{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:57:09Z","timestamp":1790351829311,"version":"4.1.0"},"reference-count":116,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,6]],"date-time":"2024-11-06T00:00:00Z","timestamp":1730851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.archger.2024.105684","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T20:14:48Z","timestamp":1731442488000},"page":"105684","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["The molecular mechanisms of steroid hormone effects on cognitive function"],"prefix":"10.1016","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8419-7784","authenticated-orcid":false,"given":"Hai Duc","family":"Nguyen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giang Huong","family":"Vu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Woong-Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.archger.2024.105684_bib0001","doi-asserted-by":"crossref","first-page":"366","DOI":"10.4161\/gmic.21287","article-title":"Gut microbial communities modulating brain development and function","volume":"3","author":"Al-Asmakh","year":"2012","journal-title":"Gut Microbes"},{"key":"10.1016\/j.archger.2024.105684_bib0002","unstructured":"Barta, T., Peskova, L., Hampl, A., 2016. miRNAsong."},{"key":"10.1016\/j.archger.2024.105684_bib0003","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.psyneuen.2015.04.020","article-title":"Distinct cognitive effects of estrogen and progesterone in menopausal women","volume":"59","author":"Berent-Spillson","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.archger.2024.105684_bib0004","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.bj.2020.11.007","article-title":"Sex hormone regulation of innate lymphoid cells","volume":"44","author":"Blanquart","year":"2021","journal-title":"Biomedical Journal"},{"key":"10.1016\/j.archger.2024.105684_bib0005","doi-asserted-by":"crossref","first-page":"4283","DOI":"10.1523\/JNEUROSCI.4814-07.2008","article-title":"Dynamics of the microglial\/amyloid interaction indicate a role in plaque maintenance","volume":"28","author":"Bolmont","year":"2008","journal-title":"The Journal of neuroscience : The Official Journal of the Society for Neuroscience"},{"key":"10.1016\/j.archger.2024.105684_bib0006","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20215403","article-title":"Meta-analysis of gene expression changes in the blood of patients with mild cognitive impairment and Alzheimer's disease dementia","volume":"20","author":"Bottero","year":"2019","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.archger.2024.105684_bib0007","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1212\/WNL.0000000000002387","article-title":"Higher brain BDNF gene expression is associated with slower cognitive decline in older adults","volume":"86","author":"Buchman","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.archger.2024.105684_bib0008","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1210\/js.2019-00119","article-title":"Testosterone supplementation and cognitive functioning in men\u2014A systematic review and meta-analysis","volume":"3","author":"Buskbjerg","year":"2019","journal-title":"Journal of the Endocrine Society"},{"key":"10.1016\/j.archger.2024.105684_bib0009","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/jnr.23863","article-title":"Sex differences in brain-derived neurotrophic factor signaling and functions","volume":"95","author":"Chan","year":"2017","journal-title":"Journal of Neuroscience Research"},{"key":"10.1016\/j.archger.2024.105684_bib0010","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.12659\/MSM.905064","article-title":"Genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease","volume":"23","author":"Chang","year":"2017","journal-title":"Medical Science Monitor : International Medical Journal of Experimental and Clinical Research"},{"key":"10.1016\/j.archger.2024.105684_bib0011","unstructured":"Chen, J., Bardes, E.E., Aronow, B.J., Jegga, A.G., 2009. ToppGene suite."},{"key":"10.1016\/j.archger.2024.105684_bib0012","first-page":"371","article-title":"[Effect of HIF-1alpha on sex hormone levels and germ cell apoptosis of mice]","volume":"29","author":"Chen","year":"2013","journal-title":"Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese Journal of Applied Physiology"},{"key":"10.1016\/j.archger.2024.105684_bib0013","article-title":"Regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders","volume":"13","author":"Chen","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.archger.2024.105684_bib0014","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/260896","article-title":"Dopamine treatment and cognitive functioning in individuals with Parkinson's disease: The \"cognitive flexibility\" hypothesis seems to work","volume":"2014","author":"Costa","year":"2014","journal-title":"Behavioural Neurology"},{"key":"10.1016\/j.archger.2024.105684_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2019.146385","article-title":"The sex-specific interaction of the microbiome in neurodegenerative diseases","volume":"1724","author":"Cox","year":"2019","journal-title":"Brain Research"},{"key":"10.1016\/j.archger.2024.105684_bib0016","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0266144","article-title":"Anti-inflammatory effects of progesterone through NF-\u03baB and MAPK pathway in lipopolysaccharide- or Escherichia coli-stimulated bovine endometrial stromal cells","volume":"17","author":"Cui","year":"2022","journal-title":"PloS One"},{"key":"10.1016\/j.archger.2024.105684_bib0017","doi-asserted-by":"crossref","first-page":"6385","DOI":"10.1523\/JNEUROSCI.19-15-06385.1999","article-title":"Estradiol modulates bcl-2 in cerebral ischemia: A potential role for estrogen receptors","volume":"19","author":"Dena","year":"1999","journal-title":"The Journal of Neuroscience"},{"key":"10.1016\/j.archger.2024.105684_bib0018","doi-asserted-by":"crossref","first-page":"18509","DOI":"10.1038\/s41598-019-54782-y","article-title":"Investigating the energy crisis in Alzheimer disease using transcriptome study","volume":"9","author":"Dharshini","year":"2019","journal-title":"Scientific Reports"},{"key":"10.1016\/j.archger.2024.105684_bib0019","doi-asserted-by":"crossref","unstructured":"dos Santos, R.L., da Silva, F.B., Ribeiro, R.F., Stefanon, I., 2014. Sex hormones in the cardiovascular system. 18, 89-103.","DOI":"10.1515\/hmbci-2013-0048"},{"key":"10.1016\/j.archger.2024.105684_bib0020","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1261\/rna.2414110","article-title":"MicroRNA sponges: progress and possibilities","volume":"16","author":"Ebert","year":"2010","journal-title":"RNA (New York, N.Y.)"},{"key":"10.1016\/j.archger.2024.105684_bib0021","doi-asserted-by":"crossref","first-page":"e94891","DOI":"10.1371\/journal.pone.0094891","article-title":"Lactobacillus amylovorus inhibits the TLR4 inflammatory signaling triggered by enterotoxigenic Escherichia coli via modulation of the negative regulators and involvement of TLR2 in intestinal Caco-2 cells and pig explants","volume":"9","author":"Finamore","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.archger.2024.105684_bib0022","article-title":"Progesterone's effects on cognitive performance of male mice are independent of progestin receptors but relate to increases in GABA(A) activity in the hippocampus and cortex","volume":"11","author":"Frye","year":"2020","journal-title":"Frontiers in Endocrinology (Lausanne)"},{"key":"10.1016\/j.archger.2024.105684_bib0023","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.ajpath.2021.11.013","article-title":"Apolipoprotein E proteinopathy is a major dementia-associated pathologic biomarker in individuals with or without the APOE epsilon 4 allele","volume":"192","author":"Gal","year":"2022","journal-title":"The American Journal of Pathology"},{"key":"10.1016\/j.archger.2024.105684_bib0024","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1097\/00001756-199803090-00006","article-title":"Estradiol upregulates Bcl-2 expression in adult brain neurons","volume":"9","author":"Garcia-Segura","year":"1998","journal-title":"Neuroreport"},{"key":"10.1016\/j.archger.2024.105684_bib0025","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1476-4598-11-80","article-title":"Hypoxia and estrogen are functionally equivalent in breast cancer-endothelial cell interdependence","volume":"11","author":"George","year":"2012","journal-title":"Molecular Cancer"},{"key":"10.1016\/j.archger.2024.105684_bib0026","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.937133","article-title":"Neuronal cell death mechanisms in Alzheimer's disease: An insight","volume":"15","author":"Goel","year":"2022","journal-title":"Frontiers in Molecular Neuroscience"},{"key":"10.1016\/j.archger.2024.105684_bib0027","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhepr.2022.100509","article-title":"Abnormal brain oxygen homeostasis in an animal model of liver disease","volume":"4","author":"Hadjihambi","year":"2022","journal-title":"JHEP Reports: Innovation in Hepatology"},{"key":"10.1016\/j.archger.2024.105684_bib0028","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1758-2946-4-17","article-title":"Avogadro: An advanced semantic chemical editor, visualization, and analysis platform","volume":"4","author":"Hanwell","year":"2012","journal-title":"Journal of Cheminformatics"},{"key":"10.1016\/j.archger.2024.105684_bib0029","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1126\/science.1566067","article-title":"Alzheimer's disease: The amyloid cascade hypothesis","volume":"256","author":"Hardy","year":"1992","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.archger.2024.105684_bib0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155632","article-title":"MIF-mediated NF-\u03baB signaling pathway regulates the pathogenesis of polycystic ovary syndrome in rats","volume":"146","author":"He","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.archger.2024.105684_bib0031","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/bpa.12688","article-title":"Early growth response-1 regulates acetylcholinesterase and its relation with the course of Alzheimer's disease","volume":"29","author":"Hu","year":"2019","journal-title":"Brain Pathology (Zurich, Switzerland)"},{"key":"10.1016\/j.archger.2024.105684_bib0032","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1097\/WNN.0000000000000104","article-title":"Effects of testosterone therapy on cognitive function in aging: A systematic review","volume":"29","author":"Hua","year":"2016","journal-title":"Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology"},{"key":"10.1016\/j.archger.2024.105684_bib0033","first-page":"e67","article-title":"Impact of hypertension on cognitive function: A scientific statement from the American heart association","volume":"68","author":"Iadecola","year":"2016","journal-title":"Hypertension (Dallas, Tex. : 1979)"},{"key":"10.1016\/j.archger.2024.105684_bib0034","unstructured":"ICD-10, 2010. Mild cognitive disorder."},{"key":"10.1016\/j.archger.2024.105684_bib0035","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1007\/s10571-016-0440-6","article-title":"The role of hypoxia-inducible factor 1 in mild cognitive impairment","volume":"37","author":"Iyalomhe","year":"2017","journal-title":"Cellular and Molecular Neurobiology"},{"key":"10.1016\/j.archger.2024.105684_bib0036","doi-asserted-by":"crossref","first-page":"5467","DOI":"10.1210\/en.2012-1464","article-title":"17\u03b2-estradiol and progesterone regulate expression of \u03b2-amyloid clearance factors in primary neuron cultures and female rat brain","volume":"153","author":"Jayaraman","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.archger.2024.105684_bib0037","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00023210-200822010-00001","article-title":"The role of peroxisome proliferator-activated receptor-gamma (PPARgamma) in Alzheimer's disease: Therapeutic implications","volume":"22","author":"Jiang","year":"2008","journal-title":"CNS Drugs"},{"key":"10.1016\/j.archger.2024.105684_bib0038","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/aja.2008.12","article-title":"Testosterone alleviates tumor necrosis factor-alpha-mediated tissue factor pathway inhibitor downregulation via suppression of nuclear factor-kappa B in endothelial cells","volume":"11","author":"Jin","year":"2009","journal-title":"Asian Journal of Andrology"},{"key":"10.1016\/j.archger.2024.105684_bib0039","unstructured":"KEGG, 2023. HIF-1 signaling pathway - Homo sapiens (human)."},{"key":"10.1016\/j.archger.2024.105684_bib0040","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12974-022-02549-0","article-title":"Nilotinib modulates LPS-induced cognitive impairment and neuroinflammatory responses by regulating P38\/STAT3 signaling","volume":"19","author":"Kim","year":"2022","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.archger.2024.105684_bib0041","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.molmet.2014.05.007","article-title":"ER\u03b1 upregulates Phd3 to ameliorate HIF-1 induced fibrosis and inflammation in adipose tissue","volume":"3","author":"Kim","year":"2014","journal-title":"Molecular Metabolism"},{"key":"10.1016\/j.archger.2024.105684_bib0042","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2020.110954","article-title":"miR-16-5p is upregulated by amyloid \u03b2 deposition in Alzheimer's disease models and induces neuronal cell apoptosis through direct targeting and suppression of BCL-2","volume":"136","author":"Kim","year":"2020","journal-title":"Experimental Gerontology"},{"key":"10.1016\/j.archger.2024.105684_bib0043","doi-asserted-by":"crossref","first-page":"11512","DOI":"10.1074\/jbc.M008556200","article-title":"Progesterone stimulates adipocyte determination and differentiation 1\/sterol regulatory element-binding protein 1c gene expression: Potential mechanism for the lipogenic effect of progesterone in adipose tissue*","volume":"276","author":"Lacasa","year":"2001","journal-title":"The Journal of Biological Chemistry"},{"key":"10.1016\/j.archger.2024.105684_bib0044","doi-asserted-by":"crossref","unstructured":"Lagunin, A., Stepanchikova, A., Filimonov, D., Poroikov, V.J.B., 2000. PASS: prediction of activity spectra for biologically active substances. 16, 747-748.","DOI":"10.1093\/bioinformatics\/16.8.747"},{"key":"10.1016\/j.archger.2024.105684_bib0045","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/alz.12610","article-title":"Role of chronic neuroinflammation in neuroplasticity and cognitive function: A hypothesis","volume":"18","author":"Lecca","year":"2022","journal-title":"Alzheimer's & Dementia"},{"key":"10.1016\/j.archger.2024.105684_bib0046","first-page":"2316","article-title":"The etiological effect of a new low-frequency ESR1 variant on mild cognitive impairment and Alzheimer's disease: A population-based study","volume":"10","author":"Li","year":"2018","journal-title":"Aging (Albany N. Y.)"},{"key":"10.1016\/j.archger.2024.105684_bib0047","unstructured":"Liao, Y., Wang, J., Jaehnig, E.J., Shi, Z., Zhang, B., 2019a. WebGestalt."},{"key":"10.1016\/j.archger.2024.105684_bib0048","doi-asserted-by":"crossref","first-page":"W199","DOI":"10.1093\/nar\/gkz401","article-title":"WebGestalt 2019: Gene set analysis toolkit with revamped UIs and APIs","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.archger.2024.105684_bib0049","unstructured":"Licursi, V., 2019. MIENTURNET (MicroRNA ENrichment TURned NETwork)."},{"key":"10.1016\/j.archger.2024.105684_bib0050","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1186\/s12859-019-3105-x","article-title":"MIENTURNET: An interactive web tool for microRNA-target enrichment and network-based analysis","volume":"20","author":"Licursi","year":"2019","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.archger.2024.105684_bib0051","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13195-022-00997-7","article-title":"Subclinical carotid artery atherosclerosis and cognitive function in older adults","volume":"14","author":"Lin","year":"2022","journal-title":"Alzheimer's Research & Therapy"},{"key":"10.1016\/j.archger.2024.105684_bib0052","article-title":"Testosterone improves the differentiation efficiency of insulin-producing cells from human induced pluripotent stem cells","volume":"12","author":"Liu","year":"2017","journal-title":"PloS One"},{"key":"10.1016\/j.archger.2024.105684_bib0053","first-page":"8595","article-title":"ESR1 dysfunction triggers neuroinflammation as a critical upstream causative factor of the Alzheimer's disease process","volume":"14","author":"Liu","year":"2022","journal-title":"Aging (Albany N. Y.)"},{"key":"10.1016\/j.archger.2024.105684_bib0054","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11357-011-9367-5","article-title":"Effect of Bcl-2 rs956572 SNP on regional gray matter volumes and cognitive function in elderly males without dementia","volume":"35","author":"Liu","year":"2013","journal-title":"Age (Dordrecht, Netherlands)"},{"key":"10.1016\/j.archger.2024.105684_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112681","article-title":"MicroRNAs in Alzheimer's disease: Potential diagnostic markers and therapeutic targets","volume":"148","author":"Liu","year":"2022","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.archger.2024.105684_bib0056","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/1567202617666200414142637","article-title":"Overexpression of miR-26a-5p suppresses tau phosphorylation and A\u03b2 accumulation in the Alzheimer's disease mice by targeting DYRK1A","volume":"17","author":"Liu","year":"2020","journal-title":"Current Neurovascular Research"},{"key":"10.1016\/j.archger.2024.105684_bib0057","doi-asserted-by":"crossref","DOI":"10.3390\/ijms221810139","article-title":"Brain renin-angiotensin system as novel and potential therapeutic target for Alzheimer's disease","volume":"22","author":"Loera-Valencia","year":"2021","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.archger.2024.105684_bib0058","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1002\/alz.12341","article-title":"Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1\u03b2 drives amplified responses in primed astrocytes and neuronal network dysfunction","volume":"17","author":"Lopez-Rodriguez","year":"2021","journal-title":"Alzheimer's & Dementia: The Journal of the Alzheimer's Association"},{"key":"10.1016\/j.archger.2024.105684_bib0059","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/alz.12529","article-title":"Lower serum testosterone concentrations are associated with a higher incidence of dementia in men: The UK Biobank prospective cohort study","volume":"18","author":"Marriott","year":"2022","journal-title":"Alzheimer's & Dementia"},{"key":"10.1016\/j.archger.2024.105684_bib0060","doi-asserted-by":"crossref","first-page":"373","DOI":"10.31887\/DCNS.2016.18.4\/jmarrocco","article-title":"Sex in the brain: Hormones and sex differences","volume":"18","author":"Marrocco","year":"2016","journal-title":"Dialogues in Clinical Neuroscience"},{"key":"10.1016\/j.archger.2024.105684_bib0061","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1007\/s12035-022-03152-3","article-title":"The interaction between NF-\u03baB and estrogen in Alzheimer's disease","volume":"60","author":"Mishra","year":"2023","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.archger.2024.105684_bib0062","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2012.10.002","article-title":"PI3K\/Akt and NF-\u03baB activation following intravitreal administration of 17\u03b2-estradiol: Neuroprotection of the rat retina from light-induced apoptosis","volume":"228","author":"Mo","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.archger.2024.105684_bib0063","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/s41579-020-00460-0","article-title":"The gut microbiota\u2013brain axis in behaviour and brain disorders","volume":"19","author":"Morais","year":"2021","journal-title":"Nature Reviews Microbiology"},{"key":"10.1016\/j.archger.2024.105684_bib0064","unstructured":"NC_State_University, 2023. Comparative toxicogenomics database."},{"key":"10.1016\/j.archger.2024.105684_bib0065","article-title":"Resveratrol, endocrine disrupting chemicals, neurodegenerative diseases and depression: Genes, transcription factors, microRNAs, and sponges involved","author":"Nguyen","year":"2022","journal-title":"Neurochemical Research"},{"key":"10.1016\/j.archger.2024.105684_bib0066","article-title":"The effects of a mixture of cadmium, lead, and mercury on metabolic syndrome and its components, as well as cognitive impairment: Genes, MicroRNAs, transcription factors, and sponge relationships","author":"Nguyen","year":"2022","journal-title":"Biological Trace Element Research"},{"key":"10.1016\/j.archger.2024.105684_bib0067","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153164","article-title":"Exposure to a mixture of heavy metals induces cognitive impairment: Genes and microRNAs involved","author":"Nguyen","year":"2022","journal-title":"Toxicology"},{"key":"10.1016\/j.archger.2024.105684_bib0068","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2022.109326","article-title":"The protective effects of curcumin on metabolic syndrome and its components: In-silico analysis for genes, transcription factors, and microRNAs involved","volume":"727","author":"Nguyen","year":"2022","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"10.1016\/j.archger.2024.105684_bib0069","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiolchem.2023.107872","article-title":"Identification of promising inhibitory heterocyclic compounds against acetylcholinesterase using QSAR, ADMET, biological activity, and molecular docking","author":"Nguyen","year":"2023","journal-title":"Computational Biology and Chemistry"},{"key":"10.1016\/j.archger.2024.105684_bib0070","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neuro.2023.04.011","article-title":"In silico identification of molecular mechanisms for stroke risk caused by heavy metals and their mixtures: Sponges and drugs involved","volume":"96","author":"Nguyen","year":"2023","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.archger.2024.105684_bib0071","doi-asserted-by":"crossref","first-page":"2842","DOI":"10.1073\/pnas.0438041100","article-title":"Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression","volume":"100","author":"Nilsen","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.archger.2024.105684_bib0072","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s41465-019-00156-1","article-title":"Sex hormones as cognitive enhancers?","volume":"4","author":"N\u00fa\u00f1ez","year":"2020","journal-title":"Journal of Cognitive Enhancement"},{"key":"10.1016\/j.archger.2024.105684_bib0073","first-page":"266","article-title":"Interactions between oestrogen and the renin angiotensin system - potential mechanisms for gender differences in Alzheimer's disease","volume":"1","author":"O'Hagan","year":"2012","journal-title":"American Journal of Neurodegenerative Disease"},{"key":"10.1016\/j.archger.2024.105684_bib0074","unstructured":"Organization, W.H., 2021. Dementia (Basel, Switzerland)."},{"key":"10.1016\/j.archger.2024.105684_bib0075","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1212\/WNL.0b013e3181b6bbe3","article-title":"Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease","volume":"73","author":"Pilotto","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.archger.2024.105684_bib0076","doi-asserted-by":"crossref","unstructured":"Pittman, R.N., 2016. Regulation of tissue oxygenation.","DOI":"10.4199\/C00140ED2V01Y201606ISP065"},{"key":"10.1016\/j.archger.2024.105684_bib0077","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114295","article-title":"Minocycline treatment improves cognitive and functional plasticity in a preclinical mouse model of major depressive disorder","volume":"441","author":"Poggini","year":"2023","journal-title":"Behavioural Brain Research"},{"key":"10.1016\/j.archger.2024.105684_bib0078","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1007\/BF02245226","article-title":"Post-training minaprine enhances memory storage in mice: Involvement of D1 and D2 dopamine receptors","volume":"113","author":"Puglisi-Allegra","year":"1994","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.archger.2024.105684_bib0079","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1742-2094-8-34","article-title":"The CCAAT\/enhancer binding protein (C\/EBP) \u03b4 is differently regulated by fibrillar and oligomeric forms of the Alzheimer amyloid-\u03b2 peptide","volume":"8","author":"Ramberg","year":"2011","journal-title":"Journal of Neuroinflammation"},{"key":"10.1016\/j.archger.2024.105684_bib0080","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1056\/NEJMc2215148","article-title":"Multiple cerebral hemorrhages in a patient receiving Lecanemab and treated with t-PA for stroke","volume":"388","author":"Reish","year":"2023","journal-title":"The New England Journal of Medicine"},{"key":"10.1016\/j.archger.2024.105684_bib0081","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.3389\/fmicb.2020.02032","article-title":"Berry polyphenols and fibers modulate distinct microbial metabolic functions and gut microbiota enterotype-like clustering in obese mice","volume":"11","author":"Rodr\u00edguez-Daza","year":"2020","journal-title":"Frontiers in Microbiology"},{"key":"10.1016\/j.archger.2024.105684_bib0082","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25235681","article-title":"Capsaicin and gut microbiota in health and disease","volume":"25","author":"Rosca","year":"2020","journal-title":"Molecules (Basel, Switzerland)"},{"key":"10.1016\/j.archger.2024.105684_bib0083","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1176\/jnp.2009.21.4.445","article-title":"Sertraline improves executive function in patients with vascular cognitive impairment","volume":"21","author":"Royall","year":"2009","journal-title":"The Journal of Neuropsychiatry and Clinical Neurosciences"},{"key":"10.1016\/j.archger.2024.105684_bib0084","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1016\/j.celrep.2016.09.093","article-title":"A Gata2-dependent transcription network regulates uterine progesterone responsiveness and endometrial function","volume":"17","author":"Rubel","year":"2016","journal-title":"Cell Reports"},{"key":"10.1016\/j.archger.2024.105684_bib0085","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1038\/ni.1657","article-title":"Triggering the succinate receptor GPR91 on dendritic cells enhances immunity","volume":"9","author":"Rubic","year":"2008","journal-title":"Nature Immunology"},{"key":"10.1016\/j.archger.2024.105684_bib0086","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1007\/s10571-019-00733-0","article-title":"The impact of estradiol on neurogenesis and cognitive functions in Alzheimer's Disease","volume":"40","author":"Sahab-Negah","year":"2020","journal-title":"Cellular and Molecular Neurobiology"},{"key":"10.1016\/j.archger.2024.105684_bib0087","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/jamaneurol.2021.4161","article-title":"Amyloid-Related Imaging Abnormalities in 2 Phase 3 studies evaluating aducanumab in patients with early Alzheimer disease","volume":"79","author":"Salloway","year":"2022","journal-title":"JAMA Neurology"},{"key":"10.1016\/j.archger.2024.105684_bib0088","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1248\/bpb.b12-00868","article-title":"The effect of sex hormones on peroxisome proliferator-activated receptor gamma expression and activity in mature adipocytes","volume":"36","author":"Sato","year":"2013","journal-title":"Biological & Pharmaceutical Bulletin"},{"key":"10.1016\/j.archger.2024.105684_bib0089","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/s11626-019-00328-5","article-title":"Repression of insulin gene transcription by indirect genomic signaling via the estrogen receptor in pancreatic beta cells","volume":"55","author":"Sekido","year":"2019","journal-title":"In Vitro Cellular & Developmental Biology - Animal"},{"key":"10.1016\/j.archger.2024.105684_bib0090","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.682868","article-title":"Serotonin reuptake inhibitors and the gut microbiome: Significance of the gut microbiome in relation to mechanism of action, treatment response, side effects, and tachyphylaxis","volume":"12","author":"Sj\u00f6stedt","year":"2021","journal-title":"Frontiers in Psychiatry"},{"key":"10.1016\/j.archger.2024.105684_bib0091","doi-asserted-by":"crossref","first-page":"4535","DOI":"10.1523\/JNEUROSCI.0462-04.2004","article-title":"Cortical synaptic integration in vivo is disrupted by amyloid-beta plaques","volume":"24","author":"Stern","year":"2004","journal-title":"The Journal of Neuroscience : The Official Journal of the Society for Neuroscience"},{"key":"10.1016\/j.archger.2024.105684_bib0092","article-title":"Comparative metagenomics and metabolomes reveals abnormal metabolism activity is associated with gut microbiota in Alzheimer's disease mice","volume":"23","author":"Sun","year":"2022","journal-title":"International Journal of Molecular Sciences"},{"key":"10.1016\/j.archger.2024.105684_bib0093","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13293-020-00310-x","article-title":"Sex differences in Alzheimer's-related Tau biomarkers and a mediating effect of testosterone","volume":"11","author":"Sundermann","year":"2020","journal-title":"Biology of Sex Differences"},{"key":"10.1016\/j.archger.2024.105684_bib0094","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S1474-4422(23)00248-X","article-title":"Time to get serious about the global action plan on dementia","volume":"22","year":"2023","journal-title":"The Lancet Neurology"},{"key":"10.1016\/j.archger.2024.105684_bib0095","doi-asserted-by":"crossref","first-page":"21","DOI":"10.5021\/ad.2020.32.1.21","article-title":"Minocycline and its impact on microbial dysbiosis in the skin and gastrointestinal tract of acne patients","volume":"32","author":"Thompson","year":"2020","journal-title":"Annals of Dermatology"},{"key":"10.1016\/j.archger.2024.105684_bib0096","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1007\/s12035-021-02283-3","article-title":"Targeting insulin resistance to treat cognitive dysfunction","volume":"58","author":"Tyagi","year":"2021","journal-title":"Molecular Neurobiology"},{"key":"10.1016\/j.archger.2024.105684_bib0097","unstructured":"University_of_Toronto, 2022. GeneMANIA."},{"key":"10.1016\/j.archger.2024.105684_bib0098","unstructured":"USFDA, 2021. FDA grants accelerated approval for Alzheimer's drug."},{"key":"10.1016\/j.archger.2024.105684_bib0099","unstructured":"USFDA, 2023. FDA grants accelerated approval for Alzheimer's disease treatment."},{"key":"10.1016\/j.archger.2024.105684_bib0100","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1161\/STROKEAHA.123.040499","article-title":"Cognitive impairment in patients with cardiac disease: implications for clinical practice","volume":"54","author":"van Nieuwkerk","year":"2023","journal-title":"Stroke"},{"key":"10.1016\/j.archger.2024.105684_bib0101","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1038\/mp.2012.147","article-title":"Associations between gonadotropins, testosterone and \u03b2 amyloid in men at risk of Alzheimer's disease","volume":"19","author":"Verdile","year":"2014","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.archger.2024.105684_bib0102","unstructured":"VIB\/UGent, 2022. Veen diagram."},{"key":"10.1016\/j.archger.2024.105684_bib0103","doi-asserted-by":"crossref","first-page":"13537","DOI":"10.1038\/s41598-017-13601-y","article-title":"Gut microbiome alterations in Alzheimer's disease","volume":"7","author":"Vogt","year":"2017","journal-title":"Scientific Reports"},{"key":"10.1016\/j.archger.2024.105684_bib0104","doi-asserted-by":"crossref","first-page":"93","DOI":"10.2174\/1567202617666200128141938","article-title":"MiR-335-5p inhibits \u03b2-Amyloid (A\u03b2) accumulation to attenuate cognitive deficits through targeting c-jun-N-terminal Kinase 3 in Alzheimer's disease","volume":"17","author":"Wang","year":"2020","journal-title":"Current Neurovascular Research"},{"key":"10.1016\/j.archger.2024.105684_bib0105","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/s41398-020-00918-y","article-title":"Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer's disease-type pathology and cognitive deficits in APP\/PS1 mice","volume":"10","author":"Wang","year":"2020","journal-title":"Translational Psychiatry"},{"key":"10.1016\/j.archger.2024.105684_bib0106","unstructured":"Way2Drug, 2011. PASS online."},{"key":"10.1016\/j.archger.2024.105684_bib0107","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s11897-022-00555-0","article-title":"Evaluation of the interaction of sex hormones and cardiovascular function and health","volume":"19","author":"Willemars","year":"2022","journal-title":"Current Heart Failure Reports"},{"key":"10.1016\/j.archger.2024.105684_bib0108","doi-asserted-by":"crossref","first-page":"e36890","DOI":"10.1371\/journal.pone.0036890","article-title":"Estrogen modulates NF\u03baB signaling by enhancing I\u03baB\u03b1 levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-\u03b2","volume":"7","author":"Xing","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.archger.2024.105684_bib0109","doi-asserted-by":"crossref","first-page":"15172","DOI":"10.1073\/pnas.1422015112","article-title":"Estrogen receptor-\u03b1 directly regulates the hypoxia-inducible factor 1 pathway associated with antiestrogen response in breast cancer","volume":"112","author":"Yang","year":"2015","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.archger.2024.105684_bib0110","doi-asserted-by":"crossref","first-page":"30557","DOI":"10.1021\/acsami.2c06283","article-title":"Multifunctional selenium nanoparticles with different surface modifications ameliorate neuroinflammation through the gut microbiota-NLRP3 inflammasome-brain axis in APP\/PS1 mice","volume":"14","author":"Yang","year":"2022","journal-title":"ACS Applied Materials & Interfaces"},{"key":"10.1016\/j.archger.2024.105684_bib0111","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114544","article-title":"The potential roles of ATF family in the treatment of Alzheimer's disease","volume":"161","author":"Yang","year":"2023","journal-title":"Biomedicine & Pharmacotherapy"},{"key":"10.1016\/j.archger.2024.105684_bib0112","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.bja.2021.08.028","article-title":"Testosterone attenuates sevoflurane-induced tau phosphorylation and cognitive impairment in neonatal male mice","volume":"127","author":"Yang","year":"2021","journal-title":"British Journal of Anaesthesia"},{"key":"10.1016\/j.archger.2024.105684_bib0113","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.gendis.2018.04.008","article-title":"The effect of NR4A1 on APP metabolism and tau phosphorylation","volume":"5","author":"Zhao","year":"2018","journal-title":"Genes & Diseases"},{"key":"10.1016\/j.archger.2024.105684_bib0114","doi-asserted-by":"crossref","unstructured":"Zhou,Y., Zhou, B., Pache, L., Chang, M., Khodabakhshi, AH, Tanaseichuk, O., Benner, C., Chanda, S.K. (2019a). Metascape provides a biologist-oriented resource for the analysis of systems-level datasets. Nature Communications 10(1),1523. 10.1038\/s41467-019-09234-6.","DOI":"10.1038\/s41467-019-09234-6"},{"key":"10.1016\/j.archger.2024.105684_bib0115","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nature Communications"},{"key":"10.1016\/j.archger.2024.105684_bib0116","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.953417","article-title":"The role of sex and ovarian hormones in hippocampal damage and cognitive deficits induced by chronic exposure to hypobaric hypoxia","volume":"16","author":"Zhu","year":"2022","journal-title":"Frontiers in Neuroscience"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494324003601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494324003601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,7]],"date-time":"2024-12-07T09:12:03Z","timestamp":1733562723000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494324003601"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":116,"alternative-id":["S0167494324003601"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2024.105684","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The molecular mechanisms of steroid hormone effects on cognitive function","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2024.105684","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"105684"}}