderly patients with atrial fibrillation: Results from the All Nippon AF In the Elderly (ANAFIE) Registry","author":"Yamashita","year":"2021","journal-title":"European Heart Journal - Quality of Care and Clinical Outcomes"},{"key":"10.1016\/j.archger.2022.104661_bib0033","doi-asserted-by":"crossref","first-page":"E25940","DOI":"10.1097\/MD.0000000000025940","article-title":"Exercise interventions for older people at risk for frailty: A protocol for systematic review and meta-analysis","volume":"100","author":"Zhang","year":"2021","journal-title":"Medicine"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494322000425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494322000425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:10:00Z","timestamp":1759090200000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494322000425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":33,"alternative-id":["S0167494322000425"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2022.104661","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frailty and outcomes in older adults with non-valvular atrial fibrillation from the ANAFIE registry","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2022.104661","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"104661"}}