{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T14:34:09Z","timestamp":1777473249935,"version":"3.51.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81,971,160"],"award-info":[{"award-number":["81,971,160"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["BYSYZHKC2021106"],"award-info":[{"award-number":["BYSYZHKC2021106"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.archger.2023.105302","type":"journal-article","created":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T07:34:52Z","timestamp":1701588892000},"page":"105302","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["The causal effect of sarcopenia-associated traits on brain cortical structure: A Mendelian randomization study"],"prefix":"10.1016","volume":"118","author":[{"given":"Shilong","family":"Su","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruideng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.archger.2023.105302_bib0001","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s00221-011-2991-6","article-title":"Asymmetry in grasp force matching and sense of effort","volume":"217","author":"Adamo","year":"2012","journal-title":"Exp Brain Res"},{"issue":"1","key":"10.1016\/j.archger.2023.105302_bib0002","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s11682-021-00496-7","article-title":"Associations between gait speed and brain structure in amnestic mild cognitive impairment: a quantitative neuroimaging study","volume":"16","author":"Ali","year":"2022","journal-title":"Brain Imaging Behav"},{"issue":"5","key":"10.1016\/j.archger.2023.105302_bib0003","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1002\/jcsm.13055","article-title":"Role of sarcopenia in the frailty transitions in older adults: a population-based cohort study","volume":"13","author":"Alvarez-Bustos","year":"2022","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"8","key":"10.1016\/j.archger.2023.105302_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/nu15081853","article-title":"Sarcopenia and Cognitive Decline in Older Adults: Targeting the Muscle-Brain Axis","volume":"15","author":"Arosio","year":"2023","journal-title":"Nutrients"},{"issue":"6566","key":"10.1016\/j.archger.2023.105302_bib0005","doi-asserted-by":"crossref","first-page":"eabm7211","DOI":"10.1126\/science.abm7211","article-title":"The genetic architecture of the human cerebral cortex","volume":"374","author":"Article","year":"2021","journal-title":"Science"},{"issue":"15","key":"10.1016\/j.archger.2023.105302_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10153271","article-title":"Evidence of a Muscle-Brain Axis by Quantification of the Neurotrophic Myokine METRNL (Meteorin-Like Protein) in Human Cerebrospinal Fluid and Serum","volume":"10","author":"Berghoff","year":"2021","journal-title":"J Clin Med"},{"key":"10.1016\/j.archger.2023.105302_bib0007","doi-asserted-by":"crossref","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.1","article-title":"Guidelines for performing Mendelian randomization investigations","volume":"4","author":"Burgess","year":"2019","journal-title":"Wellcome Open Res"},{"issue":"7","key":"10.1016\/j.archger.2023.105302_bib0008","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/gepi.21998","article-title":"Bias due to participant overlap in two-sample Mendelian randomization","volume":"40","author":"Burgess","year":"2016","journal-title":"Genet Epidemiol"},{"issue":"4","key":"10.1016\/j.archger.2023.105302_bib0009","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1001\/archneurol.2010.38","article-title":"Reduced lean mass in early Alzheimer disease and its association with brain atrophy","volume":"67","author":"Burns","year":"2010","journal-title":"Arch Neurol"},{"issue":"12","key":"10.1016\/j.archger.2023.105302_bib0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22126479","article-title":"The Muscle-Brain Axis and Neurodegenerative Diseases: The Key Role of Mitochondria in Exercise-Induced Neuroprotection","volume":"22","author":"Burtscher","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.archger.2023.105302_bib0011","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.neurobiolaging.2018.07.023","article-title":"Get a grip: individual variations in grip strength are a marker of brain health","volume":"71","author":"Carson","year":"2018","journal-title":"Neurobiol Aging"},{"issue":"12","key":"10.1016\/j.archger.2023.105302_bib0012","doi-asserted-by":"crossref","first-page":"1164e7","DOI":"10.1016\/j.jamda.2016.09.013","article-title":"Association Between Sarcopenia and Cognitive Impairment: A Systematic Review and Meta-Analysis","volume":"17","author":"Chang","year":"2016","journal-title":"J Am Med Dir Assoc"},{"issue":"7726","key":"10.1016\/j.archger.2023.105302_bib0013","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/d41586-018-06948-3","article-title":"UK Biobank shares the promise of big data","volume":"562","author":"Cox","year":"2018","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.archger.2023.105302_bib0014","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1093\/ageing\/afq034","article-title":"Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People","volume":"39","author":"Cruz-Jentoft","year":"2010","journal-title":"Age Ageing"},{"issue":"1","key":"10.1016\/j.archger.2023.105302_bib0015","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/ageing\/afy169","article-title":"Sarcopenia: revised European consensus on definition and diagnosis","volume":"48","author":"Cruz-Jentoft","year":"2019","journal-title":"Age Ageing"},{"issue":"10191","key":"10.1016\/j.archger.2023.105302_bib0016","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1016\/S0140-6736(19)31138-9","volume":"393","author":"Cruz-Jentoft","year":"2019","journal-title":"Lancet"},{"issue":"R1","key":"10.1016\/j.archger.2023.105302_bib0017","doi-asserted-by":"crossref","first-page":"R89","DOI":"10.1093\/hmg\/ddu328","article-title":"Mendelian randomization: genetic anchors for causal inference in epidemiological studies","volume":"23","author":"Davey Smith","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"3","key":"10.1016\/j.archger.2023.105302_bib0018","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"issue":"19","key":"10.1016\/j.archger.2023.105302_bib0019","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1001\/jama.2017.17219","volume":"318","author":"Emdin","year":"2017","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.archger.2023.105302_bib0020","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.clnu.2013.01.010","article-title":"Sarcopenia: prevalence and prognostic significance in hospitalized patients","volume":"32","author":"Gariballa","year":"2013","journal-title":"Clin Nutr"},{"key":"10.1016\/j.archger.2023.105302_bib0021","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/bs.pmbts.2015.07.002","article-title":"Exercise and Regulation of Adipokine and Myokine Production","volume":"135","author":"Gorgens","year":"2015","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"6484","key":"10.1016\/j.archger.2023.105302_bib0022","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay6690","article-title":"The genetic architecture of the human cerebral cortex","volume":"367","author":"Grasby","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.archger.2023.105302_bib0023","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1221653","article-title":"Muscle-Brain crosstalk in cognitive impairment","volume":"15","author":"Han","year":"2023","journal-title":"Front Aging Neurosci"},{"issue":"2","key":"10.1016\/j.archger.2023.105302_bib0024","first-page":"136","article-title":"Association between structural changes in brain with muscle function in sarcopenic older women: the women's healthy ageing project (WHAP)","volume":"19","author":"Hassan","year":"2019","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"10.1016\/j.archger.2023.105302_bib0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2021.111402","article-title":"Sarcopenia is independently associated with parietal atrophy in older adults","volume":"151","author":"Hsu","year":"2021","journal-title":"Exp Gerontol"},{"issue":"11","key":"10.1016\/j.archger.2023.105302_bib0026","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1111\/j.1532-5415.2011.03664.x","article-title":"Depression is associated with sarcopenia, not central obesity, in elderly korean men","volume":"59","author":"Kim","year":"2011","journal-title":"J Am Geriatr Soc"},{"issue":"1","key":"10.1016\/j.archger.2023.105302_bib0027","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1002\/jcsm.12651","article-title":"Sarcopenia: prevalence, associated factors, and the risk of mortality and disability in Japanese older adults","volume":"12","author":"Kitamura","year":"2021","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"4","key":"10.1016\/j.archger.2023.105302_bib0028","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1002\/jcsm.12195","article-title":"Muscle mass decline, arterial stiffness, white matter hyperintensity, and cognitive impairment: Japan Shimanami Health Promoting Program study","volume":"8","author":"Kohara","year":"2017","journal-title":"J Cachexia Sarcopenia Muscle"},{"issue":"3","key":"10.1016\/j.archger.2023.105302_bib0029","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s10571-017-0510-4","article-title":"BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity","volume":"38","author":"Kowianski","year":"2018","journal-title":"Cell Mol Neurobiol"},{"issue":"8","key":"10.1016\/j.archger.2023.105302_bib0030","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jagp.2019.02.018","article-title":"Deterioration of Brain Neural Tracts in Elderly Women with Sarcopenia. The American journal of geriatric psychiatry: official journal of the American Association for","volume":"27","author":"Kwak","year":"2019","journal-title":"Geriatric Psychiatry"},{"issue":"11","key":"10.1016\/j.archger.2023.105302_bib0031","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1111\/j.1467-9280.2009.02447.x","article-title":"Asymmetrical body perception: a possible role for neural body representations","volume":"20","author":"Linkenauger","year":"2009","journal-title":"Psychol Sci"},{"issue":"1","key":"10.1016\/j.archger.2023.105302_bib0032","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1038\/s42003-022-04221-y","article-title":"Representations and decodability of diverse cognitive functions are preserved across the human cortex, cerebellum, and subcortex","volume":"5","author":"Nakai","year":"2022","journal-title":"Commun Biol"},{"issue":"3","key":"10.1016\/j.archger.2023.105302_bib0033","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1177\/0962280210394459","article-title":"Using multiple genetic variants as instrumental variables for modifiable risk factors","volume":"21","author":"Palmer","year":"2012","journal-title":"Stat Methods Med Res"},{"issue":"5","key":"10.1016\/j.archger.2023.105302_bib0034","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s11914-015-0279-7","article-title":"Sarcopenia and the Common Mental Disorders: a Potential Regulatory Role of Skeletal Muscle on Brain Function?","volume":"13","author":"Pasco","year":"2015","journal-title":"Curr Osteoporos Rep"},{"issue":"8","key":"10.1016\/j.archger.2023.105302_bib0035","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrendo.2012.49","article-title":"Muscles, exercise and obesity: skeletal muscle as a secretory organ","volume":"8","author":"Pedersen","year":"2012","journal-title":"Nat Rev Endocrinol"},{"issue":"7","key":"10.1016\/j.archger.2023.105302_bib0036","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41574-019-0174-x","article-title":"Physical activity and muscle-brain crosstalk","volume":"15","author":"Pedersen","year":"2019","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"10.1016\/j.archger.2023.105302_bib0037","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s42003-020-01334-0","article-title":"The genetic architecture of appendicular lean mass characterized by association analysis in the UK Biobank study","volume":"3","author":"Pei","year":"2020","journal-title":"Commun Biol"},{"issue":"2","key":"10.1016\/j.archger.2023.105302_bib0038","article-title":"Sarcopenia and Cognitive Function: Role of Myokines in Muscle Brain Cross-Talk","volume":"11","author":"Scisciola","year":"2021","journal-title":"Life (Basel)"},{"issue":"11","key":"10.1016\/j.archger.2023.105302_bib0039","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1093\/gerona\/glr138","article-title":"Increases in muscle strength and balance using a resistance training program administered via a telecommunications system in older adults","volume":"66","author":"Sparrow","year":"2011","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"20","key":"10.1016\/j.archger.2023.105302_bib0040","doi-asserted-by":"crossref","first-page":"3207","DOI":"10.1093\/bioinformatics\/btw373","article-title":"PhenoScanner: a database of human genotype-phenotype associations","volume":"32","author":"Staley","year":"2016","journal-title":"Bioinformatics"},{"issue":"1","key":"10.1016\/j.archger.2023.105302_bib0041","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1038\/s41467-022-29886-1","article-title":"Genetic and phylogenetic uncoupling of structure and function in human transmodal cortex","volume":"13","author":"Valk","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.archger.2023.105302_bib0042","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.neuroimage.2012.09.005","article-title":"Fat-free body mass but not fat mass is associated with reduced gray matter volume of cortical brain regions implicated in autonomic and homeostatic regulation","volume":"64","author":"Weise","year":"2013","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.archger.2023.105302_bib0043","doi-asserted-by":"crossref","first-page":"igac073","DOI":"10.1093\/geroni\/igac073","article-title":"Muscle Health Patterns and Brain MRI Indices: A Cluster Analysis","volume":"7","author":"Wu","year":"2023","journal-title":"Innov Aging"},{"key":"10.1016\/j.archger.2023.105302_bib0044","article-title":"Epidemiology of sarcopenia: Prevalence, risk factors, and consequences","author":"Yuan","year":"2023","journal-title":"Metabolism"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494323003801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494323003801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:14:25Z","timestamp":1759090465000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494323003801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":44,"alternative-id":["S0167494323003801"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2023.105302","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The causal effect of sarcopenia-associated traits on brain cortical structure: A Mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2023.105302","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"105302"}}