{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T18:54:46Z","timestamp":1784400886087,"version":"3.55.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Archives of Gerontology and Geriatrics"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.archger.2024.105703","type":"journal-article","created":{"date-parts":[[2024,11,25]],"date-time":"2024-11-25T07:44:03Z","timestamp":1732520643000},"page":"105703","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The polygenic hazard score mediates the association between plasma neurofilament light chain and brain morphometry in dementia spectrum"],"prefix":"10.1016","volume":"130","author":[{"given":"Hamide","family":"Nasiri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4285-3530","authenticated-orcid":false,"given":"Mohammad Hossein","family":"Azaraein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Shakeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Sadeghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmadreza","family":"Sohrabi-Ashlaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soorin","family":"Berenjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Karimian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Hoseinzadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoumeh Saberi","family":"Rounkian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Mayeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.archger.2024.105703_bib0001","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/6668159","article-title":"Novel biomarkers for Alzheimer's disease: plasma neurofilament light and cerebrospinal fluid","volume":"2024","author":"Abukuri","year":"2024","journal-title":"International journal of Alzheimer's disease"},{"issue":"1","key":"10.1016\/j.archger.2024.105703_bib0002","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.biopsych.2006.10.027","article-title":"Greater cortical gray matter density in lithium-treated patients with bipolar disorder","volume":"62","author":"Bearden","year":"2007","journal-title":"Biological psychiatry"},{"key":"10.1016\/j.archger.2024.105703_bib0003","doi-asserted-by":"crossref","DOI":"10.1007\/s10654-024-01131-7","article-title":"Serum neurofilament light chain as a prognostic marker of all-cause mortality in a national sample of US adults","author":"Beydoun","year":"2024","journal-title":"European journal of epidemiology"},{"issue":"2","key":"10.1016\/j.archger.2024.105703_bib0004","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25021231","article-title":"Multi-omic blood biomarkers as dynamic risk predictors in late-onset Alzheimer's disease","volume":"25","author":"Bhalala","year":"2024","journal-title":"International journal of molecular sciences"},{"issue":"5","key":"10.1016\/j.archger.2024.105703_bib0005","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/acn3.51529","article-title":"Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease","volume":"9","author":"Brickman","year":"2022","journal-title":"Annals of clinical and translational neurology"},{"issue":"1","key":"10.1016\/j.archger.2024.105703_bib0006","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1109\/42.750253","article-title":"Global, voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain","volume":"18","author":"Bullmore","year":"1999","journal-title":"IEEE Transactions on medical imaging"},{"key":"10.1016\/j.archger.2024.105703_bib0007","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1017\/S1355617723003235","article-title":"4 Association between plasma neurofilament light chain (NfL) and non-verbal abstract reasoning in a colombian cohort with autosomal dominant Alzheimer's disease","volume":"29","author":"Cabrera","year":"2023","journal-title":"Journal of the International Neuropsychological Society"},{"issue":"S2","key":"10.1016\/j.archger.2024.105703_bib0008","doi-asserted-by":"crossref","DOI":"10.1002\/alz.062045","article-title":"Differential associations between plasma neurofilament light and brain functional connectivity in patients with Alzheimer's disease and fronto-temporal dementia","volume":"19","author":"Chong","year":"2023","journal-title":"Alzheimer's & Dementia"},{"key":"10.1016\/j.archger.2024.105703_bib0009","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-231251","article-title":"Plasma neurofilament light relates to divergent default and salience network connectivity in Alzheimer's disease and behavioral variant frontotemporal dementia","author":"Chong","year":"2024","journal-title":"Journal of Alzheimer's disease : JAD"},{"issue":"2","key":"10.1016\/j.archger.2024.105703_bib0010","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/00004728-199403000-00005","article-title":"Automatic 3D intersubject registration of MR volumetric data in standardized Talairach space","volume":"18","author":"Collins","year":"1994","journal-title":"Journal of computer assisted tomography"},{"issue":"7","key":"10.1016\/j.archger.2024.105703_bib0011","article-title":"Neuropathology, neuroimaging, and fluid biomarkers in Alzheimer's disease","volume":"14","author":"Colvee-Martin","year":"2024","journal-title":"Diagnostics (Basel, Switzerland)"},{"issue":"2","key":"10.1016\/j.archger.2024.105703_bib0012","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jneumeth.2013.05.009","article-title":"A comparison of automated anatomical-behavioural mapping methods in a rodent model of stroke","volume":"218","author":"Crum","year":"2013","journal-title":"Journal of neuroscience methods"},{"issue":"23","key":"10.1016\/j.archger.2024.105703_bib0013","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1161\/CIRCULATIONAHA.115.015489","article-title":"Polygenic overlap between C-reactive protein, plasma lipids, and Alzheimer disease","volume":"131","author":"Desikan","year":"2015","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.archger.2024.105703_bib0014","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/brain\/awaa054","article-title":"Plasma tau, neurofilament light chain and amyloid-\u03b2 levels and risk of dementia; a population-based cohort study","volume":"143","author":"de Wolf","year":"2020","journal-title":"Brain : A journal of neurology"},{"issue":"5","key":"10.1016\/j.archger.2024.105703_bib0015","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/00004728-199809000-00031","article-title":"Modeling brain deformations in Alzheimer disease by fluid registration of serial 3D MR images","volume":"22","author":"Freeborough","year":"1998","journal-title":"Journal of computer assisted tomography"},{"issue":"2","key":"10.1016\/j.archger.2024.105703_bib0016","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1159\/000524390","article-title":"Alzheimer's disease plasma biomarkers distinguish clinical diagnostic groups in memory clinic patients","volume":"51","author":"Gerards","year":"2022","journal-title":"Dementia and geriatric cognitive disorders"},{"issue":"3","key":"10.1016\/j.archger.2024.105703_bib0017","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.neuroimage.2008.07.013","article-title":"Tensor-based morphometry as a neuroimaging biomarker for Alzheimer's disease: An MRI study of 676 AD, MCI, and normal subjects","volume":"43","author":"Hua","year":"2008","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.archger.2024.105703_bib0018","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.neuroimage.2009.07.011","article-title":"Optimizing power to track brain degeneration in Alzheimer's disease and mild cognitive impairment with tensor-based morphometry: An ADNI study of 515 subjects","volume":"48","author":"Hua","year":"2009","journal-title":"NeuroImage"},{"key":"10.1016\/j.archger.2024.105703_bib0019","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1375302","article-title":"Plasma GFAP, NfL and pTau 181 detect preclinical stages of dementia","volume":"15","author":"Ingannato","year":"2024","journal-title":"Frontiers in endocrinology"},{"issue":"4","key":"10.1016\/j.archger.2024.105703_bib0020","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1002\/jmri.21049","article-title":"The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods","volume":"27","author":"Jack","year":"2008","journal-title":"Journal of Magnetic Resonance Imaging"},{"key":"10.1016\/j.archger.2024.105703_bib0021","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fnins.2018.00260","article-title":"Combining polygenic hazard score with volumetric MRI and cognitive measures improves prediction of progression from mild cognitive impairment to alzheimer's disease","volume":"12","author":"Kauppi","year":"2018","journal-title":"Frontiers in neuroscience"},{"issue":"1","key":"10.1016\/j.archger.2024.105703_bib0022","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s13195-024-01477-w","article-title":"Blood biomarkers of neurodegeneration associate differently with amyloid deposition, medial temporal atrophy, and cerebrovascular changes in APOE \u03b54-enriched cognitively unimpaired elderly","volume":"16","author":"Koivum\u00e4ki","year":"2024","journal-title":"Alzheimer's research & therapy"},{"key":"10.1016\/j.archger.2024.105703_bib0023","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3389\/fnins.2020.00804","article-title":"Entorhinal and transentorhinal atrophy in preclinical Alzheimer's disease","volume":"14","author":"Kulason","year":"2020","journal-title":"Frontiers in neuroscience"},{"issue":"1","key":"10.1016\/j.archger.2024.105703_bib0024","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13195-021-00953-x","article-title":"Serum neurofilament light chain level as a predictor of cognitive stage transition","volume":"14","author":"Lee","year":"2022","journal-title":"Alzheimers Res Ther"},{"issue":"3","key":"10.1016\/j.archger.2024.105703_bib0025","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1002\/acn3.716","article-title":"Polygenic risk and hazard scores for Alzheimer's disease prediction","volume":"6","author":"Leonenko","year":"2019","journal-title":"Annals of clinical and translational neurology"},{"issue":"3","key":"10.1016\/j.archger.2024.105703_bib0026","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.neuroimage.2009.01.004","article-title":"Alzheimer's disease neuroimaging initiative: A one-year follow up study using tensor-based morphometry correlating degenerative rates, biomarkers and cognition","volume":"45","author":"Leow","year":"2009","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.archger.2024.105703_bib0027","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13195-023-01221-w","article-title":"Plasma NfL is associated with the APOE \u03b54 allele, brain imaging measurements of neurodegeneration, and lower recall memory scores in cognitively unimpaired late-middle-aged and older adults","volume":"15","author":"Malek-Ahmadi","year":"2023","journal-title":"Alzheimer's research & therapy"},{"issue":"7","key":"10.1016\/j.archger.2024.105703_bib0028","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1001\/jamaneurol.2019.0765","article-title":"Association between longitudinal plasma neurofilament light and neurodegeneration in patients with Alzheimer disease","volume":"76","author":"Mattsson","year":"2019","journal-title":"JAMA neurology"},{"issue":"1412","key":"10.1016\/j.archger.2024.105703_bib0029","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1098\/rstb.2001.0915","article-title":"A probabilistic atlas and reference system for the human brain: International consortium for brain mapping (ICBM)","volume":"356","author":"Mazziotta","year":"2001","journal-title":"Philosophical transactions of the Royal Society of London. Series B, Biological sciences"},{"issue":"3","key":"10.1016\/j.archger.2024.105703_bib0030","doi-asserted-by":"crossref","first-page":"e252","DOI":"10.1212\/WNL.0000000000007767","article-title":"Plasma and CSF neurofilament light: Relation to longitudinal neuroimaging and cognitive measures","volume":"93","author":"Mielke","year":"2019","journal-title":"Neurology"},{"issue":"9","key":"10.1016\/j.archger.2024.105703_bib0031","first-page":"1797","article-title":"Plasma p-tau231 and p-tau217 as state markers of amyloid-\u03b2 pathology in preclinical Alzheimer's disease","volume":"28","author":"Mil\u00e0-Alom\u00e0","year":"2022","journal-title":"Nature medicine"},{"issue":"47","key":"10.1016\/j.archger.2024.105703_bib0032","doi-asserted-by":"crossref","first-page":"29338","DOI":"10.1073\/pnas.1912338117","article-title":"Representations of common event structure in medial temporal lobe and frontoparietal cortex support efficient inference","volume":"117","author":"Morton","year":"2020","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"10.1016\/j.archger.2024.105703_bib0033","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1186\/s13195-021-00919-z","article-title":"Dysregulated expression levels of APH1B in peripheral blood are associated with brain atrophy and amyloid-\u03b2 deposition in Alzheimer's disease","volume":"13","author":"Park","year":"2021","journal-title":"Alzheimer's research & therapy"},{"issue":"7","key":"10.1016\/j.archger.2024.105703_bib0034","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1016\/j.jalz.2015.05.009","article-title":"Genetic studies of quantitative MCI and AD phenotypes in ADNI: Progress, opportunities, and plans","volume":"11","author":"Saykin","year":"2015","journal-title":"Alzheimer's & dementia : The journal of the Alzheimer's Association"},{"key":"10.1016\/j.archger.2024.105703_bib0035","doi-asserted-by":"crossref","unstructured":"Schwinne, M., et al., The association of alzheimer's disease-related blood-based biomarkers with cognitive screening test performance in the congolese population in kinshasa. 2023.","DOI":"10.1101\/2023.08.28.23294740"},{"issue":"2","key":"10.1016\/j.archger.2024.105703_bib0036","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S1361-8415(02)00054-3","article-title":"BrainSuite: An automated cortical surface identification tool","volume":"6","author":"Shattuck","year":"2002","journal-title":"Medical image analysis"},{"issue":"4","key":"10.1016\/j.archger.2024.105703_bib0037","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1002\/ana.21610","article-title":"Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects","volume":"65","author":"Shaw","year":"2009","journal-title":"Annals of neurology"},{"issue":"3","key":"10.1016\/j.archger.2024.105703_bib0038","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.3233\/JAD-170531","article-title":"A decade of blood biomarkers for alzheimer's disease research: An evolving field, improving study designs, and the challenge of replication","volume":"62","author":"Shi","year":"2018","journal-title":"Journal of Alzheimer's disease : JAD"},{"issue":"4","key":"10.1016\/j.archger.2024.105703_bib0039","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0211575","article-title":"Plasma neurofilament light chain: A potential prognostic biomarker of dementia in adult down syndrome patients","volume":"14","author":"Shinomoto","year":"2019","journal-title":"PloS one"},{"issue":"1","key":"10.1016\/j.archger.2024.105703_bib0040","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s40478-020-01033-1","article-title":"Assessment of genetic risk for improved clinical-neuropathological correlations","volume":"8","author":"Spencer","year":"2020","journal-title":"Acta neuropathologica communications"},{"issue":"3","key":"10.1016\/j.archger.2024.105703_bib0041","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer's disease: Recommendations from the national institute on aging-Alzheimer's association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimer's & dementia : The journal of the Alzheimer's Association"},{"issue":"1","key":"10.1016\/j.archger.2024.105703_bib0042","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1002\/alz.13445","article-title":"CT-based volumetric measures obtained through deep learning: Association with biomarkers of neurodegeneration","volume":"20","author":"Srikrishna","year":"2024","journal-title":"Alzheimer's & dementia : the journal of the Alzheimer's Association"},{"issue":"3","key":"10.1016\/j.archger.2024.105703_bib0043","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/ana.25029","article-title":"Polygenic hazard scores in preclinical Alzheimer disease","volume":"82","author":"Tan","year":"2017","journal-title":"Annals of Neurology"},{"key":"10.1016\/j.archger.2024.105703_bib0044","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1196\/annals.1379.017","article-title":"Tracking Alzheimer's disease","volume":"1097","author":"Thompson","year":"2007","journal-title":"Annals of the New York Academy of Sciences"},{"key":"10.1016\/j.archger.2024.105703_bib0045","series-title":"Brain warping","author":"Toga","year":"1999"},{"issue":"1","key":"10.1016\/j.archger.2024.105703_bib0046","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s13195-021-00841-4","article-title":"A neurologist's perspective on serum neurofilament light in the memory clinic: A prospective implementation study","volume":"13","author":"Willemse","year":"2021","journal-title":"Alzheimer's research & therapy"}],"container-title":["Archives of Gerontology and Geriatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494324003789?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0167494324003789?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T19:09:44Z","timestamp":1736276984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0167494324003789"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":46,"alternative-id":["S0167494324003789"],"URL":"https:\/\/doi.org\/10.1016\/j.archger.2024.105703","relation":{},"ISSN":["0167-4943"],"issn-type":[{"value":"0167-4943","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The polygenic hazard score mediates the association between plasma neurofilament light chain and brain morphometry in dementia spectrum","name":"articletitle","label":"Article Title"},{"value":"Archives of Gerontology and Geriatrics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.archger.2024.105703","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105703"}}